Abstract:
BACKGROUND:Reliable antenatal identification of pre-eclampsia and small for gestational age is crucial to judicious allocation of monitoring resources and use of preventative treatment with the prospect of improving maternal/perinatal outcome. The purpose of this systematic review was to determine the accuracy of five serum analytes used in Down's serum screening for prediction of pre-eclampsia and/or small for gestational age. METHODS:The data sources included Medline, Embase, Cochrane library, Medion (inception to February 2007), hand searching of relevant journals, reference list checking of included articles, contact with experts. Two reviewers independently selected the articles in which the accuracy of an analyte used in Downs's serum screening before the 25th gestational week was associated with the occurrence of pre-eclampsia and/or small for gestational age without language restrictions. Two authors independently extracted data on study characteristics, quality and results. RESULTS:Five serum screening markers were evaluated. 44 studies, testing 169,637 pregnant women (4376 pre-eclampsia cases) and 86 studies, testing 382,005 women (20,339 fetal growth restriction cases) met the selection criteria. The results showed low predictive accuracy overall. For pre-eclampsia the best predictor was inhibin A>2.79MoM positive likelihood ratio 19.52 (8.33,45.79) and negative likelihood ratio 0.30 (0.13,0.68) (single study). For small for gestational age it was AFP>2.0MoM to predict birth weight < 10th centile with birth < 37 weeks positive likelihood ratio 27.96 (8.02,97.48) and negative likelihood ratio 0.78 (0.55,1.11) (single study). A potential clinical application using aspirin as a treatment is given as an example.There were methodological and reporting limitations in the included studies thus studies were heterogeneous giving pooled results with wide confidence intervals. CONCLUSION:Down's serum screening analytes have low predictive accuracy for pre-eclampsia and small for gestational age. They may be a useful means of risk assessment or of use in prediction when combined with other tests.
journal_name
BMC Pregnancy Childbirthjournal_title
BMC pregnancy and childbirthauthors
Morris RK,Cnossen JS,Langejans M,Robson SC,Kleijnen J,Ter Riet G,Mol BW,van der Post JA,Khan KSdoi
10.1186/1471-2393-8-33subject
Has Abstractpub_date
2008-08-04 00:00:00pages
33issn
1471-2393pii
1471-2393-8-33journal_volume
8pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:There are several international guidelines on oxytocin regimens for induction and augmentation of labour, but no agreement on a standardised regimen in Germany. This study collated and reviewed the oxytocin regimens used for labour augmentation in university hospitals, with the long-term aim of contributing ...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/s12884-019-2348-x
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:Freebirthing or unassisted birth is the active choice made by a woman to birth without a trained professional present, even where there is access to maternity provision. This is a radical childbirth choice, which has potential morbidity and mortality risks for mother and baby. While a number of studies have ...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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abstract:BACKGROUND:Use of maternal health services is an effective means for reducing the risk of maternal morbidity and mortality, especially in places where the general health status of women is poor. This study was guided by the following objectives: 1) To determine the relationship between timing of first antenatal care (A...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-11-1
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abstract:BACKGROUND:Early initiation of breastfeeding (within an hour of birth) has benefits for newborn health and survival. Optimal breastfeeding supports growth, health, and development. Health facilities provide essential pregnancy, maternal, and newborn care and offer support for early breastfeeding. We examined the relati...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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journal_title:BMC pregnancy and childbirth
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-7-16
更新日期:2007-08-06 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,meta分析
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abstract:BACKGROUND:The perinatal period, i.e. pregnancy, childbirth and early infancy, is a significant transition period where the biological and the social strongly intersect. In low and middle-income countries the disease burden arising from the perinatal period, is still substantial. The perinatal period is also a crucial ...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2017-01-26 00:00:00
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journal_title:BMC pregnancy and childbirth
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更新日期:2016-08-08 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12884-017-1425-2
更新日期:2017-08-01 00:00:00
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doi:10.1186/s12884-016-0845-8
更新日期:2016-03-16 00:00:00
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更新日期:2018-06-18 00:00:00
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更新日期:2018-04-06 00:00:00
abstract:BACKGROUND:Gestational diabetes mellitus (GDM) in singleton pregnancies represent a high-risk scenario. The incidence, associated factors and outcomes of GDM in twin pregnancies is not known in the UAE. METHODS:This was five years retrospective analysis of hospital records of twin pregnancies in the city of Al Ain, Ab...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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更新日期:2018-10-19 00:00:00
abstract::BACKGROUND: Although the debate on the safety and women's right of choice to a home delivery vs. hospital delivery continues in the developed countries, an undesirable outcome of home delivery, such as high maternal and perinatal mortality, is documented in developing countries. The objective was to study whether soci...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-4-8
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更新日期:2018-12-29 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-02-20 00:00:00
abstract:BACKGROUND:Use of skilled health provider (SBA) during and after childbirth has been reported to reduce maternal and newborn deaths; and is one of the key indicators monitored in Sustainable Development Goals (SDGs). Progress, levels and factors influencing utilization of SBA differ within and between countries. In Tan...
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pub_type: 杂志文章
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abstract:BACKGROUND:The reduction of the preterm delivery (PTD) rate is a maternal and child health target. Elevated rates have been found among several immigrant groups, but few studies have distinguished between PTD according to the mode of birth start. In addition, migrants' birth outcomes have further been shown to be affec...
journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-14-239
更新日期:2014-07-21 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章,评审
doi:10.1186/1471-2393-12-23
更新日期:2012-03-31 00:00:00
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
doi:10.1186/1471-2393-7-8
更新日期:2007-06-21 00:00:00