Controversies Surrounding Vitamin D: Focus on Supplementation and Cancer.

Abstract:

:There has recently been a huge number of publications concerning various aspects of vitamin D, from the physiological to therapeutic fields. However, as a consequence of this very fast-growing scientific area, some issues still remain surrounded by uncertainties, without a final agreement having been reached. Examples include the definitions of vitamin D sufficiency and insufficiency, (i.e., 20 vs. 30 ng/mL), the relationship between 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone, (i.e., linear vs. no linear), the referent to consider, (i.e., total vs. free determination), the utility of screening versus universal supplementation, and so on. In this review, the issues related to vitamin D supplementation in subjects with documented hypovitaminosis, and the role of vitamin D in cancer will be concisely considered. Daily, weekly, or monthly administration of cholecalciferol generally leads to essentially similar results in terms of an increase in 25(OH)D serum levels. However, we should also consider possible differences related to a number of variables, (i.e., efficiency of intestinal absorption, binding to vitamin D binding protein, and so on). Thus, adherence to therapy may be more important than the dose regimen chosen in order to allow long-term compliance in a sometimes very old population already swamped by many drugs. It is difficult to draw firm conclusions at present regarding the relationship between cancer and vitamin D. In vitro and preclinical studies seem to have been more convincing than clinical investigations. Positive results in human studies have been mainly derived from post-hoc analyses, secondary end-points or meta-analyses, with the last showing not a decrease in cancer incidence but rather in mortality. We must therefore proceed with a word of caution. Until it has been clearly demonstrated that there is a causal relationship, these positive "non-primary, end-point results" should be considered as a background for generating new hypotheses for future investigations.

authors

Minisola S,Ferrone F,Danese V,Cecchetti V,Pepe J,Cipriani C,Colangelo L

doi

10.3390/ijerph16020189

subject

Has Abstract

pub_date

2019-01-11 00:00:00

issue

2

eissn

1661-7827

issn

1660-4601

pii

ijerph16020189

journal_volume

16

pub_type

杂志文章,评审
  • Mental Health Status of University Healthcare Workers during the COVID-19 Pandemic: A Post-Movement Lockdown Assessment.

    abstract::This study investigated the prevalence and severity of depression, anxiety, and stress and determined the association between various factors, social support, and depression, anxiety, and stress among university healthcare workers in Malaysia after the government lifted the movement control order (MCO) put in place to...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17249155

    authors: Woon LS,Sidi H,Nik Jaafar NR,Leong Bin Abdullah MFI

    更新日期:2020-12-08 00:00:00

  • Association of Infant Eczema with Childhood and Adult Asthma: Analysis of Data from the 1958 Birth Cohort Study.

    abstract::The influence of early life exposures on later life disease has for some time provided clues to modifiable risk factors of disease. The “atopic march” is thought to play a role in the progression of allergic diseases and may offer an opportunity to lower asthma’s health and socioeconomic burden, alth...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15071415

    authors: Abo-Zaid G,Sharpe RA,Fleming LE,Depledge M,Osborne NJ

    更新日期:2018-07-05 00:00:00

  • Cross-Cultural Variation in BMI, Sedentary Behavior, and Physical Activity in International School Girls Residing in Saudi Arabia.

    abstract:BACKGROUND:The current study was done to assess the cross-cultural difference in physical activity and sedentary behavior among girls from culturally, environmentally, and geographically diverse countries residing in Saudi Arabia. METHODS:This was a comparative cross-sectional study conducted among expatriate girls (N...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17062057

    authors: Alhusaini AA,Melam GR,Buragadda S

    更新日期:2020-03-20 00:00:00

  • Green Space Attachment and Health: A Comparative Study in Two Urban Neighborhoods.

    abstract::The positive relationships between urban green space and health have been well documented. Little is known, however, about the role of residents' emotional attachment to local green spaces in these relationships, and how attachment to green spaces and health may be promoted by the availability of accessible and usable...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph121114342

    authors: Zhang Y,van Dijk T,Tang J,van den Berg AE

    更新日期:2015-11-12 00:00:00

  • An Examination of the Variation in Estimates of E-Cigarette Prevalence among U.S. Adults.

    abstract::Introduction: Accurate estimates of e-cigarette use are needed to gauge its impact on public health. We compared the results of online and traditional, large scale surveys and provide additional estimates from the Population Assessment of Tobacco and Health (PATH) survey, with the aim of assessing the extent of variat...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16173164

    authors: Levy DT,Yuan Z,Li Y,Mays D,Sanchez-Romero LM

    更新日期:2019-08-30 00:00:00

  • A Multiple Streams Approach to Understanding the Issues and Challenges of Lyme Disease Management in Canada's Maritime Provinces.

