Abstract：
OBJECTIVE:Brain-derived nerve growth factor (BDNF) plays an important role in cochlear development so it is plausible that it could restore hearing loss if delivered directly into the cochlea. We wished to confirm our previous report that a single intracochlear injection of brain-derived nerve growth factor (BDNF) was beneficial for hearing in guinea pigs. We wished to assess the reproducibility of our results and assess possible improved methods with a view to developing a clinical treatment for sensorineural hearing loss. METHODS:CDDP was used to create partial hearing loss in 25 guinea pigs. After 30 days the animals underwent ABR testing and unilateral BDNF injection through the round window in one ear and saline injection into the other ear. After allowing possible effects to stabilize, thirty days later, ABR threshold testing was repeated to assess change in threshold. RESULTS:Final ABR thresholds were 60-70 dB and were about 11 dB better in the ears treated with BDNF. CONCLUSION:Our original finding that Intracochlear BDNF can improve hearing in guinea pigs was confirmed, but the improvement demonstrated by the methods in this paper is too small for clinical application.
journal_name
J Otolaryngol Head Neck Surgjournal_title
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeauthors
Blakley BW,Seaman M,Alenezi Adoi
10.1186/s40463-020-00432-7subject
Has Abstractpub_date
2020-06-05 00:00:00pages
37issue
1eissn
1916-0208issn
1916-0216pii
10.1186/s40463-020-00432-7journal_volume
49pub_type
杂志文章abstract：OBJECTIVES:To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN:Prospective, double-blind, randomi...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Sudden sensorineural hearing loss (SSHL) is a disease, which severely affects the patient's social and relational life. The underlying pathomechanisms have not been finally clarified yet and outcome is not predictable. METHODS:We conducted a retrospective study in order to identify parameters that influence...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-017-0207-1
更新日期：2017-04-04 00:00:00
abstract：OBJECTIVE:To describe residents' satisfaction with Canadian Otolaryngology-Head and Neck Surgery programs. DESIGN:Electronic survey of 21 items scored on a 5-point Likert scale. SETTING:All Canadian Otolaryngology-Head and Neck Surgery residency programs were surveyed between February and April 2008. Responses were a...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Flexible nasolaryngoscopy is an essential component of the otolaryngological physical exam. Historically, the ability to create and share video recordings of these endoscopic exams has been limited by poor mobility of fixed endoscopy towers. The advent of smartphone endoscope adapters has allowed physicians ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,评审
doi：10.1186/s40463-018-0279-6
更新日期：2018-05-08 00:00:00
abstract：OBJECTIVE:The aim of the present study was to investigate cerebral hemodynamics in patients with sleep-disordered breathing of variable severity using cerebral near-infrared spectroscopy. DESIGN:Prospective study. SETTING:Tertiary training and research hospital. METHODS:The study was performed in patients referred f...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVES:To assess patient adherence to nasal spray regimens after endoscopic sinus surgery (ESS) and to study factors that predict adherence. METHODS:A three-arm, randomized, blinded, controlled trial was conducted at a tertiary care academic hospital, studied via a prospective longitudinal survey, of 60 consecutiv...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To perform a systematic review of measurement tools utilized for the diagnosis of nasal septal deviation (NSD). METHODS:Electronic database searches were performed using MEDLINE (from 1966 to second week of August 2013), EMBASE (from 1966 to second week of August 2013), Web of Science (from 1945 to second we...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,评审
doi：10.1186/1916-0216-43-11
更新日期：2014-04-24 00:00:00
abstract：BACKGROUND:Cisplatin-induced hearing loss is frequent and severe. Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin. The objective of the trial was to test the efficacy of trans-tympanic injections of a STS gel to prevent cisplatin-induced ototoxicity. METHODS:Eligible participants ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,随机对照试验
doi：10.1186/s40463-019-0327-x
更新日期：2019-01-16 00:00:00
abstract：OBJECTIVE:To better understand the differences in auditory systems across species. METHODS:Auditory brainstem response (ABR) click thresholds were obtained from normal 3- to 6-week-old animals including 15 guinea pigs, 62 mice, and 6 rats. Pure-tone ABR thresholds were obtained in 7 guinea pigs, 6 mice, and 13 rats. T...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVES:The efficacy and toxicity of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy or radiotherapy only and their impact on laryngeal preservation and survival were studied in patients with supraglottic cancer. METHODS:Forty-four patients with newly diagnosed supraglottic squamous cell carcinoma...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Lip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to defects under 65 %. METHODS:We describe a two-stage "modified Abbé island flap" technique whereby a ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-016-0148-0
更新日期：2016-05-31 00:00:00
abstract：BACKGROUND:Various methods have been described for tonsillectomy. Convincing evidence in the literature is still lacking regarding the optimal method of performing this surgical procedure. AIM:To investigate the outcome of bipolar scissors tonsillectomy and compare it to bipolar diathermy forceps tonsillectomy. METHO...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To assess wait times for surgery and radiotherapy in head and neck cancer patients from the Maritime provinces. METHODS:A retrospective chart review of 275 Maritime head and neck cancer patients treated between 2007 and 2009 by the tertiary Otolaryngology-Head and Neck Surgery Service at the Queen Elizabeth ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:The diagnosis of chronic rhinosinusitis (CRS) based on clinical presentation alone remains challenging. To improve the accuracy of clinical diagnosis, the Canadian Rhinosinusitis Guidelines recommend the use of specific symptom and endoscopic criteria. Our study objective was to determine whether symptom and...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-017-0243-x
