Abstract:
BACKGROUND:Long non-coding RNAs (lncRNAs) have been confirmed to be involved in the pathologi-cal processes of multiple diseases. However, the characteristic expression of lncRNAs in peripheral blood of coronary artery disease (CAD) patients and whether some of these lncRNAs can be used as diagnostic biomarkers for CAD requires further investigation. METHODS:Six healthy and CAD individuals were selected for microarray analysis, and 5 differentially expressed lncRNAs were selected and confirmed in the second cohort consisting of 30 control individu-als and 30 CAD patients with different SYNTAX scores. Upperhand were verified in the third cohort consisting of 115 controls and 137 CAD patients. RESULTS:Thirty one lncRNAs were differentially expressed between the two groups, among whom, 25 were upregulated in the CAD group and 6 were downregulated. Four of the selected five lncRNAs were significantly upregulated in the CAD group, and Upperhand had the largest area under the curve (AUC). The diagnostic value of Upperhand was tested further, and it remained having a high diagnostic value. CONCLUSIONS:The expression level of Upperhand in peripheral blood of CAD patients is significantly higher than in control individuals, and is correlated with severity of CAD. Upperhand is a potential diagnostic biomarker of CAD, and when combined with TCONS_00029157, diagnostic value slightly increased.
journal_name
Cardiol Jjournal_title
Cardiology journalauthors
Li X,Zhao Z,Gao C,Rao L,Hao P,Jian D,Li W,Tang H,Li Mdoi
10.5603/CJ.a2017.0133subject
Has Abstractpub_date
2018-01-01 00:00:00pages
393-402issue
3issn
1897-5593pii
VM/OJS/J/50732journal_volume
25pub_type
杂志文章abstract::Congenital diverticulum of the left ventricle is a very rare cardiac abnormality characterized by a local embryological development failure of the ventricular muscle. It may present as an isolated disorder or may be associated with other cardiac abnormalities. Clinically, it has been reported that it can lead to chest...
journal_title:Cardiology journal
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Herein is hypothesised that a comprehensive optical coherence tomography (OCT)-guided implantation protocol for bioresorbable scaffolds (BRS) can improve expansion and apposition, thus resulting in better clinical outcomes, particularly in reducing thrombotic events. METHODS:Patients considered suitable for...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2018.0055
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Subcostal planes allow demonstration of the entire right ventricular cavity and are frequently used in patients with congenital heart disease; however, their clinical utility in the evaluation of systemic right ventricular function after atrial switch procedure for complete transposition has never been verif...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Distortion of the terminal portion of the QRS in the initial electrocardiogram (ECG) is a strong predictor of adverse outcome in myocardial infarction. Our purpose is to assess the relationship of distortion of QRS and other ECG characteristics with older age. METHODS AND RESULTS:We analysed 634 consecutive...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:This paper describes the clinical outcomes from a novel direct access arrhythmia monitoring service. METHODS:The study was carried out in the north of Scotland. Data was collected over a 29 month period between 18 June 2008 and 8 November 2010 from consecutive cases from two groups of patients, general prac...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/cj.2012.0010
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:To investigate the effects of a noninvasive positive pressure ventilation therapy on cardiac structure and function in patients with coronary heart disease combined with obstructive sleep apnea/hypopnea syndrome (OSAHS). METHODS:80 coronary heart disease OSAHS patients from three hospitals in Shanghai were ...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2014.0042
更新日期:2014-05-20 00:00:00
abstract:BACKGROUND:The aim of the study was to identify differences between proximal and distal cell rewir-ing with subsequent kissing balloon inflation (KBI) in the presence of a link connected to a carina on the jailed side branch ostium (SBO). METHODS:Kaname stents were deployed in bifurcation models (n = 12) with subseque...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2017.0076
更新日期:2018-01-01 00:00:00
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journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2013.0143
更新日期:2014-01-01 00:00:00
abstract::Takotsubo syndrome (TTS) is still a relatively understudied and often undetected disease. It is usually preceded by emotional or physical triggers. We here report a case of TTS following a car accident. Typical apical ballooning with moderate reduction of left ventricular ejection fraction (LVEF) and increased level o...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.2016.0034
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Whereas coronary artery ectasia (CAE) is a rare abnormality of the coronary arteries, co-existent coronary artery disease (CAD) is commonly seen in CAE patients. Since a causative relationship has been shown to exist between oxidative stress and CAD, we sought to determine whether any relationship exists bet...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The second-generation cryoballoon (CB2) provides effective and durable pulmonary vein isolation (PVI) associated with encouraging and reproducible clinical outcome data. The latest- -generation cryoballoon (CB3) incorporates a 40% shorter distal tip, thus allowing for an increased rate of PVI real-time signa...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2018.0056
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Red cell distribution width (RDW) in acute heart failure (AHF) is accepted as a prognostic indicator with unclear pathophysiological ties. The aim of this study was to evaluate the prognostic value of RDW in AHF patients in relation to clinical and echocardiographic data. METHODS:170 patients with AHF were ...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2018.0103
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In those without symptoms of coronary artery disease (CAD), the incidence of coronary events is still high. The aim of this study was to evaluate whether flow mediated dilatation (FMD) is a useful tool in identifying those with CAD in who are under 45 years of age. METHODS AND RESULTS:Seventy five men below...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Device optimization is not routinely performed in patients who underwent cardiac resynchronization therapy (CRT) device implantation. Noninvasive optimization of CRT devices by measurement of cardiac output (CO) can be used as a simple method to assess ventricular systolic performance. The aim of this study ...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.2013.0100
更新日期:2013-01-01 00:00:00
abstract::Present day 24-h Holter monitors have been shown to miss many arrhythmias that may occur infrequently or under specific circumstances. The advancement in electronic and adhesive technologies have enabled the development of first generation wearable long-term 14-day patch ECG monitors that attach directly to the skin a...
