Overall, anti-malarial, and non-malarial effect of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine on birthweight: a mediation analysis.

Abstract:

BACKGROUND:Trials of intermittent preventive treatment (IPTp) of malaria in pregnant women that compared dihydroartemisinin-piperaquine with the standard of care, sulfadoxine-pyrimethamine, showed dihydroartemisinin-piperaquine was superior at preventing malaria infection, but not at improving birthweight. We aimed to assess whether sulfadoxine-pyrimethamine shows greater non-malarial benefits for birth outcomes than does dihydroartemisinin-piperaquine, and whether dihydroartemisinin-piperaquine shows greater antimalarial benefits for birth outcomes than does sulfadoxine-pyrimethamine. METHODS:We defined treatment as random assignment to sulfadoxine-pyrimethamine or dihydroartemisinin-piperaquine before pooling individual participant-level data from 1617 HIV-uninfected pregnant women in Kenya (one trial; n=806) and Uganda (two trials; n=811). We quantified the relative effect of treatment on birthweight (primary outcome) attributed to preventing placental malaria infection (mediator). We estimated antimalarial (indirect) and non-malarial (direct) effects of IPTp on birth outcomes using causal mediation analyses, accounting for confounders. We used two-stage individual participant data meta-analyses to calculate pooled-effect sizes. FINDINGS:Overall, birthweight was higher among neonates of women randomly assigned to sulfadoxine-pyrimethamine compared with women assigned to dihydroartemisinin-piperaquine (mean difference 69 g, 95% CI 26 to 112), despite placental malaria infection being lower in the dihydroartemisinin-piperaquine group (relative risk [RR] 0·64, 95% CI 0·39 to 1·04). Mediation analyses showed sulfadoxine-pyrimethamine conferred a greater non-malarial effect than did dihydroartemisinin-piperaquine (mean difference 87 g, 95% CI 43 to 131), whereas dihydroartemisinin-piperaquine conferred a slightly larger antimalarial effect than did sulfadoxine-pyrimethamine (8 g, -9 to 26), although more frequent dosing increased the antimalarial effect (31 g, 3 to 60). INTERPRETATION:IPTp with sulfadoxine-pyrimethamine appears to have potent non-malarial effects on birthweight. Further research is needed to evaluate monthly dihydroartemisinin-piperaquine with sulfadoxine-pyrimethamine (or another compound with non-malarial effects) to achieve greater protection against malarial and non-malarial causes of low birthweight. FUNDING:Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bill & Melinda Gates Foundation, and Worldwide Antimalarial Resistance Network.

journal_name

Lancet Glob Health

authors

Roh ME,Kuile FOT,Rerolle F,Glymour MM,Shiboski S,Gosling R,Gutman J,Kakuru A,Desai M,Kajubi R,L'Ianziva A,Kamya MR,Dorsey G,Chico RM

doi

10.1016/S2214-109X(20)30119-4

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

e942-e953

issue

7

issn

2214-109X

pii

S2214-109X(20)30119-4

journal_volume

8

pub_type

杂志文章,随机对照试验
  • Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study.

    abstract:BACKGROUND:To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision loss burden, presenting estimates for 2020, temporal change over three decades between 1990-2020, an...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(20)30425-3

    authors: GBD 2019 Blindness and Vision Impairment Collaborators.,Vision Loss Expert Group of the Global Burden of Disease Study.

    更新日期:2021-02-01 00:00:00

  • National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis.

    abstract:BACKGROUND:Low birthweight (LBW) of less than 2500 g is an important marker of maternal and fetal health, predicting mortality, stunting, and adult-onset chronic conditions. Global nutrition targets set at the World Health Assembly in 2012 include an ambitious 30% reduction in LBW prevalence between 2012 and 2025. Esti...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(18)30565-5

    authors: Blencowe H,Krasevec J,de Onis M,Black RE,An X,Stevens GA,Borghi E,Hayashi C,Estevez D,Cegolon L,Shiekh S,Ponce Hardy V,Lawn JE,Cousens S

    更新日期:2019-07-01 00:00:00

  • Self-assessment of the outcome of early medical abortion versus clinic follow-up in India: a randomised, controlled, non-inferiority trial.

