Lorcaserin for prevention and remission of type 2 diabetes mellitus in people with overweight or obesity: protocol for a systematic review and meta-analysis.

Abstract:

INTRODUCTION:High body mass index (BMI) is associated with risk of diabetes. Lorcaserin is a selective 5-hydroxytryptamine 2C agonist which exerts robust benefits on long-term weight loss by suppressing appetite among adults with overweight or obesity. The magnitude of efficacy of lorcaserin for preventing and remitting type 2 diabetes mellitus (T2DM) among those people remains undefined. Therefore, we plan to conduct this systematic review and meta-analysis to aggregate data from all published studies with regard to the issue to acquire reliable evidence. METHODS AND ANALYSIS:We will search various databases for relevant trials published up to June 2019. Randomised controlled trials investigating the efficacy of lorcaserin for preventing and remitting T2DM among overweight and obese population will be included. A standardised data form will be used to complete data search and extraction in duplicate. All discrepancies will be resolved by consensus. The primary outcome will be incidence of T2DM in patients with pre-diabetes. Secondary outcomes will include achievement of normoglycaemia in people with pre-diabetes, remission of hyperglycaemia in patients with diabetes, the proportion of patients with weight loss of at least 5% or 10% and hypoglycaemia incident. Data synthesis and statistical analysis will be performed for each outcome with Stata V.14.0. ETHICS AND DISSEMINATION:Ethics approval is not required. Results of our study will be submitted to a peer-review journal. PROSPERO REGISTRATION NUMBER:CRD42019119136.

journal_name

BMJ Open

journal_title

BMJ open

authors

Zeng H,Luo M,Li Z,Wen J,He G,Jin Y,Fu W,Zhou P

doi

10.1136/bmjopen-2019-029426

subject

Has Abstract

pub_date

2019-07-27 00:00:00

pages

e029426

issue

7

issn

2044-6055

pii

bmjopen-2019-029426

journal_volume

9

pub_type

杂志文章

相关文献

BMJ Open文献大全
  • Implementation of maternal and perinatal death reviews: a scoping review protocol.

    abstract:INTRODUCTION:Maternal and perinatal death surveillance and response (MPDSR), or any related form of audit, is a systematic process used to prevent future maternal and perinatal deaths. While the existence of MPDSR policies is routinely measured, measurement and understanding of policy implementation has lagged behind. ...

    journal_title:BMJ open

    pub_type: 杂志文章,评审

    doi:10.1136/bmjopen-2019-031328

    authors: Kinney MV,Walugembe DR,Wanduru P,Waiswa P,George AS

    更新日期:2019-11-27 00:00:00

  • Awareness of occupational hazards and use of safety measures among welders: a cross-sectional study from Eastern Nepal.

    abstract:OBJECTIVE:The proper use of safety measures by welders is an important way of preventing and/or reducing a variety of health hazards that they are exposed to during welding. There is a lack of knowledge about hazards and personal protective equipments (PPEs) and the use of PPE among the welders in Nepal is limited. We ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-004646

    authors: Budhathoki SS,Singh SB,Sagtani RA,Niraula SR,Pokharel PK

    更新日期:2014-06-02 00:00:00

  • Evaluation of patient experience in county-level public hospitals in China: a multicentred, cross-sectional study.

    abstract:OBJECTIVES:Patient experience is being widely considered in the evaluation of healthcare service quality, which is a key target for public hospitals under China's New Healthcare Reform. This study aimed to illustrate patients' experiences in county-level public hospitals, and identify aspects that need to be improved. ...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2019-034225

    authors: Min R,Li L,Zi C,Fang P,Wang B,Tang C

    更新日期:2019-11-14 00:00:00

  • Proactive community case management and child survival: protocol for a cluster randomised controlled trial.

    abstract:INTRODUCTION:Community health workers (CHWs)-shown to improve access to care and reduce maternal, newborn, and child morbidity and mortality-are re-emerging as a key strategy to achieve health-related Sustainable Development Goals (SDGs). However, recent evaluations of national programmes for CHW-led integrated communi...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmjopen-2018-027487

    authors: Whidden C,Treleaven E,Liu J,Padian N,Poudiougou B,Bautista-Arredondo S,Fay MP,Samaké S,Cissé AB,Diakité D,Keita Y,Johnson AD,Kayentao K

