The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer.

abstract：INTRODUCTION:Studies on the association between the cytochrome P450c17alpha gene (CYP17) 5'-untranslated region MspA1 genetic polymorphism and breast cancer risk have yielded inconsistent results. Higher levels of estrogen have been reported among young nulliparous women with the A2 allele. Therefore we assessed the im...

journal_title：Breast cancer research : BCR

authors： Verla-Tebit E,Wang-Gohrke S,Chang-Claude J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) regulate gene expression and influence cancer. Primary transcripts of miRNAs (pri-miRNAs) are poorly annotated and little is known about the role of germline variation in miRNA genes and breast cancer (BC). We sought to identify germline miRNA variants associated with BC risk and tumor sub...

journal_title：Breast cancer research : BCR

authors： Bensen JT,Graff M,Young KL,Sethupathy P,Parker J,Pecot CV,Currin K,Haddad SA,Ruiz-Narváez EA,Haiman CA,Hong CC,Sucheston-Campbell LE,Zhu Q,Liu S,Yao S,Bandera EV,Rosenberg L,Lunetta KL,Ambrosone CB,Palmer JR,Troes

更新日期：2018-06-05 00:00:00

abstract：:Breast cancer arising at a young age is relatively uncommon, particularly in the developed world. Several studies have demonstrated that younger patients often experience a more aggressive disease course and have poorer outcome compared to older women. Expression of key biomarkers, including endocrine receptors, HER2 ...

journal_title：Breast cancer research : BCR

authors： Azim HA Jr,Partridge AH

更新日期：2014-08-27 00:00:00

abstract：INTRODUCTION:The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and reflects the cell of origin of these tumors. However, approximately 20% of breast cancers that de...

journal_title：Breast cancer research : BCR

authors： Tung N,Miron A,Schnitt SJ,Gautam S,Fetten K,Kaplan J,Yassin Y,Buraimoh A,Kim JY,Szász AM,Tian R,Wang ZC,Collins LC,Brock J,Krag K,Legare RD,Sgroi D,Ryan PD,Silver DP,Garber JE,Richardson AL

更新日期：2010-01-01 00:00:00

abstract：:Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well ...

journal_title：Breast cancer research : BCR

authors： LaMarca HL,Rosen JM

更新日期：2007-01-01 00:00:00

abstract：:Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of menarche, and age at menopause are major risk factors drawing attention to the important role of the endocrine system in d...

journal_title：Breast cancer research : BCR

authors： Jerry DJ,Minter LM,Becker KA,Blackburn AC

更新日期：2002-01-01 00:00:00

abstract：:STATEMENT OF FINDINGS: We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association between AIB1 genotype and breast cancer incidence, or specific tumor char...

journal_title：Breast cancer research : BCR

authors： Haiman CA,Hankinson SE,Spiegelman D,Colditz GA,Willett WC,Speizer FE,Brown M,Hunter DJ

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:An increasing number of women are evaluated for potential breast cancer and may experience mental distress during evaluation. We aim to assess the risks of psychiatric disorders and cardiovascular diseases during the diagnostic workup of potential breast cancer. METHODS:All women with a new diagnosis of uns...

journal_title：Breast cancer research : BCR

authors： Shen Q,Jöud A,Schelin MEC,Sjölander A,Cao Y,Sparén P,Fall K,Czene K,Valdimarsdóttir U,Fang F

更新日期：2019-12-10 00:00:00

abstract：INTRODUCTION:Menopausal hormone therapy has been reported to increase the risk of certain subtypes of breast cancer and to be associated with a favorable survival. These associations could either be due to an increased mammographic surveillance or to a biological effect. We assessed these associations in a Swedish coho...

journal_title：Breast cancer research : BCR

authors： Rosenberg LU,Granath F,Dickman PW,Einarsdóttir K,Wedrén S,Persson I,Hall P

更新日期：2008-01-01 00:00:00

abstract：:Therapeutic choices for metastatic tumors are, in most cases, based upon the histological and molecular analysis of the corresponding primary tumor. Understanding whether and to what extent the genomic landscape of metastasis differs from the tumors from which they originated is critical yet largely unknown. A recent ...

journal_title：Breast cancer research : BCR

authors： Zecchin D,Bardelli A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase that is highly expressed in Human Epidermal Growth Factor 2(+) (Her2(+)) breast cancers. Overexpression of PTK6 enhances anchorage-independent survival, proliferation, and migration of breast cancer cells. We hypothesized that PTK6 inhibiti...

