Abstract：
:The conversion of lysine to glutamate is needed for signaling in all plants and animals. In mouse embryonic stem (mES) cells, and probably their progenitors, endogenous glutamate production and signaling help maintain cellular pluripotency and proliferation, although the source of glutamate is yet to be determined. If the source of glutamate is lysine, then lysine deprivation caused by maternal low-protein diets could alter early embryo development and, consequently, the health of the offspring in adulthood. For these reasons, we measured three pertinent variables in human embryonic stem (hES) cells as a model for the inner cell masses of human blastocysts. We found that RNA encoding the alpha-aminoadipic semialdehyde synthase enzyme, which regulates glutamate production from lysine, was highly expressed in hES cells. Moreover, the mean amount of lysine consumed by hES cells was 50% greater than the mean amount of glutamate they produced, indicating that lysine is likely converted to glutamate in these cells. Finally, hES cells expressed RNA encoding at least two glutamate receptors. Since this may also be the case for hES progenitor cells in blastocysts, further studies are warranted to verify the presence of this signaling process in hES cells and to determine whether lysine deprivation alters early mammalian embryo development.
journal_name
Int J Environ Res Public Healthauthors
Van Winkle LJ,Galat V,Iannaccone PMdoi
10.3390/ijerph17155462subject
Has Abstractpub_date
2020-07-29 00:00:00issue
15eissn
1661-7827issn
1660-4601pii
ijerph17155462journal_volume
17pub_type
杂志文章abstract：:The coronavirus disease 2019 (COVID-19) was declared a global pandemic in early 2020. Due to the rapid spread of the virus and limited availability of effective treatments, health and social care systems worldwide quickly became overwhelmed. Such stressful circumstances are likely to have negative impacts on health an...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2020-07-20 00:00:00
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更新日期：2018-03-05 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of environmental research and public health
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journal_title：International journal of environmental research and public health
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
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pub_type： 杂志文章
doi：10.3390/ijerph17197229
更新日期：2020-10-02 00:00:00
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journal_title：International journal of environmental research and public health
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更新日期：2019-09-10 00:00:00