journal_title:Cardiology journal
pub_type: 杂志文章,评审
doi:10.5603/cj.2012.0039
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Reduced heart rate variability (HRV) is associated with a poor outcome in patients with sinus rhythm (SR) or atrial fibrillation (AF). However, cut-off points for HRV measures differ between SR and AF. We hypothesized that a global index of 24-hour HRV based on evaluation of scatterplot would describe HRV ir...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/cj.2011.0010
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the correlation of the selected biomarkers and collagen turn-over indices with advanced echocardiographic parameters among patients with preserved and reduced ejection fraction (EF). METHODS:We included 62 patients with the symptomatic heart failure. The patients were divi...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2016.0098
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:We aimed to prospectively assess the influence of the recommended dose, 1.0 g of polyunsaturated fatty acids (N-3 PUFA) daily, on platelet reactivity in patients with stable angina pectoris (SAP) after elective percutaneous coronary intervention (PCI). METHODS:Forty consecutive patients with SAP and success...
journal_title:Cardiology journal
pub_type: 杂志文章,随机对照试验
doi:10.5603/CJ.2013.0132
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The associations between statin and coronary plaque compositional changes were re-ported according to the use of high dose or not. An evaluation of the impact of low-density lipoprotein cholesterol (LDL-C) < 70 mg/dL by using real world dosages of statin on coronary plaque composition was undertaken. METHOD...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2018.0002
更新日期:2018-01-01 00:00:00
abstract::n/a - brief communication. ...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.2019.0099
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Multi-slice computed tomography (MSCT) can be used to visualize the anatomy of the coronary venous system (CVS). A pre-procedural evaluation of target veins is a very important element of cardiac resynchronization. Thus, the quality of visualization of the CVS is of great importance. The aim of this study wa...
journal_title:Cardiology journal
pub_type: 临床试验,杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Vasovagal syncope (VVS) is a common symptom with empirical therapy and high recurrence rate. Our goal was to determine whether the pattern of presyncopal prodromal symptoms can predict the recurrence probability of vasovagal syncope. METHODS:Seventy-nine consecutive patients (male/female: 53/26) with histor...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility of the use of a quadripolar left ventricular (LV) lead for cardiac resynchronization therapy and to compare its acute and mid-term outcomes with those obtained with bipolar leads. Cardiac resynchronization exhibits a high incidence of problems involvi...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/cj.2012.0087
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Rheumatic mitral stenosis (MS) is still a common disease in developing countries with high morbidity and mortality rates. The purpose of the study was to evaluate arterial stiffness in severe MS before and after percutaneous mitral balloon valvuloplasty (PMBV). METHODS:Thirty patients with MS in sinus rhyth...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/cj.2012.0109
更新日期:2012-01-01 00:00:00
abstract::Dual antiplatelet therapy is currently recommended for all patients with acute coronary syndromes, independent of whether they receive pharmacological treatment or undergo percutaneous coronary intervention. Antiplatelet agents are the cornerstone of pharmacological treatment in interventional cardiology. However, the...
journal_title:Cardiology journal
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The authors analyzed data from Polish national POL-TAVI registry in terms of paravalvular leak (PVL) occurrence after transcatheter aortic valve implantation (TAVI) and its impact on clinical outcomes. METHODS:A total of 331 patients with severe aortic stenosis underwent TAVI (Edwards Sapien, n = 141; CoreV...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.a2015.0071
更新日期:2016-01-01 00:00:00
abstract::In this article, the authors take a closer look at the figure of Josephus Struthius Polonus (1510- -1568), one of the most famous physicians of the European Renaissance, on the 500(th) anniversary of his birth. Struthius became famous for his critical analysis of Galen's works and his own research into the circulatory...
journal_title:Cardiology journal
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::The identification of high-risk patients with hypertrophic cardiomyopathy (HC) for primary prevention of sudden cardiac death (SCD) remains a challenging issue, since major risk factors sometimes lack specificity. We report the case of a patient with HC and association of apical aneurysm and myocardial bridging who...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/cj.2012.0119
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Antiplatelet therapy has proven beneficial in the treatment of cardiovascular disease. Proton pump inhibitors (PPIs) are commonly used for gastroprotection in patients receiving antiplatelet therapy. Several trials have been carried out to establish interactions between PPIs, clopidogrel and soluble formulat...
journal_title:Cardiology journal
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Ultrasonic tissue characterization (UTC) has been widely used to investigate left ventricular (LV) dysfunction in various cardiac disorders. The aim of this study was to investigate the correlation between functional capacity and UTC in patients with idiopathic dilated cardiomyopathy (IDCM). METHODS AND RES...
journal_title:Cardiology journal
pub_type: 杂志文章
doi:10.5603/CJ.2013.0082
更新日期:2013-01-01 00:00:00