Abstract：
:The herbicide atrazine is widely used across the globe, which is a great concern. To investigate its potential toxicity in the human body, human serum albumin (HSA) was selected as a model protein. The interaction between atrazine and HSA was investigated using steady-state fluorescence spectroscopy, synchronous fluorescence spectroscopy, UV-Vis spectroscopy, three-dimensional (3D) fluorescence spectroscopy and circular dichroism (CD) spectroscopy. The intrinsic fluorescence of HSA was quenched by the atrazine through a static quenching mechanism. Fluorescence spectra at two excitation wavelengths (280 and 295 nm) showed that the fluorescence quenched in HSA was mainly contributed to by tryptophan residues. In addition, the atrazine bound to HSA, which induced changes in the conformation and secondary structure of HSA and caused an energy transfer. Thermodynamic parameters revealed that this binding is spontaneous. Moreover, electrostatic interactions play a major role in the combination of atrazine and HSA. One atrazine molecule can only bind to one HSA molecule to form a complex, and the atrazine molecule is bound at site II (subdomain IIIA) of HSA. This study furthers the understanding of the potential effects posed by atrazine on humans at the molecular level.
journal_name
Int J Environ Res Public Healthauthors
Zhu M,Wang L,Wang Y,Zhou J,Ding J,Li W,Xin Y,Fan S,Wang Z,Wang Ydoi
10.3390/ijerph15010116subject
Has Abstractpub_date
2018-01-11 00:00:00issue
1eissn
1661-7827issn
1660-4601pii
ijerph15010116journal_volume
15pub_type
杂志文章abstract：:The Nordic countries are among the world's leading countries in international rankings on prosperity, productivity, social equity, trust, and health. Such positive results may be linked to how these countries have organized their working life. The aim of this article is to describe core elements of the Nordic working ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
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journal_title：International journal of environmental research and public health
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abstract：:Previous research has highlighted the relationship between being cybervictimised and the presence of clinical symptoms, such as depression. To date, however, there has been no comparative analysis of the personal resources profiles of adolescent victims of cyberbullying with and without depressive symptoms. The curren...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2020-12-12 00:00:00
abstract：:Socioeconomic development and consumption are among the key drivers of environmental degradation. Legal measures and the appropriate funding are required to effectively protect the natural environment. The aim of this study was to analyze the dynamics of changes and spatial differences in the measures undertaken to pr...
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更新日期：2020-06-30 00:00:00
abstract：:Background: Delivering a child is a very stressful experience for women. Pregnancy and labor entail complex events that are unique to each individual female. The management of labor pain is often done using analgesics and anesthesia, which have been shown to have some side effects. More comprehensive data are needed t...
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
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更新日期：2019-12-06 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16040649
更新日期：2019-02-22 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,多中心研究
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2019-10-17 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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journal_title：International journal of environmental research and public health
pub_type： 社论
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更新日期：2020-04-16 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,随机对照试验
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更新日期：2020-03-22 00:00:00
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pub_type： 杂志文章
doi：10.3390/ijerph15030414
更新日期：2018-02-27 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17238969
更新日期：2020-12-02 00:00:00
abstract：OBJECTIVE:The primary objective was to assess the satisfaction of patients undergoing hemodialysis regarding counseling services provided by pharmacists. The secondary objectives were to compare the effect of years on dialysis and the presence of comorbidities on patient satisfaction. METHODS:A total of 138 patients w...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17072399
更新日期：2020-04-01 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,多中心研究
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更新日期：2020-06-01 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17197066
更新日期：2020-09-27 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.3390/ijerph17114010
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更新日期：2019-11-22 00:00:00
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pub_type： 杂志文章
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journal_title：International journal of environmental research and public health
pub_type： 社论
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更新日期：2019-12-08 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2019-03-16 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, infertility, obesity, and insulin resistance, which results in increased concentrations of testosterone (T), which disturbs follicular growth and ovulation. This study aimed to assess PCOS women's clinical, endocrinological, ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17249291
更新日期：2020-12-11 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17249552
更新日期：2020-12-20 00:00:00
