Characteristics of glycopeptide-resistant Staphylococcus aureus strains isolated from inpatients of three teaching hospitals in Warsaw, Poland.

Abstract:

Background:Vancomycin is still one of the most commonly used drug for treatment of severe methicillin-resistant Staphylococcus aureus (MRSA) infections. Vancomycin-resistant S. aureus (VRSA) strains are a serious danger for public health. This study aimed to characterize healthcare-associated MRSA (HA-MRSA) strains, resistant to at least one of glycopeptide antibiotics: vancomycin (VRSA) and/or teicoplanin (TRSA), isolated at three Warsaw hospitals over a period of 17-years (1991-2007). Methods:Among 600 HA-MRSA strains, isolated from patients with symptomatic infections, 47 were subjected to detailed analysis. In the study, mechanisms behind VRSA phenotypes were determined (E-tests, GRD-test, agar-dilution method and vanA/B detection). Characteristics of selected isolates on molecular level: i) by detection of resistance genes ermA/ermB/ermC, msrA/msrB, linA/linA', aacA-aphD, aadD, aph(3")-IIIa; ii) SCCmec-typing and iii) MLST-typing was done. Results:In general population of studied strains, 11/47 (23.4%) were VRSA and 36/47 (76.6%) were resistant only to teicoplanin. All isolates exhibited van-independent mechanisms of resistance. Over 80% of isolates belonged to clonal complex CC8, with the following predominant sequence types (STs)/clones: ST247-IA/Iberian, ST241-III/Finland-UK, and ST239-III/Brazilian. Most of the isolated strains harboured ermA and aacA-aphD genes, encoding additional resistance to macrolides, lincosamides, streptogramin B, and majority of aminoglycosides. They occurred also in Polish VRSA/TRSA population over the period, which was subjected for analysis: an increase in MIC values for glycopeptides, evolution in terms of the level and extent of resistance, and genetic re-assortment in epidemic clones. Conclusions:VRSA strains isolated from patients hospitalized at three Warsaw teaching hospitals in Poland, over a period of 17-years do not pose a threat as potential donors of van genes in horizontal-gene transfer processes, but are constantly evolving and represent international epidemic clones.

authors

Szymanek-Majchrzak K,Mlynarczyk A,Mlynarczyk G

doi

10.1186/s13756-018-0397-y

subject

Has Abstract

pub_date

2018-08-29 00:00:00

pages

105

issn

2047-2994

pii

397

journal_volume

7

pub_type

杂志文章
  • Hip and knee arthroplasty: quo vadis?

    abstract::Despite of the steady decrease of surgical site infection (SSI) over the last two decades, the incidence of SSI after hip and knee arthroplasty has recently surged. This may be explained by technical changes that may result in an increased risk of SSI, such as the broad implementation of fast track programs, and/or ea...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-015-0060-9

    authors: Ho J,Meis JF,Nabuurs-Franssen M,Voss A

    更新日期:2015-05-15 00:00:00

  • Implementation of a surgical unit-based safety programme in African hospitals: a multicentre qualitative study.

    abstract:Background:A Surgical Unit-based Safety Programme (SUSP) has been shown to improve perioperative prevention practices and to reduce surgical site infections (SSI). It is critical to understand the factors influencing the successful implementation of the SUSP approach in low- and middle-income settings. We undertook a q...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s13756-019-0541-3

    authors: Clack L,Willi U,Berenholtz S,Aiken AM,Allegranzi B,Sax H

    更新日期:2019-05-30 00:00:00

  • Keeping PPE barriers in COVID-19 wards while doing proper auscultation.

    abstract::The emerging COVID-19 pandemic poses many difficulties to medical professionals. One of them is the need to use personal protective equipment (PPE) in order to protect themselves and their families, while not compromising their care. Physical examination is one of the cornerstones of medical assessment but parts of it...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 信件

    doi:10.1186/s13756-020-00854-y

    authors: Seidel E,Luski S,Ribak Y,Nama A,Saraya T,Nishiyama T,Oster Y,Nir-Paz R

    更新日期:2020-12-09 00:00:00

  • Using the best available data to estimate the cost of antimicrobial resistance: a systematic review.

