The Burden of Pediatric Asthma.

Abstract:

:Asthma is the most common chronic disease in children, imposing a consistent burden on health system. In recent years, prevalence of asthma symptoms became globally increased in children and adolescents, particularly in Low-Middle Income Countries (LMICs). Host (genetics, atopy) and environmental factors (microbial exposure, exposure to passive smoking and air pollution), seemed to contribute to this trend. The increased prevalence observed in metropolitan areas with respect to rural ones and, overall, in industrialized countries, highlighted the role of air pollution in asthma inception. Asthma accounts for 1.1% of the overall global estimate of "Disability-adjusted life years" (DALYs)/100,000 for all causes. Mortality in children is low and it decreased across Europe over recent years. Children from LMICs particularly suffer a disproportionately higher burden in terms of morbidity and mortality. Global asthma-related costs are high and are usually are classified into direct, indirect and intangible costs. Direct costs account for 50-80% of the total costs. Asthma is one of the main causes of hospitalization which are particularly common in children aged < 5 years with a prevalence that has been increased during the last two decades, mostly in LMICs. Indirect costs are usually higher than in older patients, including both school and work-related losses. Intangible costs are unquantifiable, since they are related to impairment of quality of life, limitation of physical activities and study performance. The implementation of strategies aimed at early detect asthma thus providing access to the proper treatment has been shown to effectively reduce the burden of the disease.

journal_name

Front Pediatr

journal_title

Frontiers in pediatrics

authors

Ferrante G,La Grutta S

doi

10.3389/fped.2018.00186

subject

Has Abstract

pub_date

2018-06-22 00:00:00

pages

186

issn

2296-2360

journal_volume

6

pub_type

杂志文章,评审
  • Is Autosomal Dominant Polycystic Kidney Disease Becoming a Pediatric Disorder?

    abstract::Autosomal dominant polycystic kidney disease (ADPKD) affects 1 in 400 to 1,000 live births, making it the most common monogenic cause of renal failure. Although no definite cure is available yet, it is important to affect disease progression by influencing modifiable factors such as hypertension and proteinuria. Besid...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2017.00272

    authors: De Rechter S,Breysem L,Mekahli D

    更新日期:2017-12-20 00:00:00

  • Robotic Management of Urolithiasis in the Pediatric Population.

    abstract::A variety of surgical techniques exist for the management of urolithiasis. Minimally invasive techniques have replaced open surgery in the last few decades. For complex stone management, robotic-assisted laparoscopic surgery (RALS) has emerged as a safe and feasible alternative in adults. The literature for RALS for u...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2019.00351

    authors: Ballesteros N,Snow ZA,Moscardi PRM,Ransford GA,Gomez P,Castellan M

    更新日期:2019-08-22 00:00:00

  • How Salty Are Your Fluids? Pediatric Maintenance IV Fluid Prescribing Practices Among Hospitalists.

    abstract::Objective: The primary goal of this study was to assess current maintenance intravenous fluid (mIVF) prescribing practices of pediatric hospitalists after the release of the American Academy of Pediatrics Clinical Practice Guideline (AAP CPG), specifically assessing the rates of various isotonic vs. hypotonic solution...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2019.00549

    authors: Hall AM,Ayus JC,Moritz ML

    更新日期:2020-01-15 00:00:00

  • Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children.

    abstract::This review presents up-to-date understanding of immunotherapy in the treatment of children with allergic asthma. The principal types of allergen immunotherapy (AIT) are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Both of them are indicated for patients with allergic rhinitis and/or asthma, ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2017.00082

    authors: Tsabouri S,Mavroudi A,Feketea G,Guibas GV

    更新日期:2017-04-21 00:00:00

  • Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children.

    abstract::Genetic polymorphisms in genes coding for inflammasome components nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) and caspase recruitment domain-containing protein 8 (CARD8) have been associated with autoinflammatory and autoimmune diseases. On the other hand...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2019.00063

    authors: Smigoc Schweiger D,Goricar K,Hovnik T,Mendez A,Bratina N,Brecelj J,Vidan-Jeras B,Battelino T,Dolzan V

    更新日期:2019-03-12 00:00:00

  • Segmental Colitis Associated Diverticulosis-A Possible Diagnosis in Teenagers.

    abstract::Segmental colitis associated with diverticulosis (SCAD) is manifested by active chronic inflammation of the colonic segments affected by diverticulosis, luminal-mucosal inflammation, independent of the presence of inflammation within and/or around the diverticula, and it usually spares the rectum. We present the case ...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2018.00168

    authors: Mǎrginean CO,Meliţ LE,Mǎrginean MO

    更新日期:2018-06-05 00:00:00

  • Thrombin Generation in Preterm Newborns With Intestinal Failure-Associated Liver Disease.

