当前位置： SCI文献检索 > Cardiology Journal期刊下所有文献 > Neprilysin inhibition: A brief review of past pharmacological strategies for heart failure treatment and future directions.

Neprilysin inhibition: A brief review of past pharmacological strategies for heart failure treatment and future directions.

Abstract：

:Heart failure (HF) is a manifestation of aberrant vascular responses and remains a public health concern with a worldwide prevalence of around 23 million and a 5-year mortality numerically equivalent to many cancers. Over the last two decades, mortality from HF reached a plateau with current pharmaceutical agents and mechanical cardiac support. In the last several years, various "novel" pharmaceutical agents have been tested in clinical trials and ultimately met with disappointment, showing only incremental benefit in the treatment of HF. Designing a HF drug with enhanced efficacy over existing agents seemed like a Sisyphean task. Yet again, pharmaceutical chemists have demonstrated their prowess in lateral thinking by developing a vasoactive agent which is a co-crystallized compound of valsartan and sacubitril in a one-to-one molar ratio; the former molecule belongs to a family of agents that are the current standard of care for HF and the latter molecule is a novel agent which inhibits neprilysin - a neutral endopeptidase found in human plasma which alters neurohumoral responses. In July of 2015, a drug which is a combination of valsartan and sacubitril was formally licensed by the United States Food and Drug Administration for the treatment of HF. This review describes the evolution of HF medications focusing on rational drug design with the first HF medication, the beta-adrenergic receptor antagonist. We then discuss the biochemical and physiological properties of sacubitril/valsartan which likely lead to its dramatic ability to ameliorate HF mortality.

journal_name

Cardiol J

journal_title

Cardiology journal

authors

Howell EH,Cameron SJ

doi

10.5603/CJ.a2016.0063

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

591-598

issue

6

issn

1897-5593

pii

VM/OJS/J/47549

journal_volume

23

pub_type

杂志文章,评审

相关文献

Cardiology Journal文献大全
  • Risk factor paradox: No prognostic impact of arterial hypertension and smoking in patients with ventricular tachyarrhythmias.

    abstract：BACKGROUND:Data regarding the outcome of patients with ventricular tachyarrhythmias related to arterial hypertension (AHT) and smoking is limited. The study sought to assess the prognostic impact of AHT and smoking on survival in patients presenting with ventricular tachyarrhythmias. METHODS:All consecutive patients s...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2018.0158

    authors： Weidner K,Behnes M,Rusnak J,Taton G,Schupp T,Reiser L,Bollow A,Reichelt T,Ellguth D,Engelke N,Kuche P,Hoppner J,El-Battrawy I,Lang S,Nienaber CA,Mashayekhi K,Ferdinand D,Weiß C,Borggrefe M,Akin I

    更新日期：2020-01-01 00:00:00

  • Importance of cardiac biomarkers in risk stratification in acute pulmonary embolism.

    abstract：:At present there is consent that patients with acute pulmonary embolism (APE) and hemodynamic instability have poor prognosis and benefit from thrombolytic therapy or embolectomy, whereas hemodynamically stable patients without echocardiographic signs of right ventricular overload/dysfunction (RVO) have good prognosis...

    journal_title：Cardiology journal

    pub_type： 杂志文章,评审

    doi：

    authors： Mikulewicz M,Lewczuk J

    更新日期：2008-01-01 00:00:00

  • Pulmonary arterial hypertension in the elderly: Clinical perspectives.

    abstract：:Pulmonary hypertension (PH) is a rare and devastating disease characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, which eventually leads to right ventric-ular failure and death. Pulmonary arterial hypertension (PAH) (World Health Organization Group I), a subset of P...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2018.0096

    authors： Rothbard N,Agrawal A,Fischer C,Talwar A,Sahni S

    更新日期：2020-01-01 00:00:00

  • Low permanent pacemaker rates following Lotus device implantation for transcatheter aortic valve replacement due to modified implantation protocol.

    abstract：BACKGROUND:Conduction disturbances requiring permanent pacemaker implantation following transcatheter aortic valve replacement (TAVR) are a common problem. Pacemaker implantation rates after TAVR appear to be higher compared to conventional aortic valve replacement. The aim of this study was to analyze whether a high a...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2017.0024

    authors： Krackhardt F,Kherad B,Krisper M,Pieske B,Laule M,Tschöpe C

    更新日期：2017-01-01 00:00:00

  • Dual antiplatelet therapy and antithrombotic treatment: Recommendations and controversies.

    abstract：:Dual antiplatelet therapy is currently recommended for all patients with acute coronary syndromes, independent of whether they receive pharmacological treatment or undergo percutaneous coronary intervention. Antiplatelet agents are the cornerstone of pharmacological treatment in interventional cardiology. However, the...