    abstract::This study examines potential challenges facing Lyme disease patients in Canada's Maritime provinces-New Brunswick, Nova Scotia, Prince Edward Island-and considers how issues could be addressed. Reviews of both the academic and grey literature are complemented by surveys targeting both medical professionals and decisi...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16091531

    authors: Levesque M,Klohn M

    更新日期:2019-04-30 00:00:00

  • Susceptibility to Enterocins and Lantibiotic Bacteriocins of Biofilm-Forming Enterococci Isolated from Slovak Fermented Meat Products Available on the Market.

    abstract::This study investigated eight types of Slovak dry fermented meat products (salami and sausages) that are available on the market and were produced by three different producers in different regions of Slovakia. The total counts of enterococci in these products ranged from 2.0 up to 6.0 cfu/g (log10). Three species were...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17249586

    authors: Lauková A,Kandričáková A,Bino E

    更新日期:2020-12-21 00:00:00

  • Factors Affecting Transfer of Pyrethroid Residues from Herbal Teas to Infusion and Influence of Physicochemical Properties of Pesticides.

    abstract::The transfer of pesticide residues from herbal teas to their infusion is a subject of particular interest. In this study, a multi-residue analytical method for the determination of pyrethroids (fenpropathrin, beta-cypermethrin, lambda-cyhalothrin, and fenvalerate) in honeysuckle, chrysanthemum, wolfberry, and licorice...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph14101157

    authors: Xiao JJ,Li Y,Fang QK,Shi YH,Liao M,Wu XW,Hua RM,Cao HQ

    更新日期:2017-09-30 00:00:00

  • Hepatitis C Virus Treatment Status and Barriers among Patients in Methadone Maintenance Treatment Clinics in Guangdong Province, China: A Cross-Sectional, Observational Study.

    abstract::We aimed to evaluate the status and barriers related to hepatitis C virus (HCV) treatment among Chinese methadone maintenance treatment (MMT) clients, and the willingness and barriers of patients to accept directly observed treatment (DOT) service and oral direct-acting antivirals (DAAs). We conducted a cross-sectiona...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16224436

    authors: Liu Y,Zou X,Chen W,Gong C,Ling L

    更新日期:2019-11-12 00:00:00

  • Impact of Indoor Physical Environment on Learning Efficiency in Different Types of Tasks: A 3 × 4 × 3 Full Factorial Design Analysis.

    abstract::Indoor physical environments appear to influence learning efficiency nowadays. For improvement in learning efficiency, environmental scenarios need to be designed when occupants engage in different learning tasks. However, how learning efficiency is affected by indoor physical environment based on task types are still...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15061256

    authors: Xiong L,Huang X,Li J,Mao P,Wang X,Wang R,Tang M

    更新日期:2018-06-13 00:00:00

  • Effects of Particulate Matter on the Incidence of Respiratory Diseases in the Pisan Longitudinal Study.

    abstract::The current study aimed at assessing the effects of exposure to Particulate Matter (PM) on the incidence of respiratory diseases in a sub-sample of participants in the longitudinal analytical epidemiological study in Pisa, Italy. Three hundred and five subjects living at the same address from 1991 to 2011 were include...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17072540

    authors: Fasola S,Maio S,Baldacci S,La Grutta S,Ferrante G,Forastiere F,Stafoggia M,Gariazzo C,Viegi G,On Behalf Of The Beep Collaborative Group

    更新日期:2020-04-08 00:00:00

  • Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment.

    abstract::The hepatitis C virus (HCV) RNA replication cycle is a dynamic intracellular process occurring in three-dimensional space (3D), which is difficult both to capture experimentally and to visualize conceptually. HCV-generated replication factories are housed within virus-induced intracellular structures termed membranous...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16030513

    authors: Knodel MM,Targett-Adams P,Grillo A,Herrmann E,Wittum G

    更新日期:2019-02-12 00:00:00

  • Cardiac Autonomic Modulation during on-Call Duty under Working Hours Restriction.

    abstract::Background: Medical residency is a time of high stress and long working hours, which increase the risk of cardiovascular disease. This study aimed to investigate the autonomic modulation of resident physicians throughout the on-call duty cycle. Methods: Spectral analysis of heart rate variability (HRV) was used to com...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17031118

    authors: Chien JW,Chen CY,Lin SH,Lin SW,Lin YH

    更新日期:2020-02-10 00:00:00

  • Wave Energy Assessment at Valencia Gulf and Comparison of Energy Production of Most Suitable Wave Energy Converters.