    abstract::Background and Aim: Intestinal failure-associated liver disease (IFALD) affects one-fifth of neonates receiving parenteral nutrition (PN) for more than 2 weeks. We aimed to define the effect of IFALD on hemostasis of preterm infants. Methods: This is an ancillary analysis of a prospective study aimed at defining coagu...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00510

    authors: Ghirardello S,Raffaeli G,Scalambrino E,Cortesi V,Roggero P,Peyvandi F,Mosca F,Tripodi A

    更新日期:2020-08-26 00:00:00

  • Vitamin D-Resistant Rickets and Cinacalcet-One More Favorable Experience.

    abstract::Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder characterized by early onset of severe rickets, with a complete triad of clinical, biochemical and skeletal abnormalities. Homozygous or heterozygous mutations in the vitamin D receptor (VDR) gene leading to complete or partial target or...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2018.00376

    authors: Nicolescu RC,Lombet J,Cavalier E

    更新日期:2018-11-28 00:00:00

  • Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID).

    abstract::Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the in...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2019.00481

    authors: Haddad E,Hoenig M

    更新日期:2019-11-19 00:00:00

  • Utility of Soluble CD163 in the Clinical Management of Patients With Kawasaki Disease.

    abstract::Objective: Intravenous immunoglobulin (IVIG) therapy is a useful first-line treatment for Kawasaki disease (KD); however, 10-20% of patients fail to respond and require additional IVIG. Soluble CD163 (sCD163) is considered a biomarker for macrophage activation. There are no reports measuring serum sCD163 in KD patient...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00148

    authors: Azuma Y,Suzuki Y,Okada S,Matsuguma C,Wakiguchi H,Ohnishi Y,Furuta T,Miyake A,Yasudo H,Ichihara K,Ohga S,Hasegawa S

    更新日期:2020-04-07 00:00:00

  • New Therapeutics Options for Pediatric Neuromuscular Disorders.

    abstract::Neuromuscular disorders (NMDs) of Childhood onset are a genetically heterogeneous group of diseases affecting the anterior horn cell, the peripheral nerve, the neuromuscular junction, or the muscle. For many decades, treatment of NMDs has been exclusively symptomatic. But this has changed fundamentally in recent years...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2020.583877

    authors: Flotats-Bastardas M,Hahn A

    更新日期:2020-11-23 00:00:00

  • The Dark Side of Antibiotics: Adverse Effects on the Infant Immune Defense Against Infection.

    abstract::Although antibiotics confer significant health benefits in treating or preventing bacterial infections, an accumulating wealth of evidence illustrates their detrimental effect on host-microbiota homeostasis, posing a serious menace to the global public health. In recent years, it is becoming evident that infants, who ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2020.544460

    authors: Shekhar S,Petersen FC

    更新日期:2020-10-15 00:00:00

  • Beta Blocker Therapy for Congenital Hepatic Arteriovenous Fistula in Two Neonates.

    abstract::Introduction: Hepatic arteriovenous fistula (HAVF) is an abnormal communication between the hepatic arteries and hepatic veins. This condition is treated mainly using interventional closure and surgery. However, these procedures are associated with many postoperative complications and high mortality. Propranolol and o...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00163

    authors: Ba H,Xu L,Peng H,Lin Y,Li X,Qin Y,Wang H

    更新日期:2020-04-21 00:00:00

  • Late-Onset Ornithine Transcarbamylase Deficiency and Variable Phenotypes in Vietnamese Females With OTC Mutations.

    abstract::Background: Ornithine transcarbamylase deficiency (OTCD) is an X- linked recessive disorder and the most common error of the urea cycle, caused by the mutations in the OTC gene. Due to X-inactivation, 15-20% of female carriers present symptoms of OTCD at late onset. Early diagnosis of OTCD by molecular analysis in fem...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00321

    authors: Nguyen HH,Khanh Nguyen N,Dung Vu C,Thu Huong Nguyen T,Nguyen NL

    更新日期:2020-07-23 00:00:00

  • Counseling for Prenatal Congenital Heart Disease-Recommendations Based on Empirical Assessment of Counseling Success.

