Abstract:
INTRODUCTION:Chronic obstructive pulmonary disease (COPD) exacerbations progress the course of disease and impair lung function. Inhaled maintenance therapy reduces exacerbations. It is not yet established which inhaled therapy combination is best to reduce exacerbations, lung function decline and symptom burden. METHODS AND ANALYSIS:MEDLINE, EMBASE and the Cochrane Library will be searched for articles between January 2011 and May 2018 using a pre-specified search strategy. Conference proceedings will be searched. Systematic reviews (with or without meta-analysis), randomised controlled trials (RCTs), cohort studies and case controlled studies comparing six interventions comprising different combinations of long-acting bronchodilators and inhaled corticosteroids in unison or on their own. The primary outcome is the reduction in moderate-to-severe exacerbations. Secondary outcomes include: lung function, quality of life, mortality and other adverse events. Titles and abstracts will screened by the primary researcher. A second reviewer will repeat this on a proportion of records. The Population, Intervention, Comparator, Outcomes and Study framework will be used for data extraction. A network meta-analyses of outcomes from RCTs and real-world evidence will be integrated if feasible. The 95% credible interval will be used to assess the statistical significance of each summary effect. Ranking of interventions will be based on their surface under cumulative ranking area. ETHICS AND DISSEMINATION:COPD exacerbations are burdensome to patients. We aim to report results that provide clinicians with a more informed choice of which inhaled therapy combinations are best to reduce exacerbations, improve disease burden and reduce lung function and exercise capacity decline, compared with the potential harms, in certain populations with COPD. PROSPERO REGISTRATION NUMBER:CRD42018088013.
journal_name
BMJ Openjournal_title
BMJ openauthors
Lewis A,Axson EL,Potts J,Tarnowska R,Vioix H,Quint JKdoi
10.1136/bmjopen-2018-025048subject
Has Abstractpub_date
2019-02-20 00:00:00pages
e025048issue
2issn
2044-6055pii
bmjopen-2018-025048journal_volume
9pub_type
杂志文章相关文献
BMJ Open文献大全abstract:PURPOSE:Inherited peripheral neuropathies (IPN) represent a large heterogenous group of hereditary diseases with more than 100 causative genes reported to date. In this context, targeted next-generation sequencing (NGS) offers the opportunity to screen all these genes with high efficiency in order to unravel the geneti...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021632
更新日期:2018-10-28 00:00:00
abstract:INTRODUCTION:Hypercholesterolaemia is estimated to cause 2.6 million deaths annually and one-third of the cases of ischaemic heart disease. In Argentina, the prevalence of hypercholesterolaemia increased between 2005 and 2013 from 27.9% to 29.8%. Only one out of four subjects with a self-reported diagnosis of coronary ...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-014420
更新日期:2017-01-31 00:00:00
abstract:OBJECTIVES:To identify the sociodemographic factors associated with variation in area-based breastfeeding in England; to calculate the predicted breastfeeding rates adjusted for sociodemographic variations. DESIGN:Ecological analysis of routine data using random effects logistic regression. SETTING:All 151 primary ca...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002765
更新日期:2013-06-20 00:00:00
abstract:OBJECTIVE:This study evaluated knowledge, opinions and compliance related to Uganda's comprehensive smoke-free law among hospitality venues in Kampala Uganda. DESIGN:This multi-method study presents cross-sectional findings of the extent of compliance in the early phase of Uganda's comprehensive smoke-free law (2 mont...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017601
更新日期:2018-01-05 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of diabetes mellitus (DM) and new detection of DM using fasting plasma glucose (FPG) and 2 h plasma glucose (2-hPG) in hypertensive outpatients in China. DESIGN:Multicenter cross-sectional study. SETTING:46 hospitals in China. PARTICIPANTS:Study patients were consecutively re...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003798
更新日期:2013-11-20 00:00:00
abstract:INTRODUCTION:Stroke is a major health problem and transient ischaemic attack (TIA) is an important risk factor for stroke. Primary prevention of stroke and TIA will have the greatest impact on reducing the burden of these conditions. Evidence-based guidelines for stroke/TIA prevention identify individuals eligible for ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006622
更新日期:2014-11-11 00:00:00
