lncRNA IGF2 AS Regulates Bovine Myogenesis through Different Pathways.

abstract：:As the world population grows, muscle atrophy leading to muscle wasting could become a bigger risk. Long noncoding RNAs (lncRNAs) are known to play important roles in muscle growth and muscle atrophy. Meanwhile, it has recently come to light that many putative small open reading frames (sORFs) are hidden in lncRNAs; h...

journal_title：Molecular therapy. Nucleic acids

authors： Cai B,Li Z,Ma M,Zhang J,Kong S,Abdalla BA,Xu H,Jebessa E,Zhang X,Lawal RA,Nie Q

更新日期：2020-12-10 00:00:00

abstract：:Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) such that diminishing ALDH2 activity leads to the aversive effects of blood acetaldehyde upon alcoh...

journal_title：Molecular therapy. Nucleic acids

authors： Sapag A,Irrazábal T,Lobos-González L,Muñoz-Brauning CR,Quintanilla ME,Tampier L

更新日期：2016-07-12 00:00:00

abstract：:DNA vaccine can be modified to increase protein production and modulate immune response. To enhance the efficiency of a P815 mastocytoma DNA vaccine, the P1A gene sequence was optimized by substituting specific codons with synonymous ones while modulating the number of CpG motifs. The P815A murine antigen production w...

journal_title：Molecular therapy. Nucleic acids

authors： Lopes A,Vanvarenberg K,Préat V,Vandermeulen G

更新日期：2017-09-15 00:00:00

abstract：:Antisense oligonucleotides complementary to RNA targets promise generality and ease of drug design. The first systemically administered antisense drug was recently approved for treatment and others are in clinical development. Chemical modifications that increase the hybridization affinity of oligonucleotides are reas...

journal_title：Molecular therapy. Nucleic acids

authors： Pedersen L,Hagedorn PH,Lindholm MW,Lindow M

更新日期：2014-02-18 00:00:00

abstract：:The role of microglia in the pathophysiology of ischemic retinal diseases has been studied extensively. Exosomes from microglial cells exert protective effects during several nervous system diseases, but their roles in hypoxia-induced retinopathy remain unclear. In our study, exosomes derived from microglial cells wer...

journal_title：Molecular therapy. Nucleic acids

authors： Xu W,Wu Y,Hu Z,Sun L,Dou G,Zhang Z,Wang H,Guo C,Wang Y

更新日期：2019-06-07 00:00:00

abstract：:The acute hepatic porphyrias are caused by inherited enzymatic deficiencies in the heme biosynthesis pathway. Induction of the first enzyme 5-aminolevulinic acid synthase 1 (ALAS1) by triggers such as fasting or drug exposure can lead to accumulation of neurotoxic heme intermediates that cause disease symptoms. We hav...

journal_title：Molecular therapy. Nucleic acids

authors： Chan A,Liebow A,Yasuda M,Gan L,Racie T,Maier M,Kuchimanchi S,Foster D,Milstein S,Charisse K,Sehgal A,Manoharan M,Meyers R,Fitzgerald K,Simon A,Desnick RJ,Querbes W

更新日期：2015-11-03 00:00:00

abstract：:Neovascular age-related macular degeneration (AMD) is characterized by the formation of choroidal neovascularization, which is responsible for more than 80% of cases of severe vision loss. Ubiquitin protein ligase E3D (UBE3D) gene missense has been proven to be associated with neovascular AMD in the East Asian populat...

journal_title：Molecular therapy. Nucleic acids

authors： Xia H,Zhang Q,Shen Y,Bai Y,Ma X,Zhang B,Qi Y,Zhang J,Hu Q,Du W,Zhu L,Zhou P,Wang B,Xu H,Huang L,Li X

更新日期：2020-06-05 00:00:00

abstract：:[This corrects the article DOI: 10.1038/mtna.2016.46.]. ...

journal_title：Molecular therapy. Nucleic acids

authors： Cao L,Han G,Lin C,Gu B,Gao X,Moulton HM,Seow Y,Yin H

更新日期：2020-11-19 00:00:00

abstract：:Abnormal synthesis of extracellular matrix (ECM), especially collagen type IV (Col IV), in human retinal capillary endothelial cells (HRCECs) and resultant basement membrane (BM) thickening is the most prominent and characteristic feature of early diabetic retinopathy (DR). Osteopontin (OPN) has been shown to play an ...

journal_title：Molecular therapy. Nucleic acids

authors： Duan P,Chen S,Zeng Y,Xu H,Liu Y

更新日期：2020-06-05 00:00:00

abstract：:Precise genome editing using engineered nucleases can significantly facilitate biological studies and disease treatment. In particular, clustered regularly interspaced short palindromic repeats (CRISPR) with CRISPR-associated (Cas) proteins are a potentially powerful tool for modifying a genome by targeted cleavage of...