    abstract::Seaports' energy strategy should rely on the use of renewable energy. Presently, the share of renewable energy used by many of the ports worldwide is negligible. Some initiatives are in the process of implementation to produce some of the energy used by the Port of Valencia, one the largest ports in the Mediterranean ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17228473

    authors: Cascajo R,García E,Quiles E,Morant F,Correcher A

    更新日期:2020-11-16 00:00:00

  • The Effect of Perioral Scan and Artificial Skin Markers on the Accuracy of Virtual Dentofacial Integration: Stereophotogrammetry Versus Smartphone Three-Dimensional Face-Scanning.

    abstract::This study evaluated the effects of different matching methods on the accuracy of dentofacial integration in stereophotogrammetry and smartphone face-scanning systems. The integration was done (N = 30) with different matching areas (n = 10), including teeth image only (TO), perioral area without markers (PN) and with ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph18010229

    authors: Mai HN,Lee DH

    更新日期:2020-12-30 00:00:00

  • Dairy Production under Climatic Risks: Perception, Perceived Impacts and Adaptations in Punjab, Pakistan.

    abstract::The changing climatic conditions coupled with fodder availability have posed severe challenges and threats for the dairy sector in Pakistan. The current paper determines the influence of climate change on the dairy sector in Pakistan. Comprehensive data set was collected from 450 farmers. The majority of farmers exper...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16204036

    authors: Abbas Q,Han J,Adeel A,Ullah R

    更新日期:2019-10-21 00:00:00

  • Florida Arsenic Distribution Index: Quantifying the Distribution of Past and Present Arsenic Usage.

    abstract::Arsenic is an abundant, highly toxic element that is a global health concern due to damage from acute and chronic exposure and the potential for high local concentrations in heavily populated areas. In Florida, arsenic has been used heavily in agricultural, commercial, and industrial applications for decades. While st...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16050744

    authors: Scott-Richardson M,O'Hara Ruiz M,Smith RL

    更新日期:2019-03-01 00:00:00

  • Validation of a Cell-Based Assay for Detection of Active Shiga Toxins Produced by Escherichia coli in Water.

    abstract::Shiga toxin-producing Escherichia coli (STEC) causes a wide spectrum of diseases, including hemorrhagic colitis and hemolytic uremic syndrome (HUS). Almost 5% of STEC infections result from waterborne exposures, yet there is no test listed in the EPA's current Selected Analytical Methods for the detection of active Sh...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17217901

    authors: Hughes AC,Patfield S,Rasooly R,He X

    更新日期:2020-10-28 00:00:00

  • Body Mass Index Trajectory-Specific Changes in Economic Circumstances: A Person-Oriented Approach Among Midlife and Ageing Finns.

    abstract::Economic disadvantage is related to a higher risk of adulthood obesity, but few studies have considered whether changes in economic circumstances depend on a person's body mass index (BMI) trajectory. We identified latent BMI trajectories among midlife and ageing Finns and captured individual-level changes in economic...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17103668

    authors: Salmela J,Lallukka T,Mauramo E,Rahkonen O,Kanerva N

    更新日期:2020-05-22 00:00:00

  • Design of Incentive Contract for Technological Innovation of New Energy Vehicles with Asymmetric Information.

    abstract::The improvement of China's new energy automobile technology is one of the most pressing issues for the government and manufacturers, given that the existing new energy automobile subsidy policy is about to be withdrawn completely. Considering that the manufacturer has the private information of the initial technology ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16224544

    authors: Cai D,Guo C,Tan Y

    更新日期:2019-11-17 00:00:00

  • Using Calcination Remediation to Stabilize Heavy Metals and Simultaneously Remove Polycyclic Aromatic Hydrocarbons in Soil.

    abstract::Co-contaminated soils containing heavy metals and polycyclic aromatic hydrocarbons (PAHs) are an environmental and human health risk. Research into the remediation of these soils is imperative. In this paper, a novel investigation utilizing calcination technique to stabilize heavy metals and simultaneously remove PAHs...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15081731

    authors: Wang P,Hu X,He Q,Waigi MG,Wang J,Ling W

    更新日期:2018-08-13 00:00:00

  • Recruiting Diverse Smokers: Enrollment Yields and Cost.

    abstract::To help tobacco control research better include vulnerable populations, we sought to identify effective ways to recruit diverse smokers. In 2014-2015, we recruited 2149 adult cigarette smokers in California and North Carolina, United States, to participate in a randomized trial of pictorial cigarette pack warnings. Th...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph13121251

    authors: Brodar KE,Hall MG,Butler EN,Parada H,Stein-Seroussi A,Hanley S,Brewer NT

    更新日期:2016-12-16 00:00:00

  • Hypertension Prevalence and Determinants among Black South African Adults in Semi-Urban and Rural Areas.

