Abstract:
:Phthalates, widely used in flexible plastics and consumer products, have become ubiquitous contaminants worldwide. This study evaluated the acute toxicity and estrogenic endocrine disrupting activity of butyl benzyl phthalate (BBP), di(n-butyl) phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), di-n-octyl phthalate (DNOP) and their mixtures. Using a 72 h zebrafish embryo toxicity test, the LC50 values of BBP, DBP and a mixture of the six phthalates were found to be 0.72, 0.63 and 0.50 ppm, respectively. The other four phthalates did not cause more than 50% exposed embryo mortality even at their highest soluble concentrations. The typical toxicity symptoms caused by phthalates were death, tail curvature, necrosis, cardio edema and no touch response. Using an estrogen-responsive ChgH-EGFP transgenic medaka (Oryzias melastigma) eleutheroembryos based 24 h test, BBP demonstrated estrogenic activity, DBP, DEHP, DINP and the mixture of the six phthalates exhibited enhanced-estrogenic activity and DIDP and DNOP showed no enhanced- or anti-estrogenic activity. These findings highlighted the developmental toxicity of BBP and DBP, and the estrogenic endocrine disrupting activity of BBP, DBP, DEHP and DINP on intact organisms, indicating that the widespread use of these phthalates may cause potential health risks to human beings.
journal_name
Int J Environ Res Public Healthauthors
Chen X,Xu S,Tan T,Lee ST,Cheng SH,Lee FW,Xu SJ,Ho KCdoi
10.3390/ijerph110303156subject
Has Abstractpub_date
2014-03-14 00:00:00pages
3156-68issue
3eissn
1661-7827issn
1660-4601pii
ijerph110303156journal_volume
11pub_type
杂志文章abstract::The availability of practical tools to assess dietary knowledge and adherence is essential to evaluate the effectiveness of dietary interventions. The aims of this paper were to develop reliable dietary knowledge and adherence questionnaires, suitable for Lebanese adolescents and their parents, and to estimate the fea...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17010147
更新日期:2019-12-24 00:00:00
abstract::In this study of autoimmunity among a population of Gullah African Americans in South Carolina, the links between environmental exposures and autoimmunity (presence of antinuclear antibodies (ANA)) have been assessed. The study population included patients with systemic lupus erythematosus (n = 10), their first degree...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph110302764
更新日期:2014-03-07 00:00:00
abstract::In this review, the career of a pediatric exercise physiologist (HCGK) is given over a period of almost 50 years. His research was concentrated on the relationship of physical activity (physical education, sport, and daily physical activity) with health and fitness in teenagers in secondary schools. (1) His first expe...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph17082888
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:This study compared the efficacy of two multi-component m-health interventions with a wait-list control group on body weight (primary outcome), and secondary outcomes of cardiovascular risk factors, lifestyle behaviours, and mental health. METHODS:Three-arm randomised controlled trial (Enhanced: physical ac...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,随机对照试验
doi:10.3390/ijerph17176200
更新日期:2020-08-26 00:00:00
abstract::In recent years, environmental awareness has received a great deal of public attention. However, little emphasis has been put on the influence of environmental factors (weather, personal attitudes, policies, physical structures, transportation, etc.) on the quality of life of persons infected with HIV/AIDS. The goal o...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph6072041
更新日期:2009-07-01 00:00:00
abstract::Mothers in the United States (U.S.) who are of non-dominant culture and socioeconomically disadvantaged experience depression during postpartum at a rate 3 to 4 times higher than mothers in the general population, but these mothers are least likely to receive services for improving mood. Little research has focused on...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17238978
更新日期:2020-12-02 00:00:00
abstract::There has been a great deal of international discussion on the nature and relevance of endocrine disrupting compounds in the environment. Changes in reproductive organs of fish and mollusks have been demonstrated in rivers downstream of sewage discharges in Europe and in North America, which have been attributed to es...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph2006030020
更新日期:2006-06-01 00:00:00
abstract::The escalated burden of diabetes on the population's health has catalyzed rigorous scientific research to produce appropriate evidence for treatment and control. Malaysia suffers from the leading diabetes epidemic within the Western Pacific region. It is crucial to map the scientific landscape of diabetes research for...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18010318
更新日期:2021-01-04 00:00:00
abstract::Arsenic in drinking water is causally linked with cancer of the skin, lung, and urinary bladder, but there is very little data on a possible role for arsenic in the etiology of cervical cancer, a disease in which human papilloma virus is held to be a necessary but not sufficient cause. All histopathology results from ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14101185
更新日期:2017-10-06 00:00:00
abstract::Background: Children's health is a current concern and data suggests that poor fundamental movement skills (FMS) could be associated with poor health, which may or may not be mediated by low physical activity level. However, tools to assess FMS have not been standardized, and could consequently lead to different assoc...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14091010
更新日期:2017-09-04 00:00:00
abstract::The aim of the study was to evaluate the effect of herbicidal ionic liquids on the population changes of microorganisms used in a batch anaerobic digester. The influence of the following ionic liquids: benzalkonium (2,4-dichlorophenoxy)acetate (BA)(2,4-D), benzalkonium (4-chloro-2-methylphenoxy)acetate (BA)(MCPA), did...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16060916
更新日期:2019-03-14 00:00:00
abstract::Vegetable and fruit consumption in childhood remains below recommendations in many countries. As the intake of fruit and/or vegetables during childhood in a few studies was associated with breastfeeding, it may be suggested as a serious interfering factor while analyzing the association between breastfeeding and its l...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17113755
更新日期:2020-05-26 00:00:00
abstract::The main object of the present study was to explore the effect of perinatal bisphenol A (BPA) exposure on glucose metabolism in early and later life of male rat offspring, and to establish the potential mechanism of BPA-induced dysglycemia. Pregnant rats were treated with either vehicle or BPA by drinking water at con...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph110403728