journal_title：Molecular therapy. Nucleic acids

authors： Cradick TJ,Qiu P,Lee CM,Fine EJ,Bao G

更新日期：2014-12-02 00:00:00

abstract：:Colon cancer is one of the most common malignancies causing death worldwide. It is well known that the cells of the tumor microenvironment contribute to the progression and prognosis of colon cancer. However, the gene alterations and potential remodeling mechanisms in the tumor microenvironment of colon cancer remain ...

journal_title：Molecular therapy. Nucleic acids

authors： Wang Y,Wang Y,Xu C,Liu Y,Huang Z

更新日期：2020-08-29 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) has significantly improved the quality of life and the life expectancy of HIV-infected individuals. Still, drug-induced side effects and emergence of drug-resistant viral variants remain important issues that justify the exploration of alternative therapeutic options. One s...

journal_title：Molecular therapy. Nucleic acids

authors： Centlivre M,Legrand N,Klamer S,Liu YP,Jasmijn von Eije K,Bohne M,Rijnstra ES,Weijer K,Blom B,Voermans C,Spits H,Berkhout B

更新日期：2013-09-03 00:00:00

abstract：:Acid fibroblast growth factor (aFGF) has shown neuroprotection in Alzheimer's disease (AD) models in previous studies, yet its mechanism is still uncertain. Here we report that the efficacy of Tat-haFGF14-154 is markedly increased when loaded cationic liposomes for intranasal delivery are intranasally administered to ...

journal_title：Molecular therapy. Nucleic acids

authors： Meng T,Cao Q,Lei P,Bush AI,Xiang Q,Su Z,He X,Rogers JT,Chiu IM,Zhang Q,Huang Y

更新日期：2017-06-16 00:00:00

abstract：:The RNA-guided, modified type II prokaryotic CRISPR with CRISPR-associated proteins (CRISPR/Cas9) system represents a simple gene-editing platform with applications in biotechnology and also potentially as a therapeutic modality. The system requires a small guide RNA (sgRNA) and a catalytic Cas9 protein to induce non-...

journal_title：Molecular therapy. Nucleic acids

authors： Scott T,Soemardy C,Morris KV

更新日期：2020-03-06 00:00:00

abstract：:Non-coding uridine-rich small nuclear RNAs (UsnRNAs) have emerged in recent years as effective tools for exon skipping for the treatment of Duchenne muscular dystrophy (DMD), a degenerative muscular genetic disorder. We recently showed the high capacity of a recombinant adeno-associated virus (rAAV)-U7snRNA vector to ...

journal_title：Molecular therapy. Nucleic acids

authors： Domenger C,Allais M,François V,Léger A,Lecomte E,Montus M,Servais L,Voit T,Moullier P,Audic Y,Le Guiner C

更新日期：2018-03-02 00:00:00

abstract：:Acute lung injury (ALI) is a pulmonary disorder that causes acute respiratory failure, thus leading to relative high mortality worldwide. However, the molecular mechanisms of ALI remain largely unknown. MicroRNA (miRNA)-dependent control of gene expression at a post-transcriptional level has been recently reported. He...

journal_title：Molecular therapy. Nucleic acids

authors： Ying Y,Mao Y,Yao M

更新日期：2019-12-06 00:00:00

abstract：:With the development of science and biotechnology, many evidences show that ncRNAs play an important role in the development of important biological processes, especially in chromatin modification, cell differentiation and proliferation, RNA progressing, human diseases, etc. Moreover, lncRNAs account for the majority ...

journal_title：Molecular therapy. Nucleic acids

authors： Zhao Q,Yu H,Ming Z,Hu H,Ren G,Liu H

更新日期：2018-12-07 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most lethal human malignancies. Chemotherapeutic agents, such as sorafenib and lenvatinib, can improve the outcomes of HCC patients. Nevertheless, chemoresistance has become a major hurdle in the effective treatment of HCC. Noncoding RNAs (ncRNAs), including mircoRNAs (miRN...

journal_title：Molecular therapy. Nucleic acids

authors： Wang M,Yu F,Chen X,Li P,Wang K

更新日期：2020-09-04 00:00:00

abstract：:Recent reports underscore the unparalleled potential of antisense-oligonucleotide (ASO)-based approaches to ameliorate various pathological conditions. However, in vivo studies validating the effectiveness of a short ASO (<10-mer) in the context of a human disease have not been performed. One disease with proven amena...

journal_title：Molecular therapy. Nucleic acids

authors： Keil JM,Seo J,Howell MD,Hsu WH,Singh RN,DiDonato CJ

更新日期：2014-07-08 00:00:00

abstract：:miR-221 is overexpressed in several malignancies where it promotes tumor growth and survival by interfering with gene transcripts, including p27Kip1, PUMA, PTEN, and p57Kip2. We previously demonstrated that a novel 13-mer miR-221 inhibitor (locked nucleic acid [LNA]-i-miR-221) exerts antitumor activity against human c...

journal_title：Molecular therapy. Nucleic acids

authors： Di Martino MT,Arbitrio M,Caracciolo D,Scionti F,Tagliaferri P,Tassone P

更新日期：2020-06-05 00:00:00

abstract：:Glioblastoma is the most common malignant primary brain tumor among adults and one of the most lethal cancers. It is characterized by the deregulation of signaling pathways involving proliferation, growth, survival, and other factors. MicroRNAs (miRNAs) play a role in the regulation of genes by affecting the 3' untran...