    abstract:Background:Valuation of the economic cost of antimicrobial resistance (AMR) is important for decision making and should be estimated accurately. Highly variable or erroneous estimates may alarm policy makers and hospital administrators to act, but they also create confusion as to what the most reliable estimates are an...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章,meta分析

    doi:10.1186/s13756-019-0472-z

    authors: Wozniak TM,Barnsbee L,Lee XJ,Pacella RE

    更新日期:2019-02-01 00:00:00

  • Evaluation of co-transfer of plasmid-mediated fluoroquinolone resistance genes and bla NDM gene in Enterobacteriaceae causing neonatal septicaemia.

    abstract:Background:The blaNDM-1 (New Delhi Metallo-β-lactamase-1) gene has disseminated around the globe. NDM-1 producers are found to co-harbour resistance genes against many antimicrobials, including fluoroquinolones. The spread of large plasmids, carrying both blaNDM and plasmid-mediated fluoroquinolone resistance (PMQR) ma...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-019-0477-7

    authors: Mitra S,Mukherjee S,Naha S,Chattopadhyay P,Dutta S,Basu S

    更新日期:2019-02-27 00:00:00

  • Alcohol-based surgical hand preparation: translating scientific evidence into clinical practice.

    abstract:Background:Although alcohol-based surgical hand preparation offers potential advantages over the traditional surgical scrubbing technique, implementing it may be challenging due to resistance of surgeons in changing their practice. We aimed to implement alcohol-based surgical hand preparation in the hospital setting ev...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-018-0372-7

    authors: Gaspar GG,Menegueti MG,Lopes AER,Santos ROC,de Araújo TR,Nassiff A,Ferreira LR,Dallora MELV,Canini SRMS,Bellissimo-Rodrigues F

    更新日期:2018-07-09 00:00:00

  • Efficacy of the decolonization of methicillin-resistant Staphylococcus aureus carriers in clinical practice.

    abstract:BACKGROUND:Nasal and extra nasal carriage of methicillin-resistant S. aureus (MRSA) is a pre-existing condition that often leads to invasive MRSA infection, as MRSA colonization is associated with a high risk of acquiring MRSA infection during hospital stays. Decolonization may reduce the risk of meticillin-resistant S...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-015-0096-x

    authors: Sai N,Laurent C,Strale H,Denis O,Byl B

    更新日期:2015-12-18 00:00:00

  • Changing epidemiology of infections due to extended spectrum beta-lactamase producing bacteria.

    abstract:BACKGROUND:Community-associated infections caused by extended-spectrum beta-lactamase (ESBL) producing bacteria are a growing concern. METHODS:Retrospective cohort study of clinical infections due to ESBL-producing bacteria requiring admission from 2006-2011 at a tertiary care academic medical center in Providence, RI...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/2047-2994-3-9

    authors: Kassakian SZ,Mermel LA

    更新日期:2014-03-25 00:00:00

  • High prevalence of ESBL-Producing E. coli in private and shared latrines in an informal urban settlement in Dar es Salaam, Tanzania.

    abstract:Background:Data about the burden of extended-spectrum beta-lactamase (ESBL)-producing microorganisms in Africa are limited. Our study aimed to estimate the prevalence of human faecal ESBL carriage in the community of an informal urban settlement in Dar es Salaam (Tanzania, East Africa) by using environmental contaminat...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-017-0292-y

    authors: Erb S,D'Mello-Guyett L,Malebo HM,Njee RM,Matwewe F,Ensink J,Hinic V,Widmer A,Frei R

    更新日期:2018-01-06 00:00:00

  • Influence of severity of infection on the effect of appropriate antimicrobial therapy for Acinetobacter baumannii bacteremic pneumonia.

    abstract:BACKGROUND:The impact of appropriate antimicrobial therapy for A. baumannii bacteremic pneumonia has not been well established due to the inclusion of the three phenotypically indistinguishable Acinetobacter species and confounding factors including underlying diseases and severity of infection. This retrospective stud...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-020-00824-4

    authors: Kang FY,How CK,Wang YC,Cheng A,Yang YS,Kuo SC,Liu CP,Liu YM,Chen TL,Lee YT

    更新日期:2020-09-29 00:00:00

  • Surface micropattern limits bacterial contamination.

    abstract:BACKGROUND:Bacterial surface contamination contributes to transmission of nosocomial infections. Chemical cleansers used to control surface contamination are often toxic and incorrectly implemented. Additional non-toxic strategies should be combined with regular cleanings to mitigate risks of human error and further de...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/2047-2994-3-28

    authors: Mann EE,Manna D,Mettetal MR,May RM,Dannemiller EM,Chung KK,Brennan AB,Reddy ST

