Abstract:
BACKGROUND:Melanotic Xp11-associated tumors are rare mesenchymal-derived tumors. So far, most primary melanotic Xp11-associated tumors have been reported in the kidney, and reports of this tumor in the gastrointestinal tract are rare. CASE SUMMARY:Here we describe the case of a 25-year-old woman who presented with a melanotic Xp11-associated tumor in the sigmoid colon. Colonoscopy revealed a large mucosal bulge in the sigmoid colon, approximately 32 cm inside the anus. The surface was rough with local erosion. The tumor was brittle on biopsy and bled easily. Computed tomography revealed thickening of the rectal wall with edema. Postoperative pathology indicated the likelihood of a perivascular epithelioid cell tumor. Histologically, the tumor comprised plump epithelioid cells with abundant clear to lightly eosinophilic cytoplasm and round nuclei arranged in an alveolar or trabecular pattern. The tumor cells were strongly positive for HMB-45, Melan-A, Cathepsin K, and TFE3 but negative for vimentin, smooth muscle actin, S100 protein, CD10, CK20, and desmin. The tumor cells had a low Ki-67 labeling index (approximately 2%). Fluorescence in situ hybridization revealed TFE3 fracture. Based on these histologic and immunohistochemical features, a diagnosis of melanotic Xp11-associated tumor of the sigmoid colon was made. CONCLUSION:In summary, we report the clinicopathological features of a primary tumor that is extremely rare in the sigmoid colon and review the clinicopathological characteristics of melanotic Xp11-associated tumors, compatible with the very rare tumor termed "melanotic Xp11 translocation renal cancer" in all aspects.
journal_name
World J Clin Casesjournal_title
World journal of clinical casesauthors
Wang G,Li GG,Zhu SM,Cai BJ,Yu PJ,Zhang CWdoi
10.12998/wjcc.v7.i5.684subject
Has Abstractpub_date
2019-03-06 00:00:00pages
684-690issue
5issn
2307-8960journal_volume
7pub_type
abstract:BACKGROUND:The prognosis of paediatric primary refractory/relapsed acute myeloid leukaemia (R/R AML) remains poor. Intensive therapy is typically used as salvage treatment for those with R/R AML. No data are currently available about the use of the CLAG-M protocol as salvage therapy in paediatric patients with R/R AML....
journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v8.i22.5603
更新日期:2020-11-26 00:00:00
abstract:BACKGROUND:In rare cases, odontogenic keratocysts (ODs) transform into squamous cell carcinoma. Intervals between the first attendance of a patient and the diagnosis of OD with malignant transformation vary from weeks to years. In this article, we report a case of malignancy derived from OD with a five-day delay in dia...
journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v8.i11.2374
更新日期:2020-06-06 00:00:00
abstract:AIM:To investigate the complex relationships between resting energy expenditure (REE), eating psychopathology, and Hypothalamus Pituitary Adrenal axis functioning in patients with eating disorders. METHODS:The study was designed as a cross-sectional survey, and it was planned by the Clinic for Eating Disorders of the ...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v2.i7.257
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
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journal_title:World journal of clinical cases
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abstract:BACKGROUND:Systemic amyloidosis in which multiple systems can be involved has become a common clinical disease. When the liver is affected, symptoms such as abdominal distension, fatigue, edema, liver, and jaundice could appear. To date, hepatic amyloidosis combined with hepatic venular occlusive disease and Budd-Chiar...
journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v7.i20.3282
更新日期:2019-10-26 00:00:00
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journal_title:World journal of clinical cases
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doi:10.12998/wjcc.v7.i11.1351
更新日期:2019-06-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v5.i2.61
更新日期:2017-02-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i21.5353
更新日期:2020-11-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v5.i1.1
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i4.489
更新日期:2019-02-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i20.4908
更新日期:2020-10-26 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v8.i11.2111
更新日期:2020-06-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v8.i18.4034
更新日期:2020-09-26 00:00:00
abstract::Quorum sensing (QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate tha...
journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v3.i7.575
更新日期:2015-07-16 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i9.1674
更新日期:2020-05-06 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v9.i1.36
更新日期:2021-01-06 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v2.i2.39
更新日期:2014-02-16 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章,评审
doi:10.12998/wjcc.v5.i7.258
更新日期:2017-07-16 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v7.i18.2838
更新日期:2019-09-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i7.1326
更新日期:2020-04-06 00:00:00
abstract:BACKGROUND:Fiberoptic bronchoscopic intubation is the gold standard for endotracheal intubation in difficult or compromised airway situations. However, oxygen insufflation through the working channel of a fiberscope is a controversial method because of the possibility of gastric distention and rupture during an awake f...
journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v6.i16.1189
更新日期:2018-12-26 00:00:00
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v3.i10.915
更新日期:2015-10-16 00:00:00
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journal_title:World journal of clinical cases
pub_type:
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更新日期:2013-06-16 00:00:00
abstract:BACKGROUND:Spontaneous peritonitis is one of the most common infectious complications in cirrhotic patients with ascites. Spontaneous fungal peritonitis (SFP) is a type of spontaneous peritonitis that is a less recognized but devastating complication in end-stage cirrhosis. Although high mortality was previously noted,...
journal_title:World journal of clinical cases
pub_type: 杂志文章
doi:10.12998/wjcc.v7.i17.2438
更新日期:2019-09-06 00:00:00
abstract:BACKGROUND:Pathological complete response (pCR) is rare in hormone receptor-positive (HR+) HER2-negative breast cancer (BC) treated with either endocrine therapy (ET) or chemotherapy. Radical resection of locoregional relapse, although potentially curative in some cases, is challenging when the tumor invades critical s...
journal_title:World journal of clinical cases
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journal_title:World journal of clinical cases
pub_type:
doi:10.12998/wjcc.v8.i10.2050
更新日期:2020-05-26 00:00:00
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journal_title:World journal of clinical cases
pub_type: 杂志文章
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更新日期:2020-12-06 00:00:00