Abstract:
INTRODUCTION:It has been reported that post-hospitalisation behaviour change (PHBC) occurs in over 50% of children undergoing a general anaesthetic and manifests as behaviours such as sleep and eating disorders, defiance of authority, nightmares, enuresis and temper tantrums. The effect is usually short-lived (2-4 weeks); however, in 5-10% of children, these behaviours can last up to 12 months. The risk factors for developing PHBC include underlying anxiety in the child or parent, a previous bad hospital experience, emergence delirium and preschool age. A recent meta-analysis of alpha-2 agonists (including dexmedetomidine) found that they effectively reduce the incidence of emergence delirium but none of the studies looked at longer term outcomes, such as PHBC. METHODS AND ANALYSIS:Two-year-old to seven-year-old children requiring general anaesthesia for common day-case procedures will be randomly assigned to one of three groups: a dexmedetomidine pre medication group, an intraoperative dexmedetomidine group and a control group. Baseline anxiety levels of the parent will be recorded and the anxiety of the child during induction of anaesthesia will also be recorded using validated tools. The primary outcome will be negative behaviours after hospitalisation and these will be measured using the Post Hospitalisation Behaviour Questionnaire for Ambulatory Surgery and the Strengths and Difficulties Questionnaire. These questionnaires will be administered by a blinded researcher at days 3, 14 and 28 post surgery. ETHICS AND DISSEMINATION:Ethics approval has been granted by the Children's Health Queensland human research ethics committee (HREC/15/QRCH/248) and the University of Queensland human research ethics office (#2016001715). Any amendments to this protocol will be submitted to the ethics committees for approval. TRIAL REGISTRATION NUMBER:ANZCTR:12616000096459; Pre-results.
journal_name
BMJ Openjournal_title
BMJ openauthors
Lee-Archer P,McBride C,Paterson R,Reade M,Regli-von Ungern-Sternberg B,Long Ddoi
10.1136/bmjopen-2017-019915subject
Has Abstractpub_date
2018-04-17 00:00:00pages
e019915issue
4issn
2044-6055pii
bmjopen-2017-019915journal_volume
8pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVES:There has been increased interest in screening for atrial fibrillation (AF) with commissioned pilot schemes, ongoing large clinical trials and the emergence of inexpensive consumer single-lead ECG devices that can be used to detect AF. This qualitative study aimed to explore patients' views and understanding...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033061
更新日期:2020-03-18 00:00:00
abstract:INTRODUCTION:Sub-Saharan Africa remains the epicentre of the HIV pandemic, yet enormous knowledge gaps still exist to elicit a comprehensive portrait of multimorbidity and HIV linkage. This study aims to conduct a systematic meta-analysis of peer-reviewed literature to investigate the current status of multimorbidity e...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-036988
更新日期:2020-12-12 00:00:00
abstract:INTRODUCTION:Ageing--along with its associated physiological and pathological changes--places individuals at a higher risk of multimorbidity and treatment-related complications. Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the elderly in all popula...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010989
更新日期:2016-03-24 00:00:00
abstract::Objectives To develop and validate a scoring tool based on demographic and injecting risk behaviours to identify those who require additional, non-routine serological screening for hepatitis C virus (HCV) by assessing their personal risk. Design Cross-sectional and prospective cohorts. Setting People who inject drug...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000387
更新日期:2012-01-04 00:00:00
abstract:OBJECTIVE:To assess the psychometric properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire. METHODS:This study was a cross-sectional, multinational study. Participants were enrolled if they were more than 10 years old and people with haemophilia A or B or people without a bleeding ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-021900
更新日期:2018-08-08 00:00:00
abstract:INTRODUCTION:The transfer of patient care between the intensive care unit (ICU) and the hospital ward is associated with increased risk of medical error and adverse events. This study will describe patient transfer from ICU to hospital ward by documenting (1) patient, family and provider experiences related to ICU tran...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2015-007913
更新日期:2015-07-08 00:00:00
abstract:OBJECTIVES:To determine mental health outcomes for children with a history of child protection system involvement, accounting for pre-existing adversity, and to examine variation in risk across diagnostic groupings and child protection subgroups. DESIGN:A longitudinal, population-based record-linkage study. PARTICIPA...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029675
更新日期:2019-07-29 00:00:00
abstract:OBJECTIVE:To report outcomes of patients with localised prostate cancer (PCa) managed with active surveillance (AS) in a standard clinical setting. DESIGN:Single-centre, prospective, observational study. SETTING:Non-academic, average-size hospital in Switzerland. PARTICIPANTS:Prospective, observational study at a no...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010191
更新日期:2016-02-17 00:00:00
abstract:OBJECTIVES:To assess trends in prescribing practices of antidiabetic agents and glycaemic control in patients with type 2 diabetes mellitus (T2DM). DESIGN:Cross-sectional analysis using yearly clinical data and antidiabetic treatments prescribed obtained from an electronic population database. SETTING:Primary healthc...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012463
更新日期:2016-10-05 00:00:00
abstract:INTRODUCTION:Spinal and bulbar muscular atrophy (SBMA) is a slowly progressive neuromuscular disease. Cold exposure often leads to worsening of motor symptoms including paresis. Although mexiletine hydrochloride administration has been shown to be effective for the treatment of several muscular diseases, its effectiven...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2018-023041
更新日期:2018-09-11 00:00:00
abstract:OBJECTIVES:Most studies reporting evidence of adverse effects of lead and cadmium on the ability to balance have been conducted in high-exposure groups or have included adults. The effects of prenatal exposure have not been well studied, nor have the effects in children been directly studied. The aim of the study was t...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009635
更新日期:2015-12-30 00:00:00
abstract:OBJECTIVES:A Demographic and Health Platform was established in Magude in 2015, prior to the deployment of a project aiming to evaluate the feasibility of malaria elimination in southern Mozambique, named the Magude project. This platform aimed to inform the design, implementation and evaluation of the Magude project, ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033985
