Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status.

Abstract:

OBJECTIVE:Acute brain ischemia is accompanied by a disruption of low-molecular-weight aminothiols (LMWTs) homeostasis, such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). We investigated the redox balance of LMWTs in blood plasma and its influence on ischemic stroke severity and the functional outcome in patients with an acute period. PATIENTS AND METHODS:A total of 177 patients were examined. Total and reduced forms of LMWTs were determined in the first 10-24 h. Stroke severity and functional state were estimated using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRs) at admission and after 21 days. RESULTS:Patients with high levels of total Hcy (> 19 μM) showed significantly reduced redox statuses of all LMWTs. Patients with low total GSH levels (≤ 1.07 μM) were at an increased risk of higher stroke severity (NIHSS > 10) compared to patients with a total GSH level > 2.64 μM (age/gender-adjusted odds ratio: 4.69, 95% CI: 1.43-15.4). DISCUSSION:(1) low total GSH level can be considered as a novel risk marker for the severity of acute stroke in conditions of low redox status of LMWTs and (2) high Hcy levels associated with low redox status of LMWTs.

journal_name

Redox Rep

authors

Maksimova MY,Ivanov AV,Virus ED,Nikiforova KA,Ochtova FR,Suanova ET,Kruglova MP,Piradov MA,Kubatiev AA

doi

10.1080/13510002.2021.1952819

keywords:

["Acute stroke","aminothiols‌","cysteine","glutathione","homocysteine","redox status","stroke severity","‌ischemic stroke"]

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

117-123

issue

1

eissn

1351-0002

issn

1743-2928

journal_volume

26

pub_type

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