Abstract:
BACKGROUND:Gestational diabetes mellitus (GDM) is a growing global epidemic. Our study aims to confirm the association between circulatory coiled-coil domain-containing 80 (CCDC80) in pregnant women with GDM, to investigate the discriminatory power of CCDC80 on GDM, and to explore the relationships between this molecular level and clinical cardiometabolic parameters. METHODS:A 1:2 matched case-control study with 61 GDM patients and 122 controls was conducted using a propensity score matching protocol. All participants were screened from a multicenter prospective pre-birth cohort: Born in Shenyang Cohort Study (BISCS). During 24 and 28 weeks of gestation, follow-up individuals underwent an oral glucose tolerance test (OGTT) and blood sampling for cardiometabolic characterization. RESULTS:Following propensity score matching adjustment for clinical variables, including maternal age, gestational age, body mass index, SBP and DBP, plasma CCDC80 levels were significantly decreased in patients with GDM when compared with controls (0.25 ± 0.10 vs. 0.31 ± 0.12 ng/ml, P = 0.003). Conditional multi-logistic regression analyses after adjustments for potential confounding factors revealed that CCDC80 was a strong and independent protective factor for GDM (ORs < 1). In addition, the results of the ROC analysis indicated the CCDC80 exhibited the capability to identify pregnant women with GDM (AUC = 0.633). Finally, multivariate regression analyses showed that CCDC80 levels were positively associated with AST, monoamine oxidase, complement C1q, LDL-C, apolipoprotein A1and B, and negatively associated with blood glucose levels at 1 h post- OGTT. CONCLUSIONS:Biomarker CCDC80 could be of great value for the development of prediction, diagnosis and therapeutic strategies against GDM in pregnant women.
journal_name
BMC Pregnancy Childbirthjournal_title
BMC pregnancy and childbirthauthors
Liu L,Hu J,Wang N,Liu Y,Wei X,Gao M,Ma Y,Wen Ddoi
10.1186/s12884-020-2743-3subject
Has Abstractpub_date
2020-01-28 00:00:00pages
53issue
1issn
1471-2393pii
10.1186/s12884-020-2743-3journal_volume
20pub_type
杂志文章abstract:BACKGROUND:Posttraumatic stress symptoms (PTSS) after childbirth may affect mother-infant bonding. This study examined the relationship between aspects of PTSS after childbirth and bonding failure for mothers at 1 month and 4 months after delivery. METHODS:This longitudinal study surveyed 130 mothers at 1 month (T1) a...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-020-03099-0
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:This study aimed to investigate the percentage of the needs and expectations of pregnant women with Gestational Diabetes Mellitus (GDM) about the best sources of information on GDM, their satisfaction with the diagnostic process and information provision. METHODS:Questionnaires were completed by 116 pregnan...
journal_title:BMC pregnancy and childbirth
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,随机对照试验
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-015-0786-7
更新日期:2015-12-28 00:00:00
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journal_title:BMC pregnancy and childbirth
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doi:10.1186/s12884-020-03367-z
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-12-5
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,多中心研究
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更新日期:2014-12-12 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-13-147
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,随机对照试验
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journal_title:BMC pregnancy and childbirth
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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更新日期:2020-09-18 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,评审
doi:10.1186/s12884-017-1634-8
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-14-250
更新日期:2014-07-29 00:00:00
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journal_title:BMC pregnancy and childbirth
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doi:10.1186/s12884-019-2569-z
更新日期:2019-11-27 00:00:00
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更新日期:2014-06-06 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-017-1630-z
更新日期:2018-01-10 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-6-8
更新日期:2006-03-19 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-016-1183-6
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:Pregnancy is an important phase in a woman's life, with health status at this stage affecting both the woman and her child's life. Global evidence suggests that many women engage in low levels of physical activity (PA) and exercise during pregnancy despite its beneficial effects. This is particularly the cas...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-09-03 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,评审
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更新日期:2017-02-16 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-018-1941-8
更新日期:2018-07-31 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-10-21 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,meta分析,评审
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更新日期:2008-08-04 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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更新日期:2020-06-23 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,评审
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更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Vaginal birth after Caesarean section (VBAC) is a relevant question for a large number of women due to the internationally rising Caesarean section (CS) rate. There is a great deal of research based on quantitative studies but few qualitative studies about women's experiences. METHOD:A metasynthesis based o...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2393-12-85
更新日期:2012-08-21 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-018-1744-y
更新日期:2018-04-20 00:00:00