Abstract:
:We report the first molecular defect in an NADH-dehydrogenase gene presenting as isolated myopathy. The proband had lifelong exercise intolerance but no weakness. A muscle biopsy showed cytochrome c oxidase (COX)-positive ragged-red fibers (RRFs), and analysis of the mitochondrial enzymes revealed complex I deficiency. Sequence analysis of the mitochondrial genes encoding the seven NADH-dehydrogenase subunits showed a G-to-A transition at nucleotide 11832 in the subunit 4 (ND4) gene, which changed an encoded tryptophan to a stop codon. The mutation was heteroplasmic (54%) in muscle DNA. Defects in mitochondrially encoded complex I subunits should be added to the differential diagnosis of mitochondrial myopathies.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Andreu AL,Tanji K,Bruno C,Hadjigeorgiou GM,Sue CM,Jay C,Ohnishi T,Shanske S,Bonilla E,DiMauro Sdoi
10.1002/1531-8249(199906)45:6<820::aid-ana22>3.0.ckeywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
820-3issue
6eissn
0364-5134issn
1531-8249journal_volume
45pub_type
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journal_title:Annals of neurology
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更新日期:2003-04-01 00:00:00
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journal_title:Annals of neurology
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更新日期:1982-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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