abstract:OBJECTIVES:To estimate hepatitis B vaccination (HBVc) coverage, and knowledge and sociodemographic determinants of full dose uptake in Federal Road Safety Corps (FRSC) members, Kaduna State, Nigeria, to inform relevant targeted vaccination policies. DESIGN:A cross sectional survey of FRSC members, Kaduna Sector Comman...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-015845
更新日期:2017-06-02 00:00:00
abstract:INTRODUCTION:Pectus excavatum repair is associated with substantial postoperative pain, despite the use of epidural analgesia and other analgesic regimens. Perioperative recorded music interventions have been shown to alleviate pain and anxiety in adults, but evidence for children and adolescents is still lacking. This...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036380
更新日期:2020-07-08 00:00:00
abstract:OBJECTIVES:Improving outcomes for older people with long-term conditions and multimorbidity is a priority. Current policy commits to substantial expansion of social prescribing to community assets, such as charity, voluntary or community groups. We use longitudinal data to add to the limited evidence on whether this is...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033186
更新日期:2020-02-06 00:00:00
abstract:INTRODUCTION:Community health workers (CHWs)-shown to improve access to care and reduce maternal, newborn, and child morbidity and mortality-are re-emerging as a key strategy to achieve health-related Sustainable Development Goals (SDGs). However, recent evaluations of national programmes for CHW-led integrated communi...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2018-027487
更新日期:2019-08-26 00:00:00
abstract:OBJECTIVE:As healthcare organisations endeavour to improve the quality and safety of their services, there is increasing recognition of the importance of building a culture of safety to promote patient safety and improve the outcomes of patient care. Surveys of safety culture/climate have not knowingly been conducted i...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-028666
更新日期:2019-05-30 00:00:00
abstract:OBJECTIVE:To explore patients' experience of receiving pain relief injection for suspected hip fracture from paramedics at the location of the injury. DESIGN:Qualitative interviews within a feasibility trial about an alternative to routine prehospital pain management for patients with suspected hip fracture. SETTING:...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033398
更新日期:2019-12-19 00:00:00
abstract:OBJECTIVES:Dealing with multiple workflow interruptions is a major challenge in emergency department (ED) work. This study aimed to establish a taxonomy of workflow interruptions that takes into account the content and purpose of interruptive communication. It further aimed to identify associations of workflow interrup...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019074
更新日期:2017-12-22 00:00:00
abstract:OBJECTIVES:This study aimed to identify intrauterine growth differences according to infertility treatment compared with spontaneous conception and to describe intrauterine growth trajectories. DESIGN:Retrospective cohort study. SETTING:A single primary and tertiary medical centre in Japan. PARTICIPANTS:This study i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033675
更新日期:2020-04-28 00:00:00
abstract:OBJECTIVE:To explore experts' views on factors influencing national and global active case-finding (ACF) policy development and implementation, and the use of evidence in these processes. DESIGN:This is an exploratory study based on semistructured expert interviews. Framework analysis was applied. PARTICIPANTS:The st...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036285
更新日期:2020-06-03 00:00:00
abstract:INTRODUCTION:Obesity is a global epidemic and is a risk factor for developing other comorbidities. Young adulthood is a critical period for body weight change and establishing healthy lifestyle behaviours. The 'Freshman 15' suggests that undergraduate students gain 15 lbs (6.8 kg) during their first year of university,...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019365
更新日期:2017-12-10 00:00:00
abstract:INTRODUCTION:Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society. The onset and continuation of depression may be related to a wide variety of biological and psychosocial factors, many of which are linked to different lifestyle asp...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038457
更新日期:2020-12-28 00:00:00
abstract:INTRODUCTION:Persistent infection with sexually transmitted, high-risk human papillomavirus (HPV) types is the cause of all cervical cancers and some anogenital and oropharyngeal cancers. HPV is an extremely common asymptomatic infection but little known and poorly understood by the public. Patients with HPV-related ca...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011205
更新日期:2016-04-25 00:00:00
