Abstract：
:Surgically induced duodenal reflux results in cancer development in the rat esophagus. One proposed mechanism of carcinogenesis relies on the production of carcinogens in the presence of bacterial overgrowth. Against this background, intestinal microflora in the rat jejunum was analyzed before and after reflux-inducing surgery. Total gastrectomy and esophagojejunostomy were performed on Sprague-Dawley rats to produce esophageal reflux of duodenal juice (n = 12). Three days before surgery they were randomized into three groups: animals which received tap water; animals which received acidified water at pH 1.8; and animals subjected to oral decontamination with triple antibiotics. During surgery and at autopsy after 2 weeks, intestinal juice was aspirated and analyzed immediately for bacterial content. The physiologic microflora of the rat jejunum contained Lactobacillus spp. and Bacteroides spp., both of which were resistant to the antibiotic regimen. Bacterial overgrowth with fecal bacteria was found following surgery. Acidified water did not alter the intestinal microflora. Triple antibiotics eliminated Escherichia coli and Proteus spp. and reduced the concentration of Enterococcus spp. Bacterial overgrowth by bacteria of the fecal flora occurs in the rat model of esophageal adenocarcinoma with the potential to catalyze the production of carcinogens.
journal_name
Dis Esophagusjournal_title
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagusauthors
Fein M,Fuchs KH,DeMeester TR,Peters JH,Wittmann D,Weig Mdoi
10.1046/j.1442-2050.2000.00023.xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
39-43issue
1eissn
1120-8694issn
1442-2050journal_volume
13pub_type
杂志文章abstract：:Prevalence data for heartburn in the urban Black American community is lacking. In order to estimate prevalence for this community, we analyzed data from an ongoing cohort study in progress at our hospital. Comprehensive interviews allowed for exploration of factors associated with heartburn. Complex, stratified sampl...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12007
更新日期：2013-08-01 00:00:00
abstract：:Unconsciously caustic ingestion is one of the most common causes of serious esophageal strictures in children. The aim of this study is to determine the efficiency of polaprezinc in preventing stricture formation after corrosive esophageal burns (CEB); this was the first time it has been used to treat experimental CEB...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/dox104
更新日期：2017-11-01 00:00:00
abstract：:Interferon (IFN)-β has efficient antitumor effect both in vitro and in vivo, but its clinical implication is limited by short half-life and systemic toxicities. Gene therapy could be the choice to avoid the defects. Adenovirus vector containing human IFN-β gene was transfected into esophageal squamous cell carcinoma K...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12081
更新日期：2014-02-01 00:00:00
abstract：:This study assessed the clinical value of CYFRA 21-1 in comparison with squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) in patients with esophageal squamous cell carcinoma. In 112 primary cancer patients, the diagnostic sensitivity of CYFRA 21-1 (33.9%) ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/11.1.35
更新日期：2017-11-01 00:00:00
abstract：:One of the most common causes of a failed Nissen fundoplication is disruption of the crural repair. We investigated the thickness of the subdiaphragmatic fascia overlying the right and left limb of the right crus in cadavers to determine any difference. Sub-diaphragmatic fascia specimens were obtained from three sites...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2006.00554.x
更新日期：2006-01-01 00:00:00
abstract：:In a prior study, baseline mutational load (ML) predicted progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE) with an area under the curve (AUC) of 0.95. We aimed to validate the test characteristics of this predictive biomarker panel using crude DNA lysates in a la...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/doy026
更新日期：2018-11-01 00:00:00
abstract：:The diagnosis of Barrett's esophagus is based on the presence of intestinal metaplasia (IM) at the distal esophagus. The aim of this study was to determine the prevalence of IM in patients with symptoms of gastroesophageal reflux in whom endoscopically a segment of distal esophagus was covered by columnar epithelium (...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1046/j.1442-2050.2003.00284.x
更新日期：2003-01-01 00:00:00
abstract：:Benign esophagorespiratory fistula is a relatively rare condition in adults that poses a technical challenge to manage. This case series describes our experience in the treatment of benign esophagorespiratory fistula in 12 adults. A retrospective review of case records of 12 patients with benign esophagorespiratory fi...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2012.01347.x
