Abstract：
BACKGROUND:Long time exposure to particular matter has been linked to myocardial infarction, stroke and blood pressure, but its association with atherosclerosis is not clear. This meta-analysis was aimed at assessing whether PM₂.₅ and PM₁₀ have an effect on subclinical atherosclerosis measured by carotid intima-media thickness (CIMT). METHODS:Pubmed, Ovid Medline, Embase and NICK between 1948 and 31 March 2015 were searched by combining the keywords about exposure to the outcome related words. The random-effects model was applied in computing the change of CIMT and their corresponding 95% confidence interval (95% CI). The effect of potential confounding factors was assessed by stratified analysis and the impact of traffic proximity was also estimated. RESULTS:Among 56 identified studies, 11 articles satisfied the inclusion criteria. In overall analysis increments of 10 μg/m³ in PM₂.₅ and PM₁₀ were associated with an increase of CIMT (16.79 μm; 95% CI, 4.95-28.63 μm and 4.13 μm; 95% CI, -5.79-14.04 μm, respectively). RESULTS shown in subgroup analysis had reference value for comparing with those of the overall analysis. The impact of traffic proximity on CIMT was uncertain. CONCLUSIONS:Exposure to PM₂.₅ had a significant association with CIMT and for women the effect may be more obvious.
journal_name
Int J Environ Res Public Healthauthors
Liu X,Lian H,Ruan Y,Liang R,Zhao X,Routledge M,Fan Zdoi
10.3390/ijerph121012924subject
Has Abstractpub_date
2015-10-15 00:00:00pages
12924-40issue
10eissn
1661-7827issn
1660-4601pii
ijerph121012924journal_volume
12pub_type
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