更新日期：2017-12-04 00:00:00
abstract：OBJECTIVE:To analyze the hearing results of malleovestibulopexy (MVP) technique in the special situations encountered in revision stapedotomies and congenital middle ear malformations. DESIGN:Retrospective chart review. SETTING:Tertiary referral stapes surgery center, community hospital. METHODS:Audiometric results ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Despite significant anatomical variation amongst patients, cochlear implant frequency-mapping has traditionally followed a patient-independent approach. Basilar membrane (BM) length is required for patient-specific frequency-mapping, however cochlear duct length (CDL) measurements generally extend to the api...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-019-0398-8
更新日期：2020-01-06 00:00:00
abstract：OBJECTIVE:congenital anosmia is extremely rare and tends to present late. We report on a series of patients with congenital anosmia to analyze its clinical characteristics and present illustrative cases. DESIGN:retrospective chart review. SETTINGS:tertiary care centre. METHODS:thirty-five patients with congenital an...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-018-0280-0
更新日期：2018-05-09 00:00:00
abstract：BACKGROUND:our group has previously demonstrated that serum calcium levels measured in conjunction with parathyroid hormone (PTH) levels early in the postoperative period can help identify and prophylactically treat patients at significant risk for postthyroidectomy hypocalcemia. This study evaluated whether preoperati...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital. METHODS:Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period. RESULTS:Two-hundred-fifteen patients with adenoid...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-015-0097-z
更新日期：2015-10-29 00:00:00
abstract：INTRODUCTION:Otalgia is a common presenting disorder. We describe a pain entity characterized by localized pain at the anterolateral tip of the mastoid (ATOM), which can be diagnosed by location and response to lidocaine (Xylocaine) injection. Long-term therapeutic results are described following a single injection of ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:To assess the probability of nasopharyngeal carcinoma (NPC) being present among adults who appeared to suffer only from otitis media with effusion (OME). DESIGN AND SETTING:The clinical features of 87 adults suffering from OME but who demonstrated no other apparent symptoms and signs suggestive of NPC at the...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Snoring is a main concern in patients who consult an otolaryngologist (ENT physicians) and patients who have cardiovascular comorbidities or excessive daytime sleepiness who usually consult with other specialists. The aim of this study was to describe the clinical differences in patients with obstructive sle...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-019-0373-4
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:Fish bones are of particular interest to the otolaryngologist as accidental ingestion is one of the most common reasons for otolaryngology-related emergency department referrals. Furthermore, removal of fish bones deeply lodged in the oropharynx or hypopharynx can be both hazardous and technically difficult,...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,评审
doi：
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:Velopharyngeal insufficiency (VPI) is an often underrecognized disorder of palatal and nasopharyngeal closure that leads to the production of hypernasal speech. However, the potential clinical association between VPI and neurofibromatosis type 1 (NF1) remains undefined in the literature. The purpose of this s...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:The use of pre-operatively applied topical tissue expansion tapes have previously demonstrated increased rates of primary closure of radial forearm free flap donor sites. This is associated with a reduced cost of care as well as improved cosmetic appearance of the donor site. Unfortunately, little is known a...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/1916-0216-43-8
更新日期：2014-04-16 00:00:00
abstract：BACKGROUND:This study aims to assess the effectiveness of delayed facial nerve decompression for Bell's palsy (BP). METHODS:We performed a retrospective case review of all patients having undergone facial nerve decompression for severe refractory BP between 1984 and 2009 at our tertiary referral center. Demographics, ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-017-0250-y
更新日期：2018-01-04 00:00:00
abstract：:Primary hyperparathyroisim is a relatively common condition, for which the standard treatment is surgical excision of one or more of the parathyroid glands. Primary hyperparathyroidism can be due to a single adenoma or multiple gland hyperplasia. In recent decades localizing imaging has improved and there has been a s...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 信件
doi：10.1186/s40463-014-0044-4
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:(1) To determine the causative bacteriology of discharging ears in a case series from a tertiary/quaternary academic centre serving an urban population and from a review of the literature and (2) to develop treatment guidelines for methicillin-resistant Staphylococcus aureus (MRSA) otorrhea based on the best...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,评审
doi：
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Two options exist for restoring structure and function after maxillectomy. Prosthodontic rehabilitation requires that an obturator be constructed to address the oronasal communication that exists after resection of the maxilla. Surgical reconstruction of the defect is another option, often accomplished with ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2011-02-01 00:00:00