    更新日期:2019-08-26 00:00:00

  • Is fascia iliaca compartment block administered by paramedics for suspected hip fracture acceptable to patients? A qualitative study.

    abstract:OBJECTIVE:To explore patients' experience of receiving pain relief injection for suspected hip fracture from paramedics at the location of the injury. DESIGN:Qualitative interviews within a feasibility trial about an alternative to routine prehospital pain management for patients with suspected hip fracture. SETTING:...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-033398

    authors: Evans BA,Brown A,Fegan G,Ford S,Guy K,Jones J,Jones S,Keen L,Khanom A,Longo M,Pallister I,Rees N,Russell IT,Seagrove AC,Watkins A,Snooks H

    更新日期:2019-12-19 00:00:00

  • Risk of invasive candidiasis with prolonged duration of ICU stay: a systematic review and meta-analysis.

    abstract:OBJECTIVE:This study aimed to evaluate the duration of intensive care unit (ICU) stay prior to onset of invasive candidiasis (IC)/candidaemia. DESIGN:Systematic review and meta-analysis. DATA SOURCES:PubMed, Cochrane, Embase and Web of Science databases were searched through June 2019 to identify relevant studies. E...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-036452

    authors: Zhang Z,Zhu R,Luan Z,Ma X

    更新日期:2020-07-12 00:00:00

  • Medication use in pregnancy: a cross-sectional, multinational web-based study.

    abstract:OBJECTIVES:Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with medications use in pregnancy from a multinational perspective, with emphasis on type of medication ut...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-004365

    authors: Lupattelli A,Spigset O,Twigg MJ,Zagorodnikova K,Mårdby AC,Moretti ME,Drozd M,Panchaud A,Hämeen-Anttila K,Rieutord A,Gjergja Juraski R,Odalovic M,Kennedy D,Rudolf G,Juch H,Passier A,Björnsdóttir I,Nordeng H

    更新日期:2014-02-17 00:00:00

  • Remote ischaemic conditioning on recipients of deceased renal transplants, effect on immediate and extended kidney graft function: a multicentre, randomised controlled trial protocol (CONTEXT).

    abstract:INTRODUCTION:Delayed graft function due to ischaemia-reperfusion injury is a frequent complication in deceased donor renal transplantation. Experimental evidence indicates that remote ischaemic conditioning (RIC) provides systemic protection against ischaemia-reperfusion injury in various tissues. METHODS AND ANALYSIS...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmjopen-2015-007941

    authors: Krogstrup NV,Oltean M,Bibby BM,Nieuwenhuijs-Moeke GJ,Dor FJ,Birn H,Jespersen B

    更新日期:2015-08-20 00:00:00

  • 'Hobson's choice': a qualitative study of consent in acute surgery.

    abstract:OBJECTIVES:The study aimed to understand through qualitative research what patients considered material in their decision to consent to an acute surgical intervention. PARTICIPANTS, SETTING AND INTERVENTION:The patients selected aged between 18 and 90, having been admitted to a major trauma centre to undergo an acute ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-037657

    authors: Howard A,Webster J,Quinton N,Giannoudis PV

    更新日期:2020-10-08 00:00:00

  • Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia.

    abstract:OBJECTIVES:There is growing evidence that antihypertensive agents, particularly centrally acting ACE inhibitors (CACE-Is), which cross the blood-brain barrier, are associated with a reduced rate of cognitive decline. Given this, we compared the rates of cognitive decline in clinic patients with dementia receiving CACE-...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-002881

    authors: Gao Y,O'Caoimh R,Healy L,Kerins DM,Eustace J,Guyatt G,Sammon D,Molloy DW

    更新日期:2013-07-25 00:00:00

  • Increased household financial strain, the Great Recession and child health-findings from the UK Millennium Cohort Study.

