Abstract:
:Within the PREVIENI project, infertile and fertile women were enrolled from metropolitan, urban and rural Italian areas. Blood/serum levels of several endocrine disrupters (EDs) (perfluorooctane sulfonate, PFOS; perfluorooctanoic acid, PFOA; di-2-ethylhexyl-phthalate, DEHP; mono-(2-ethylhexyl)-phthalate, MEHP; bisphenol A, BPA) were evaluated concurrently with nuclear receptors (NRs) gene expression levels (ERa, ERb, AR, AhR, PPARg, PXR) in peripheral blood mononuclear cells (PBMCs). Infertile women from the metropolitan area displayed significantly higher levels of: BPA compared to fertile women (14.9 vs. 0.5 ng/mL serum); BPA and MEHP compared to infertile women from urban and rural areas; enhanced expression levels of NRs, except PPARg. Infertile women from urban and rural areas had PFOA levels significantly higher than those from metropolitan areas. Our study indicates the relevance of the living environment when investigating the exposure to EDs and the modulation of the NR panel in PBMC as a suitable biomarker of the effect, to assess the EDs impact on reproductive health.
journal_name
Int J Environ Res Public Healthauthors
La Rocca C,Tait S,Guerranti C,Busani L,Ciardo F,Bergamasco B,Stecca L,Perra G,Mancini FR,Marci R,Bordi G,Caserta D,Focardi S,Moscarini M,Mantovani Adoi
10.3390/ijerph111010146subject
Has Abstractpub_date
2014-09-29 00:00:00pages
10146-64issue
10eissn
1661-7827issn
1660-4601pii
ijerph111010146journal_volume
11pub_type
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