    abstract::Objectives: Empirical assessment of parental needs and affecting factors for counseling success after prenatal diagnosis of congenital heart disease (CHD). Methods:Counseling success after fetal diagnosis of CHD was assessed by a validated standardized questionnaire. The dependent variable "Effective Counseling" was m...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00026

    authors: Kovacevic A,Simmelbauer A,Starystach S,Elsässer M,Müller A,Bär S,Gorenflo M

    更新日期:2020-02-26 00:00:00

  • Surgical Management of Neurogenic Sphincter Incompetence in Children.

    abstract::We report on the results of a literature review regarding the indications and results of operations to increase bladder outlet resistance to achieve dryness in children with neurogenic sphincter incompetence (NSBD). The relative advantages and disadvantages of injection of bulking agents, periurethral slings, bladder ...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2019.00097

    authors: Ludwikowski BM,Bieda JC,Lingnau A,González R

    更新日期:2019-03-26 00:00:00

  • Exercise-Induced Laryngeal Obstruction: When Pediatric Exertional Dyspnea Does not Respond to Bronchodilators.

    abstract::Exertional dyspnea is a common complaint in general pediatric practice. While a high proportion of the general pediatric population has asthma, other diagnoses, including exercise-induced laryngeal obstruction should be considered, especially when asthma therapy is not sufficient to control symptoms. This review descr...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2019.00052

    authors: Olin JT

    更新日期:2019-03-01 00:00:00

  • Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis.

    abstract::Background: Mounting evidence suggests that childhood asthma is closely associated with maternal weight before pregnancy and gestational weight gain (GWG), yet the results are not often reproducible. Objectives: We conducted a comprehensive meta-analysis, aiming to evaluate the association of pre-pregnancy maternal ob...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00134

    authors: Liu S,Zhou B,Wang Y,Wang K,Zhang Z,Niu W

    更新日期:2020-04-03 00:00:00

  • Pulmonary Alveolar Proteinosis Due to Pneumocystis carinii in Type 1 Hyper-IgM Syndrome: A Case Report.

    abstract::Background: Pulmonary alveolar proteinosis (PAP) is a rare diffuse lung disease. Reports of rare cases of PAP due to Pneumocystis jirovecii (P. jirovecii) exist in infants with immunodeficiency diseases, but no cases have been reported to date in pediatric patients with type 1 hyper-IgM syndrome (HIGM1). Case Presenta...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00264

    authors: Zhang FZ,Yuan JX,Qin L,Tang LF

    更新日期:2020-06-11 00:00:00

  • High vs. Low Initial Oxygen to Improve the Breathing Effort of Preterm Infants at Birth: Study Protocol for a Randomized Controlled Trial.

    abstract::Background: Although most preterm infants breathe at birth, their respiratory drive is weak and supplemental oxygen is often needed to overcome hypoxia. This could in turn lead to hyperoxia. To reduce the risk of hyperoxia, currently an initial low oxygen concentration (21-30%) is recommended during stabilization at b...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2019.00179

    authors: Dekker J,Hooper SB,Giera M,McGillick EV,Hutten GJ,Onland W,van Kaam AH,Te Pas AB

    更新日期:2019-05-07 00:00:00

  • Ceftolozane/Tazobactam for Treating Children With Exacerbations of Cystic Fibrosis Due to Pseudomonas aeruginosa: A Review of Available Data.

    abstract::Ceftolozane-tazobactam is a novel fifth-generation cephalosporin/β-lactamase inhibitor combination recently approved for treatment of both complicated intra-abdominal and urinary tract infections in adults. Considering its potent bactericidal activity against Pseudomonas aeruginosa, it might represent an important opt...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2020.00173

    authors: Garazzino S,Altieri E,Silvestro E,Pruccoli G,Scolfaro C,Bignamini E

    更新日期:2020-05-05 00:00:00

  • Effects of Nasal Continuous Positive Airway Pressure and High-Flow Nasal Cannula on Sucking, Swallowing, and Breathing during Bottle-Feeding in Lambs.

    abstract::The use of prolonged respiratory support under the form of high-flow nasal cannula (HFNC) or nasal continuous positive airway pressure (nCPAP) is frequent in newborn infants. Introduction of oral feeding under such nasal respiratory support is, however, highly controversial among neonatologists, due to the fear that i...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2017.00296

    authors: Samson N,Nadeau C,Vincent L,Cantin D,Praud JP

    更新日期:2018-01-17 00:00:00

  • Management of COVID-19-Positive Pediatric Patients Undergoing Minimally Invasive Surgical Procedures: Systematic Review and Recommendations of the Board of European Society of Pediatric Endoscopic Surgeons.