    abstract:BACKGROUND:There is a growing body of evidence associating financial strain (FS) with poor health but most of this research has been cross-sectional and adult-focused. During the 'Great Recession' many UK households experienced increased FS. The primary aim of this study was to determine the impact of increased FS on c...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-015559

    authors: McKenna C,Law C,Pearce A

    更新日期:2017-03-09 00:00:00

  • Sociodemographic patterning of long-term diabetes mellitus control following Japan's 3.11 triple disaster: a retrospective cohort study.

    abstract:OBJECTIVE:To assess the sociodemographic patterning of changes in glycaemic control of patients with diabetes affected by the 2011 triple disaster in Japan (earthquake, tsunami and nuclear accident). METHODS:A retrospective cohort study was undertaken with 404 patients with diabetes at a public hospital in Minamisoma ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-011455

    authors: Leppold C,Tsubokura M,Ozaki A,Nomura S,Shimada Y,Morita T,Ochi S,Tanimoto T,Kami M,Kanazawa Y,Oikawa T,Hill S

    更新日期:2016-07-07 00:00:00

  • Study protocol for a multicentre, controlled non-randomised trial: benefits of exercise physiology services for type 2 diabetes (BEST).

    abstract:INTRODUCTION:Controlled trials support the efficacy of exercise as a treatment modality for chronic conditions, yet effectiveness of real-world Exercise Physiology services is yet to be determined. This study will investigate the efficacy and cost-effectiveness of services provided by Accredited Exercise Physiologists ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-027610

    authors: Kitic CM,Selig S,Davison K,Best TLB,Parmenter B,Pumpa K,Furzer B,Rice V,Hardcastle S,Cheney M,Palmer AJ,Fraser S,Williams AD

    更新日期:2019-08-21 00:00:00

  • Unmet care needs of community-dwelling stroke survivors: a protocol for systematic review and theme analysis of quantitative and qualitative studies.

    abstract:INTRODUCTION:Stroke is a leading cause of disability worldwide. The average hospital length of stay ranges from 3 to 28 days, and after discharge home the stroke survivors will live with physical, cognitive, even psychological disorders for the rest of their lives. It is essential to review the unmet needs of stroke su...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-029160

    authors: Lin B,Ding C,Mei Y,Wang P,Ma F,Zhang ZX

    更新日期:2019-06-21 00:00:00

  • Fostering humanism: a mixed methods evaluation of the Footprints Project in critical care.

    abstract:OBJECTIVES:The objectives of this mixed-methods study were to assess the uptake, sustainability and influence of the Footprints Project. SETTING:Twenty-two-bed university-affiliated ICU in Hamilton, Canada. PARTICIPANTS:ICU patients admitted and their families, as well as clinicians. INTERVENTIONS:We developed a per...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-029810

    authors: Hoad N,Swinton M,Takaoka A,Tam B,Shears M,Waugh L,Toledo F,Clarke FJ,Duan EH,Soth M,Cook DJ

    更新日期:2019-11-02 00:00:00

  • Patients' experiences of life after bariatric surgery and follow-up care: a qualitative study.

    abstract:OBJECTIVES:Bariatric surgery is the most clinically effective treatment for people with severe and complex obesity, however, the psychosocial outcomes are less clear. Follow-up care after bariatric surgery is known to be important, but limited guidance exists on what this should entail, particularly related to psycholo...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-035013

    authors: Coulman KD,MacKichan F,Blazeby JM,Donovan JL,Owen-Smith A

    更新日期:2020-02-06 00:00:00

  • Menstrual cups and sanitary pads to reduce school attrition, and sexually transmitted and reproductive tract infections: a cluster randomised controlled feasibility study in rural Western Kenya.

    abstract:OBJECTIVES:Conduct a feasibility study on the effect of menstrual hygiene on schoolgirls' school and health (reproductive/sexual) outcomes. DESIGN:3-arm single-site open cluster randomised controlled pilot study. SETTING:30 primary schools in rural western Kenya, within a Health and Demographic Surveillance System. ...

