Successful treatment of plasma exchange-refractory thrombotic thrombocytopenic purpura with rituximab: A case report.

Abstract:

BACKGROUND:Thrombotic thrombocytopenic purpura (TTP), a subtype of thrombotic microangiopathy, has a very high fatality rate if there is no timely diagnosis or treatment. Here, we report a case of TTP refractory to high displacement plasma exchange, which was later successfully treated with rituximab. CASE SUMMARY:Here we report a case of refractory TTP in a 63-year-old woman with a low platelet count and decreased ADAMTS13 activity. Her platelet count was 9 × 109/L, hemoglobin level was 81 g/L, and ADAMTS13 was < 5%. She was diagnosed with thrombotic thrombocytopenic purpura. After 8 d of daily plasma exchange (PEX), her platelet levels were still low. However, after 6 d of treatment with rituximab, her platelet count increased and ADAMTS13 activity returned to normal. CONCLUSION:PEX can cure most patients, but the relapse rate can be up to 50%-60%. This case suggested that rituximab can improve the curative efficiency of PEX and prevent disease relapse in TTP.

journal_name

World J Clin Cases

authors

Chen J,Jin JX,Xu XF,Zhang XX,Ye XN,Huang J

doi

10.12998/wjcc.v8.i12.2617

subject

Has Abstract

pub_date

2020-06-26 00:00:00

pages

2617-2622

issue

12

issn

2307-8960

journal_volume

8

pub_type

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