Abstract：
OBJECTIVES:The efficacy and toxicity of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy or radiotherapy only and their impact on laryngeal preservation and survival were studied in patients with supraglottic cancer. METHODS:Forty-four patients with newly diagnosed supraglottic squamous cell carcinoma (stage II, III, IV) were treated with either two to three cycles of neoadjuvant chemotherapy with cisplatin 100 mg/m2 on day 1 and fluorouracil 800 to 1000 mg/m2 on days 1 to 5, followed by radiotherapy (NC + RT group, from March 1995 to December 1999; median 68.7 Gy, 1.8 to 2 Gy per fraction) or concurrent chemoradiotherapy (NC + CCRT group, from January 2000 to February 2003; radiotherapy concurrently with cisplatin 60 to 80 mg/m2 on day 1 and fluorouracil 600 to 800 mg/m2 on days 1 to 5). The median follow-up was 60.6 months. RESULTS:The overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) at 5 years were 52%, 66%, and 44%, respectively. Age, nodal stage, and tumour response after neoadjuvant chemotherapy were significant prognostic factors for OS and DSS (p < .05). The 5-year disease-specific survival rates with larynx preservation were 42% in the NC + RT group and 73% in the NC + CCRT group (p = .028). The complete response rate was 81.8% in the NC + RT group and 86.4% in the NC + CCRT group. There was no difference in OS and DFS between the two groups (p > .05). CONCLUSIONS:Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy with cisplatin and fluorouracil was effective as primary therapy for supraglottic cancer with laryngeal preservation.
journal_name
J Otolaryngol Head Neck Surgjournal_title
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeauthors
Yoon TM,Lee JK,Cho JS,Lim SC,Chung WKsubject
Has Abstractpub_date
2010-04-01 00:00:00pages
142-9issue
2eissn
1916-0208issn
1916-0216journal_volume
39pub_type
杂志文章abstract：OBJECTIVE:Brain-derived nerve growth factor (BDNF) plays an important role in cochlear development so it is plausible that it could restore hearing loss if delivered directly into the cochlea. We wished to confirm our previous report that a single intracochlear injection of brain-derived nerve growth factor (BDNF) was ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-020-00432-7
更新日期：2020-06-05 00:00:00
abstract：BACKGROUND:The proportion of females enrolling into medical schools has been growing steadily. However, the representation of female residents among individual specialties has shown considerable variation. The purpose of this study was to compare the trends of gender representation in Otolaryngology - Head and Neck Sur...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-017-0232-0
更新日期：2017-08-29 00:00:00
abstract：BACKGROUND:Flexible nasolaryngoscopy is an essential component of the otolaryngological physical exam. Historically, the ability to create and share video recordings of these endoscopic exams has been limited by poor mobility of fixed endoscopy towers. The advent of smartphone endoscope adapters has allowed physicians ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,评审
doi：10.1186/s40463-018-0279-6
更新日期：2018-05-08 00:00:00
abstract：INTRODUCTION:Adenoid cystic carcinoma (ACC) of the head and neck is a rare malignancy of salivary gland origin. Few epidemiologic studies exist assessing the incidence of this tumour. The purpose of the current study was to determine the incidence of ACC of the head and neck in Nova Scotia. Furthermore, we assessed sur...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Internal derangement is the clinical and pathological condition of disc displacement of the temporomandibular joint. Management of these cases involve conservative and surgical treatment options. Minimally invasive surgical procedures namely arthrocentesis and arthroscopy are promising techniques in the mana...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-018-0282-y
更新日期：2018-05-15 00:00:00
abstract：:The influence of the female ovarian hormones on nasal physiology has been the subject of ongoing research, especially over the last 20 years, yet their role remains unclear. This review looks at the evidence to date from the studies that have looked at the different physiologic and therapeutic scenarios in which the o...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,评审
doi：
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Patulous eustachian tube (PET) has a major impact on a patient's quality of life. The purpose of this study was to understand mechanisms behind the symptoms, develop treatments based on these, and develop and use a questionnaire to measure changes in PET symptoms with a novel intervention. Our hypothesis is ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:First branchial cleft anomalies are rare, accounting for only 10% of all branchial cleft anomalies. We report an even more rare and unique case of a branchial cleft cyst with features of both first and second arch derivatives. CASE PRESENTATION:A 6-year-old boy presented to us with a left conductive hearing...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-020-00426-5
更新日期：2020-05-29 00:00:00
abstract：BACKGROUND:This study aims to assess the effectiveness of delayed facial nerve decompression for Bell's palsy (BP). METHODS:We performed a retrospective case review of all patients having undergone facial nerve decompression for severe refractory BP between 1984 and 2009 at our tertiary referral center. Demographics, ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-017-0250-y
更新日期：2018-01-04 00:00:00
abstract：OBJECTIVE:The Development of a Novel Mixed Reality (MR) Simulation. An evolving training environment emphasizes the importance of simulation. Current haptic temporal bone simulators have difficulty representing realistic contact forces and while 3D printed models convincingly represent vibrational properties of bone, t...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-014-0023-9
更新日期：2014-08-08 00:00:00
abstract：BACKGROUND:Peritonsillar abscesses (PTA) are a common complication of tonsillitis. Recent global epidemiological data regarding PTAs have demonstrated increasing antimicrobial resistance patterns. No similar studies have been conducted in Canada and no Canadian study has examined the post-discharge course of treated pa...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/1916-0216-42-5
更新日期：2013-01-31 00:00:00
abstract：BACKGROUND:To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital. METHODS:Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period. RESULTS:Two-hundred-fifteen patients with adenoid...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-015-0097-z
更新日期：2015-10-29 00:00:00
