MicroRNA-129 Inhibits Glioma Cell Growth by Targeting CDK4, CDK6, and MDM2.

abstract：:E-selectin is an adhesion molecule expressed on the luminal surface of inflamed blood vessels that mediates hematogenous metastasis by assisting shear-resistant adhesion of circulating tumor cells to the vessel surface under dynamic blood flow. Previously, we developed an E-selectin antagonistic thioaptamer (ESTA) for...

journal_title：Molecular therapy. Nucleic acids

authors： Morita Y,Kamal M,Kang SA,Zhang R,Lokesh GL,Thiviyanathan V,Hasan N,Woo S,Zhao D,Leslie M,Suh S,Razaq W,Rui H,Gorenstein DG,Volk DE,Tanaka T

更新日期：2016-12-13 00:00:00

abstract：:Circular RNA (circRNA) is a novel subclass of noncoding-RNA molecules that participate in development and progression of a variety of human diseases via sponging microRNAs (miRNAs), but the role of circRNAs in Hashimoto's thyroiditis (HT) has not been defined. In this study, peripheral blood samples from five patients...

journal_title：Molecular therapy. Nucleic acids

authors： Xiong S,Peng H,Ding X,Wang X,Wang L,Wu C,Wang S,Xu H,Liu Y

更新日期：2019-09-06 00:00:00

abstract：:The melanoma cell adhesion molecule (MCAM) is involved in melanoma development and its progression, including invasiveness, metastatic potential and angiogenesis. Therefore, MCAM represents a potential target for gene therapy of melanoma, whose expression could be hindered with posttranscriptional specific gene silenc...

journal_title：Molecular therapy. Nucleic acids

authors： Prosen L,Markelc B,Dolinsek T,Music B,Cemazar M,Sersa G

更新日期：2014-10-28 00:00:00

abstract：:5-methylcytosine (m5C) is one of the most common and abundant post-transcriptional modifications (PTCMs) in RNA. Recent studies showed that m5C plays important roles in many biological functions such as RNA metabolism and cell fate decision. Because most experimental methods that determine m5C sites across the transcr...

journal_title：Molecular therapy. Nucleic acids

authors： Fang T,Zhang Z,Sun R,Zhu L,He J,Huang B,Xiong Y,Zhu X

更新日期：2019-12-06 00:00:00

abstract：:As the human lifespan has increased due to developments in medical technology, the number of patients with neurological diseases has rapidly increased. Therefore, studies on effective treatments for neurological diseases are becoming increasingly important. To perform these studies, it is essential to obtain a large n...

journal_title：Molecular therapy. Nucleic acids

authors： Daekee K,Mi-Jung H,Minjun J,Hee-Jin A,Kwang-Won S,Kyung-Sun K

更新日期：2019-03-01 00:00:00

abstract：:Upregulation of long non-coding RNA LINC00963 has been observed in several cancer types. In this study, we analyzed the clinical and biological significance of LINC00963 in breast cancer. The key microRNA (miR) mediating the action of LINC00963 was identified. We show that LINC00963 upregulation is correlated with agg...

journal_title：Molecular therapy. Nucleic acids

authors： Zhang N,Zeng X,Sun C,Guo H,Wang T,Wei L,Zhang Y,Zhao J,Ma X

更新日期：2019-12-06 00:00:00

abstract：:Retinoic acid-inducible gene-I (RIG-I) is a cytosolic pathogen sensor that is crucial against a number of viral infections. Many viruses have evolved to inhibit pathogen sensors to suppress host innate immune responses. In the case of influenza, nonstructural protein 1 (NS1) suppresses RIG-I function, leading to viral...

journal_title：Molecular therapy. Nucleic acids

authors： Singh N,Ranjan P,Cao W,Patel J,Gangappa S,Davidson BA,Sullivan JM,Prasad PN,Knight PR,Sambhara S

更新日期：2020-03-06 00:00:00

abstract：:The acute hepatic porphyrias are caused by inherited enzymatic deficiencies in the heme biosynthesis pathway. Induction of the first enzyme 5-aminolevulinic acid synthase 1 (ALAS1) by triggers such as fasting or drug exposure can lead to accumulation of neurotoxic heme intermediates that cause disease symptoms. We hav...

