Abstract:
BACKGROUND:Systemic sclerosis (SSc) is an autoimmune chronic disease characterized by diffuse fibrosis involving several organs, including heart. Aim of our study was to analyze left ventricular (LV) myocardial deformation, by use of 2D strain, in asymptomatic SSc patients with normal LV ejection fraction. METHODS:We enrolled 29 SSc patients (28 female, 65±4 years) and 30 controls (23 female, 64±2 years). Echocardiographic study with tissue Doppler imaging (TDI) and 2D strain analysis was performed; moreover, patients were submitted to a two-year follow-up for the occurrence of cardiovascular events. RESULTS:Standard echocardiographic parameters and TDI velocities were comparable between groups. LV longitudinal (LS) and circumferential (CS) strains were lower in patients than in controls (-13.1±4.8 vs -22.6±4.1, p < 0.001; -15.3±6.2 vs -20.4±5.6, p = 0.001), whereas radial strain (RS) was comparable between groups; moreover, a significant correlation of LS and CS with serum levels of Scl-70 antibodies was found (r = 0.74, p = 0.001; r = 0.53, p = 0.025). In addition, patients with cardiovascular events during follow-up showed a greater impairment of LS and CS (-10.3±2.5 vs -14.4±4.1, p = 0.015; -14.2±3.1 vs -20.1±1.6, p = 0.048) and higher values of Scl-70 antibodies serum levels (p = 0.047). CONCLUSION:The impairment of LV function, often subclinical, worsens prognosis of SSc patients, leading to increased risk of cardiovascular complications. 2D strain, allowing the early detection of LV abnormalities and the identification of patients at greater cardiovascular risk, may be a useful tool in order to provide a more accurate management of SSc patients.
journal_name
Cardiovasc Ultrasoundjournal_title
Cardiovascular ultrasoundauthors
Cusmà Piccione M,Zito C,Bagnato G,Oreto G,Di Bella G,Bagnato G,Carerj Sdoi
10.1186/1476-7120-11-6subject
Has Abstractpub_date
2013-02-03 00:00:00pages
6issn
1476-7120pii
1476-7120-11-6journal_volume
11pub_type
杂志文章abstract:OBJECTIVE:Cardiac resynchronization therapy is proven efficacious in patients with heart failure (HF). Presence of biventricular HF is associated with a worse prognosis than having only left ventricular (LV) HF and pacing might deteriorate heart function. The aim of the study was to assess a possible significance of ri...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-9-28
更新日期:2011-10-26 00:00:00
abstract:PURPOSE:Left ventricular (LV) wall thickness can be measured at the posterior wall (PW) and the intraventricular septum (IVS) in a parasternal long axis view by transthoracic echocardiography. Thus, there are three methods to calculate relative wall thickness as follows: RWTPW = 2 × PWth/LVDd; RWTIVS + PW = (IVSth + PW...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-019-0179-6
更新日期:2019-12-03 00:00:00
abstract:BACKGROUND:In studies where cross-sectional images of coronary arteries obtained with different imaging modalities are compared, the importance of correct co-localization and matching of images along the coronary artery longitudinal axis is obvious. However, it appears neglected that correct spatial orientation of the ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-10-12
更新日期:2012-03-22 00:00:00
abstract::In this case report we describe a rare case of right atrium myxoma that coexisted with antiphospholipid syndrome in a young woman. We describe the unusual findings and diagnostic challenges combined with a review of the literature. ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-47
更新日期:2009-10-11 00:00:00
abstract:BACKGROUND:Non-ischemic dilated cardiomyopathy (DCM) is the most common cardiomyopathy worldwide, with significant mortality. Correct evaluation of the patient's myocardial function has important clinical significance in the diagnosis, therapeutic effect assessment and prognosis in non-ischemic DCM patients. This study...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-10-8
更新日期:2012-03-07 00:00:00
abstract:BACKGROUND:Ultrasound contrast agents (UCAs) allow the enhancement of vascular definition, thereby providing more diagnostic information. LK565 is a new second-generation UCA based on synthetic polymers of aspartic acid which is eliminated from the blood stream via phagocytosis. LK565 forms very stable air-filled micro...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-2-16
更新日期:2004-09-10 00:00:00
abstract:BACKGROUND:Tissue Doppler Imaging (TDI) is a sensible and feasible method to detect longitudinal left ventricular (LV) systolic dysfunction (LVSD) in patients with diabetes mellitus, hypertension or ischemic heart disease. In this study, we hypothesized that longitudinal LVSD assessed by TDI predicted inducible myocard...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-016-0064-5
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Calcification is an independent predictor of mortality in calcific aortic valve disease (CAVD). The aim of this study was to evaluate the use of non-invasive, non-ionizing echocardiographic calibrated integrated backscatter (cIB) for monitoring progression and subsequent regression of aortic valvular calcifi...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-11-4
更新日期:2013-01-26 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-019-0173-z
更新日期:2019-10-31 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-020-00195-1
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-4-31
更新日期:2006-08-10 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-015-0027-2
