Abstract:
:Protein-based Pickering emulsions have received considerable attention as nutraceutical vehicles. However, the oral bioavailability of nutraceuticals encapsulated in Pickering emulsions was not well established. In this work, a simulated gastrointestinal tract/Caco-2 cell culture model was applied to investigate the oral bioavailability of quercetin encapsulated in zein-based Pickering emulsions with quercetin in zein particles as the control. Pickering emulsions with shell (ZCP-QE) and core quercetin (ZCPE-Q) were constructed, and quercetin bioaccessibility, cell uptake and secretion, and the overall bioavailability were evaluated and compared. The overall oral bioavailability of quercetin was increased from 2.71% (bulk oil) to 38.18% (ZCPs-Q) and 18.97% (ZCPE-Q), particularly reached 41.22% for ZCP-QE. This work took new insights into the contributions of bioaccessibility and absorption (cell uptake plus secretion) to the overall oral bioavailability of quercetin. A schematic representation is proposed to relate the types of colloidal nanostructures in the digesta to the uptake, cell absorption, and overall oral bioavailability of quercetin. This study provided an attractive basis for identifying effective strategies to improve the oral bioavailability of hydrophobic nutraceuticals.
journal_name
Food Chemjournal_title
Food chemistryauthors
Ma JJ,Huang XN,Yin SW,Yu YG,Yang XQdoi
10.1016/j.foodchem.2021.130152keywords:
["Bioaccessibility","Caco-2 monolayer","Cell uptake and transport","Oral bioavailability","Pickering emulsion","Quercetin","Zein\/chitosan nanoparticles"]subject
Has Abstractpub_date
2021-10-30 00:00:00pages
130152eissn
0308-8146issn
1873-7072pii
S0308-8146(21)01158-4journal_volume
360pub_type
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