Abstract:
OBJECTIVE:Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but serious side effect of bisphosphonates (BPs). Since this disease has no independent code in either of the diseases' or in the medical procedures' classifications, it is hard to estimate how many BP patients are affected. DESIGN:A retrospective observational epidemiological registry-based study was carried out, using the data of the national service of Hungary on the incidence of BRONJ and related factors. SETTING:A data analysis was performed, which is relevant for the whole Hungarian population from 2010 to 2014. The socioeconomic and medication data of 236 207 BP patients were analysed, and a method was worked out to define BRONJ patients from the Hungarian BP population. PRIMARY AND SECONDARY OUTCOME MEASURES:The incidences of BRONJ were analysed according to genders and the types of the BP drugs administered. The marginal interdependence between the types of BP drugs, modes of administration and main indication was calculated. RESULTS:340 BP patients (0.1%) developed BRONJ. The incidence of BRONJ in Hungary in the malignant indication of BPs is 0.9%, and 0.1% in the non-malignant indication, and the OR to develop BRONJ was OR=9.7 (95% CI 7.8 to 12.1) between them. Although more women developed BRONJ, the proportion of men was significantly higher than that of women. Steroids increase the risk of jaw osteonecrosis, and differences were also found between the BP drugs. CONCLUSIONS:Oncology indicated, intravenously administered and steroid comedicated BP therapies pose a high risk of developing BRONJ in the Hungarian population.
journal_name
BMJ Openjournal_title
BMJ openauthors
Veszelyné Kotán E,Bartha-Lieb T,Parisek Z,Meskó A,Vaszilkó M,Hankó Bdoi
10.1136/bmjopen-2018-025600subject
Has Abstractpub_date
2019-05-22 00:00:00pages
e025600issue
5issn
2044-6055pii
bmjopen-2018-025600journal_volume
9pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVES:Dementia with Lewy bodies (DLB) accounts for 10%-15% of dementia cases at autopsy and has distinct clinical features associated with earlier institutionalisation and a higher level of carer distress than are seen in Alzheimer's disease (AD). At present, there is on-going debate as to whether DLB is associate...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000380
更新日期:2012-02-08 00:00:00
abstract:OBJECTIVES:It remains unclear if geriatric patients with different delirium motor subtypes express different levels of motor activity. Thus, we used two accelerometer-based devices to simultaneously measure upright activity and wrist activity across delirium motor subtypes in geriatric patients. DESIGN:Cross-sectional...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026401
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of congruence between preferred and perceived learning environments on learning outcomes of nursing students. SETTING:A nursing course at a university in central Taiwan. PARTICIPANTS:124 Taiwanese nursing students enrolled in a 13-week problem-based Fundamental Nursing curriculum....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009925
更新日期:2016-05-20 00:00:00
abstract:OBJECTIVES:Fibre-endoscopic evaluation of swallowing (FEES) to detect dysphagia is gaining more and more importance as a diagnostic tool. Therefore, we have investigated the impact of FEES in neurological patients in a clinical setting. DESIGN:Cross-sectional hospital-based registry. SETTING:Primary acute care in a n...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019016
更新日期:2018-03-06 00:00:00
abstract:OBJECTIVES:To evaluate the cost-effectiveness of immediate treatment with ranibizumab in patients with neovascular age-related macular degeneration (nAMD) with good (better than 6/12) starting visual acuity compared with current UK clinical guidance of waiting until vision falls below 6/12 to begin treatment, using rea...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2014-006535
更新日期:2015-05-05 00:00:00
abstract:OBJECTIVE:To quantify general practitioners' (GPs) sensitivity to anxiety disorders (ADs) when confronted with the range of symptoms common to children with ADs. Also, to explore GPs' conscious preferences and implicit tendencies for referral of children with ADs to mental healthcare. DESIGN AND SETTING:In a cross-sec...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035799
更新日期:2020-04-15 00:00:00
abstract:OBJECTIVES:This study aimed to assess the association of socioeconomic conditions with female fertility impairment among women who delivered a live birth. DESIGN:Cross-sectional analysis. SETTING:Population-based birth cohort (Generation XXI) assembled in 2005/2006 from five public maternity units in Porto Metropolit...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003985
更新日期:2014-01-02 00:00:00