journal_title：Breast cancer research : BCR

authors： Park SH,Ito K,Olcott W,Katsyv I,Halstead-Nussloch G,Irie HY

更新日期：2015-06-19 00:00:00

abstract：:Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. Ab...

journal_title：Breast cancer research : BCR

authors： Hui M,Cazet A,Nair R,Watkins DN,O'Toole SA,Swarbrick A

更新日期：2013-03-28 00:00:00

abstract：INTRODUCTION:Triple-negative breast cancer (TNBC), a subtype of breast cancer with negative expressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2), is frequently diagnosed in younger women and has poor prognosis for disease-free and overall survival. Due to the lack...

journal_title：Breast cancer research : BCR

authors： Chen YJ,Yeh MH,Yu MC,Wei YL,Chen WS,Chen JY,Shih CY,Tu CY,Chen CH,Hsia TC,Chien PH,Liu SH,Yu YL,Huang WC

更新日期：2013-11-12 00:00:00

abstract：INTRODUCTION:Classification of breast cancers according to the HER-2 oncogene status is of central importance in the selection of post-surgical therapies. A decrease in the proportion of HER-2-positive breast cancer has been suspected, but no data on the incidence trends at population level have been reported. METHODS...

journal_title：Breast cancer research : BCR

authors： Köninki K,Tanner M,Auvinen A,Isola J

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:We present a fully automated method for deriving quantitative measures of background parenchymal enhancement (BPE) from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perform a preliminary evaluation of these measures to assess the effect of risk-reducing salpingo-oophorectomy (R...

journal_title：Breast cancer research : BCR

authors： Wu S,Weinstein SP,DeLeo MJ 3rd,Conant EF,Chen J,Domchek SM,Kontos D

更新日期：2015-05-19 00:00:00

abstract：INTRODUCTION:There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways associated with human epidermal growth factor receptor 2-positive (HER2+) brain metastasis. METHODS:We...

journal_title：Breast cancer research : BCR

authors： McMullin RP,Wittner BS,Yang C,Denton-Schneider BR,Hicks D,Singavarapu R,Moulis S,Lee J,Akbari MR,Narod SA,Aldape KD,Steeg PS,Ramaswamy S,Sgroi DC

更新日期：2014-03-14 00:00:00

abstract：:The mammary gland develops as an appendage of the ectoderm. The prenatal stage of mammary development is hormone independent and is regulated by sequential and reciprocal signaling between the epithelium and the mesenchyme. A number of recent studies using human and mouse genetics, in particular targeted gene deletion...

journal_title：Breast cancer research : BCR

authors： Robinson GW

更新日期：2004-01-01 00:00:00

abstract：:Breast cancer arises from multiple genetic events that together contribute to the established, irreversible malignant phenotype. The development of inducible tissue-specific transgenics has allowed a careful dissection of the events required for induction and subsequent maintenance of tumorigenesis. Mammary gland targ...

journal_title：Breast cancer research : BCR

authors： Hulit J,Di Vizio D,Pestell RG

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) breast cancer. We compared the antitumor activity of Z-endoxifen with tamoxifen and letrozole in the letrozole-sensitive MCF7 aromatase expressing model (MCF7AC1), as well ...

journal_title：Breast cancer research : BCR

authors： Jayaraman S,Hou X,Kuffel MJ,Suman VJ,Hoskin TL,Reinicke KE,Monroe DG,Kalari KR,Tang X,Zeldenrust MA,Cheng J,Bruinsma ES,Buhrow SA,McGovern RM,Safgren SL,Walden CA,Carter JM,Reid JM,Ingle JN,Ames MM,Hawse JR,Goet

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with somatic mutations in the gene encoding the ...

journal_title：Breast cancer research : BCR

authors： Toomey S,Eustace AJ,Fay J,Sheehan KM,Carr A,Milewska M,Madden SF,Teiserskiene A,Kay EW,O'Donovan N,Gallagher W,Grogan L,Breathnach O,Walshe J,Kelly C,Moulton B,Kennedy MJ,Gullo G,Hill AD,Power C,Duke D,Hambly N

更新日期：2017-07-27 00:00:00

abstract：BACKGROUND:Mesenchymal transformation of pulmonary endothelial cells contributes to the formation of a metastatic microenvironment, but it is not known whether this precedes or follows early metastasis formation. In the present work, we characterize the development of nitric oxide (NO) deficiency and markers of endothe...