abstract:OBJECTIVES:(1) To explain general practitioners' (GPs') approaches to prostate-specific antigen (PSA) testing and overdiagnosis; (2) to explain how GPs reason about their PSA testing routines and (3) to explain how these routines influence GPs' personal experience as clinicians. SETTING:Primary care practices in Austr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006367
更新日期:2015-03-17 00:00:00
abstract:BACKGROUND:First responders (police, fire and ambulance officers) are at a significantly increased risk of experiencing poor mental health, including depression and post-traumatic stress disorder. These conditions are associated with high rates of cardiovascular disease, in part due to low levels of physical activity (...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030668
更新日期:2019-09-11 00:00:00
abstract:OBJECTIVE:We aimed to epidemiologically assess rubella herd immunity as a function of time, age and gender in Japan, with reference to the recent 2012-2014 rubella epidemic. DESIGN:This study is a retrospective seroepidemiological analysis. MAIN OUTCOME MEASURES:The susceptible fraction of the population was examined...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009928
更新日期:2016-01-27 00:00:00
abstract:OBJECTIVES:We investigated the clinical characteristics of patients with stroke recurrence in the first year after cardioembolic stroke, and determined the predictors associated with recurrence. DESIGN:A prospective cohort study. SETTING:Multicentre study at the Fukuoka prefecture in Japan. PARTICIPANTS:We enroled 2...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003678
更新日期:2013-11-14 00:00:00
abstract:INTRODUCTION:Hearing loss is a common chronic problem which can be effectively managed with hearing devices. At present, only a limited number of people with hearing loss use hearing aids (HAs) and cochlear implants (CIs) to improve hearing and sound quality and enhance quality of life. Clinical equipoise, by which we ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030100
更新日期:2019-09-08 00:00:00
abstract:INTRODUCTION:Smoking remains the leading cause of preventable death in the USA but can be reduced through policy interventions. Computational models of smoking can provide estimates of the projected impact of tobacco control policies and can be used to inform public health decision making. We outline a protocol for sim...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019169
更新日期:2018-03-23 00:00:00
abstract::Objectives (1) To assess endorsement of trial registration in author instructions of urology-related journals and (2) to assess whether randomised controlled trials (RCTs) in the field of urology were effectively registered. Design Cross-sectional study of author instructions and published trials. Setting Journals p...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000430
更新日期:2011-12-06 00:00:00
abstract:INTRODUCTION:Children with acute respiratory tract infections (ARTIs) are prescribed up to 11.4 million unnecessary antibiotic prescriptions annually. Inadequate parent-provider communication is a chief contributor, yet efforts to reduce overprescribing have only indirectly targeted communication or been impractical. T...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-020981
更新日期:2018-05-09 00:00:00
abstract:OBJECTIVES:Physical activity is widely recommended in the treatment and management of cystic fibrosis (CF). Despite the numerous physical and psychological benefits, many young people with CF are not achieving the recommended levels of physical activity. The aim of this systematic review was to identify and synthesise ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035261
更新日期:2020-02-20 00:00:00
abstract:INTRODUCTION:Depressive, anxiety and adjustment disorders are highly prevalent among mental health outpatients. The lack of funding for mental health problems produces inefficient results and a high burden of disease. New cost-effective group interventions aimed at treating these symptoms might be an appropriate soluti...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029909
更新日期:2019-10-08 00:00:00
abstract:OBJECTIVE:To examine the association between obese-years and the risk of cardiovascular disease (CVD). STUDY DESIGN:Prospective cohort study. SETTING:Boston, USA. PARTICIPANTS:5036 participants of the Framingham Heart Study were examined. METHODS:Obese-years was calculated by multiplying for each participant the nu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005629
更新日期:2014-09-17 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyse the rate of knee arthroplasty in the population of patients with a history of arthroscopic chondroplasty of the knee, in England, over 10 years, with comparison to general population data for patients without a history of chondroplasty. DESIGN:Retrospective cohort stu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030609
更新日期:2020-04-16 00:00:00