    abstract:BACKGROUND:The need for multiple clinical visits remains a barrier to women accessing safe legal medical abortion services. Alternatives to routine clinic follow-up visits have not been assessed in rural low-resource settings. We compared the effectiveness of standard clinic follow-up versus home assessment of outcome ...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/S2214-109X(15)00150-3

    authors: Iyengar K,Paul M,Iyengar SD,Klingberg-Allvin M,Essén B,Bring J,Soni S,Gemzell-Danielsson K

    更新日期:2015-09-01 00:00:00

  • Health gains and financial risk protection afforded by public financing of selected interventions in Ethiopia: an extended cost-effectiveness analysis.

    abstract:BACKGROUND:The way in which a government chooses to finance a health intervention can affect the uptake of health interventions and consequently the extent of health gains. In addition to health gains, some policies such as public finance can insure against catastrophic health expenditures. We aimed to evaluate the hea...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(14)70346-8

    authors: Verguet S,Olson ZD,Babigumira JB,Desalegn D,Johansson KA,Kruk ME,Levin CE,Nugent RA,Pecenka C,Shrime MG,Memirie ST,Watkins DA,Jamison DT

    更新日期:2015-05-01 00:00:00

  • Quality of basic maternal care functions in health facilities of five African countries: an analysis of national health system surveys.

    abstract:BACKGROUND:Global efforts to increase births at health-care facilities might not reduce maternal or newborn mortality if quality of care is insufficient. However, little systematic evidence exists for the quality at health facilities caring for women and newborn babies in low-income countries. We analysed the quality o...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(16)30180-2

    authors: Kruk ME,Leslie HH,Verguet S,Mbaruku GM,Adanu RMK,Langer A

    更新日期:2016-11-01 00:00:00

  • Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study.

    abstract:BACKGROUND:Tuberculosis is recognised as a major cause of morbidity and mortality in children, with most cases in children going undiagnosed and resulting in poor outcomes. Household contact management, which aims to identify children with active tuberculosis and to provide preventive therapy for those with HIV or thos...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(18)30401-7

    authors: Dodd PJ,Yuen CM,Becerra MC,Revill P,Jenkins HE,Seddon JA

    更新日期:2018-12-01 00:00:00

  • Progress and priorities for reproductive, maternal, newborn, and child health in Kenya: a Countdown to 2015 country case study.

    abstract:BACKGROUND:Progress in reproductive, maternal, newborn, and child health (RMNCH) in Kenya has been inconsistent over the past two decades, despite the global push to foster accountability, reduce child mortality, and improve maternal health in an equitable manner. Although several cross-sectional assessments have been ...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(17)30246-2

    authors: Keats EC,Ngugi A,Macharia W,Akseer N,Khaemba EN,Bhatti Z,Rizvi A,Tole J,Bhutta ZA

    更新日期:2017-08-01 00:00:00

  • Access to emergency hospital care provided by the public sector in sub-Saharan Africa in 2015: a geocoded inventory and spatial analysis.

    abstract:BACKGROUND:Timely access to emergency care can substantially reduce mortality. International benchmarks for access to emergency hospital care have been established to guide ambitions for universal health care by 2030. However, no Pan-African database of where hospitals are located exists; therefore, we aimed to complet...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(17)30488-6

    authors: Ouma PO,Maina J,Thuranira PN,Macharia PM,Alegana VA,English M,Okiro EA,Snow RW

    更新日期:2018-03-01 00:00:00

  • Ethnoracial and social trends in breast cancer staging at diagnosis in Brazil, 2001-14: a case only analysis.

    abstract:BACKGROUND:Policies for early detection of breast cancer, including clinical breast examinations and mammographic screening, were introduced in Brazil in 2004, but their effect on disease stage at diagnosis is unclear. We aimed to assess whether these policies have led to a decrease in the prevalence of late-stage brea...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(19)30151-2

    authors: Dos-Santos-Silva I,De Stavola BL,Renna NL Junior,Nogueira MC,Aquino EML,Bustamante-Teixeira MT,Azevedo E Silva G

    更新日期:2019-06-01 00:00:00

  • Trends in premature avertable mortality from non-communicable diseases for 195 countries and territories, 1990-2017: a population-based study.