    更新日期:2014-09-17 00:00:00

  • The function of the thyroid gland in patients with multi-drug resistant tuberculosis.

    abstract:BACKGROUND:Multidrug-resistant tuberculosis (MDRTB) remains a health problem for many countries in the world. The share of MDRTB is 10-30% among newly diagnosed cases and 20-70% among relapses and treatment failure. The aim of the study is to define the side effects of second line drugs used in the treatment of MDRTB o...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-017-0238-4

    authors: Matveyeva SL,Shevchenko OS,Pogorelova OO

    更新日期:2017-08-16 00:00:00

  • Antibiotic use in a tertiary healthcare facility in Ghana: a point prevalence survey.

    abstract:Background:The global rise and spread of antibiotic resistance is limiting the usefulness of antibiotics in the prevention and treatment of infectious diseases. The use of antibiotic stewardship programs guided by local data on prescribing practices is a useful strategy to control and reduce antibiotic resistance. Our ...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-018-0299-z

    authors: Labi AK,Obeng-Nkrumah N,Nartey ET,Bjerrum S,Adu-Aryee NA,Ofori-Adjei YA,Yawson AE,Newman MJ

    更新日期:2018-01-26 00:00:00

  • Effects of an antimicrobial stewardship intervention on perioperative antibiotic prophylaxis in pediatrics.

    abstract:Purpose:This study aims to determine the effectiveness of an Antimicrobial Stewardship Program based on a Clinical Pathway (CP) to improve appropriateness in perioperative antibiotic prophylaxis (PAP). Materials and methods:This pre-post quasi-experimental study was conducted in a 12 month period (six months before an...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-019-0464-z

    authors: Donà D,Luise D,La Pergola E,Montemezzo G,Frigo A,Lundin R,Zaoutis T,Gamba P,Giaquinto C

    更新日期:2019-01-15 00:00:00

  • Adjustment of the MRSA Search and Destroy policy for outpatients in the Netherlands: a prospective cohort study with repeated prevalence measurements.

    abstract:BACKGROUND:In the Netherlands a successful MRSA Search and Destroy policy is applied in healthcare institutes. We determined the effect of an adjustment in the MRSA Search and Destroy policy for patients in the outpatient clinic on the MRSA transmission to health care workers (HCW). METHODS:In June 2008 an adjustment ...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/2047-2994-3-3

    authors: van Rijen MM,Kluytmans JA

    更新日期:2014-01-15 00:00:00

  • Evaluating risk factors for Clostridium difficile infection in adult and pediatric hematopoietic cell transplant recipients.

    abstract:BACKGROUND:Although hematopoietic cell transplant (HCT) recipients are routinely exposed to classic risk factors for Clostridium difficile infection (CDI), few studies have assessed CDI risk in these high-risk patients, and data are especially lacking for pediatric HCT recipients. We aimed to determine incidence and ri...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-015-0081-4

    authors: Boyle NM,Magaret A,Stednick Z,Morrison A,Butler-Wu S,Zerr D,Rogers K,Podczervinski S,Cheng A,Wald A,Pergam SA

    更新日期:2015-10-14 00:00:00

  • Association between antibiotic consumption and the rate of carbapenem-resistant Gram-negative bacteria from China based on 153 tertiary hospitals data in 2014.

    abstract:Background:This study aimed to investigate the relationship between the rate of carbapenem-resistant Gram-negative bacteria and antibiotic consumption intensity in 153 tertiary hospitals from China in 2014. Methods:A retrospective study using national surveillance data from 2014 was conducted. Data on the annual consu...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-018-0430-1

    authors: Yang P,Chen Y,Jiang S,Shen P,Lu X,Xiao Y

    更新日期:2018-11-19 00:00:00

  • Are three antiseptic paints needed for safe preparation of the surgical field? A prospective cohort study with 239 patients.

    abstract:BACKGROUND:Preoperative skin antisepsis is an essential component of safe surgery. However, it is unclear how many antiseptic paints are needed to eliminate bacteria prior to incision. This study compared microbial skin counts after two and three antiseptic paints. METHODS:We conducted a prospective cohort study in no...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-020-00780-z

    authors: Roth JA,Schwab C,Atkinson A,von Flüe M,Kettelhack C,Eckstein FS,Battegay M,Klimke S,Frei R,Widmer AF