    journal_title：Cardiology journal

    pub_type： 杂志文章,评审

    doi：

    authors： Bryniarski L,Pelc-Nowicka A,Zabojszcz M,Mirek-Bryniarska E

    更新日期：2009-01-01 00:00:00

  • Evaluation of a direct access cardiac arrhythmia monitoring service.

    abstract：BACKGROUND:This paper describes the clinical outcomes from a novel direct access arrhythmia monitoring service. METHODS:The study was carried out in the north of Scotland. Data was collected over a 29 month period between 18 June 2008 and 8 November 2010 from consecutive cases from two groups of patients, general prac...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/cj.2012.0010

    authors： Skipsey DA,Dawson FM,Breen C,Leslie SJ

    更新日期：2012-01-01 00:00:00

  • The comparison of contrast echocardiography and tissue Doppler imaging for evaluation of reperfused myocardium in patients with acute anterior myocardial infarction.

    abstract：BACKGROUND:Prediction of functional myocardial recovery post acute myocardial infarction should be based not only on flow patency of the infarct related artery (IRA) but also on the quality of microcirculation in at-risk segments. Myocardial blush grade (MBG) is a method of perfusion assessment which has an established...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Streb W,Duszańska A,Stabryła-Deska J,Pluta S,Swierad M,Was T,Kalarus Z,Kukulski T

    更新日期：2008-01-01 00:00:00

  • The impact of transferring patients with ST-segment elevation myocardial infarction to percutaneous coronary intervention-capable hospitals on clinical outcomes.

    abstract：BACKGROUND:Primary percutaneous coronary intervention (PCI) is recommended for ST-segment elevation myocardial infarction (STEMI) patients even when the patient must be transported to a PCI-capable hospital. This study aimed to evaluate the long-term clinical outcomes of STEMI patients who were transferred for primary ...

    journal_title：Cardiology journal

    pub_type： 杂志文章,多中心研究

    doi：10.5603/CJ.a2016.0003

    authors： Kim BW,Cha KS,Park MJ,Choi JH,Yun EY,Park JS,Lee HW,Oh JH,Kim JS,Choi JH,Park YH,Lee HC,Kim JH,Chun KJ,Hong TJ,Ahn Y,Jeong MH

    更新日期：2016-01-01 00:00:00

  • Low admission triglyceride and mortality in acute coronary syndrome patients.

    abstract：BACKGROUND:The relationship between admission triglyceride (TG) levels and long-term outcomes has not been established in patients with acute coronary syndrome. We tested the hypothesis that patients who develop non-ST segment elevation myocardial infarction (NSTEMI) despite low TG have a worse cardiovascular outcome i...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Khawaja OA,Hatahet H,Cavalcante J,Khanal S,Al-Mallah MH

    更新日期：2011-01-01 00:00:00

  • Arrhythmogenic effect of flecainide toxicity.

    abstract：:Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. In overdose cases, flecainide can induce life treating ventricular arrhythmias and cardiogenic shock. We report the case of a 72-year-old woman admitted to our intensive care unit for a regular monomorphic w...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.2013.0035

    authors： Courand PY,Sibellas F,Ranc S,Mullier A,Kirkorian G,Bonnefoy E

    更新日期：2013-01-01 00:00:00

  • The treatment of acute myocardial infarction due to the occlusion of the left main coronary disease.

    abstract：:Acute myocardial infarction (AMI) due to the occlusion of the left main coronary artery (LMCA) is a rare but serious condition in the era of percutaneus coronary intervention (PCI). Even more rare is AMI involved with both LMCA and its branches like trifurcartion or bifurcation: this is challenging for interventional ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Can MM,Tanboga H,Karabay CY,Güler A,Akgun T,Turkyilmaz E,Ozveren O,Mutlu B

    更新日期：2011-01-01 00:00:00

  • Myocardial strain characteristics and outcomes after transcatheter aortic valve replacement.

    abstract：BACKGROUND:Objective of this study was to make an assessment of standard functional and defor-mation parameters (strain) in patients after transcatheter aortic valve replacement (TAVR) by cardiac magnetic resonance imaging (CMR) and the evaluation of their prognostic impact. METHODS:Patients undergoing TAVR received C...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2017.0121

    authors： Buckert D,Tibi R,Cieslik M,Radermacher M,Qu YY,Rasche V,Bernhardt P,Hombach V,Rottbauer W,Wöhrle J

    更新日期：2018-01-01 00:00:00

  • Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats.

    abstract：BACKGROUND:Recent clinical studies have shown that treatment with LCZ696, a complex containing the angiotensin receptor blocker valsartan and neprilysin inhibitor sacubitril, improves the prognosis of heart failure patients with a reduced ejection fraction. This study evaluated whether LCZ696 affects left ventricular h...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2018.0048

    authors： Miyoshi T,Nakamura K,Miura D,Yoshida M,Saito Y,Akagi S,Ohno Y,Kondo M,Ito H