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:The aim of this study was to define the independent determinants of left atrial appendage (LAA) thrombus among various echocardiographic parameters measured by Velocity Vector Imaging (VVI) in patients with nonvalvular atrial fibrillation (AF) receiving warfarin, particularly in patients with a low CHADS2 sc...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-10-50
更新日期:2012-12-27 00:00:00
abstract:BACKGROUND:Primary intracardiac tumours are rare, there are however several entities that can mimic tumours. Contrast echocardiography has been suggested to aid the differentiation of various suspected masses. We present a case where transthoracic echocardiography completely misdiagnosed a left atrial mass, partly due ...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-4
更新日期:2009-01-29 00:00:00
abstract::This review article summarizes the results of histopathological studies to assess heart failure in humans. Different histopathological features underlying the clinical manifestations of heart failure are reviewed. In addition, the present role of echocardiographic techniques in assessing the failing heart is briefly s...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/1476-7120-5-5
更新日期:2007-01-30 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-37
更新日期:2009-07-26 00:00:00
abstract:OBJECTIVE:Correlate the anatomic features of atrioventricular septal defect with echocardiographic images. MATERIALS AND METHODS:Sixty specimen hearts were studied by sequential segmental analysis. Echocardiograms were performed on 34 patients. Specimen hearts with findings equivalent to those of echocardiographic ima...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-6-33
更新日期:2008-06-24 00:00:00
abstract::In the standard accepted concept, contractility is the intrinsic ability of heart muscle to generate force and to shorten, independently of changes in the preload or afterload with fixed heart rates. At molecular level the crux of the contractile process lies in the changing concentrations of Ca2+ ions in the myocardi...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/1476-7120-3-27
更新日期:2005-09-08 00:00:00
abstract:BACKGROUND:We hypothesized that longitudinal pulmonary arterial deformation during the cardiac cycle reflects pulmonary arterial capacitance. To examine this hypothesis, we assessed whether tissue Doppler-derived pulmonary annular motion could serve as a novel way to evaluate pulmonary arterial capacitance in pediatric...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-016-0081-4
更新日期:2016-09-07 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-2-12
更新日期:2004-08-12 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-7-46
更新日期:2009-09-25 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-015-0039-y
更新日期:2015-11-20 00:00:00
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journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/s12947-016-0080-5
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:The most widely used experimental models of infective endocarditis (IE) are the rabbit and rat models, in which cardiac valve lesions are induced by a polyethylene catheter introduced into the left ventricle through the aortic valve. Our study was designed to create a rabbit model of IE right-sided with echo...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-11-3
更新日期:2013-01-14 00:00:00
abstract::A 63-year-old man was admitted to our hospital with a complaint of right lateroabdominal pain. He was diagnosed with metastatic colon cancer, and then developed multiple brain embolic infarctions 7 days after admission. Transesophageal echocardiography showed that mobile, echo-dense masses were attached to the anterio...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-9-8
更新日期:2011-02-28 00:00:00
abstract:BACKGROUND:The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-015-0036-1
更新日期:2015-10-05 00:00:00
abstract:BACKGROUND:The goal of this study was to determine if left ventricular (LV) global longitudinal strain (GLS) predicts heart failure (HF) readmission in patients with acute decompensated heart failure. METHODS AND RESULTS:Two hundred ninety one patients were enrolled at the time of admission for acute decompensated hea...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/s12947-017-0098-3
更新日期:2017-03-15 00:00:00
abstract:INTRODUCTION:In vivo and in vitro evidence suggests that adenosine and its agonists play key roles in the process of ischemic preconditioning. The effects of low-dose adenosine infusion on ischemic preconditioning have not been thoroughly studied in humans. AIMS:We hypothesised that a low-dose adenosine infusion could...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,随机对照试验
doi:10.1186/1476-7120-7-52
更新日期:2009-11-05 00:00:00
abstract:OBJECTIVE:Left ventricular wall stress has been investigated in a variety of populations, but the effect of food intake has not been evaluated. We assessed whether left ventricular wall stress is affected by food intake in healthy subjects. METHODS:Twenty-three healthy subjects aged 25.6 ± 4.5 years were investigated....
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章
doi:10.1186/1476-7120-12-2
更新日期:2014-01-28 00:00:00
abstract::The growing need for coronary evaluation has raised interest in non-radioactive, non-invasive monitoring systems. In particular, radiation exposure during coronary investigations has been shown to be a possible cause of an enhanced risk of secondary tumors. Literature search has indicated that transthoracic echocardio...
journal_title:Cardiovascular ultrasound
pub_type: 杂志文章,评审
doi:10.1186/s12947-016-0048-5
更新日期:2016-01-19 00:00:00