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Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5, 7-pentoxocanes and 1,2,4,5-tetroxanes.

Abstract：

:A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Kim HS,Shibata Y,Wataya Y,Tsuchiya K,Masuyama A,Nojima M

doi

10.1021/jm990014j

keywords:

subject

Has Abstract

pub_date

1999-07-15 00:00:00

pages

2604-9

issue

14

eissn

0022-2623

issn

1520-4804

pii

jm990014j

journal_volume

42

pub_type

杂志文章

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