abstract:OBJECTIVES:To describe the major characteristics of reported notifiable gastrointestinal illness (NGI) data in the Northwest Territories (NWT) from January 1991 through December 2008. DESIGN:Descriptive analysis of 708 reported cases of NGI extracted from the Northwest Territories Communicable Disease Registry (NWT CD...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000732
更新日期:2012-07-02 00:00:00
abstract:BACKGROUND:The last two decades have seen an increase in literature reporting an increase in knowledge and use of contraceptives among individuals and couples in Kenya, as in the rest of Africa, but there is a dearth of information regarding knowledge about benefits of family planning (FP) in Kenya. OBJECTIVES:To asse...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004643
更新日期:2014-03-18 00:00:00
abstract:OBJECTIVES:The Stretching And strengthening for Rheumatoid Arthritis of the Hand (SARAH) randomised controlled trial evaluated the effectiveness of a hand exercise programme and demonstrated it was clinically effective and cost-effective at 12 months. The aim of this extended follow-up was to evaluate the effects of th...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2016-013121
更新日期:2017-04-12 00:00:00
abstract:IMPORTANCE:The Use of a Multidrug Pill In Reducing cardiovascular Events (UMPIRE) trial has shown improved adherence with the use of a polypill strategy when compared with usual medications for cardiovascular disease (CVD) prevention. To advance from efficacy to impact, we need a better understanding of why and how suc...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2015-008018
更新日期:2015-09-30 00:00:00
abstract:OBJECTIVES:To examine the association between smoking cessation attempts during the previous 12 months, motivators to quit smoking and nicotine dependence levels among current male smokers after Japan's massive 2010 tobacco tax increase. DESIGN:Cross-sectional study. SETTING:A self-reported questionnaire about smokin...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006658
更新日期:2015-03-20 00:00:00
abstract:OBJECTIVES:Prevalence estimates of multimorbidity vary widely due to inconsistent definitions and measurement methods. This study examines the independent effects on prevalence estimates of how 'disease entity' is defined-as a single chronic condition or chapters/domains in the International Classification of Primary C...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2013-004694
更新日期:2014-07-11 00:00:00
abstract:OBJECTIVE:To systematically review the literature exploring the impact of isolation on hospitalised patients who are infectious: psychological and non-psychological outcomes. DESIGN:Systematic review with meta-analysis. DATA SOURCES:Embase, Medline and PsycINFO were searched from inception until December 2018. Refere...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030371
更新日期:2020-02-18 00:00:00
abstract:INTRODUCTION:Expectant mothers in low-income and middle-income countries often lack access to vital information about pregnancy, preparation for birth and best practices when caring for their newborn. Innovative solutions are needed to bridge this knowledge gap and dramatically improve maternal and neonatal health in t...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2015-011016
更新日期:2016-08-10 00:00:00
abstract:OBJECTIVES:To assess the effects of a home-based telehealth intervention on the use of secondary healthcare and mortality. DESIGN:Observational study of a mainstream telehealth service, using person-level administrative data. Time to event analysis (Cox regression) was performed comparing telehealth patients with cont...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009221
更新日期:2016-02-03 00:00:00
abstract:OBJECTIVE:To evaluate the clinical efficacy and effectiveness of using 3D printing to develop medical devices across all medical fields. DESIGN:Systematic review compliant with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. DATA SOURCES:PubMed, Web of Science, OVID, IEEE Xplore and Google Scholar...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-016891
更新日期:2017-12-21 00:00:00
abstract:INTRODUCTION:There is an increasing need for the adoption of effective preschool obesity prevention interventions to combat the high levels of early-childhood obesity in the UK. This study will examine the feasibility and acceptability of the adapted version of the ToyBox intervention-a preschool obesity prevention pro...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023707
更新日期:2018-10-27 00:00:00
abstract:PURPOSE:To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-016505
更新日期:2017-06-08 00:00:00
abstract:OBJECTIVE:To systematically search for research about the effectiveness of mandatory reporting of child maltreatment and to synthesise qualitative research that explores mandated reporters' (MRs) experiences with reporting. DESIGN:As no studies assessing the effectiveness of mandatory reporting were retrieved from our...
