Abstract:
BACKGROUND:Studying temporal changes in resistant pathogens causing healthcare-associated infections (HAIs) is crucial in improving local antimicrobial and infection control practices. The objective was to describe ten-year trends of resistance in pathogens causing HAIs in a tertiary care setting in Saudi Arabia and to compare such trends with those of US National Health Surveillance Network (NHSN). METHODS:Pooled analysis of surveillance data that were prospectively collected between 2007 and 2016 in four hospitals of Ministry of National Guard Health Affairs. Definitions and methodology of HAIs and antimicrobial resistance were based on NHSN. Consecutive NHSN reports were used for comparisons. RESULTS:A total 1544 pathogens causing 1531 HAI events were included. Gram negative pathogens (GNP) were responsible for 63% of HAIs, with a significant increasing trend in Klebsiella spp. and a decreasing trend in Acinetobacter. Methicillin-resistant Staphylococcus aureus (27.0%) was consistently less frequent than NHSN. Vancomycin-resistant Enterococci (VRE, 20.3%) were more than doubled during the study, closing the gap with NHSN. Carbapenem resistance was highest with Acinetobacter (68.3%) and Pseudomonas (36.8%). Increasing trends of carbapenem resistance were highest in Pseudomonas and Enterobacteriaceae, closing initial gaps with NHSN. With the exception of Klebsiella and Enterobacter, multidrug-resistant (MDR) GNPs were generally decreasing, mainly due to the decreasing resistance towards cephalosporins, fluoroquinolones, and aminoglycosides. CONCLUSION:The findings showed increasing trends of carbapenem resistance and VRE, which may reflect heavy use of carbapenems and vancomycin. These findings may highlight the need for effective antimicrobial stewardship programs, including monitoring and feedback on antimicrobial use and resistance.
journal_name
Antimicrob Resist Infect Controljournal_title
Antimicrobial resistance and infection controlauthors
Balkhy HH,El-Saed A,Alshamrani MM,Alsaedi A,Al Nasser W,El Gammal A,Aljohany SM,Almunif S,Arabi Y,Alqahtani S,Bonnie HB,Alghoribi M,Alothman A,Almohrij SAdoi
10.1186/s13756-020-0678-0subject
Has Abstractpub_date
2020-01-30 00:00:00pages
21issue
1issn
2047-2994pii
10.1186/s13756-020-0678-0journal_volume
9pub_type
杂志文章abstract:BACKGROUND:To determine the prevalence, antimicrobial susceptibility patterns and related presence of mutations in quinolone resistance-determining region (QRDR) genes and plasmid-mediated quinolone resistance (PMQR) among Shigella flexneri isolates obtained from Jiangsu Province, China. METHODS:A total of 400 Shigell...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0249-1
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
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journal_title:Antimicrobial resistance and infection control
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journal_title:Antimicrobial resistance and infection control
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journal_title:Antimicrobial resistance and infection control
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journal_title:Antimicrobial resistance and infection control
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abstract::[This corrects the article DOI: 10.1186/s13756-018-0315-3.]. ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章,已发布勘误
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journal_title:Antimicrobial resistance and infection control
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0477-7
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journal_title:Antimicrobial resistance and infection control
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journal_title:Antimicrobial resistance and infection control
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journal_title:Antimicrobial resistance and infection control
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doi:10.1186/s13756-016-0119-2
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00814-6
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/2047-2994-3-28
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/2047-2994-1-32
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
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journal_title:Antimicrobial resistance and infection control
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journal_title:Antimicrobial resistance and infection control
pub_type: 信件
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0171-6
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
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更新日期:2017-09-08 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0666-4
更新日期:2019-12-30 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-015-0071-6
更新日期:2015-07-25 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0464-z
更新日期:2019-01-15 00:00:00
abstract:BACKGROUND:The impact of appropriate antimicrobial therapy for A. baumannii bacteremic pneumonia has not been well established due to the inclusion of the three phenotypically indistinguishable Acinetobacter species and confounding factors including underlying diseases and severity of infection. This retrospective stud...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00824-4
更新日期:2020-09-29 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00874-8
更新日期:2021-01-22 00:00:00