Non-Exosomal and Exosomal Circulatory MicroRNAs: Which Are More Valid as Biomarkers?

abstract：:Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, the therapeutic mechanisms of action are not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore po...

journal_title：Frontiers in pharmacology

authors： Xu J,Li X,Zhang F,Tang L,Wei J,Lei X,Wang H,Zhang Y,Li D,Tang X,Li G,Tang S,Wu H,Yang H

更新日期：2019-12-06 00:00:00

abstract：:Introduction: Over the past decades, early awareness and alert (EAA) activities and systems have gained importance and become a key early health technology assessment (HTA) tool. While a pioneer in HTA, Sweden had no national level EAA activities until 2010. We describe the evolution and current status of the Swedish ...

journal_title：Frontiers in pharmacology

authors： Eriksson I,Wettermark B,Persson M,Edström M,Godman B,Lindhé A,Malmström RE,Ramström H,von Euler M,Bergkvist Christensen A

更新日期：2017-10-05 00:00:00

abstract：:SARS-CoV-2 is the most recent coronavirus which crossed the species barrier in 2019 and provoked a still ongoing and dangerous pandemic known as coronavirus disease 2019 (COVID-19). The SARS-CoV-2 infection has triggered an impressive amount of clinical and experimental studies to identify an effective and safe therap...

journal_title：Frontiers in pharmacology

authors： Iacob S,Iacob DG

更新日期：2020-08-26 00:00:00

abstract：:"RenqingMangjue" pill (RMP), as an effective prescription of Traditional Tibetan Medicine (TTM), has been widely used in treating digestive diseases and ulcerative colitis for over a thousand years. In certain classical Tibetan Medicine, heavy metal may add as an active ingredient, but it may cause contamination unint...

journal_title：Frontiers in pharmacology

authors： Xu C,Rezeng C,Li J,Zhang L,Yan Y,Gao J,Wang Y,Li Z,Chen J

更新日期：2017-09-04 00:00:00

abstract：:This article highlights several refractory oral diseases, such as stomatitis, burning mouth syndrome (BMS), glossalgia, atypical facial pain (AFP), oral cancer, dry mouth, and Sjögren's syndrome (SJS), in which use of Japanese herbal medicines, Kampo medicines (KM), on the basis of Kampo theory could exert the maximum...

journal_title：Frontiers in pharmacology

authors： Yamaguchi K

更新日期：2015-08-28 00:00:00

abstract：:Objective: This research aimed to validate the therapeutic effect of losmapimod and explore the underlying mechanism in its treatment of epilepsy. Methods: A rat model of epilepsy was constructed with an injection of pilocarpine. Microarray analysis was performed to screen aberrantly expressed mRNAs and activated sign...

journal_title：Frontiers in pharmacology

authors： Li M,Cui L,Feng X,Wang C,Zhang Y,Wang L,Ding Y,Zhao T

更新日期：2019-06-07 00:00:00

abstract：:The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a...

journal_title：Frontiers in pharmacology

authors： Brilli M,Trabocchi A,Weil T,Cavalieri D,Stefanini I

更新日期：2017-03-30 00:00:00

abstract：:Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for a...

journal_title：Frontiers in pharmacology

authors： Ma DSL,Tan LT,Chan KG,Yap WH,Pusparajah P,Chuah LH,Ming LC,Khan TM,Lee LH,Goh BH

更新日期：2018-02-19 00:00:00

abstract：:Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system,...

journal_title：Frontiers in pharmacology

authors： Yadav E,Singh D,Yadav P,Verma A

更新日期：2018-05-23 00:00:00

abstract：:Drug discovery field has tremendously progressed during last few decades, however, an effective radiation countermeasure agent for the safe administration to the victims of radiation exposure is still unavailable. This multi-model study is aimed at elucidating the mechanistic aspects of a novel podophyllotoxin and rut...

journal_title：Frontiers in pharmacology

authors： Yashavarddhan MH,Shukla SK,Chaudhary P,Srivastava NN,Joshi J,Suar M,Gupta ML

更新日期：2017-10-31 00:00:00

abstract：:Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment exits for them; likely as result of the absence of neural markers associated to memory. Neurotransmitter systems and signaling pathways have been implicated in memory and dysfunctional memory; however, their role is poorly under...