    abstract:BACKGROUND:The reduction by a third of premature non-communicable disease (NCD) mortality by 2030 is the ambitious target of Sustainable Development Goal (SDG) 3.4. However, the indicator is narrowly defined, including only four major NCDs (cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases) an...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(20)30035-8

    authors: Martinez R,Lloyd-Sherlock P,Soliz P,Ebrahim S,Vega E,Ordunez P,McKee M

    更新日期:2020-04-01 00:00:00

  • Effect on mortality of increasing the cutoff blood glucose concentration for initiating hypoglycaemia treatment in severely sick children aged 1 month to 5 years in Malawi (SugarFACT): a pragmatic, randomised controlled trial.

    abstract:BACKGROUND:Low blood glucose concentrations are common in sick children who present to hospital in low-resource settings and are associated with increased mortality. The cutoff blood glucose concentration for the diagnosis and treatment of hypoglycaemia currently recommended by WHO (2·5 mmol/L) is not evidence-based. W...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/S2214-109X(20)30388-0

    authors: Baker T,Ngwalangwa F,Masanjala H,Dube Q,Langton J,Marrone G,Hildenwall H

    更新日期:2020-12-01 00:00:00

  • Effects of health-system strengthening on under-5, infant, and neonatal mortality: 11-year provincial-level time-series analyses in Mozambique.

    abstract:BACKGROUND:Knowledge of the relation between health-system factors and child mortality could help to inform health policy in low-income and middle-income countries. We aimed to quantify modifiable health-system factors and their relation with provincial-level heterogeneity in under-5, infant, and neonatal mortality ove...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(14)70276-1

    authors: Fernandes QF,Wagenaar BH,Anselmi L,Pfeiffer J,Gloyd S,Sherr K

    更新日期:2014-08-01 00:00:00

  • Prevalence of cerebral palsy in Uganda: a population-based study.

    abstract:BACKGROUND:Few population-based studies of cerebral palsy have been done in low-income and middle-income countries. We aimed to examine cerebral palsy prevalence and subtypes, functional impairments, and presumed time of injury in children in Uganda. METHODS:In this population-based study, we used a nested, three-stag...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(17)30374-1

    authors: Kakooza-Mwesige A,Andrews C,Peterson S,Wabwire Mangen F,Eliasson AC,Forssberg H

    更新日期:2017-12-01 00:00:00

  • Levels and trends in contraceptive prevalence, unmet need, and demand for family planning for 29 states and union territories in India: a modelling study using the Family Planning Estimation Tool.

    abstract:BACKGROUND:Improving access to reproductive health services and commodities is central to development. Efforts to assess progress on this front have been largely focused on national estimates, but such analyses can mask local disparities. We assessed progress in reproductive health services subnationally in India. MET...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(17)30033-5

    authors: New JR,Cahill N,Stover J,Gupta YP,Alkema L

    更新日期:2017-03-01 00:00:00

  • Towards safe drinking water and clean cooking for all.

    abstract::The public health community has tried for decades to show, through evidence-based research, that safe water, sanitation, and hygiene (WASH) and clean cooking fuels that reduce household air pollution are essential to safeguard health and save lives in low-income and middle-income countries. In the past 40 decades, the...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章,评审

    doi:10.1016/S2214-109X(20)30476-9

    authors: Ray I,Smith KR

    更新日期:2021-01-11 00:00:00

  • Seasonal malaria chemoprevention in the Sahel subregion of Africa: a cost-effectiveness and cost-savings analysis.

    abstract:BACKGROUND:The intermittent administration of seasonal malaria chemoprevention (SMC) is recommended to prevent malaria among children aged 3-59 months in areas of the Sahel subregion in Africa. However, the cost-effectiveness and cost savings of SMC have not previously been evaluated in large-scale studies. METHODS:We...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(20)30475-7

    authors: Gilmartin C,Nonvignon J,Cairns M,Milligan P,Bocoum F,Winskill P,Moroso D,Collins D

    更新日期:2021-02-01 00:00:00

  • Progress towards universal health coverage in Myanmar: a national and subnational assessment.

    abstract:BACKGROUND:Attainment of universal health coverage is a global health priority. The Myanmar Government has committed to attainment of universal health coverage by 2030, but progress so far has not been assessed. We aimed to estimate national and subnational health service coverage and financial risk protection. METHOD...