    abstract::The burden of hypertension is reported to be on the rise in developing countries, such as South Africa, despite increased efforts to address it. Using a cross-sectional study design, we assessed and compared the prevalence of and risk factors associated with hypertension amongst adults aged ≥18 years in semi-urban and...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17207463

    authors: Mphekgwana PM,Malema N,Monyeki KD,Mothiba TM,Makgahlela M,Kgatla N,Makgato I,Sodi T

    更新日期:2020-10-14 00:00:00

  • Caregiving, Employment and Social Isolation: Challenges for Rural Carers in Australia.

    abstract::Australia has one of the world's highest life expectancy rates, and there is a rapidly growing need for informal caregivers to support individuals who are ageing, have chronic illness or a lifelong disability. These informal carers themselves face numerous physical and psychological stressors in attempting to balance ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15102267

    authors: Hussain R,Wark S,Ryan P

    更新日期:2018-10-16 00:00:00

  • Knowledge, Attitude, and Practices of Healthcare Professionals on COVID-19 and Risk Assessment to Prevent the Epidemic Spread: A Multicenter Cross-Sectional Study from Punjab, Pakistan.

    abstract::In the current outbreak of novel coronavirus (COVID-19), healthcare professionals (HCPs) have a primary role in combating the epidemic threat. HCPs are at high risk of not only contracting the infection but also spreading it unknowingly. It is of utmost importance to evaluate their knowledge, attitudes, and practices ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章,多中心研究

    doi:10.3390/ijerph17176395

    authors: Malik UR,Atif N,Hashmi FK,Saleem F,Saeed H,Islam M,Jiang M,Zhao M,Yang C,Fang Y

    更新日期:2020-09-02 00:00:00

  • Adapting Translational Research Methods to Water, Sanitation, and Hygiene.

    abstract::Translational research applies scientific techniques to achieve practical outcomes, connecting pure research and pure practice. Many translational research types have arisen since the mid-1900s, reflecting the need to better integrate scientific advancement with policy and practice. Water, sanitation, and hygiene (WaS...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章,评审

    doi:10.3390/ijerph16204049

    authors: Setty K,Cronk R,George S,Anderson D,O'Flaherty G,Bartram J

    更新日期:2019-10-22 00:00:00

  • Antimicrobial Resistance Profiles of Staphylococcus aureus Isolated from Meat Carcasses and Bovine Milk in Abattoirs and Dairy Farms of the Eastern Cape, South Africa.

    abstract::Background: Staphylococcus aureus (S. aureus) occasionally threatens the life of the host as a persistent pathogen even though it is normal flora of humans and animals. We characterized drug resistance in S. aureus isolated from animal carcasses and milk samples from the abattoirs and dairy farms in the Eastern Cape P...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph15102223

    authors: Pekana A,Green E

    更新日期:2018-10-11 00:00:00

  • Relationship between Difficulty in Emotion Regulation and Internet Addiction in College Students: A One-Year Prospective Study.

    abstract::This prospective study evaluated the predictive effect of difficulty in emotion regulation on the occurrence and remission of Internet addiction (IA) and determined whether IA has a role in changing emotion regulation among college students during a follow-up period of 1 year. A total of 500 college students (262 wome...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph17134766

    authors: Tsai JK,Lu WH,Hsiao RC,Hu HF,Yen CF

    更新日期:2020-07-02 00:00:00

  • Willingness to Pay for Condoms among Men in Sub-Saharan Africa.

    abstract::HIV/AIDS and other sexually transmitted infections (STIs) continue to be among the greatest public health threats worldwide, especially in sub-Saharan Africa (SSA). Condom use remains an essential intervention to eradicate AIDS, and condom use is now higher than ever. However, free and subsidized condom funding is dec...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章

    doi:10.3390/ijerph16010034

    authors: Evans W,Kadirov K,Thior I,Ganesan R,Ulasevich A,Deperthes B

    更新日期:2018-12-24 00:00:00

  • Effects of FDI on the Efficiency of Government Expenditure on Environmental Protection Under Fiscal Decentralization: A Spatial Econometric Analysis for China.

    abstract::Most governments strive for an ecological civilization so the efficiency of government expenditure on environmental protection (EPEE) is an important issue. While it is recognized that foreign direct investment (FDI) enhances environmental protection, this investigation focuses on the effects of FDI on the efficiency ...

    journal_title:International journal of environmental research and public health

    pub_type: 杂志文章,评审

    doi:10.3390/ijerph16142496

    authors: Zhang J,Qu Y,Zhang Y,Li X,Miao X

    更新日期:2019-07-12 00:00:00