journal_title：Molecular therapy. Nucleic acids

authors： Chan A,Liebow A,Yasuda M,Gan L,Racie T,Maier M,Kuchimanchi S,Foster D,Milstein S,Charisse K,Sehgal A,Manoharan M,Meyers R,Fitzgerald K,Simon A,Desnick RJ,Querbes W

更新日期：2015-11-03 00:00:00

abstract：:Diabetic retinopathy (DR) is a serious complication of diabetes, which is the main cause of blindness among adults. Traditional Chinese medicines (TCMs) have been proven to delay the development of DR. Nonetheless, the effect of Schizandrin A (SchA) on DR remains uninvestigated. The present study aimed to probe the pr...

journal_title：Molecular therapy. Nucleic acids

authors： Dong Y,Qian C,Wan G,Yan P,Liang S,Wang J

更新日期：2020-03-06 00:00:00

abstract：:Methyltransferase-like 3 (METTL3) is the main enzyme for N6-methyladenosine (m6A)-based methylation of RNAs and it has been implicated in many biological and pathophysiological processes. In this study, we aimed to explore the potential involvement of METTL3 in osteoblast differentiation and decipher the underlying ce...

journal_title：Molecular therapy. Nucleic acids

authors： Yan G,Yuan Y,He M,Gong R,Lei H,Zhou H,Wang W,Du W,Ma T,Liu S,Xu Z,Gao M,Yu M,Bian Y,Pang P,Li X,Yu S,Yang F,Cai B,Yang L

更新日期：2020-03-06 00:00:00

abstract：:A number of studies have reported that aberrant expression of microRNAs (miRNAs) closely correlates with the bone metastasis of prostate cancer (PCa). However, clinical significance and functional roles of both strands of a single miRNA in bone metastasis of PCa remain undefined. Here, we reported that miR-582-3p and ...

journal_title：Molecular therapy. Nucleic acids

authors： Huang S,Zou C,Tang Y,Wa Q,Peng X,Chen X,Yang C,Ren D,Huang Y,Liao Z,Huang S,Zou X,Pan J

更新日期：2019-06-07 00:00:00

abstract：:Cardiomyocyte differentiation derived from embryonic stem cells (ESCs) is a complex process involving molecular regulation of multiple levels. In this study, we first identify and compare differentially expressed gene (DEG) signatures of ESC-derived cardiomyocyte differentiation (ESCDCD) in humans and mice. Then, the ...

journal_title：Molecular therapy. Nucleic acids

authors： Wang Y,Yi N,Hu Y,Zhou X,Jiang H,Lin Q,Chen R,Liu H,Gu Y,Tong C,Lu M,Zhang J,Zhang B,Peng L,Li L

更新日期：2020-09-04 00:00:00

abstract：:Emerging evidence has demonstrated that miR-223 is critically involved in the progression of pancreatic cancer (PC); however, the underlying mechanisms are not fully elucidated. In the present study, we explored the molecular basis of miR-223-mediated tumor progression in PC. We performed numerous approaches including...

journal_title：Molecular therapy. Nucleic acids

authors： Ma J,Cao T,Cui Y,Zhang F,Shi Y,Xia J,Wang ZP

更新日期：2019-03-01 00:00:00

abstract：:Precise genome editing using engineered nucleases can significantly facilitate biological studies and disease treatment. In particular, clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR-associated (Cas) proteins are a potentially powerful tool for modifying a genome by targeted cleavage of...

journal_title：Molecular therapy. Nucleic acids

authors： Cradick TJ,Qiu P,Lee CM,Fine EJ,Bao G

更新日期：2014-12-02 00:00:00

abstract：:Cystic fibrosis (CF) is a recessive inherited disease associated with multiorgan damage that compromises epithelial and inflammatory cell function. Induced pluripotent stem cells (iPSCs) have significantly advanced the potential of developing a personalized cell-based therapy for diseases like CF by generating patient...

