Abstract:
BACKGROUND:Ultrasound contrast agents (UCAs) allow the enhancement of vascular definition, thereby providing more diagnostic information. LK565 is a new second-generation UCA based on synthetic polymers of aspartic acid which is eliminated from the blood stream via phagocytosis. LK565 forms very stable air-filled microspheres and is capable of repeated passage through the pulmonary capillary bed after peripheral intravenous injection. This characteristic allows examination of the cardiac function or extracardiac vessel abnormalities up to 15 minutes. METHODS:A phase one clinical study was conducted on 15 healthy volunteers to identify the development of an undesirable immune response. Phagocytosis capacity, TNF-alpha secretion, and MHC class II upregulation of monocytes was monitored, as well as microsphere specific antibody development (IgM, IgG). Furthermore, the kinetics of the activation surface markers CD69, CD25, CD71, and CD11b on leukocytes were analyzed. RESULTS:Due to LK565-metabolism the administration of the UCA led to saturation of phagocytes which was reversible after 24 hrs. Compared to positive controls neither significant TNF-alpha elevation, neither MHC class II and activation surface markers upregulation, nor specific antibody development was detectable. CONCLUSION:The administration of LK565 provides a comfortable duration of signal enhancement, esp. in echocardiography, without causing a major activation cascade or triggering an adaptive immune response. To minimize the risk of undesirable adverse events such as anaphylactoid reactions, immunological studies should be included in clinical trials for new UCAs. The use of LK565 as another new ultrasound contrast agent should be encouraged as a safe means to provide additional diagnostic information.
journal_name
Cardiovasc Ultrasoundjournal_title
Cardiovascular ultrasoundauthors
Funke B,Maerz HK,Okorokow S,Polata S,Lehmann I,Sack U,Wild P,Geisler T,Zotz RJdoi
10.1186/1476-7120-2-16keywords:
subject
Has Abstractpub_date
2004-09-10 00:00:00pages
16issn
1476-7120pii
1476-7120-2-16journal_volume
2pub_type
杂志文章abstract:BACKGROUND:The developments in echocardiography or ultrasound cardiography (UCG) have improved our clinical capabilities. However, advanced hardware and software capabilities have resulted in UCG facilities of dubious clinical benefits. Is tissue Doppler echocardiography (TDE) is one such example? PRESENTATION OF THE ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-2-12
更新日期:2004-08-12 00:00:00
abstract:BACKGROUND:The percentage of hypertrophic cardiomyopathy (HCM) patients who are in high risk for Sudden Death (SD) constitutes only a minority of all HCM population but the incidence of SD in this subset is high (at least 5% annually). The identification of this small but important proportion of high risk HCM patients ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-37
更新日期:2009-07-26 00:00:00
abstract:OBJECTIVES:To describe the findings and evaluate appropriateness of a carotid artery study including the measurement of IMT, the presence of atherosclerotic plaque, and their correlation with cardiovascular risk factors. METHODS:555 patients (220 men; 67.06 +/- 12.44 years) were included in the study. 120 patients (21...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-6-52
更新日期:2008-10-16 00:00:00
abstract:BACKGROUND:Atrial septal defect (ASD) accounts for 10% of all congenital heart lesions and represent the third most congenital cardiac defect seen in adults. Atrial natriuretic peptide (ANP) is an important regulator of the sodium and volume homeostasis. This study was designed to investigate the changes in plasma ANP ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-6-35
更新日期:2008-07-07 00:00:00
abstract:BACKGROUND:Human immunodeficiency virus (HIV) infection and antiretroviral treatment are associated with metabolic and cardiovascular complications that potentially increase the risk of atherosclerosis and cardiovascular disease in this population. Measurement of arterial wall thickness has been used as a surrogate of ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-9-9
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-015-0036-1
更新日期:2015-10-05 00:00:00
abstract:INTRODUCTION:Serial monitoring of patients participating in clinical trials of carotid artery therapy requires noninvasive precision methods that are inexpensive, safe and widely available. Noninvasive ultrasonic duplex Doppler velocimetry provides a precision method that can be used for recruitment qualification, pre-...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-39
更新日期:2010-09-07 00:00:00
