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Corrected QT interval as a predictor of mortality in elderly patients with syncope.

Abstract：

BACKGROUND:Prolonged corrected QT interval (QTc) holds independent prognostic importance in predicting mortality in patients with coronary artery disease, diabetes mellitus and congestive heart failure. However, its association with all cause or cardiac mortality in the general population remains unclear. We evaluated the relationship between prolonged QTc and total mortality among patients with syncope. METHODS:This was a retrospective study of 348 patients presenting to the emergency department with syncope of any etiology over a period of one year. All patients with atrial fibrillation, left bundle branch block and cardiac devices (pacemaker/defibrillator) were excluded. Prolonged QTc interval was defined as QTc interval ≥ 440 ms. The primary end point for this study was total mortality in patients presenting with syncope. RESULTS:There were 58 (16%) deaths in this population during a mean follow-up of 30 months. Patients with prolonged QTc interval had significantly higher mortality when compared to those with normal QTc interval (22% vs 11%; p = 0.004). This significance was not retained after adjustment for covariates in the Cox regression model, where we found that age ≥ 65 years (hazard ratio [HR] 7.9; 95% confidence interval [CI] 1.9-32.9; p = 0.004) and QTc interval ≥ 500 ms (HR 3.5; 95% CI 1.56-8.12; p = 0.002) were predictors of increased mortality among patients with syncope. CONCLUSIONS:In elderly patients presenting to the emergency department with syncope, QTc interval ≥ 500 ms helps identify patients at higher risk of adverse outcomes.

journal_name

Cardiol J

journal_title

Cardiology journal

authors

Aggarwal A,Sherazi S,Levitan B,Lakshmanadoss U,Choudhary N,Shah A,Hsi D

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

395-400

issue

4

issn

1897-5593

journal_volume

18

pub_type

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