journal_title：Molecular therapy. Nucleic acids

authors： Suzuki S,Sargent RG,Illek B,Fischer H,Esmaeili-Shandiz A,Yezzi MJ,Lee A,Yang Y,Kim S,Renz P,Qi Z,Yu J,Muench MO,Beyer AI,Guimarães AO,Ye L,Chang J,Fine EJ,Cradick TJ,Bao G,Rahdar M,Porteus MH,Shuto T,Kai H,

更新日期：2016-01-05 00:00:00

abstract：:Circular RNAs (circRNAs) were recently reported to be involved in the pathogenesis of ovarian cancer (OC); however, the molecular mechanisms of circRNAs in tumor progression and paclitaxel (PTX) resistance of OC remain largely undetermined. Here, we focused on circTNPO3 (hsa_circ_0001741), which is located on chromoso...

journal_title：Molecular therapy. Nucleic acids

authors： Xia B,Zhao Z,Wu Y,Wang Y,Zhao Y,Wang J

更新日期：2020-09-04 00:00:00

abstract：:Recent studies reported that DNA methylation was involved in retinal cell death. Methyl-CpG binding domain protein 2 (Mbd2) is one of the DNA methylation readers. Its role and mechanism of regulation remain unclear. The ischemia/reperfusion (I/R) model in mice primary culture retinal ganglion cells (RGCs) and Mbd2 kno...

journal_title：Molecular therapy. Nucleic acids

authors： Ge Y,Zhang R,Feng Y,Li H

更新日期：2020-03-06 00:00:00

abstract：:Inflammatory mediators play a key role in the pathogenesis of acute respiratory distress syndrome (ARDS). In this study, we aimed to explore the involvement of the Kcnq1 opposite strand/antisense transcript 1 (Kcnq1ot1)/miR-381-3p/E26 transformation-specific proto-oncogene 2 (ETS2) axis in inflammation of lipopolysacc...

journal_title：Molecular therapy. Nucleic acids

authors： Jiang X,Yu M,Zhu T,Lou L,Chen X,Li Q,Wei D,Sun R

更新日期：2020-03-06 00:00:00

abstract：:The role of long non-coding RNA (lncRNA) in the regulation of bovine skeletal muscle development remains poorly understood. The present study investigated the function and regulatory mechanism of a novel lncRNA, insulin-like growth factor 2 antisense transcript (IGF2 AS), in bovine myoblast proliferation and different...

journal_title：Molecular therapy. Nucleic acids

authors： Song C,Yang Z,Jiang R,Cheng J,Yue B,Wang J,Sun X,Huang Y,Lan X,Lei C,Chen H

更新日期：2020-09-04 00:00:00

abstract：:Analysis of the tissue distribution of plasmid DNA after administration of nonviral gene delivery systems is best accomplished using quantitative real-time polymerase chain reaction (qPCR), although published strategies do not allow determination of the absolute mass of plasmid delivered to different tissues. Generall...

journal_title：Molecular therapy. Nucleic acids

authors： Ho JK,White PJ,Pouton CW

更新日期：2016-10-04 00:00:00

abstract：:Numerous studies have suggested that dysregulated long noncoding RNAs (lncRNAs) contributed to the development and progression of many cancers. lncRNA OIP5 antisense RNA 1 (OIP5-AS1) has been reported to be increased in several cancers. However, the roles of OIP5-AS1 in liver hepatocellular carcinoma (LIHC) remain to ...

journal_title：Molecular therapy. Nucleic acids

authors： Ma YS,Chu KJ,Ling CC,Wu TM,Zhu XC,Liu JB,Yu F,Li ZZ,Wang JH,Gao QX,Yi B,Wang HM,Gu LP,Li L,Tian LL,Shi Y,Jiang XQ,Fu D,Zhang XW

更新日期：2020-09-04 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell differentiation program is crucial to the bone microenvironment and bone development. MicroRNAs (miRNAs) have played a critical role in regulati...

journal_title：Molecular therapy. Nucleic acids

authors： Li Y,Yang F,Gao M,Gong R,Jin M,Liu T,Sun Y,Fu Y,Huang Q,Zhang W,Liu S,Yu M,Yan G,Feng C,He M,Zhang L,Ding F,Ma W,Bi Z,Xu C,Yuan Y,Cai B,Yang L