abstract:BACKGROUND:The association of a Classical left bundle branch block (LBBB) contraction pattern and better outcome after cardiac resynchronization therapy (CRT) has only been studied using vendor-specific software for echocardiographic speckle-tracked longitudinal strain analysis. The purpose of this study was to assess ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-019-0160-4
更新日期:2019-05-21 00:00:00
abstract::The growing need for coronary evaluation has raised interest in non-radioactive, non-invasive monitoring systems. In particular, radiation exposure during coronary investigations has been shown to be a possible cause of an enhanced risk of secondary tumors. Literature search has indicated that transthoracic echocardio...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/s12947-016-0048-5
更新日期:2016-01-19 00:00:00
abstract::Real-time three-dimensional (RT-3D) echocardiography has entered the clinical practice but true incremental value over standard two-dimensional echocardiography (2D) remains uncertain when applied to stress echo. The aim of the present study is to establish the additional value of RT-3D stress echo over standard 2D st...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-6-31
更新日期:2008-06-20 00:00:00
abstract::A 25-year-old woman with a history of kidney transplantation for lupus nephritis was referred for the evaluation and management of a mass incidentally found on echocardiography. An oval and pedunculated mass attached to the tricuspid valve was managed with nonsurgical treatment. No symptoms and complications attributa...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-44
更新日期:2009-09-04 00:00:00
abstract:BACKGROUND:Tissue Doppler Imaging (TDI) is a sensible and feasible method to detect longitudinal left ventricular (LV) systolic dysfunction (LVSD) in patients with diabetes mellitus, hypertension or ischemic heart disease. In this study, we hypothesized that longitudinal LVSD assessed by TDI predicted inducible myocard...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-016-0064-5
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:A hybrid approach to minimally invasive perventricular closure of VSD in infants is safe and effective, and has been performed under guidance of transesophageal echocardiography (TEE). We applied transthoracic echocardiographic (TTE) guidance to this hybrid approach, and compare results guided by TTE with th...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-11-8
更新日期:2013-03-11 00:00:00
abstract:AIMS:We sought to determine which echocardiographic markers of left ventricular (LV) remodeling and diastolic dysfunction can contribute as incremental and independent prognostic information in addition to current clinical risk markers of ischemic LV systolic dysfunction in the Surgical Treatment for Ischemic Heart Fai...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-020-00195-1
更新日期:2020-05-28 00:00:00
abstract:BACKGROUND:We hypothesized that longitudinal pulmonary arterial deformation during the cardiac cycle reflects pulmonary arterial capacitance. To examine this hypothesis, we assessed whether tissue Doppler-derived pulmonary annular motion could serve as a novel way to evaluate pulmonary arterial capacitance in pediatric...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-016-0081-4
更新日期:2016-09-07 00:00:00
abstract::Quadricuspid aortic valve is a rare congenital malformation of the aortic valve. Its diagnosis is often missed even with the use of transthoracic echocardiogram. Many of these patients progress to aortic incompetence later in life, hence requiring surgical intervention. In the case described in this report, a 61-year-...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-36
更新日期:2010-09-02 00:00:00
abstract:BACKGROUND:To explore the association between the ratio of tricuspid annular plane systolic excursion (TAPSE) and pulmonary arterial systolic pressure (PASP), and long- and short-term outcomes in mechanically ventilated septic shock patients. METHODS:Septic shock patients admitted to the intensive care unit (ICU) were...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-020-00198-y
更新日期:2020-06-12 00:00:00
abstract:OBJECTIVE:Cardiac resynchronization therapy is proven efficacious in patients with heart failure (HF). Presence of biventricular HF is associated with a worse prognosis than having only left ventricular (LV) HF and pacing might deteriorate heart function. The aim of the study was to assess a possible significance of ri...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-9-28
更新日期:2011-10-26 00:00:00