更新日期：2013-02-01 00:00:00
abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most malignant cancers in Japan. Anticancer chemotherapy has been useful for ESCC treatment. However, therapeutic options are limited. Recently, bisphosphonates (BPs), which are osteoporosis drugs, have shown anticancer effects in several cancer cell lines, but t...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12370
更新日期：2016-08-01 00:00:00
abstract：:The aim of the present study was to evaluate the long-term outcomes of laparoscopic Heller myotomy with Dor fundoplication (LHD) and its effect on chest pain. Between June 1995 and August 2009, a total of 35 patients with achalasia underwent an LHD. The symptom scores were calculated by combining the frequency and the...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2009.01032.x
更新日期：2010-05-01 00:00:00
abstract：:A wide variety of pieces of evidence has suggested that obesity is associated with a significant increase in the risk for gastroesophageal reflux disease (GERD) symptoms and its complications. The aim of this study was to evaluate the effect of weight loss on reflux symptoms in overweight/obese patients with proven GE...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12319
更新日期：2016-02-01 00:00:00
abstract：:Curative treatment of esophageal cancer with definitive or preoperative high-dose chemoradiotherapy inflicts a major strain on the patients with potentially severe physical, emotional, and social consequences. The aim of this study was to assess various aspects of quality of life and fatigue in long-term survivors fol...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2010.01104.x
更新日期：2011-01-01 00:00:00
abstract：:The increasing incidence of adenocarcinoma of the lower esophagus and cardia arising in Barrett's metaplastic epithelium continues to be of great concern because medical and surgical efforts to reverse the process have been disappointing. A potential answer to the problem is removal of the metaplastic epithelium. Mode...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type：
doi：10.1093/dote/11.1.1
更新日期：2017-11-01 00:00:00
abstract：:Esophageal adenocarcinoma (EAC) has had the fastest increasing incidence of any solid tumor in the United States in the last 30 years. Long standing gastroesophageal reflux disease is a well-established risk factor with strong associations with obesity, alcohol and tobacco. However, there are likely additional contrib...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/doaa036
更新日期：2020-12-07 00:00:00
abstract：:Postesophagectomy anastomotic leak is a common postsurgical complication. The current standard method of detecting leak is esophagram usually late in the postoperative period. Perianastomotic drain amylase level had shown promising results in early detection anastomosis leak. Previous studies have shown that postopera...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/doy041
更新日期：2018-10-01 00:00:00
abstract：:There has been increasing application of endoscopic ablation therapy for patients with high-grade dysplasia (HGD) and Barrett's esophagus (BE). Three cases are reported in which the patient developed adenocarcinoma of the gastric cardia after thermal ablation of HGD. A definition of BE including endoscopic abnormality...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2006.00577.x
更新日期：2006-01-01 00:00:00
abstract：:The cancer stem cell theory states that cancers contain tumor-forming cells that have the ability to self-renew as well as give rise to cells that differentiate. Cancer stem cells have been identified in several solid tumors, but stem cells in normal human esophagus or in Barrett's esophagus or adenocarcinoma have not...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2010.01061.x
更新日期：2010-09-01 00:00:00
abstract：:A 69-year-old patient underwent simultaneous transhiatal esophagectomy for carcinoma of the esophagogastric junction and benign spindle cell gastric tumor and coronary artery bypass grafting without cardiopulmonary bypass. A standard technique of transhiatal esophagectomy was used. The long saphenous vein was grafted ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1046/j.1442-2050.1999.00053.x
更新日期：1999-01-01 00:00:00
abstract：:It is still controversial whether adjuvant chemotherapy of cisplatin, 5-fluorouracil and leucovorin can increase the overall survival of esophageal cancer patients, and which subgroup of patients get most benefits from it. Between 1998 and 2004, 66 esophageal cancer patients with adjuvant chemotherapy and 160 well-mat...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2007.00748.x
