Abstract：
BACKGROUND:The purpose of this study was to determine whether first trimester trisomy screening (FTS) parameters are affected by alcohol and drug use. METHODS:A routine combined FTS including measurements of maternal serum levels of free β-human chorionic gonadotropin subunit (free β-hCG) and pregnancy-associated plasma protein A (PAPP-A) were measured at 9-11 weeks of gestation, and fetal nuchal translucency thickness (NTT) at 11-13 weeks of gestation. In total 544 women with singleton pregnancies [71 alcohol and drug abusers, 88 smokers, 168 non-smokers delivering a small for gestational age (SGA) child, and 217 unexposed control women] were assessed. RESULTS:Free β-hCG levels were higher in alcohol and drug abusing than in unexposed pregnant women [mean 1.5 vs. 1.2 multiples of medians (MoM); P = 0.013]. However, stepwise multiple linear regression analyses suggested that smoking could explain increased free β-hCG. Additionally, we observed lower PAPP-A levels in the smoking mothers (0.9 vs. 1.2 MoM; P = 0.045) and in those giving birth to an SGA child compared to the controls (1.1 vs.. 1.2 MoM; P < 0.001). Fetal NTT did not differ significantly between any of the groups. CONCLUSIONS:The present study shows increased free β-hCG levels in alcohol and drug abusers, but maternal smoking may explain the result. Maternal serum PAPP-A levels were lower in smoking than non-smoking mothers, and in mothers delivering an SGA child. However, FTS parameters (PAPP-A, free β-hCG and NTT) seem not to be applicable for the use as alcohol biomarkers because of their clear overlap between alcohol abusers and healthy controls.
journal_name
BMC Pregnancy Childbirthjournal_title
BMC pregnancy and childbirthauthors
Lehikoinen A,Voutilainen R,Romppanen J,Heinonen Sdoi
10.1186/s12884-020-03171-9subject
Has Abstractpub_date
2020-09-25 00:00:00pages
562issue
1issn
1471-2393pii
10.1186/s12884-020-03171-9journal_volume
20pub_type
杂志文章abstract：BACKGROUND:Enemas are used during labour in obstetric settings with the belief that they reduce puerperal and neonatal infections, shorten labour duration, and make delivery cleaner for attending personnel. However, a systematic review of the literature found insufficient evidence to support the use of enemas. The obje...
journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
doi：10.1186/1471-2393-6-8
更新日期：2006-03-19 00:00:00
abstract：BACKGROUND:The use of tocolytic hospitalization in antenatal care is controversial and worthy of more research. We investigated individual, institutional, and area factors that affect the use of tocolytic hospitalizations in Taiwan where fertility has rapidly declined. METHODS:Longitudinal data from the 1996 to 2004 N...
journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
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abstract：BACKGROUND:The literature shows a variable and inconsistent relationship between socioeconomic position and preterm birth. We examined risk factors for spontaneous and iatrogenic preterm birth, with a focus on socioeconomic position and clinical risk factors, in order to explain the observed inconsistency. METHODS:We ...
journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
doi：10.1186/1471-2393-14-117
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abstract：BACKGROUND:Late booking and infrequent antenatal care (ANC) are common but avoidable patient-related risk factors for maternal deaths in South Africa. The aim of the study was to examine the association of psychosocial factors with early initiation of ANC and adequate frequency of attendance of ANC clinics among women ...
journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
doi：10.1186/s12884-016-0807-1
更新日期：2016-01-25 00:00:00
abstract：BACKGROUND:Placenta percreta is a rare obstetric condition associated with the risk of massive intraoperative hemorrhage. Recently, conservative management of placenta percreta has been performed to reduce maternal morbidity. However, various complications have been reported during such management. Only a few cases of ...
journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章,评审
doi：10.1186/s12884-017-1634-8
更新日期：2017-12-29 00:00:00
abstract：BACKGROUND:Intimate partner violence (IPV) during pregnancy is a serious matter which threatens maternal and fetal health. The aim of this study was to develop a grounded theoretical model of women's experience of IPV during pregnancy and how they handle their situation. METHOD:Ten interviews with women who had experi...
journal_title：BMC pregnancy and childbirth
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doi：10.1186/1471-2393-14-293
更新日期：2014-08-28 00:00:00
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journal_title：BMC pregnancy and childbirth
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
doi：10.1186/s12884-016-1065-y
更新日期：2016-09-21 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
doi：10.1186/1471-2393-7-8
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journal_title：BMC pregnancy and childbirth
pub_type： 临床试验,杂志文章
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更新日期：2015-03-28 00:00:00
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journal_title：BMC pregnancy and childbirth
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更新日期：2017-11-09 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
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更新日期：2019-05-08 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
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更新日期：2020-01-13 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
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更新日期：2019-10-28 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章,meta分析
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更新日期：2013-11-11 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章,随机对照试验
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章,评审
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更新日期：2012-02-10 00:00:00
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journal_title：BMC pregnancy and childbirth
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更新日期：2019-12-21 00:00:00
abstract：BACKGROUND:Fear of childbirth is a common health concern for women during pregnancy. The Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) is widely used to measure childbirth fear during pregnancy. However, this instrument is yet to be validated in Malawi, Africa. Our study aimed to assess the psychometric pr...
journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
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更新日期：2020-08-08 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
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更新日期：2020-03-26 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章,评审
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更新日期：2017-02-16 00:00:00
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journal_title：BMC pregnancy and childbirth
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更新日期：2019-09-18 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
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更新日期：2015-10-16 00:00:00
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journal_title：BMC pregnancy and childbirth
pub_type： 杂志文章
doi：10.1186/1471-2393-7-16
更新日期：2007-08-06 00:00:00
