Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol.

abstract：OBJECTIVE:To determine if observational studies examining the association of wholegrain foods with cardiovascular disease (CVD) with food industry sponsorship and/or authors with conflicts of interest (COI) with the food industry are more likely to have results and/or conclusions that are favourable to industry than th...

journal_title：BMJ open

authors： Chartres N,Fabbri A,McDonald S,Turton J,Allman-Farinelli M,McKenzie J,Bero L

更新日期：2019-05-19 00:00:00

abstract：OBJECTIVE:Cancer of the oral cavity is the leading malignancy among males in Sri Lanka, and sixth among women. This study aimed to estimate costs of managing patients with oral cancer (OCA) in Sri Lanka for a 12 month period from diagnosis. DESIGN:Hospital based costing study. SETTINGS:Four selected cancer treatment ...

journal_title：BMJ open

authors： Amarasinghe H,Jayasinghe RD,Dharmagunawardene D,Attygalla M,Scuffham PA,Johnson N,Kularatna S

更新日期：2019-07-19 00:00:00

abstract：OBJECTIVES:Although novel early breast cancer prognostic factors are being continuously discovered, only rare factors predicting survival in metastatic breast cancer have been validated. The prognostic role of early breast cancer prognostic factors in metastatic disease also remains mostly unclear. DESIGN AND SETTING:...

journal_title：BMJ open

authors： Karihtala P,Jääskeläinen A,Roininen N,Jukkola A

更新日期：2020-10-12 00:00:00

abstract：OBJECTIVE:Insomnia is highly prevalent in prisoners and is a risk factor for poor mental well-being, depression, suicidality and aggression, all common concerns in this vulnerable population. Improving sleep management options in prison offers the potential to impact positively on a number of these common risk factors....

journal_title：BMJ open

authors： Dewa LH,Hassan L,Shaw J,Senior J

更新日期：2018-08-29 00:00:00

abstract：OBJECTIVES:Develop predictive models for a paediatric population that provide information for paediatricians and health authorities to identify children at risk of hospitalisation for conditions that may be impacted through improved patient care. DESIGN:Retrospective healthcare utilisation analysis with multivariable ...

journal_title：BMJ open

authors： Louis DZ,Callahan CA,Robeson M,Liu M,McRae J,Gonnella JS,Lombardi M,Maio V

更新日期：2018-05-05 00:00:00

abstract：INTRODUCTION:Persisting neurotropic viruses are proposed to increase the risk of dementia, but evidence of association from robust, adequately powered population studies is lacking. This is essential to inform clinical trials of targeted preventive interventions. METHODS AND ANALYSIS:We will carry out a comprehensive ...

journal_title：BMJ open

authors： Warren-Gash C,Forbes H,Breuer J,Hayward AC,Mavrodaris A,Ridha BH,Rossor M,Thomas SL,Smeeth L

更新日期：2017-06-23 00:00:00

abstract：OBJECTIVE:To review a sample of cluster randomised controlled trials and explore the quality of reporting of (1) enabling or support activities provided to the staff during the trial, (2) strategies used to monitor fidelity throughout the trial and (3) the extent to which the intervention being tested was delivered as ...

journal_title：BMJ open

authors： McMahon NE,Holland EJ,Miller C,Patel K,Connell LA

更新日期：2015-10-09 00:00:00

abstract：OBJECTIVES:To analyse variables associated with article placement order in serial rheumatology journals. DESIGN:Content analysis. SETTING:Original articles published in seven rheumatology journals from 2013 to 2018. PRIMARY AND SECONDARY OUTCOME MEASURES:The following data were extracted from 6787 articles: order nu...

journal_title：BMJ open

authors： Stewart S,Gamble G,Grey A,Dalbeth N

更新日期：2020-06-17 00:00:00

abstract：OBJECTIVES:To describe prevalence and predictors of poor sexual well-being for men and women over 5 years following treatment for colorectal cancer. DESIGN:Prospective longitudinal study, from presurgery to 5 years postsurgery, with eight assessment points. Logistic regression models predicted sexual well-being from p...

journal_title：BMJ open

authors： Frankland J,Wheelwright S,Permyakova NV,Wright D,Collaço N,Calman L,Winter J,Fenlon D,Richardson A,Smith PW,Foster C

更新日期：2020-11-12 00:00:00

abstract：INTRODUCTION:Providing patients with access to electronic health records (EHRs) has emerged as a promising solution to improve quality of care and safety. As the efforts to develop and implement EHR-based data sharing platforms mature and scale up worldwide, there is a need to evaluate the impact of these interventions...