更新日期：2008-01-01 00:00:00
abstract：:To determine trends in the diagnostic distribution of esophageal motility disorders after implementation of the Chicago Classification Version 3.0 (CC V3.0) for interpretation of high-resolution manometry (HRM) studies compared to non-Chicago Classification criteria. Retrospective trends analysis of patients with an H...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/dox068
更新日期：2017-12-01 00:00:00
abstract：:We describe a technique that uses the internal mammary vessels to enhance long-segment jejunal graft blood supply in addition to an intact distal mesenteric vascular arcade. We believe that this technique, called vascular augmentation, improves jejunal graft perfusion and decreases ischemic complications. ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1046/j.1442-2050.2000.00118.x
更新日期：2000-01-01 00:00:00
abstract：:Placement of self-expanding metal stents (SEMS) for palliation of malignant stenoses at the gastroesophageal junction is often associated with stent migration and reflux symptoms. SEMS with an antireflux mechanism have been developed to overcome the latter problem. The aim of this study was to evaluate the safety and ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 临床试验,杂志文章
doi：10.1111/j.1442-2050.2007.00646.x
更新日期：2007-01-01 00:00:00
abstract：:Small cell carcinoma arising in the esophagus is a relatively rare disease. In the more common small cell carcinoma of the lung, the diagnostic significance of several new markers has been recently reported. This study used immunohistochemical techniques in addition to clinicopathological analysis, in order to clarify...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1046/j.1442-2050.2003.00341.x
更新日期：2003-01-01 00:00:00
abstract：:Barrett's esophagus (BE) is a premalignant condition associated with the development of esophageal adenocarcinoma (EAC). Previous studies have implicated hydrophobic bile acids and gastric acid in BE and EAC pathogenesis. In this study, we tested the hypothesis that DNA damage, cytotoxicity and oxidative stress induce...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2009.00993.x
更新日期：2010-02-01 00:00:00
abstract：:Paraesophageal herniation can cause massive bleeding, strangulation or perforation. This study reviews the experience with 24 patients (74.6 years, range 63-89 years, 20 males, 4 females) with a total or near-total intrathoracic stomach, managed at the Royal Lancaster Infirmary. All patients were symptomatic with 3/24...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/11.3.177
更新日期：1998-07-01 00:00:00
abstract：:Chagas' disease and idiopathic achalasia have similar esophageal manifestations such as absent or incomplete lower esophageal sphincter relaxation and aperistalsis in the esophageal body (alterations seen mainly in the distal esophageal body). Our aim in this paper was to study the response of the proximal esophageal ...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2006.00601.x
更新日期：2006-01-01 00:00:00
abstract：:Day-case esophageal surgery has been demonstrated to be safe in small prospective cohorts and only for laparoscopic fundoplication. The aims of this study are to assess the feasibility and safety of a large series of esophageal day-case surgeries, including laparoscopic Nissen fundoplication (LNF), Zenker diverticulec...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1093/dote/dow036
更新日期：2017-04-01 00:00:00
abstract：:This study looks at toxicity and survival data when chemoradiation (CRT) is delivered using intensity-modulated radiation therapy (IMRT) after induction chemotherapy. Forty-one patients with esophageal adenocarcinoma treated with IMRT from March 2007 to May 2009 at Memorial Sloan-Kettering Cancer Center were analyzed....
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/dote.12082
更新日期：2014-04-01 00:00:00
abstract：:Until now, it is uncertain if the so-called pH-only reflux episodes that consist of a pH drop without evidence of retrograde bolus movement in multichannel intraluminal impedance (MII) represent reflux episodes or artifacts. Hiatal hernia (HH) may allow reflux of small volumes to occur that can be detected by pH-metry...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2012.01379.x
更新日期：2013-07-01 00:00:00
abstract：:Para-aortic lymph node (PALN) recurrence is often seen in patients with lower thoracic esophageal cancer treated by esophagectomy with extended lymph node dissection. However, the clinicopathological characteristics of patients with PALN metastasis and the significance of PALN dissection are unknown. A total of 283 pa...
journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type： 杂志文章
doi：10.1111/j.1442-2050.2011.01222.x
更新日期：2012-02-01 00:00:00