    journal_title:BMJ open

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmjopen-2016-013229

    authors: Phillips-Howard PA,Nyothach E,Ter Kuile FO,Omoto J,Wang D,Zeh C,Onyango C,Mason L,Alexander KT,Odhiambo FO,Eleveld A,Mohammed A,van Eijk AM,Edwards RT,Vulule J,Faragher B,Laserson KF

    更新日期:2016-11-23 00:00:00

  • Patient preferences, knowledge and beliefs about kidney allocation: qualitative findings from the UK-wide ATTOM programme.

    abstract:OBJECTIVE:To explore how patients who are wait-listed for or who have received a kidney transplant understand the current UK kidney allocation system, and their views on ways to allocate kidneys in the future. DESIGN:Qualitative study using semistructured interviews and thematic analysis based on a pragmatic approach....

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-013896

    authors: Gibbons A,Cinnirella M,Bayfield J,Wu D,Draper H,Johnson RJ,Tomson CR,Forsythe JL,Metcalfe W,Fogarty D,Roderick P,Ravanan R,Oniscu GC,Watson CJ,Bradley JA,Bradley C

    更新日期:2017-01-27 00:00:00

  • Should all anticoagulated patients with head injury receive a CT scan? Decision-analysis modelling of an observational cohort.

    abstract:OBJECTIVES:It is not currently clear whether all anticoagulated patients with a head injury should receive CT scanning or only those with evidence of traumatic brain injury (eg, loss of consciousness or amnesia). We aimed to determine the cost-effectiveness of CT for all compared with selective CT use for anticoagulate...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2016-013742

    authors: Kuczawski M,Stevenson M,Goodacre S,Teare MD,Ramlakhan S,Morris F,Mason S

    更新日期:2016-12-13 00:00:00

  • Did the suicide barrier work after all? Revisiting the Bloor Viaduct natural experiment and its impact on suicide rates in Toronto.

    abstract:OBJECTIVE:This research aims to determine the long-term impact of the Bloor Street Viaduct suicide barrier on rates of suicide in Toronto and whether media reporting had any impact on suicide rates. DESIGN:Natural experiment. SETTING:City of Toronto, Canada; records at the chief coroner's office of Ontario 1993-2003 ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-015299

    authors: Sinyor M,Schaffer A,Redelmeier DA,Kiss A,Nishikawa Y,Cheung AH,Levitt AJ,Pirkis J

    更新日期:2017-06-19 00:00:00

  • Relationship between role stressors, job tasks and job satisfaction among health surveillance assistants in Malawi: a cross-sectional study.

    abstract:OBJECTIVES:The objective of this study was to investigate the role stressors, sociodemographic characteristics and job tasks of health surveillance assistants (HSAs) and to explore major predictors of role stressors and job satisfaction of HSAs in Malawi. SETTING:Data were collected from health centres and hospitals o...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-037000

    authors: Ntopi S,Chirwa E,Maluwa A

    更新日期:2020-11-14 00:00:00

  • Risk factors for difficult peripheral venous cannulation in hospitalised patients. Protocol for a multicentre case-control study in 48 units of eight public hospitals in Spain.

    abstract:INTRODUCTION:Patients with difficult venous access experience undesirable effects during healthcare, such as delayed diagnosis and initiation of treatment, stress and pain related to the technique and reduced satisfaction. This study aims to identify risk factors with which to model the appearance of difficulty in achi...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2017-020420

    authors: Rodriguez-Calero MA,Fernandez-Fernandez I,Molero-Ballester LJ,Matamalas-Massanet C,Moreno-Mejias L,de Pedro-Gomez JE,Blanco-Mavillard I,Morales-Asencio JM

    更新日期:2018-02-08 00:00:00

  • Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo).

    abstract:PURPOSE:To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-016505

    authors: Maret-Ouda J,Wahlin K,Artama M,Brusselaers N,Färkkilä M,Lynge E,Mattsson F,Pukkala E,Romundstad P,Tryggvadóttir L,Euler-Chelpin MV,Lagergren J

    更新日期:2017-06-08 00:00:00

  • Doctors' approaches to PSA testing and overdiagnosis in primary healthcare: a qualitative study.