    abstract::Introduction: Hospital response to the COVID-19 outbreak has involved the cancellation of elective, deferrable surgeries throughout Europe in order to ensure capacity for emergent surgery and a selection of elective but non-deferrable surgeries. The purpose of this document is to propose technical strategies to assist...

    journal_title:Frontiers in pediatrics

    pub_type:

    doi:10.3389/fped.2020.00259

    authors: Pini Prato A,Conforti A,Almstrom M,Van Gemert W,Scuderi MG,Khen-Dunlop N,Draghici I,Mendoza-Sagaon M,Giné Prades C,Chiarenza F,Steyaert H

    更新日期:2020-05-07 00:00:00

  • Association Between Environmental Health, Ecosystem Vitality, and Early Childhood Caries.

    abstract::Background: Environmental issues lead to serious health problems in young growing children. This study aims to determine the association between a country's level of environmental health, ecosystem vitality, and prevalence of early childhood caries (ECC). Methods: This was an ecological study. The data for the explana...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00196

    authors: Folayan MO,El Tantawi M,Schroth RJ,Kemoli AM,Gaffar B,Amalia R,Feldens CA,ECCAG.

    更新日期:2020-05-19 00:00:00

  • Human Endogenous Retroviruses Are Preferentially Expressed in Mononuclear Cells From Cord Blood Than From Maternal Blood and in the Fetal Part of Placenta.

    abstract::Background: Placenta shows high transcription levels of human endogenous retroviruses (HERVs) that are overexpressed during embryonic and fetal development. Methods: In order to gather further information on the degree of HERV activation in maternal and fetal tissues we assessed the transcription levels of pol genes o...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00244

    authors: Bergallo M,Marozio L,Botta G,Tancredi A,Daprà V,Galliano I,Montanari P,Coscia A,Benedetto C,Tovo PA

    更新日期:2020-05-14 00:00:00

  • Emerging Therapies for Childhood Polycystic Kidney Disease.

    abstract::Cystic kidney diseases comprise a varied collection of hereditary disorders, where renal cysts comprise a major element of their pleiotropic phenotype. In pediatric patients, the term polycystic kidney disease (PKD) commonly refers to two specific hereditary diseases, autosomal recessive polycystic kidney disease (ARP...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2017.00077

    authors: Sweeney WE Jr,Avner ED

    更新日期:2017-04-19 00:00:00

  • Quantitative Assessment of Parenchymal Involvement Using 3D Lung Model in Adolescent With Covid-19 Interstitial Pneumonia.

    abstract::Background: Amount of parenchymal involvement in patients with interstitial pneumonia Covid-19 related, seems to be associated with a worse prognosis. Nowadays 3D reconstruction imaging is expanding its role in clinical medical practice. We aimed to use 3D lung reconstruction of a young lady affected by Sars-CoV2 infe...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00453

    authors: Borro L,Ciliberti P,Santangelo TP,Magistrelli A,Campana A,Carducci FC,Caterina M,Tomà P,Secinaro A

    更新日期:2020-08-05 00:00:00

  • Pharyngomalacia in Neonates: The Missed Issue.

    abstract::Background: Airway malacia (AM) is a weakness of the airway's frameworks making them collapsible during the respiratory phases. Although the larynx, trachea, and bronchus are the usual sites for malacia to occur, there is another important type of malacia that involves the pharynx. Pharyngomalacia (PM) or concentric p...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.555564

    authors: Moslehi MA

    更新日期:2020-10-30 00:00:00

  • Pediatric Critical Care Medicine Training in India: Past, Present, and Future.

    abstract::Pediatric critical care services in India have grown with leaps and bounds. There has been a growing need of physicians specially trained in pediatric critical care medicine (PCCM) in India. Physicians returning to India after their formal training in PCCM abroad have partly supported this growing need. Development of...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章,评审

    doi:10.3389/fped.2018.00034

    authors: Bhalala U,Khilnani P

    更新日期:2018-02-26 00:00:00

  • Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Postnatal Risk Factors.

    abstract::Objective: To identify postnatal risk factors for bronchopulmonary dysplasia (BPD) development in preterm infants with gestational age ≤32 weeks. Methods: Seventy-two preterm infants(30 with BPD and 42 non-BPD controls) admitted in the neonatal intensive care unit (NICU) of the Children's Hospital of Soochow Universit...

    journal_title:Frontiers in pediatrics

    pub_type: 杂志文章

    doi:10.3389/fped.2020.00349

    authors: Ding L,Wang H,Geng H,Cui N,Huang F,Zhu X,Zhu X

    更新日期:2020-06-26 00:00:00