Abstract：
BACKGROUND:In recent years several studies showed an association between body iron stores, represented by serum ferritin, and oxidative stress. The pathophysiological mechanism of hypertensive retinopathy (HR) is not fully established. Elevated blood pressure alone does not fully account for the extent of retinopathy; other pathogenic mechanisms may be involved, such as increased oxidative stress. Therefore this study was designed to determine whether ferritin levels change in HR and whether there is any relationship between the degree of HR and ferritin level. MATERIAL/METHODS:This study included 72 essential hypertensive patients with HR. The hypertensive patients were divided into two groups according to the Keith-Wagener classification. Group 1 comprised 36 patients with grade I HR and group 2 36 patients with grade II HR Thirty-six normotensive healthy subjects matched for age, sex, and body mass index were selected for the control group. RESULTS:The level of ferritin in group 2 was significantly higher than in group 1 (92.9+/-31.8 vs. 77.8+/-23.7 ng/ml, p=0.027) and the normotensive control group (92.9+/-31.8 vs. 59.9+/-19.2 ng/ml, p=0.001). It was also higher in group 2 than in the control group (77.8+/-23.7 vs. 59.9+/-19.2 ng/ml, p=0.018). Ferritin level also showed positive correlation with the degree of HR in the hypertensive group (r=0.31, p=0.026). CONCLUSIONS:This study suggests that there is a relationship between HR and ferritin level, which may be associated with an increased level of oxidative stress.
journal_name
Med Sci Monitjournal_title
Medical science monitor : international medical journal of experimental and clinical researchauthors
Coban E,Alkan E,Altuntas S,Akar Ysubject
Has Abstractpub_date
2010-02-01 00:00:00pages
CR92-5issue
2eissn
1234-1010issn
1643-3750pii
878359journal_volume
16pub_type
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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