journal_title：Frontiers in pharmacology

authors： Meneses A

更新日期：2015-07-21 00:00:00

abstract：Background:Patients with locally advanced rectal cancer (LARC) are at higher risk of local and distant recurrence and are thus more vulnerable to metastatic diseases. Neoadjuvant chemoradiotherapy (nCRT) and subsequent curative resection with total mesorectal excision (TME) followed by adjuvant chemotherapy have been r...

journal_title：Frontiers in pharmacology

authors： Zhong X,Zhou Y,Cui W,Su X,Guo Z,Hidasa I,Li Q,Wang Z,Song Y

更新日期：2020-05-15 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2018.00361.]. ...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Huang D,Xie S,Wang X,Pan Y,Yuan Z

更新日期：2018-11-29 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies (LBs) in the surviving SNc neurons. LBs formation is caused by the accumulation of α-synuclein (α-syn) or phosphorylated α-syn at serine-129 (pSer129-α-syn), wh...

journal_title：Frontiers in pharmacology

authors： Li T,Feng Y,Yang R,Wu L,Li R,Huang L,Yang Q,Chen J

更新日期：2018-04-19 00:00:00

abstract：:The objective of the current project was to explore the pharmacotherapeutic role of Lavandula stoechas (L) for the management of dementia. Dementia is considered a global challenge of current century seeking special attention of pharmacologists to explore its best remedies. Methanolic extract of aerial parts of L. sto...

journal_title：Frontiers in pharmacology

authors： Mushtaq A,Anwar R,Ahmad M

更新日期：2018-11-23 00:00:00

abstract：:Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil induces abuse-related effects, including rapid-onset behavioral sensitization (i.e., a type of sensiti...

journal_title：Frontiers in pharmacology

authors： Wuo-Silva R,Fukushiro-Lopes DF,Fialho BP,Hollais AW,Santos-Baldaia R,Marinho EAV,Mári-Kawamoto E,Yokoyama TS,Lopes-Silva LB,Berro LF,Frussa-Filho R,Longo BM

更新日期：2019-03-11 00:00:00

abstract：Background:Pancreatic cancer is one of the most aggressive malignancies. Bufalin, a traditional Chinese medicine, has been used to treat pancreatic cancer as an antitumor agent although the mechanism by which it exerts its effects is still unclear. c-Myc has been found to be overexpressed in more than half of human can...

journal_title：Frontiers in pharmacology

authors： Liu X,Zhou Y,Peng J,Xie B,Shou Q,Wang J

更新日期：2020-04-17 00:00:00

abstract：:Hippocampal theta activity is related to spatial information processing, and high-frequency theta activity, in particular, has been linked to efficient spatial memory performance. Theta activity is regulated by the synchronizing ascending system (SAS), which includes mesencephalic and diencephalic relays. The supramam...

journal_title：Frontiers in pharmacology

authors： Hernández-Pérez JJ,Gutiérrez-Guzmán BE,López-Vázquez MÁ,Olvera-Cortés ME

更新日期：2015-10-29 00:00:00

abstract：:Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate...

journal_title：Frontiers in pharmacology

authors： Saletti PG,Maior RS,Hori E,Nishijo H,Tomaz C

更新日期：2015-09-22 00:00:00

abstract：:At present there is no effective treatment of pathologies associated with the death of neurons and glial cells which take place as a result of physical trauma or ischemic lesions of the nervous system. Thus, researchers have high hopes for a treatment based on the use of stem cells (SC), which are potentially able to ...

journal_title：Frontiers in pharmacology

authors： Galieva LR,Mukhamedshina YO,Arkhipova SS,Rizvanov AA

更新日期：2017-09-08 00:00:00

abstract：:We prepared hybrids consisting of Angelica gigas Nakai (AGN) root or flower extract and layered double hydroxide (LDH) for potential anticancer nanomedicine, as decursin species (DS) in AGN are known to have anticancer activity. Dimethylsulfoxide solvent was determined hybridization reaction media, as it has affinity ...

