Abstract:
BACKGROUND:Gastric signet ring cell carcinoma (GSRCC) is one of the most malignant tumors. It has the features of high invasiveness, rapid progression, and resistance to chemotherapy. However, systematic analyses of mRNAs have not yet been performed for GSRCC. AIM:To identify key mRNAs and signaling pathways in GSRCC. METHODS:A transcriptome analysis of two GSRCC and two non-GSRCC samples was performed in this study. Differentially expressed mRNAs and pathways were identified based on the KEGG and PANTHER pathway annotations. The interactive relationships among the differential genes were mapped with the STRING database. Quantitative real-time polymerase chain reaction was used to validate the key gene expression in GSRCC. RESULTS:About 1162 differential genes (using a 2-fold cutoff, P < 0.05) were identified in GSRCC compared with non-GSRCC. The enriched KEGG and PANTHER pathways for the differential genes included immune response pathways, metabolic pathways, and metastasis-associated pathways. Ten genes (MAGEA2, MAGEA2B, MAGEA3, MAGEA4, MAGEA6, MUC13, GUCA2A, FFAR4, REG1A, and REG1B) were identified as hub genes in the protein-protein interaction network. The expression levels of five genes (MAGEA2, MAGEA3, MAGEA4, MAGEA6, and REG1B) showed potential clinical value. CONCLUSION:We have identified the potential key genes and pathways in GSRCC, and these hub genes and pathways could be diagnostic markers and therapeutic targets for GSRCC.
journal_name
World J Clin Casesjournal_title
World journal of clinical casesauthors
Zhao ZT,Li Y,Yuan HY,Ma FH,Song YM,Tian YTdoi
10.12998/wjcc.v8.i4.658subject
Has Abstractpub_date
2020-02-26 00:00:00pages
658-669issue
4issn
2307-8960journal_volume
8pub_type
杂志文章abstract::Inflammatory pseudotumor (IPT) has always been considered a diagnostic challenge. Its rarity and resemblance to other more common pathological entities imposes that neither clinical nor radiological characteristics can lead to a definitive diagnosis. The surgical excision of the lesion is the ultimate approach for acc...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v5.i2.61
更新日期:2017-02-16 00:00:00
abstract::We describe the case of a 67-year-old woman with L5-S1 ontogenetic spondylolisthesis treated with pedicle fixation associated with interbody arthrodesis performed with S1-L5 trans-sacral screwing according to the technique of Bartolozzi. The procedure was followed by a wide decompressive laminectomy. The patient had a...
journal_title:World journal of clinical cases
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更新日期:2013-06-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
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更新日期:2020-09-26 00:00:00
abstract:BACKGROUND:Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare. Polycythemia is significantly associated with risk of venous thromboembolism (VTE), which is further increased in case of a large pelvic mass and obesity. Here we report ...
journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v7.i19.3027
更新日期:2019-10-06 00:00:00
abstract:BACKGROUND:Fiberoptic bronchoscopic intubation is the gold standard for endotracheal intubation in difficult or compromised airway situations. However, oxygen insufflation through the working channel of a fiberscope is a controversial method because of the possibility of gastric distention and rupture during an awake f...
journal_title:World journal of clinical cases
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更新日期:2018-12-26 00:00:00
abstract:BACKGROUND:Warthin's tumor (WT) is composed of several cysts that are lined with tall, bilayered oncocytic columnar cells and lymphoid stroma. Within WT, the two components rarely transform into carcinoma or lymphoma, and when it does, carcinoma is the most common type. Approximately 28 cases of lymphoma with WT have b...
journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v7.i22.3895
更新日期:2019-11-26 00:00:00
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journal_title:World journal of clinical cases
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更新日期:2020-03-26 00:00:00
abstract:BACKGROUND:Squamous cell carcinoma antigen (SCCA) is regarded as a specific indicator of epithelial malignancies and is widely used in the diagnosis of squamous cell carcinoma (SCC). However, the expression of SCCA in gastric adenocarcinoma has not been studied in detail. CASE SUMMARY:A 52-year-old man was admitted to...
journal_title:World journal of clinical cases
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更新日期:2020-10-06 00:00:00
abstract:AIM:To investigate the complex relationships between resting energy expenditure (REE), eating psychopathology, and Hypothalamus Pituitary Adrenal axis functioning in patients with eating disorders. METHODS:The study was designed as a cross-sectional survey, and it was planned by the Clinic for Eating Disorders of the ...
journal_title:World journal of clinical cases
pub_type: 杂志文章
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i22.5821
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:Emergency department (ED) overcrowding is a severe health care concern, while anxiety and depression rates among ED patients have been reported to be substantially higher compared to the general population. We hypothesized that anxiety due to over crowdedness may lead to adverse events in EDs. AIM:To invest...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i13.2802
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:This study aimed to identify factors associated with antibiotic-associated diarrhea (AAD) in patients in the department of intensive care medicine who received antibiotic monotherapy in order to reduce the incidence of AAD and improve rational use of antibiotics in these patients. AIM:To report the incidenc...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i10.1908
更新日期:2020-05-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v3.i7.671
更新日期:2015-07-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i4.771
更新日期:2020-02-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i9.1066
更新日期:2019-05-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i21.5250
更新日期:2020-11-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i11.1262
更新日期:2019-06-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i16.3601
更新日期:2020-08-26 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i1.54
更新日期:2020-01-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i16.2256
更新日期:2019-08-26 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v8.i15.3156
更新日期:2020-08-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v2.i9.459
更新日期:2014-09-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 临床试验
doi:10.12998/wjcc.v8.i19.4410
更新日期:2020-10-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i6.1104
更新日期:2020-03-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i20.5042
更新日期:2020-10-26 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i21.3474
更新日期:2019-11-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
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更新日期:2020-10-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v4.i9.258
更新日期:2016-09-16 00:00:00
abstract::Probiotics are known as "live microorganisms" and have been proven to have a health effect on hosts at the proper dose. Recently, a kind of probiotic mixture including eight live bacterial strains, VSL#3, has attracted considerable attention for its combined effect. VSL#3 is the only probiotic considered as a kind of ...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v8.i8.1361
更新日期:2020-04-26 00:00:00