更新日期:2014-04-03 00:00:00
abstract::This study evaluated the association of functional dentition with 12-month changes in body measurements and nutrient intake among older adults. Data from 651 community dwellers, aged 60 years and over, in Phetchaburi, Thailand, were analysed (retention rate: 83%). Data were collected via interviews (including a semi-s...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17124200
更新日期:2020-06-12 00:00:00
abstract::Alzheimer's disease (AD) is an irreversible neurodegenerative disease that leads to dementia, health impairment, and high economic cost. Allergic rhinitis (AR) is a chronic inflammatory and allergic disease of the respiratory system that leads to health problems and has major effects on the daily lives of patients and...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16183357
更新日期:2019-09-11 00:00:00
abstract::Motor disability is a key feature of many neurological diseases, influencing the social roles of affected patients and their ability to perform daily life activities. Current rehabilitation capacities are overwhelmed by the age-related increase of motor dysfunctions seen, for example, in stroke, extrapyramidal or neur...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17186557
更新日期:2020-09-09 00:00:00
abstract::Recent research in range ecology has emphasized the importance of forage quality as a key indicator of rangeland condition. However, we lack tools to evaluate forage quality at scales appropriate for management. Using canopy reflectance data to measure forage quality has been conducted at both laboratory and field lev...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph7093513
更新日期:2010-09-01 00:00:00
abstract::The purpose of this study was to determine the effect of stand-biased desks on the physical activity and sedentary behavior of third, fourth and sixth grade students across the school year. Methods: This within classroom crossover design study used teacher-determined allocation for seating within each classroom. Half ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,随机对照试验
doi:10.3390/ijerph16060933
更新日期:2019-03-15 00:00:00
abstract::Industrialization has been widely regarded as a sustainable construction method in terms of its environmental friendliness. However, existing studies mainly consider the single impact of greenhouse gas emissions or material consumption in the construction process of industrialized buildings, and pay less attention to ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17228396
更新日期:2020-11-13 00:00:00
abstract::The purpose of this study was to examine the physical activity (PA) of children with physical disabilities (PD) and its associated environmental and behavioral factors at home and at school. One hundred and forty-seven Hong Kong children (mean age = 13.5 ± 2.5 years) with PD from three special schools participated. We...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16081394
更新日期:2019-04-17 00:00:00
abstract::Tetracyclines, sulfonamides and amphenicols are broad spectrum antimicrobial drugs that are widely used in poultry farming. However, a high proportion of these drugs can be excreted at high concentrations in droppings, even after the end of a therapy course. This work intended to assess and compare concentrations of f...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16010024
更新日期:2018-12-21 00:00:00
abstract::With rapid urbanization and increase in car ownership, ambient noise pollution resulting from diversified sources (e.g., road traffic, railway, commercial services) has become a severe environmental problem in the populated areas in China. However, research on the spatial variation of noise pollution and its potential...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15071479
更新日期:2018-07-13 00:00:00
abstract::The creation of walkable communities constitutes a cost-effective health promotion strategy, as walking is an accessible and free intervention for increasing physical activity and health. In this cross-sectional ecological study, we developed a walkability index for the Porto Metropolitan Area and we validated it by a...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15122767
更新日期:2018-12-06 00:00:00
abstract::A marked increase in canine leptospirosis was observed in Switzerland over 10 years with a peak incidence of 28.1 diagnosed cases/100,000 dogs/year in the most affected canton. With 95% affected dogs living at altitudes <800 m, the disease presented a seasonal pattern associated with temperature (r2 0.73) and rainfall...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph110707242
更新日期:2014-07-16 00:00:00
abstract::Introduction: Globally, there is an epidemic of opioid use disorders. Locally, in Singapore, there is an increase in the number of individuals abusing opioids. The advances in experimental psychology have highlighted the need to modify unconscious, automatic biases. These automatic, unconscious biases result in indivi...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,随机对照试验
doi:10.3390/ijerph17030752
更新日期:2020-01-24 00:00:00
abstract::This 18-month longitudinal study examined the influence of adolescents' sense of coherence (SOC) and exposure to household smoking on their commitment to a smoke-free lifestyle. This study investigated a representative sample of 8th graders from 21 randomly selected high schools in the rural Limpopo Province of South ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph10062427
更新日期:2013-06-13 00:00:00
abstract::Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients' lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables i...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17114041
更新日期:2020-06-05 00:00:00
abstract::Over the past half century, a surprising number of major pollution incidents occurred due to tailings dam failures. Most previous studies of such incidents comprised forensic analyses of environmental impacts after a tailings dam failure, with few considering the combined pollution risk before incidents occur at a wat...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph121214983
更新日期:2015-12-02 00:00:00
abstract::The aim of the present study was to compare the values of the Thylstrup & Fejerskov Index (TF index) for the determination of the prevalence of dental fluorosis using either all teeth (gold standard) or six upper anterior teeth (simplified TF index). The sample was made up of 396 individuals aged six to 22 years from ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph7030927
更新日期:2010-03-01 00:00:00
abstract::In this study, a novel coupling model for landslide susceptibility mapping is presented. In practice, environmental factors may have different impacts at a local scale in study areas. To provide better predictions, a geographically weighted regression (GWR) technique is firstly used in our method to segment study area...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13050487
更新日期:2016-05-11 00:00:00