    journal_title:The Lancet. Global health

    pub_type: 评论,杂志文章

    doi:10.1016/S2214-109X(18)30318-8

    authors: Han SM,Rahman MM,Rahman MS,Swe KT,Palmer M,Sakamoto H,Nomura S,Shibuya K

    更新日期:2018-09-01 00:00:00

  • Ethnic and regional variations in hospital mortality from COVID-19 in Brazil: a cross-sectional observational study.

    abstract:BACKGROUND:Brazil ranks second worldwide in total number of COVID-19 cases and deaths. Understanding the possible socioeconomic and ethnic health inequities is particularly important given the diverse population and fragile political and economic situation. We aimed to characterise the COVID-19 pandemic in Brazil and a...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(20)30285-0

    authors: Baqui P,Bica I,Marra V,Ercole A,van der Schaar M

    更新日期:2020-08-01 00:00:00

  • An approach to identify a minimum and rational proportion of caesarean sections in resource-poor settings: a global network study.

    abstract:BACKGROUND:Caesarean section prevalence is increasing in Asia and Latin America while remaining low in most African regions. Caesarean section delivery is effective for saving maternal and infant lives when they are provided for medically-indicated reasons. On the basis of ecological studies, caesarean delivery prevale...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章,评审

    doi:10.1016/S2214-109X(18)30241-9

    authors: Belizán JM,Minckas N,McClure EM,Saleem S,Moore JL,Goudar SS,Esamai F,Patel A,Chomba E,Garces AL,Althabe F,Harrison MS,Krebs NF,Derman RJ,Carlo WA,Liechty EA,Hibberd PL,Buekens PM,Goldenberg RL

    更新日期:2018-08-01 00:00:00

  • Estimating malaria burden among pregnant women using data from antenatal care centres in Tanzania: a population-based study.

    abstract:BACKGROUND:More timely estimates of malaria prevalence are needed to inform optimal control strategies and measure progress. Since 2014, Tanzania has implemented nationwide malaria screening for all pregnant women within the antenatal care system. We aimed to compare malaria test results during antenatal care to two po...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(19)30405-X

    authors: Kitojo C,Gutman JR,Chacky F,Kigadye E,Mkude S,Mandike R,Mohamed A,Reaves EJ,Walker P,Ishengoma DS

    更新日期:2019-12-01 00:00:00

  • Burden of dengue infection in India, 2017: a cross-sectional population based serosurvey.

    abstract:BACKGROUND:The burden of dengue virus (DENV) infection across geographical regions of India is poorly quantified. We estimated the age-specific seroprevalence, force of infection, and number of infections in India. METHODS:We did a community-based survey in 240 clusters (118 rural, 122 urban), selected from 60 distric...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(19)30250-5

    authors: Murhekar MV,Kamaraj P,Kumar MS,Khan SA,Allam RR,Barde P,Dwibedi B,Kanungo S,Mohan U,Mohanty SS,Roy S,Sagar V,Savargaonkar D,Tandale BV,Topno RK,Sapkal G,Kumar CPG,Sabarinathan R,Kumar VS,Bitragunta S,Grover GS,L

    更新日期:2019-08-01 00:00:00

  • Mortality and its risk factors in Malawian children admitted to hospital with clinical pneumonia, 2001-12: a retrospective observational study.

    abstract:BACKGROUND:Few studies have reported long-term data on mortality rates for children admitted to hospital with pneumonia in Africa. We examined trends in case fatality rates for all-cause clinical pneumonia and its risk factors in Malawian children between 2001 and 2012. METHODS:Individual patient data for children (<5...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(15)00215-6

    authors: Lazzerini M,Seward N,Lufesi N,Banda R,Sinyeka S,Masache G,Nambiar B,Makwenda C,Costello A,McCollum ED,Colbourn T

    更新日期:2016-01-01 00:00:00

  • Contraceptive use in Latin America and the Caribbean with a focus on long-acting reversible contraceptives: prevalence and inequalities in 23 countries.

    abstract:BACKGROUND:The rise in contraceptive use has largely been driven by short-acting methods of contraception, despite the high effectiveness of long-acting reversible contraceptives. Several countries in Latin America and the Caribbean have made important progress increasing the use of modern contraceptives, but important...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(18)30481-9

    authors: Ponce de Leon RG,Ewerling F,Serruya SJ,Silveira MF,Sanhueza A,Moazzam A,Becerra-Posada F,Coll CVN,Hellwig F,Victora CG,Barros AJD