    abstract:OBJECTIVES:(1) To explain general practitioners' (GPs') approaches to prostate-specific antigen (PSA) testing and overdiagnosis; (2) to explain how GPs reason about their PSA testing routines and (3) to explain how these routines influence GPs' personal experience as clinicians. SETTING:Primary care practices in Austr...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2014-006367

    authors: Pickles K,Carter SM,Rychetnik L

    更新日期:2015-03-17 00:00:00

  • Quantifying public preferences for different bowel preparation options prior to screening CT colonography: a discrete choice experiment.

    abstract:OBJECTIVES:CT colonography (CTC) may be an acceptable test for colorectal cancer screening but bowel preparation can be a barrier to uptake. This study tested the hypothesis that prospective screening invitees would prefer full-laxative preparation with higher sensitivity and specificity for polyps, despite greater bur...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-004327

    authors: Ghanouni A,Halligan S,Taylor SA,Boone D,Plumb A,Stoffel S,Morris S,Yao GL,Zhu S,Lilford R,Wardle J,von Wagner C

    更新日期:2014-04-03 00:00:00

  • Determinants of regular smoking onset in South Africa using duration analysis.

    abstract:OBJECTIVES:South Africa has achieved significant success with its tobacco control policy. Between 1994 and 2012, the real price of cigarettes increased by 229%, while regular smoking prevalence decreased from about 31% to 18.2%. METHODS:Cigarette prices and socioeconomic variables are used to examine the determinants ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-011076

    authors: Vellios N,van Walbeek C

    更新日期:2016-07-18 00:00:00

  • Patient-reported confidence in primary healthcare: are there disparities by ethnicity or language?

    abstract:OBJECTIVE:To examine whether confidence in primary healthcare (PHC) differs among ethnic-linguistic groups and which PHC experiences are associated with confidence. DESIGN:A cross-sectional study where patient surveys were administered using random digit dialling. Regression models identify whether ethnic-linguistic g...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-003884

    authors: Wong ST,Black C,Cutler F,Brooke R,Haggerty JL,Levesque JF

    更新日期:2014-02-25 00:00:00

  • Local and systemic morbidities of de novo metastatic prostate cancer in Singapore: insight from 685 consecutive patients from a large prospective Uro-oncology registry.

    abstract:OBJECTIVE:To evaluate the incidence and management of local and systemic complications afflicting patients with de novo metastatic prostate cancer (mPCa) in Singapore. DESIGN:Retrospective analysis of a large prospective Uro-oncology registry of mPCa. SETTING:This study is carried out in a tertiary hospital in Singap...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-034331

    authors: Tan YG,Pang L,Khalid F,Poon R,Huang HH,Chen K,Tay KJ,Lau W,Cheng C,Ho H,Yuen J

    更新日期:2020-02-18 00:00:00

  • The ETTAA study protocol: a UK-wide observational study of 'Effective Treatments for Thoracic Aortic Aneurysm'.

    abstract:INTRODUCTION:Chronic thoracic aortic aneurysm (CTAA) affecting the arch or descending aorta is an indolent but life-threatening condition with a rising prevalence as the UK population ages. Treatment may be in the form of open surgical repair (OSR) surgery, endovascular stent grafting (ESG) or best medical therapy (BMT...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2015-008147

    authors: Sastry P,Hughes V,Hayes P,Vallabhaneni S,Sharples L,Thompson M,Catarino P,Moorjani N,Vale L,Gray J,Cook A,Elefteriades JA,Large SR,ETTAA Collaborators.

    更新日期:2015-06-02 00:00:00

  • Theory-based self-management intervention to improve adolescents' asthma control: a cluster randomised controlled trial protocol.

    abstract:INTRODUCTION:Asthma-related morbidity and mortality in the UK is higher than elsewhere in Europe. Although the reasons for this are largely unclear, one explanation could be a higher prevalence of poorly controlled asthma in the UK. Findings from our earlier study found that, in a sample of 766 children with asthma, 45...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-025867

    authors: Harris K,Mosler G,Grigg J

    更新日期:2019-04-23 00:00:00