    更新日期：2019-01-01 00:00:00

  • Whether noninvasive optimization of AV and VV delays improves the response to cardiac resynchronization therapy.

    abstract：BACKGROUND:Device optimization is not routinely performed in patients who underwent cardiac resynchronization therapy (CRT) device implantation. Noninvasive optimization of CRT devices by measurement of cardiac output (CO) can be used as a simple method to assess ventricular systolic performance. The aim of this study ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.2013.0100

    authors： Urbanek B,Chudzik M,Klimczak A,Rosiak M,Lewek J,Wranicz JK

    更新日期：2013-01-01 00:00:00

  • Learning curve in circular multipolar phased radiofrequency ablation of atrial fibrillation.

    abstract：BACKGROUND:Although atrial fibrillation (AF) ablation is considered a technically challenging procedure, studies on the learning curve of different pulmonary vein isolation (PVI) techniques are limited. We investigated the time-dependent changes in procedural parameters, complication rates, and in the 1-year clinical o...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2014.0085

    authors： Martirosyan M,Kiss A,Nagy-Baló E,Sándorfi G,Tint D,Édes I,Csanádi Z

    更新日期：2015-01-01 00:00:00

  • Prevalence of United States adults with triglycerides ≥ 135 mg/dL: NHANES 2007-2014.

    abstract：:n/a - brief communication. ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.2019.0099

    authors： Fan W,Philip S,Toth PP,Granowitz C,Wong ND

    更新日期：2019-01-01 00:00:00

  • Risk of left atrial appendage thrombus in patients with atrial fibrillation and chronic kidney disease.

    abstract：BACKGROUND:Atrial fibrillation (AF) and chronic kidney disease (CKD) are associated with an increased risk of ischemic stroke. The aim of this study was to compare the clinical characteristics, the incidence of left atrial appendage (LAA) thrombus and its predictors, and spontaneous echo contrast (SEC) in a population ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2020.0036

    authors： Budnik M,Gawałko M,Gorczyca I,Uziębło-Życzkowska B,Krzesiński P,Kochanowski J,Scisło P,Michalska A,Jelonek O,Starzyk K,Jurek A,Kiliszek M,Wożakowska-Kapłon B,Gielerak G,Filipiak KJ,Opolski G,Kapłon-Cieślicka A

    更新日期：2020-04-27 00:00:00

  • Cardiac resynchronization therapy and atrial fibrillation.

    abstract：:Cardiac resynchronization therapy (CRT) is an important advance for the treatment of end-stage heart failure (HF). About 15-50% of HF is complicated by atrial fibrillation (AF), associated with worsened outcomes. The presence of AF may interfere with optimal delivery of CRT due to competition with biventricular (BiV) ...

    journal_title：Cardiology journal

    pub_type： 杂志文章,评审

    doi：

    authors： Kamath GS,Steinberg JS

    更新日期：2009-01-01 00:00:00

  • The ventricular assist device: a bridge to ventricular recovery, a bridge to heart transplantation or destination therapy?

    abstract：:Despite advances in pharmacological treatments aimed at a neurohormonal blockade for heart failure, there is still a growing number of patients with advanced symptoms who suffer significant morbidity and mortality. At present the most effective cure for end-stage congestive heart failure is cardiac transplantation. Th...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Bielecka A,Wierzbicka M,Goch J

    更新日期：2007-01-01 00:00:00

  • Twelve-month follow-up of left atrial appendage occlusion with Amplatzer Amulet.

    abstract：BACKGROUND:The Amplatzer Amulet (St. Jude Medical, Minneapolis, MN, USA) is a second gen-eration Amplatzer device for left atrial appendage (LAA) occlusion (LAAO) for stroke prophylaxis in patients with atrial fibrillation. This research sought to assess the clinical performance of the Amplatzer Amulet device and in fo...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2017.0017

    authors： Kleinecke C,Park JW,Gödde M,Zintl K,Schnupp S,Brachmann J

    更新日期：2017-01-01 00:00:00

  • Diagnostic value of flow mediated dilatation measurement for coronary artery lesions in men under 45 years of age.

    abstract：BACKGROUND:In those without symptoms of coronary artery disease (CAD), the incidence of coronary events is still high. The aim of this study was to evaluate whether flow mediated dilatation (FMD) is a useful tool in identifying those with CAD in who are under 45 years of age. METHODS AND RESULTS:Seventy five men below...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Kaźmierski M,Michalewska-Włudarczyk A,Krzych LJ,Tendera M