    更新日期:2020-07-31 00:00:00

  • Germs of thrones - spontaneous decolonization of Carbapenem-Resistant Enterobacteriaceae (CRE) and Vancomycin-Resistant Enterococci (VRE) in Western Europe: is this myth or reality?

    abstract:Background:In France, Carbapenem-Resistant Enterobacteriaceae (CRE) and Vancomycin-Resistant Enterococci (VRE) are considered as Extensively Drug-Resistant (XDR) bacteria. Their management requires reinforcement of hospital's hygiene policies, and currently there is few consistent data concerning the spontaneous decolo...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s13756-018-0390-5

    authors: Davido B,Moussiegt A,Dinh A,Bouchand F,Matt M,Senard O,Deconinck L,Espinasse F,Lawrence C,Fortineau N,Saleh-Mghir A,Caballero S,Escaut L,Salomon J

    更新日期:2018-08-13 00:00:00

  • The use of typing methods and infection prevention measures to control a bullous impetigo outbreak on a neonatal ward.

    abstract:UNLABELLED: BACKGROUND:We describe an outbreak of Bullous Impetigo (BI), caused by a (methicillin susceptible, fusidic acid resistant) Staphylococcus aureus (SA) strain, spa-type t408, at the neonatal and gynaecology ward of the Jeroen Bosch hospital in the Netherlands, from March-November 2011. METHODS:We performed ...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/2047-2994-1-37

    authors: Koningstein M,Groen L,Geraats-Peters K,Lutgens S,Rietveld A,Jira P,Kluytmans J,de Greeff SC,Hermans M,Schneeberger PM

    更新日期:2012-11-20 00:00:00

  • A multimodal intervention program to control a long-term Acinetobacter baumannii endemic in a tertiary care hospital.

    abstract:Background:Acinetobacter baumannii causes frequently nosocomial infections worldwide. Its ability to survive on dry surfaces facilitates its spread and the persistence of endemic situations, especially in the intensive care units (ICUs).The objective of this paper is to describe a multicomponent intervention program de...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-019-0658-4

    authors: Valencia-Martín R,Gonzalez-Galan V,Alvarez-Marín R,Cazalla-Foncueva AM,Aldabó T,Gil-Navarro MV,Alonso-Araujo I,Martin C,Gordon R,García-Nuñez EJ,Perez R,Peñalva G,Aznar J,Conde M,Cisneros JM,In representation of A. baumanni

    更新日期:2019-12-04 00:00:00

  • Non-prescribed antimicrobial use and associated factors among customers in drug retail outlet in Central Zone of Tigray, northern Ethiopia: a cross-sectional study.

    abstract:BACKGROUND:Non-prescribed antimicrobial use and their resistance are among the main public health problems, worldwide. In Ethiopia, particularly in the northern part, the magnitude of non-prescribed antimicrobial use and its major determinants is not yet well known. Thus, this study was done to assess the magnitude of ...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-017-0227-7

    authors: Gebrekirstos NH,Workneh BD,Gebregiorgis YS,Misgina KH,Weldehaweria NB,Weldu MG,Belay HS

    更新日期:2017-06-26 00:00:00

  • Risk factors and outcomes in non-transplant patients with extended-spectrum beta-lactamase-producing Escherichia coli bacteremia: a retrospective study from 2013 to 2016.

    abstract:Background:Escherichia coli is one of the most common strains of extended-spectrum β-lactam (ESBL)-producing bacteria, and the prevention and treatment of ESBL-producing E. coli infections is an ongoing challenge. The clinical characteristics and outcomes of ESBL-producing E. coli bacteremia in non-transplant patients ...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-019-0599-y

    authors: Xiao T,Yang K,Zhou Y,Zhang S,Ji J,Ying C,Shen P,Xiao Y

    更新日期:2019-08-27 00:00:00

  • Assessment of hand hygiene facilities and staff compliance in a large tertiary health care facility in northern Nigeria: a cross sectional study.

    abstract:BACKGROUND:The burden of healthcare-associated infection (HAI) is 2 to 18 times higher in developing countries. However, few data are available regarding infection prevention and control (IPC) process indicators in these countries. We evaluated hand hygiene (HH) facilities and compliance amongst healthcare workers (HCW...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-020-0693-1

    authors: Onyedibe KI,Shehu NY,Pires D,Isa SE,Okolo MO,Gomerep SS,Ibrahim C,Igbanugo SJ,Odesanya RU,Olayinka A,Egah DZ,Pittet D