journal_title：Breast cancer research : BCR

authors： Smeda M,Kieronska A,Adamski MG,Proniewski B,Sternak M,Mohaissen T,Przyborowski K,Derszniak K,Kaczor D,Stojak M,Buczek E,Jasztal A,Wietrzyk J,Chlopicki S

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Metastasis is the major cause of death from breast cancer. Colonization and adaption of metastatic cells in distant organs is a rate-limiting step of the cancer spreading. The underlying mechanisms responsible for the colonization of breast cancer to lung metastatic niches are not fully understood. METHODS:...

journal_title：Breast cancer research : BCR

authors： Hsu YL,Yen MC,Chang WA,Tsai PH,Pan YC,Liao SH,Kuo PL

更新日期：2019-02-12 00:00:00

abstract：INTRODUCTION:We previously reported an association between tumor-specific 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) expression and a good prognosis in breast cancer. Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined. METHODS:HMG-CoAR protein and RNA expr...

journal_title：Breast cancer research : BCR

authors： Brennan DJ,Laursen H,O'Connor DP,Borgquist S,Uhlen M,Gallagher WM,Pontén F,Millikan RC,Rydén L,Jirström K

更新日期：2011-01-31 00:00:00

abstract：INTRODUCTION:The tumour-suppressive effects of transforming growth factor-beta (TGF-beta) are well documented; however, the mechanistic basis of these effects is not fully understood. Previously, we showed that a non-canonical member of the Wingless-related protein family, Wnt5a, is required for TGF-beta-mediated effec...

journal_title：Breast cancer research : BCR

authors： Roarty K,Baxley SE,Crowley MR,Frost AR,Serra R

更新日期：2009-01-01 00:00:00

abstract：:Certain laminins of vascular basement membranes have been identified in human breast tumors and brain gliomas that share the same beta1 chain. These laminins are new carcinoma angiogenic markers and might represent potential targets for antiangiogenic therapy. ...

journal_title：Breast cancer research : BCR

authors： Holler E

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Breast magnetic resonance imaging (MRI) has been reported to frequently result in false-positive diagnoses, limiting its positive predictive value (PPV). However, for PPV calculation, all nonmalignant tissue changes are equally considered false-positive, although the respective prognostic importance, and thu...

journal_title：Breast cancer research : BCR

authors： Kuhl CK,Keulers A,Strobel K,Schneider H,Gaisa N,Schrading S

更新日期：2018-02-09 00:00:00

abstract：:Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clinical management of breast cancer relies on the availability of robust clinical and pathological prognostic and predictive factors to support clinical and patient de...

journal_title：Breast cancer research : BCR

authors： Rakha EA,Reis-Filho JS,Baehner F,Dabbs DJ,Decker T,Eusebi V,Fox SB,Ichihara S,Jacquemier J,Lakhani SR,Palacios J,Richardson AL,Schnitt SJ,Schmitt FC,Tan PH,Tse GM,Badve S,Ellis IO

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Developing novel strategies against treatment-resistant triple negative breast cancer (TNBC) cells remains a significant challenge. The ErbB family, including epidermal growth factor receptor (EGFR), plays key roles in metastasis, tumorigenesis, cell proliferation, and drug resistance. Recently, these charac...

journal_title：Breast cancer research : BCR

authors： Tanei T,Choi DS,Rodriguez AA,Liang DH,Dobrolecki L,Ghosh M,Landis MD,Chang JC

更新日期：2016-01-12 00:00:00

abstract：:A series of recent studies have demonstrated that the retinoblastoma tumor suppressor (RB) pathway plays a critical role in multiple clinically relevant aspects of breast cancer biology, spanning early stage lesions to targeted treatment of metastatic disease. In ductal carcinoma in situ, multiple groups have shown th...

journal_title：Breast cancer research : BCR

authors： Witkiewicz AK,Knudsen ES

更新日期：2014-05-07 00:00:00

abstract：:Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that is effective and generally well tolerated when administered as a single agent to treat advanced breast cancer. Efficacy has now been demonstrated in randomized trials as first line, second line, and later than the second line treatment of advanced breast...

journal_title：Breast cancer research : BCR

authors： Barok M,Joensuu H,Isola J

更新日期：2014-03-05 00:00:00