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Effect of active compression-decompression resuscitation (ACD-CPR) on survival: a combined analysis using individual patient data.

Abstract：

:Active compression decompression resuscitation (ACD-CPR) has been developed as an alternative to standard cardiopulmonary resuscitation (S-CPR). To determine the effect of ACD-CPR on survival and neurologic outcome in patients with out-of-hospital cardiac arrest, this combined analysis involved individual patient data from 2866 patients from seven separate randomized prospective prehospital studies who had received ACD-CPR or S-CPR after out-of-hospital cardiac arrest in seven international sites. Significant improvement in 1-h survival (odds ratio (OR) = 0.83; confidence interval (CI): 0.695-0.99; P < 0.05) was found with ACD-CPR (n = 1410) versus S-CPR (n = 1456). The odds ratio for hospital discharge after ACD-CPR was similar (OR = 0.82; CI: 0.609-1.107, P = NS), but this finding was not statistically significant. Using the chi2-test for trend, there was a significant improvement in overall survival with ACD-CPR (P < 0.05) versus S-CPR. This improvement was largely due to the influence of results from one study site. Neurological outcome and complication rates were comparable between groups. Further study is needed to determine which emergency medical services systems may benefit from out-of-hospital use of ACD-CPR.

journal_name

Resuscitation

journal_title

Resuscitation

authors

Mauer DK,Nolan J,Plaisance P,Sitter H,Benoit H,Stiell IG,Sofianos E,Keiding N,Lurie KG

doi

10.1016/s0300-9572(99)00073-8

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

249-56

issue

3

eissn

0300-9572

issn

1873-1570

pii

S0300957299000738

journal_volume

41

pub_type

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