    更新日期:2020-02-11 00:00:00

  • Newest data on fluoroquinolone resistance mechanism of Shigella flexneri isolates in Jiangsu Province of China.

    abstract:BACKGROUND:To determine the prevalence, antimicrobial susceptibility patterns and related presence of mutations in quinolone resistance-determining region (QRDR) genes and plasmid-mediated quinolone resistance (PMQR) among Shigella flexneri isolates obtained from Jiangsu Province, China. METHODS:A total of 400 Shigell...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-017-0249-1

    authors: Qin T,Qian H,Fan W,Ma P,Zhou L,Dong C,Gu B,Huo X

    更新日期:2017-09-19 00:00:00

  • Methicillin-resistant Staphylococcus aureus risk profiling: who are we missing?

    abstract:BACKGROUND:Targeted screening of patients at high risk for methicillin-resistant Staphylococcus aureus (MRSA) carriage is an important component of MRSA control programs, which rely on prediction tools to identify those high-risk patients. Most previous risk studies reported a substantial rate of patients who are eligi...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/2047-2994-2-17

    authors: Pasricha J,Harbarth S,Koessler T,Camus V,Schrenzel J,Cohen G,Pittet D,Perrier A,Iten A

    更新日期:2013-05-30 00:00:00

  • The impact of staffing on central venous catheter-associated bloodstream infections in preterm neonates - results of nation-wide cohort study in Germany.

    abstract:BACKGROUND:Very low birthweight (VLBW) newborns on neonatal intensive care units (NICU) are at increased risk for developing central venous catheter-associated bloodstream infections (CVC BSI). In addition to the established intrinsic risk factors of VLBW newborns, it is still not clear which process and structure para...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/2047-2994-2-11

    authors: Leistner R,Thürnagel S,Schwab F,Piening B,Gastmeier P,Geffers C

    更新日期:2013-04-04 00:00:00

  • Ten-year resistance trends in pathogens causing healthcare-associated infections; reflection of infection control interventions at a multi-hospital healthcare system in Saudi Arabia, 2007-2016.

    abstract:BACKGROUND:Studying temporal changes in resistant pathogens causing healthcare-associated infections (HAIs) is crucial in improving local antimicrobial and infection control practices. The objective was to describe ten-year trends of resistance in pathogens causing HAIs in a tertiary care setting in Saudi Arabia and to...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-020-0678-0

    authors: Balkhy HH,El-Saed A,Alshamrani MM,Alsaedi A,Al Nasser W,El Gammal A,Aljohany SM,Almunif S,Arabi Y,Alqahtani S,Bonnie HB,Alghoribi M,Alothman A,Almohrij SA

    更新日期:2020-01-30 00:00:00

  • Risk factors for surgical site infection after craniotomy: a prospective cohort study.

    abstract:Background:Although surgical site infection after craniotomy (SSI-CRAN) is a serious complication, risk factors for its development have not been well defined. We aim to identify the risk factors for developing SSI-CRAN in a large prospective cohort of adult patients undergoing craniotomy. Methods:A series of consecut...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-019-0525-3

    authors: Jiménez-Martínez E,Cuervo G,Hornero A,Ciercoles P,Gabarrós A,Cabellos C,Pelegrin I,García-Somoza D,Adamuz J,Carratalà J,Pujol M

    更新日期:2019-05-02 00:00:00

  • Social media posts and online search behaviour as early-warning system for MRSA outbreaks.

    abstract:Background:Despite many preventive measures, outbreaks with multi-drug resistant micro-organisms (MDROs) still occur. Moreover, current alert systems from healthcare organizations have shortcomings due to delayed or incomplete notifications, which may amplify the spread of MDROs by introducing infected patients into a ...

    journal_title:Antimicrobial resistance and infection control

    pub_type: 杂志文章

    doi:10.1186/s13756-018-0359-4

    authors: van de Belt TH,van Stockum PT,Engelen LJLPG,Lancee J,Schrijver R,Rodríguez-Baño J,Tacconelli E,Saris K,van Gelder MMHJ,Voss A

    更新日期:2018-05-30 00:00:00