journal_title：Frontiers in pharmacology

authors： Kim HJ,Lee GJ,Choi AJ,Kim TH,Kim TI,Oh JM

更新日期：2018-07-09 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin D' (OPD', a natural product extracted from a traditional Chinese medicine (Radix Ophiopogonis) against androgen-independent prostate cancer cells and to explore the underlying molecular mechanism(s) of action. Methods: The CCK-...

journal_title：Frontiers in pharmacology

authors： Lu Z,Wang H,Zhu M,Song W,Wang J,Wu C,Kong Y,Guo J,Li N,Liu J,Li Y,Xu H

更新日期：2018-04-30 00:00:00

abstract：:The inhibitors for EGF receptor tyrosine kinase (EGFR-TKIs) such as gefitinib have been used as a standard treatment for non-small cell lung cancer (NSCLC), but the increasingly occurrence of drug resistance, the associated adverse effects and the enrichment of cancer stem cells significantly impedes its clinical appl...

journal_title：Frontiers in pharmacology

authors： Cheng H,Ge X,Zhuo S,Gao Y,Zhu B,Zhang J,Shang W,Xu D,Ge W,Shi L

更新日期：2018-11-30 00:00:00

abstract：:Why antidepressants vary in terms of efficacy is currently unclear. Despite the leadership of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, the precise neurobiological mechanisms involved in their therapeutic action are poorly understood. A better knowledge of molecular interactions b...

journal_title：Frontiers in pharmacology

authors： Gardier AM

更新日期：2013-08-08 00:00:00

abstract：Background:Model-informed precision dosing (MIPD) can serve as a powerful tool during therapeutic drug monitoring (TDM) to help individualize dosing in populations with large pharmacokinetic variation. Yet, adoption of MIPD in the clinical setting has been limited. Overcoming technologic hurdles that allow access to MI...

journal_title：Frontiers in pharmacology

authors： Frymoyer A,Schwenk HT,Zorn Y,Bio L,Moss JD,Chasmawala B,Faulkenberry J,Goswami S,Keizer RJ,Ghaskari S

更新日期：2020-04-29 00:00:00

abstract：:Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic facto...

journal_title：Frontiers in pharmacology

authors： Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

更新日期：2018-11-06 00:00:00

abstract：:Objective: To evaluate therapeutic efficacy of different combined antimicrobial treatments against Acinetobacter baumannii ventilator-associated pneumonia (VAP). Methods: Clinical outcomes were retrospectively analyzed to elucidate the efficacy of four combined antimicrobial regimens. The chessboard and micro broth di...

journal_title：Frontiers in pharmacology

authors： Huang Y,Zhou Q,Wang W,Huang Q,Liao J,Li J,Long L,Ju T,Zhang Q,Wang H,Xu H,Tu M

更新日期：2019-02-13 00:00:00

abstract：:Quinoxaline 1,4-di-N-oxides (QdNOs) have manifold biological properties, including antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities. These diverse activities endow them broad applications and prospects in human and veterinary medicines. As QdNOs arouse widespread interest, the e...

journal_title：Frontiers in pharmacology

authors： Cheng G,Sa W,Cao C,Guo L,Hao H,Liu Z,Wang X,Yuan Z

更新日期：2016-03-21 00:00:00

abstract：:Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for effective drugs an urgent need. Neurodegeneration is triggered by the activation of several cellular processes, including oxidative stress, mitochondrial impairme...

journal_title：Frontiers in pharmacology

authors： de Souza JM,Goncalves BDC,Gomez MV,Vieira LB,Ribeiro FM

更新日期：2018-02-23 00:00:00

abstract：:Osteoporosis is a common health problem worldwide caused by an imbalance of bone formation vs. bone resorption. However, current therapeutic approaches aimed at enhancing bone formation or suppressing bone resorption still have some limitations. In this study, we demonstrated for the first time that cepharanthine (CEP...

journal_title：Frontiers in pharmacology

authors： Zhou CH,Meng JH,Yang YT,Hu B,Hong JQ,Lv ZT,Chen K,Heng BC,Jiang GY,Zhu J,Cheng ZH,Zhang W,Cao L,Wang W,Shen WL,Yan SG,Wu HB

更新日期：2018-03-27 00:00:00