Abstract:
:A follow-up study of a cohort of workers from a coke plant compared with a control group from the same industrial area was conducted in 2019. The recruitment and environmental and biomarker measurements were performed during 1993/1994. The environmental concentrations of polycyclic aromatic hydrocarbons (PAH), B(a)P, pyrene and nitro-PAH were measured. Personal data were collected via an individual semi-structured questionnaire by a trained physician. All biomarkers were measured after a specific blood drawing for every test. Significant risks (ORs) were observed for nitro-PAH (≥0.12 µg/m3) [OR = 7.96 (1.01-62.82)], urinary 1-hydroxypyrene (1-OHpy) (≥0.99 µmoles/moles of creatinine) [OR = 11.71 (1.47-92.90)], PAH DNA adducts (P32) (≥2.69 adducts/108 nucleotides) [OR = 5.46 (1.17-25.58)], total nitro-PAH hemoglobin adducts (≥161.68 fg/µg of Hb) [OR = 5.92 (1.26-27.86)], sister chromatid exchange (SCE) with TCR (≥377.84 SCE/cell chromosomes) [OR = 13.06 (3.95-93.10)], sister chromatid exchange with T (≥394.72 total SCE) [OR = 13.06 (3.95-93.10)], and sister chromatid exchange with X (≥8.19 mean SCE) [OR = 13.06 (3.95-93.10)]. Significant risk of death for all causes and chromosomal aberrations (48 h) (OR = 7.19 [1.19-43.44]) or micronuclei in culture at 48 h (OR = 3.86 [1.04-14.38]) were also found.
journal_name
Int J Environ Res Public Healthauthors
Vimercati L,Bisceglia L,Cavone D,Caputi A,De Maria L,Delfino MC,Corrado V,Ferri GMdoi
10.3390/ijerph17072199subject
Has Abstractpub_date
2020-03-25 00:00:00issue
7eissn
1661-7827issn
1660-4601pii
ijerph17072199journal_volume
17pub_type
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