    更新日期：2010-01-01 00:00:00

  • Prognostic significance of red cell distribution width and its relation to increased pulmonary pressure and inflammation in acute heart failure.

    abstract：BACKGROUND:Red cell distribution width (RDW) in acute heart failure (AHF) is accepted as a prognostic indicator with unclear pathophysiological ties. The aim of this study was to evaluate the prognostic value of RDW in AHF patients in relation to clinical and echocardiographic data. METHODS:170 patients with AHF were ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2018.0103

    authors： Targoński R,Sadowski J,Starek-Stelmaszczyk M,Targoński R,Rynkiewicz A

    更新日期：2020-01-01 00:00:00

  • Eisenmenger's syndrome and agenesis of the right pulmonary artery: a case of double diagnosis.

    abstract：:We present a case of patent ductus arteriosus with severe pulmonary hypertension with the rare association of absent right pulmonary artery. ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.2013.0018

    authors： Duggal B,Narayan G

    更新日期：2013-01-01 00:00:00

  • Identification of a peripheral blood long non-coding RNA (Upperhand) as a potential diagnostic marker of coronary artery disease.

    abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been confirmed to be involved in the pathologi-cal processes of multiple diseases. However, the characteristic expression of lncRNAs in peripheral blood of coronary artery disease (CAD) patients and whether some of these lncRNAs can be used as diagnostic biomarkers for CAD...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2017.0133

    authors： Li X,Zhao Z,Gao C,Rao L,Hao P,Jian D,Li W,Tang H,Li M

    更新日期：2018-01-01 00:00:00

  • Possible role of Helicobacter pylori infection via microvascular dysfunction in cardiac syndrome X.

    abstract：:Recently, some investigators have reported seeing microvascular dysfunction in patients with cardiac syndrome X (CSX). In addition, Helicobacter pylori (H. pylori), a bacterium causing chronic gastritis and peptic ulcers, has recently been associated with CSX. Yet the mechanism(s) by which H. pylori infection leads to...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Rasmi Y,Raeisi S

    更新日期：2009-01-01 00:00:00

  • Percutaneous reconstruction of the continuity of a functionally interrupted aortic arch using a stent.

    abstract：:A case of a 26-year-old man without continuity of blood flow in the level of the isthmus of the aorta is described. During interventional catheterization, we reconstructed this continuity and implanted a vascular stent. ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Kusa J,Szkutnik M,Białkowski J

    更新日期：2008-01-01 00:00:00

  • Changes in the mental and physical components of the quality of life for patients six months after pacemaker implantation.

    abstract：BACKGROUND:The additional purpose for pacemaker implantation, beyond treating arrhythmias and conduction disturbances, is to improve the quality of life (QoL) of the patient. Most previous research has shown this purpose to have been achieved. However, the question as to whether all mental and physical components impro...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Młynarski R,Włodyka A,Kargul W

    更新日期：2009-01-01 00:00:00

  • Right heart thrombus-in-transit with pulmonary embolism in a patient with primary hypercoagulable state.

    abstract：:A 25 year-old female with a history of Caesarian section ten weeks ago presented with symptoms suggestive of pulmonary embolism. Transthoracic echocardiography revealed a free-floating large thrombus traversing the right atrial cavity. Transesophageal echocardiography confirmed the presence of an unattached thrombus t...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：

    authors： Eweda II,Samir S,Abbas O,El-Gohary GM,Nammas W

    更新日期：2010-01-01 00:00:00

  • Psoriasis is an independent predictor of increased risk of allergic reaction during percutaneous coronary interventions. Big data analysis from the Polish National PCI Registry (ORPKI).

    abstract：BACKGROUND:The presence of psoriasis is currently considered by the European Society of Cardiology cardiovascular prevention guidelines of 2016 as one possible cardiovascular risk factor. Patients with psoriasis and concomitant coronary artery disease treated by means of percutaneous coronary interven-tion (PCI) are a ...

    journal_title：Cardiology journal

    pub_type： 杂志文章

    doi：10.5603/CJ.a2018.0076

    authors： Siudak Z,Wysocka-Dubielecka K,Malinowski K,Dziewierz A,Tokarek T,Plens K,Dudek D

    更新日期：2020-01-01 00:00:00

  • Quality of visualization of coronary venous system in 64-slice computed tomography.

    abstract：BACKGROUND:Multi-slice computed tomography (MSCT) can be used to visualize the anatomy of the coronary venous system (CVS). A pre-procedural evaluation of target veins is a very important element of cardiac resynchronization. Thus, the quality of visualization of the CVS is of great importance. The aim of this study wa...

    journal_title：Cardiology journal

    pub_type： 临床试验,杂志文章

    doi：

    authors： Młynarska A,Młynarski R,Kargul W,Sosnowski M

    更新日期：2011-01-01 00:00:00