更新日期：2019-09-06 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), including mircoRNAs (miRN...

journal_title：Molecular therapy. Nucleic acids

authors： Wang M,Yu F,Chen X,Li P,Wang K

更新日期：2020-09-04 00:00:00

abstract：:Long non-coding RNA (lncRNA) H19 is associated with inflammatory diseases, but the molecular mechanism of H19 in the inflammatory process of ankylosing spondylitis (AS) is unclear. Here, we investigated the role of H19 and its downstream molecules in the inflammation of AS by microarray analysis, qRT-PCR, western blot...

journal_title：Molecular therapy. Nucleic acids

authors： Zhang X,Ji S,Cai G,Pan Z,Han R,Yuan Y,Xu S,Yang J,Hu X,Chen M,Wu M,Ma Y,Deng J,Gao X,Guan S,Xu S,Shuai Z,Laslett L,Pan F

更新日期：2020-03-06 00:00:00

abstract：:Acute lung injury (ALI) is a pulmonary disorder that causes acute respiratory failure, thus leading to relative high mortality worldwide. However, the molecular mechanisms of ALI remain largely unknown. MicroRNA (miRNA)-dependent control of gene expression at a post-transcriptional level has been recently reported. He...

journal_title：Molecular therapy. Nucleic acids

authors： Ying Y,Mao Y,Yao M

更新日期：2019-12-06 00:00:00

abstract：:Osteoarthritis (OA) is the most common degenerative joint disease. One of the main pathogenic factors of OA is thought to be inflammation. Other factors associated with OA are dysregulation of microRNAs, reduced autophagic activity, oxidative stress, and altered metabolism. microRNAs are small non-coding RNAs that are...

journal_title：Molecular therapy. Nucleic acids

authors： Al-Modawi RN,Brinchmann JE,Karlsen TA

更新日期：2019-09-06 00:00:00

abstract：:As key regulators of gene expression, microRNAs (miRNAs) have emerged as targets in basic experimentation and therapy. Administration of DNA-encoded RNA molecules, targeting miRNAs through base pairing, is one viable strategy for inhibiting specific miRNAs. A naturally occurring circular RNA (circRNA), ciRS-7, serving...

journal_title：Molecular therapy. Nucleic acids

authors： Hollensen AK,Andersen S,Hjorth K,Bak RO,Hansen TB,Kjems J,Aagaard L,Damgaard CK,Mikkelsen JG

更新日期：2018-12-07 00:00:00

abstract：:Transactivation of inflammatory and immune mediators in asthma is tightly regulated by nuclear factor κB (NF-κB) and signal transducer and activator of transcription 6 (STAT6). Therefore, we investigated the efficacy of simultaneous inhibition of NF-κB and STAT6 using a chimeric decoy strategy to prevent asthma exacer...

journal_title：Molecular therapy. Nucleic acids

authors： Miyake T,Miyake T,Sakaguchi M,Nankai H,Nakazawa T,Morishita R

更新日期：2018-03-02 00:00:00

abstract：:F-box and WD repeat domain-containing protein 7 (FBW7) has been documented to be implicated in nuclear factor κB (NF-κB) signaling and inflammation, but its role in the pathogenesis of inflammatory bowel disease (IBD) remains unknown. FBW7 was increased both in colon tissues from IBD patients and trinitrobenzene sulph...

journal_title：Molecular therapy. Nucleic acids

authors： Meng Q,Wu W,Pei T,Xue J,Xiao P,Sun L,Li L,Liang D

更新日期：2020-03-06 00:00:00

abstract：:Keratinocyte proliferation and migration are crucial steps during skin wound healing. The functional role of microRNAs (miRs) remains relatively unknown during this process. miR-93 levels have been reported to increase within 24 h of skin wound healing; however, whether miR-93-3p or miR-93-5p plays a specific role in ...

journal_title：Molecular therapy. Nucleic acids

authors： Feng X,Zhou S,Cai W,Guo J

更新日期：2020-11-26 00:00:00