abstract::Miniaturization has evolved in the creation of a pocket-size imaging device which can be utilized as an ultrasound stethoscope. This study assessed the additional diagnostic power of pocket size device by both experts operators and trainees in comparison with physical examination and its appropriateness of use in comp...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-8-51
更新日期:2010-11-26 00:00:00
abstract:BACKGROUND:Almost all attempts to improve patient selection for cardiac resynchronization therapy (CRT) using echo-derived indices have failed so far. We sought to assess: the performance of homemade software for the automatic quantification of integral 3D regional longitudinal strain curves exploring left ventricular ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-017-0107-6
更新日期:2017-06-17 00:00:00
abstract:INTRODUCTION:Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database. METHODS:For this study we retrospectively reviewed 24,380 echocardiograms performed f...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-5-14
更新日期:2007-03-14 00:00:00
abstract:INTRODUCTION:Accidental hypothermia is a condition associated with significant morbidity and mortality. Hypothermia has been reported to affect left ventricular systolic and diastolic function. However, most of the data come from animal experimental studies. AIM OF THE STUDY:The purpose of the present study was to ass...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-015-0027-2
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Adrenocortical carcinoma is a rare, highly malignant tumor. Cardiac involvement of the tumor is very rare. Echocardiography facilitates the evaluation of the cardiac involvement of the tumor. CASE PRESENTATION:We describe a patient with an adrenal tumor. Transthoracic echo showed its extension into the righ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-1-5
更新日期:2003-05-16 00:00:00
abstract::To make assessment of paravalvular aortic leakage (PVL) after transcatheter aortic valve implantation (TAVI) more uniform the second Valve Academic Research Consortium (VARC) recently updated the echocardiographic criteria for mild, moderate and severe PVL. In the VARC recommendation the assessment of the circumferent...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/s12947-016-0080-5
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:In studies where cross-sectional images of coronary arteries obtained with different imaging modalities are compared, the importance of correct co-localization and matching of images along the coronary artery longitudinal axis is obvious. However, it appears neglected that correct spatial orientation of the ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-10-12
更新日期:2012-03-22 00:00:00
abstract:BACKGROUND:Systemic sclerosis (SSc) is an autoimmune chronic disease characterized by diffuse fibrosis involving several organs, including heart. Aim of our study was to analyze left ventricular (LV) myocardial deformation, by use of 2D strain, in asymptomatic SSc patients with normal LV ejection fraction. METHODS:We ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-11-6
更新日期:2013-02-03 00:00:00
abstract::In the standard accepted concept, contractility is the intrinsic ability of heart muscle to generate force and to shorten, independently of changes in the preload or afterload with fixed heart rates. At molecular level the crux of the contractile process lies in the changing concentrations of Ca2+ ions in the myocardi...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/1476-7120-3-27
更新日期:2005-09-08 00:00:00
abstract:BACKGROUND:Shear Wave Elastography (SWE) imaging is a novel ultrasound technique for quantifying tissue elasticity. Studies have demonstrated that SWE is able to differentiate between diseased and normal tissue in a wide range clinical applications. However its applicability to atherosclerotic carotid disease has not b...
journal_title:Cardiovascular ultrasound
pub_type: 临床试验,杂志文章
doi:10.1186/1476-7120-12-49
更新日期:2014-12-08 00:00:00
abstract::A 63-year-old man was admitted to our hospital with a complaint of right lateroabdominal pain. He was diagnosed with metastatic colon cancer, and then developed multiple brain embolic infarctions 7 days after admission. Transesophageal echocardiography showed that mobile, echo-dense masses were attached to the anterio...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-9-8
更新日期:2011-02-28 00:00:00
abstract::This review article summarizes the results of histopathological studies to assess heart failure in humans. Different histopathological features underlying the clinical manifestations of heart failure are reviewed. In addition, the present role of echocardiographic techniques in assessing the failing heart is briefly s...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/1476-7120-5-5
更新日期:2007-01-30 00:00:00