journal_title：BMJ open

authors： Neves AL,Carter AW,Freise L,Laranjo L,Darzi A,Mayer EK

更新日期：2018-08-13 00:00:00

abstract：OBJECTIVES:Moderation of alcohol consumption is included as a class I, level of evidence A recommendation in the current European guidelines for the management of hypertension. We investigated its awareness and self-reported implementation among European physicians across different specialties and workplaces. DESIGN A...

journal_title：BMJ open

authors： Zaidi Touis L,Bolbrinker J,Riemer TG,Kreutz R

更新日期：2018-10-21 00:00:00

abstract：OBJECTIVE:Many studies have demonstrated that elevated serum uric acid (SUA) level is linked with metabolic syndrome (MetS). However, whether there is a sex difference in the association between SUA and MetS has not been determined. This study aimed to accurately explore the impact of SUA longitudinal changes on MetS b...

journal_title：BMJ open

authors： Liu Y,Fan Y,Liu Q,Liu K,Chen F,Tang X,Li G,Hu D,Song G

更新日期：2020-07-02 00:00:00

abstract：INTRODUCTION:Systemic hypertension (HTN) is a common risk factor for cardiovascular disease. In Mexico, HTN prevalence has increased over time and is currently 31%. Nonetheless, information about the country's HTN incidence and its associated risk factors is scarce. Understanding this condition is a priority for identi...

journal_title：BMJ open

authors： Colín-Ramírez E,Rivera-Mancía S,Infante-Vázquez O,Cartas-Rosado R,Vargas-Barrón J,Madero M,Vallejo M

更新日期：2017-07-31 00:00:00

abstract：INTRODUCTION:Frailty is a common condition affecting older adults and is associated with increased mortality and adverse outcomes. Identification of older adults at risk of adverse outcomes is central to subsequent resource planning and targeted interventions. This systematic review and meta-analysis will examine the: ...

journal_title：BMJ open

authors： Leahy A,O'Connor M,Condon J,Heywood S,Shanahan E,Peters C,Galvin R

更新日期：2021-01-20 00:00:00

abstract：OBJECTIVE:To examine the association between social capital and the health of male and female left-behind older adults in rural China. STUDY DESIGN:This cross-sectional study among the left-behind older adults aged 60 and older and with all their children working outside of Hubei, Shaanxi and Guangdong provinces in Ch...

journal_title：BMJ open

authors： Ke Y,Jiang J,Chen Y

更新日期：2019-11-25 00:00:00

abstract：OBJECTIVES:Improving the quality of primary care is an important strategy to improve health outcomes. However, responses to continuous quality improvement (CQI) initiatives are variable, likely due in part to a mismatch between interventions and context. This project aimed to understand the successful implementation of...

journal_title：BMJ open

authors： Larkins S,Carlisle K,Turner N,Taylor J,Copley K,Cooney S,Wright R,Matthews V,Thompson S,Bailie R

更新日期：2019-05-24 00:00:00

abstract：INTRODUCTION:Cardiovascular morbidity is a major burden in patients with rheumatoid arthritis (RA). In this study, we compare the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment of modifiable risk factors for cardiovascular disease (CVD) in patients with early RA fulfi...

journal_title：BMJ open

authors： Svensson AL,Christensen R,Persson F,Løgstrup BB,Giraldi A,Graugaard C,Fredberg U,Blegvad J,Thygesen T,Hansen IM,Colic A,Bagdat D,Ahlquist P,Jensen HS,Hørslev-Petersen K,Sheetal E,Christensen TG,Svendsen L,Emmertsen H

更新日期：2016-04-20 00:00:00

abstract：OBJECTIVES:The aim of the study was to assess whether gastrostomy placement before 18 months of age results in a greater increase in z-score for weight and to assess whether admission rates were reduced postgastrostomy in this age group. DESIGN:Retrospective cross-sectional study. SETTING:Single-centre secondary care...

journal_title：BMJ open

authors： Sharma R,Williams AN,Zaw W

更新日期：2012-11-21 00:00:00

abstract：OBJECTIVES:To ascertain whether an ultrabrief intervention (UBI) improves mental health outcomes for patients in general practice with mild-to-moderate mental health concerns. TRIAL DESIGN:Two-arm cluster randomised controlled trial. METHODS:Participants: general practitioners (GPs) were invited based on working in a...

journal_title：BMJ open

authors： Mathieson F,Stanley J,Collings CS,Tester R,Dowell A

更新日期：2019-02-27 00:00:00

abstract：INTRODUCTION:While tobacco smoking prevalence is falling in many western societies, it remains elevated among high-priority cohorts. Rates up to 95% have been reported in women whose pregnancy is complicated by other substance use. In this group, the potential for poor pregnancy outcomes and adverse physical and neurob...