abstract：OBJECTIVE:To determine whether preoperative radiologic imaging of parotid tumours would alter the surgical approach to complete eradication of the parotid tumours. METHODS:A retrospective chart review of 173 patients with parotid tumours who underwent removal of parotid tumours at Mount Sinai Hospital in Toronto, Onta...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To compare minimally invasive parathyroidectomy (MIP) under local anesthesia (MIPULA) to minimally invasive parathyroidectomy performed under general anesthesia (MIPUGA) in terms of postoperative pain, postanesthetic side effects, patient satisfaction, and overall outcome. DESIGN:Prospective comparative coho...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To determine the effectiveness of providing written information in enhancing patient understanding and retention. DESIGN:A multicentre prospective randomized study was conducted in university-affiliated ambulatory surgical centres. One hundred consecutive patients seen for rhinoplasty consultation were inclu...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:our group has previously demonstrated that serum calcium levels measured in conjunction with parathyroid hormone (PTH) levels early in the postoperative period can help identify and prophylactically treat patients at significant risk for postthyroidectomy hypocalcemia. This study evaluated whether preoperati...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:To assess the effect of in-office intranasal application of mometasone furoate (MF) gel in reducing sinonasal mucosal inflammation in patients who have undergone endoscopic sinus surgery (ESS) for chronic rhinosinusitis. STUDY DESIGN:Retrospective review. METHODS:Symptomatic post-ESS patients were evaluated...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Flexible fibre-optic nasolaryngoscopy (FFN) is a common otolaryngology procedure that patients may find uncomfortable. Preparative agents, including topical anesthetic, vasoconstrictive, and lubricating agents, have been studied in randomized controlled trials (RCTs). METHODS:A systematic review and meta-an...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:RAAPID (Referral, Access, Advice, Placement, Information, and Destination) is a 24-h call center in Alberta, Canada, facilitating urgent telephone consultations between physicians and specialists. We evaluated the extent to which RAAPID calls to Otolaryngology-Head and Neck Surgery (OHNS) reduced visits to t...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-020-00439-0
更新日期：2020-06-22 00:00:00
abstract：OBJECTIVE:To obtain completely negative margins of 1 to 5 mm at the time of surgery for oral tongue squamous cell carcinoma by using a Mohs-like technique. STUDY DESIGN:Case series of 12 patients (4 T1, 5 T2, 2 T3, 1 T4) and a review of the literature. RESULTS:For the first six cases, complete, colored for precise or...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Metabolic tumour volume (MTV) obtained from pre-treatment 18 F-fluorodeoxydeglucose positron emission tomography with computed tomography (PET-CT) has been validated as an independent predictive factor of outcomes in head and neck cancer patients (HNC) treated with primary chemoradiotherapy (CRT). However it...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-014-0033-7
更新日期：2014-10-13 00:00:00
abstract：OBJECTIVES:To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN:Prospective, double-blind, randomi...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:With the introduction, development and commercialization of Cone Beam Computerized Tomography (CBCT) technologies in the field of head and neck reconstruction, clinicians now have increased access to the technology. Given the growth of this new user group, there is an increasing concern regarding proper use,...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/1916-0216-42-25
更新日期：2013-03-21 00:00:00
abstract：OBJECTIVE:In this cross-sectional study, we investigated the frequency tuning properties of sound-evoked vestibular myogenic potentials in extraocular muscles (OVEMPs) in normal human subjects. METHODS:Acoustic tone bursts (130 dB pSPL, 10 ms plateau, 1 ms rise/fall) with nine frequencies from 125 to 4000 Hz were pres...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:Altered immune, inflammatory, and angiogenesis responses have been noticed in head and neck cancer, and many of these responses have been associated with a poor clinical outcome. The objective of this study was to evaluate several immune mediators in the sera of patients with squamous cell carcinoma (SCC) of ...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：
更新日期：2011-04-01 00:00:00
abstract：:Due to significant differences in healthcare structure between the United States and Canada, there are unique barriers to adopting new medical technology in Canada. In this article, we describe our experience developing a transoral robotic surgery (TORS) program at Western University. Specifically, we outline the step...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/1916-0216-42-8
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:A nasal septal deviation can have a significant detrimental effect on a patient's quality of life. Nasal valve collapse (NVC) often co-exists with a septal deviation. The Cottle maneuver is one of the most common methods to diagnose NVC; however, no study has assessed the efficacy of this physical exam findi...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-018-0292-9
更新日期：2018-07-11 00:00:00
abstract：BACKGROUND:The diagnosis of chronic rhinosinusitis (CRS) based on clinical presentation alone remains challenging. To improve the accuracy of clinical diagnosis, the Canadian Rhinosinusitis Guidelines recommend the use of specific symptom and endoscopic criteria. Our study objective was to determine whether symptom and...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-017-0243-x
更新日期：2017-12-04 00:00:00
abstract：BACKGROUND:The American Thyroid Association published revised guidelines in 2015 on the management of differentiated thyroid cancer in adults. One of the key changes introduced in the revision proposes that diagnostic biopsy be based on ultrasound findings (i.e. size and nodule characteristics). The overall effect of t...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-018-0296-5
更新日期：2018-09-03 00:00:00
abstract：BACKGROUND:Oral cavity squamous cell carcinoma (OCSCC) is the most common head and neck cancer, affecting approximately 2000 Canadians yearly. Analysis of Canadian Cancer Registry data has shown that the incidence of oral cavity cancer is decreasing and survival outcomes are improving. There are significant health disp...
journal_title：Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type： 杂志文章
doi：10.1186/s40463-015-0056-8
更新日期：2015-02-03 00:00:00