journal_title：Molecular therapy. Nucleic acids

authors： Moradimotlagh A,Arefian E,Rezazadeh Valojerdi R,Ghaemi S,Jamshidi Adegani F,Soleimani M

更新日期：2020-03-06 00:00:00

abstract：:Due to highly enzymatic d-stereoselectivity, l-nucleotides (l-2'-deoxynucleoside 5'-triphosphates [l-dNTPs]) are not natural targets of polymerases. In this study, we synthesized series of l-thymidine (l-T)-modified DNA strands and evaluated the processivity of nucleotide incorporation for transcription by T7 RNA poly...

journal_title：Molecular therapy. Nucleic acids

authors： Liu Q,Ke Y,Kan Y,Tang X,Li X,He Y,Wu L

更新日期：2020-09-04 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) are hypoxia-inducible secreted proteins to promote angiogenesis, in which VEGF-A is an important molecule that binds and activates VEGF receptor-1 (VEGFR-1) and VEGFR-2. In this study, two DNA aptamers, Apt01 and Apt02, were successfully isolated by alternating consecutive s...

journal_title：Molecular therapy. Nucleic acids

authors： Yoshitomi T,Hayashi M,Oguro T,Kimura K,Wayama F,Furusho H,Yoshimoto K

更新日期：2020-03-06 00:00:00

abstract：:Circular RNA (circRNA) is a novel subclass of noncoding-RNA molecules that participate in development and progression of a variety of human diseases via sponging microRNAs (miRNAs), but the role of circRNAs in Hashimoto's thyroiditis (HT) has not been defined. In this study, peripheral blood samples from five patients...

journal_title：Molecular therapy. Nucleic acids

authors： Xiong S,Peng H,Ding X,Wang X,Wang L,Wu C,Wang S,Xu H,Liu Y

更新日期：2019-09-06 00:00:00

abstract：:Spermatogonial stem cells (SSCs) have significant applications in reproductive and regenerative medicine. However, nothing is known about genes in mediating human SSCs. Here we have explored for the first time the function and mechanism of P21-activated kinase 1 (PAK1) in regulating the proliferation and apoptosis of ...

journal_title：Molecular therapy. Nucleic acids

authors： Fu H,Zhang W,Yuan Q,Niu M,Zhou F,Qiu Q,Mao G,Wang H,Wen L,Sun M,Li Z,He Z

更新日期：2018-09-07 00:00:00

abstract：:Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA. First generation AMOs employed 2'-O-Methyl RNA nucleotides (2'OMe) with phosphorothioate (PS) internucleotide linkages positioned at both end...

journal_title：Molecular therapy. Nucleic acids

authors： Lennox KA,Owczarzy R,Thomas DM,Walder JA,Behlke MA

更新日期：2013-08-27 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of genome-encoded small RNAs that are primarily considered to be post-transcriptional negative regulators of gene expression acting in the cytoplasm. Over a decade of research has focused on this canonical paradigm of miRNA function, with many success stories. Indeed, miRNAs have been id...

journal_title：Molecular therapy. Nucleic acids

authors： Roberts TC

更新日期：2014-08-19 00:00:00

abstract：:Schizophrenia (SCZ) is a devastating genetic mental disorder. Identification of the SCZ risk genes in brains is helpful to understand this disease. Thus, we first used the minimum Redundancy-Maximum Relevance (mRMR) approach to integrate the genome-wide sequence analysis results on SCZ and the expression quantitative ...

journal_title：Molecular therapy. Nucleic acids

authors： Cai L,Huang T,Su J,Zhang X,Chen W,Zhang F,He L,Chou KC

更新日期：2018-09-07 00:00:00

abstract：:As key regulators of gene expression, microRNAs (miRNAs) have emerged as targets in basic experimentation and therapy. Administration of DNA-encoded RNA molecules, targeting miRNAs through base pairing, is one viable strategy for inhibiting specific miRNAs. A naturally occurring circular RNA (circRNA), ciRS-7, serving...

journal_title：Molecular therapy. Nucleic acids

authors： Hollensen AK,Andersen S,Hjorth K,Bak RO,Hansen TB,Kjems J,Aagaard L,Damgaard CK,Mikkelsen JG

更新日期：2018-12-07 00:00:00

abstract：:A hexanucleotide GGGGCC expansion in intron 1 of chromosome 9 open reading frame 72 (C9orf72) gene is the most frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The corresponding repeat-containing sense and antisense transcripts cause a gain of toxicity through the accumulation o...

journal_title：Molecular therapy. Nucleic acids

authors： Martier R,Liefhebber JM,García-Osta A,Miniarikova J,Cuadrado-Tejedor M,Espelosin M,Ursua S,Petry H,van Deventer SJ,Evers MM,Konstantinova P

更新日期：2019-06-07 00:00:00