journal_title：BMJ open

authors： Jackson MA,Brown AL,Baker AL,Gould GS,Dunlop AJ

更新日期：2019-11-21 00:00:00

abstract：OBJECTIVES AND SETTING:Advances in multigene panel testing for cancer susceptibility has increased the complexity of counselling, requiring particular attention to counselees' psychosocial needs. Changes in psychosocial problems before and after genetic testing were prospectively compared between genetic test results i...

journal_title：BMJ open

authors： Brédart A,Kop JL,Dick J,Cano A,De Pauw A,Anota A,Brunet J,Devilee P,Stoppa-Lyonnet D,Schmutzler R,Dolbeault S

更新日期：2019-09-24 00:00:00

abstract：OBJECTIVES:To assess the effects of a home-based telehealth intervention on the use of secondary healthcare and mortality. DESIGN:Observational study of a mainstream telehealth service, using person-level administrative data. Time to event analysis (Cox regression) was performed comparing telehealth patients with cont...

journal_title：BMJ open

authors： Steventon A,Ariti C,Fisher E,Bardsley M

更新日期：2016-02-03 00:00:00

abstract：BACKGROUND AND OBJECTIVE:A comparison of sick leave in pregnancy between countries is difficult as most studies have been conducted in single countries in Scandinavia. The objective of this study was to explore patterns of and reasons for sick leave during pregnancy on a multinational level, focusing on medication use ...

journal_title：BMJ open

authors： Truong BT,Lupattelli A,Kristensen P,Nordeng H

更新日期：2017-08-03 00:00:00

abstract：OBJECTIVES:Hospice care (HC) is seen as a comprehensive approach, that enhances quality of end-of-life (EOL) care, for terminally ill patients. Despite its positive aspects, HC enrolment is disproportionate for rural patients, who are less likely to use HC in comparison to their urban counterparts. The purpose of this ...

journal_title：BMJ open

authors： Ko E,Fuentes D,Singh-Carlson S,Nedjat-Haiem F

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Medical image analysis practices face challenges that can potentially be addressed with algorithm-based segmentation tools. In this study, we map the field of automatic MR brain lesion segmentation to understand the clinical applicability of prevalent methods and study designs, as well as challenges and limi...

journal_title：BMJ open

authors： Gryska E,Schneiderman J,Björkman-Burtscher I,Heckemann RA

更新日期：2021-01-29 00:00:00

abstract：OBJECTIVES:Guidelines and training initiatives (G/TIs) are available to support communication in cross-cultural consultations but are rarely implemented in routine practice in primary care. As part of the European Union RESTORE project, our objective was to explore whether the available G/TIs make sense to migrants and...

journal_title：BMJ open

authors： Lionis C,Papadakaki M,Saridaki A,Dowrick C,O'Donnell CA,Mair FS,van den Muijsenbergh M,Burns N,de Brún T,O'Reilly de Brún M,van Weel-Baumgarten E,Spiegel W,MacFarlane A

更新日期：2016-07-22 00:00:00

abstract：OBJECTIVE:Previous systematic reviews were not restricted to either primary or secondary prevention trials, this study aimed to investigate the effects of reduced and/or modified fat diets and dietary fatty acids on all-cause mortality, cardiovascular mortality and cardiovascular events in participants with established...

journal_title：BMJ open

authors： Schwingshackl L,Hoffmann G

更新日期：2014-04-19 00:00:00

abstract：OBJECTIVES:To describe the current provision of hospital-based liaison psychiatry services in England, and to determine different models of liaison service that are currently operating in England. DESIGN:Cross-sectional observational study comprising an electronic survey followed by targeted telephone interviews. SET...

journal_title：BMJ open

authors： Walker A,Barrett JR,Lee W,West RM,Guthrie E,Trigwell P,Quirk A,Crawford MJ,House A

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:To address the neglect of depression in multimorbidity measurement and the lack of focus on rural population in previous literature about China, this paper aimed to estimate the prevalence of multimorbidity (including depressive disorders) among the country's rural and urban population. METHODS:We used a cr...

journal_title：BMJ open

authors： Ma X,He Y,Xu J

更新日期：2020-11-16 00:00:00

abstract：INTRODUCTION:The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery. While this procedure has revolutionised treatment, the incidence of secondary events remains a concern. These repeat events ar...

journal_title：BMJ open

authors： Rathod KS,Jones DA,Van-Eijl TJ,Tsang H,Warren H,Hamshere SM,Kapil V,Jain AK,Deaner A,Poulter N,Caulfield MJ,Mathur A,Ahluwalia A

更新日期：2016-12-20 00:00:00