journal_title:BMJ open
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bmjopen-2016-013942
更新日期:2017-10-16 00:00:00
abstract:OBJECTIVE:In October 2013, the South Korean government introduced an incentive programme to increase the availability of Saturday treatment at clinics, hoping to increase the role of primary care providers as gatekeepers to medical care. To the best of our knowledge, no one has yet investigated this programme's effect ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011248
更新日期:2016-06-09 00:00:00
abstract:OBJECTIVE:To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary prevention of cardiovascular disease (CVD). METHODS:This is a cross-sectional analysis of cardiov...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018524
更新日期:2018-02-08 00:00:00
abstract:OBJECTIVES:The number of women entering medicine has increased significantly, yet women are still under-represented at senior levels in academic medicine. To support the gender equality action plan at one School of Medicine, this study sought to (1) identify the range of viewpoints held by staff on how to address gende...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015973
更新日期:2017-08-22 00:00:00
abstract:INTRODUCTION:Short-term psychodynamic psychotherapy (STPP) is an empirically supported treatment that is often used to treat depression. However, it is largely unclear if certain subgroups of depressed patients can benefit specifically from this treatment method. We describe the protocol for a systematic review and met...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2017-018900
更新日期:2018-02-20 00:00:00
abstract:OBJECTIVE:To evaluate the effects of intravenous fluid bolus compared to maintenance intravenous fluids alone as part of immediate emergency care in children with severe febrile illness and signs of impaired circulation in low-income settings. DESIGN:Systematic review of randomised controlled trials (RCTs), and observ...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2014-004934
更新日期:2014-04-30 00:00:00
abstract:OBJECTIVES:This study aimed to measure the burden of work-related upper limb amputation in Korea over a 10-year period and assess its trend. DESIGN:Ecological study. SETTING:National level data in Korea between 2004 and 2013. PARTICIPANTS:49 535 subjects who claimed Korea industrial accident compensation insurance d...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032793
更新日期:2019-11-19 00:00:00
abstract:OBJECTIVE:Hepatitis B reactivation (HBr) is strongly associated with rituximab therapy. Guidelines advise hepatitis B screening and use of preventive nucleoside analogue (NA) in patients at risk. In this study, we examined screening trends, post-screening interventions and outcomes in patients receiving rituximab in li...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-043672
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:To investigate whether high levels of screen time exposure are associated with self-perceived levels of attention problems and hyperactivity in higher education students. DESIGN:Cross-sectional study among participants of the i-Share cohort. SETTING:French-speaking students of universities and higher educat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009089
更新日期:2016-02-26 00:00:00
abstract:INTRODUCTION:Perioperative benzodiazepines are used because of their anxiolytic, sedative and amnestic effects. Evidence has demonstrated an association of benzodiazepines with adverse neuropsychiatric effects. Nonetheless, because of their potential benefits, perioperative benzodiazepines continue to be used routinely...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031895
更新日期:2019-12-11 00:00:00
abstract:PURPOSE:Chagas disease (CD) has become a global health issue mainly due to migration. Germany lacks surveillance data and is home to a large Latin American immigrant population. Recognising that Bolivia is the country with the highest CD prevalence in Latin America, this cross-sectional, descriptive pilot study investi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013960
更新日期:2017-01-16 00:00:00