    更新日期:2019-02-01 00:00:00

  • The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis.

    abstract:BACKGROUND:Amid rapid urbanisation, the HIV epidemic, and increasing rates of non-communicable diseases, people in sub-Saharan Africa are especially vulnerable to kidney disease. Little is known about the epidemiology of chronic kidney disease (CKD) in sub-Saharan Africa, so we did a systematic review and meta-analysis...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/S2214-109X(14)70002-6

    authors: Stanifer JW,Jing B,Tolan S,Helmke N,Mukerjee R,Naicker S,Patel U

    更新日期:2014-03-01 00:00:00

  • Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF.

    abstract:BACKGROUND:In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme outcomes. METHODS:We randomly allocated 20 laboratories (clusters) in medium-burde...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/S2214-109X(15)00100-X

    authors: Churchyard GJ,Stevens WS,Mametja LD,McCarthy KM,Chihota V,Nicol MP,Erasmus LK,Ndjeka NO,Mvusi L,Vassall A,Sinanovic E,Cox HS,Dye C,Grant AD,Fielding KL

    更新日期:2015-08-01 00:00:00

  • Effect of counselling on health-care-seeking behaviours and rabies vaccination adherence after dog bites in Haiti, 2014-15: a retrospective follow-up survey.

    abstract:BACKGROUND:Haiti has an integrated bite case management (IBCM) programme to counsel animal-bite victims on the risk of rabies and appropriate treatment, as well as the Haiti Animal Rabies Surveillance Program (HARSP) to examine the animals. We assessed the usefulness of the IBCM programme to promote best practices for ...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(17)30321-2

    authors: Etheart MD,Kligerman M,Augustin PD,Blanton JD,Monroe B,Fleurinord L,Millien M,Crowdis K,Fenelon N,Wallace RM

    更新日期:2017-10-01 00:00:00

  • Long-term effectiveness of one and two doses of a killed, bivalent, whole-cell oral cholera vaccine in Haiti: an extended case-control study.

    abstract:BACKGROUND:No study of long-term protection following killed oral cholera vaccination has been done outside of the historically cholera-endemic areas of south Asia, or has examined protection after a single-dose vaccination regimen. To address this, we examined the duration of protection of the standard two-dose regime...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(18)30284-5

    authors: Franke MF,Ternier R,Jerome JG,Matias WR,Harris JB,Ivers LC

    更新日期:2018-09-01 00:00:00

  • Effect of democratic reforms on child mortality: a synthetic control analysis.

    abstract:BACKGROUND:The effects of political regimes on health are unclear because empirical evidence is neither strong nor robust. Traditional econometric tools do not allow the direction of causality to be established clearly. We used a new method to investigate whether political transition into democracy affected child morta...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(16)30104-8

    authors: Pieters H,Curzi D,Olper A,Swinnen J

    更新日期:2016-09-01 00:00:00

  • Cost-effectiveness of HIV prevention for high-risk groups at scale: an economic evaluation of the Avahan programme in south India.

    abstract:BACKGROUND:Avahan is a large-scale, HIV preventive intervention, targeting high-risk populations in south India. We assessed the cost-effectiveness of Avahan to inform global and national funding institutions who are considering investing in worldwide HIV prevention in concentrated epidemics. METHODS:We estimated cost...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(14)70277-3

    authors: Vassall A,Pickles M,Chandrashekar S,Boily MC,Shetty G,Guinness L,Lowndes CM,Bradley J,Moses S,Alary M,Charme India Group.,Vickerman P

    更新日期:2014-09-01 00:00:00

  • Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants.

    abstract:BACKGROUND:Insufficient physical activity is a leading risk factor for non-communicable diseases, and has a negative effect on mental health and quality of life. We describe levels of insufficient physical activity across countries, and estimate global and regional trends. METHODS:We pooled data from population-based ...

    journal_title:The Lancet. Global health

    pub_type: 杂志文章

    doi:10.1016/S2214-109X(18)30357-7

    authors: Guthold R,Stevens GA,Riley LM,Bull FC

    更新日期:2018-10-01 00:00:00