更新日期:2020-05-05 00:00:00
abstract:OBJECTIVES:The usefulness of university admission tests to medical schools has been discussed in recent years. In the academic year 2014-15 in Italy, several students who failed the admission test appealed to the regional administrative court ('Tribunale Amministrativo Regionale'-TAR) requesting to be included, despite...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-017417
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:We examined the utility of January 2004 to April 2014 Google Trends data from information searches for cancer screenings and preparations as a complement to population screening data, which are traditionally estimated through costly population-level surveys. SETTING:State-level data across the USA. PARTICI...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-006678
更新日期:2015-06-08 00:00:00
abstract:OBJECTIVES:Conduct a feasibility study on the effect of menstrual hygiene on schoolgirls' school and health (reproductive/sexual) outcomes. DESIGN:3-arm single-site open cluster randomised controlled pilot study. SETTING:30 primary schools in rural western Kenya, within a Health and Demographic Surveillance System. ...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-013229
更新日期:2016-11-23 00:00:00
abstract:OBJECTIVES:This article presents the findings from a scoping review which explored the nature of interprofessional online learning in primary healthcare. The review was informed by the following questions: What is the nature of evidence on online postgraduate education for primary healthcare interprofessional teams? Wh...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2017-016872
更新日期:2017-08-04 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyse the rate of knee arthroplasty in the population of patients with a history of arthroscopic chondroplasty of the knee, in England, over 10 years, with comparison to general population data for patients without a history of chondroplasty. DESIGN:Retrospective cohort stu...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030609
更新日期:2020-04-16 00:00:00
abstract:OBJECTIVES:Ambient temperature has been reported to play a role in the occurrence of spontaneous intracerebral haemorrhage (ICH). This study aimed to investigate the relation between ambient temperature of onset time and ICH and the effect of hourly temperature within 72 h before ICH. DESIGN:This is a cross-sectional ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-000842
更新日期:2012-06-08 00:00:00
abstract:INTRODUCTION:Reducing length of hospital stay for stroke survivors often creates a shift in the responsibility of care towards informal carers. Adjustment to the caregiving process is experienced by many carers as overwhelming, complex and demanding and can have a detrimental impact on mental and physical health and we...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2017-018309
更新日期:2017-10-22 00:00:00
abstract:OBJECTIVE:This study aims to explore barriers to controlling gestational weight gain in pregnant Chinese women. DESIGN:Data were collected through semistructured interviews with pregnant women experiencing excessive gestational weight gain who struggled with weight management, and the data were examined using an inter...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038585
更新日期:2020-12-10 00:00:00
abstract:OBJECTIVES:To estimate the prevalence of and associations between anxiety, depression, post-traumatic stress disorder (PTSD), low subjective well-being (SWB), potential traumas and postmigration stress among refugees from Syria resettled in Sweden. DESIGN:A cross-sectional and population-based questionnaire study base...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018899
更新日期:2017-12-29 00:00:00
abstract:OBJECTIVES:To examine (1) the effect of new dock-less bicycle-sharing programmes on change in travel mode and (2) the correlates of change in travel mode. DESIGN:A retrospective natural experimental study. SETTING:12 neighbourhoods in Shanghai. PARTICIPANTS:1265 respondents were recruited for a retrospective study i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024280
更新日期:2019-02-19 00:00:00
abstract:OBJECTIVE:To identify the risk areas of deaths due to unspecified pneumonia and tuberculosis (TB) in children, and to identify if there is a relationship between these events with higher TB incidence and social determinants. METHODS:Ecological study carried out in Brazil. All cases of TB or unspecified pneumonia death...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034074
更新日期:2020-08-20 00:00:00
abstract:PURPOSE:Occupational and environmental exposures remain important modifiable risk factors of public health. Existing cohort studies are often limited by the level of detail of data collected on these factors and health. It is also often assumed that the more healthy group is over-represented in cohort studies, which is...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005858
更新日期:2014-11-26 00:00:00
abstract:OBJECTIVES:This study examines the use of expedited approval pathways by Health Canada over the period 1995 to 2016 inclusive and the relationship between the use of these pathways and the therapeutic gain offered by new products. DESIGN:Cross-sectional study. DATA SOURCES:Therapeutic Products Directorate, Biologics ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023605
更新日期:2018-08-30 00:00:00
abstract:OBJECTIVE:Most literature on length of stay (LOS) for childbirth focuses on 'early' discharge as opposed to 'optimal' time of discharge and has conflicting results due to heterogeneous definitions of 'early' discharge and differing eligibility criteria for these programmes. We aimed to determine the LOS associated with...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012007
更新日期:2016-09-14 00:00:00
abstract:OBJECTIVES:Pharmacoepidemiological studies are an important hypothesis-testing tool in the evaluation of postmarketing drug safety. Despite the potential to produce robust value-added data, interpretation of findings can be hindered due to well-recognised methodological limitations of these studies. Therefore, assessme...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001362
更新日期:2012-09-25 00:00:00
abstract:INTRODUCTION:Tobacco smoking is one of the leading causes of preventable death. This is not inevitable as tobacco control tools have become more powerful and more effective. Among these, warnings on cigarette packs have proven to be somewhat effective. Our objective is to increase the efficacy of antismoking warnings b...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036166
更新日期:2020-06-28 00:00:00
abstract:OBJECTIVES:To identify rates of potentially preventable complications for dementia patients compared with non-dementia patients. DESIGN:Retrospective cohort design using hospital discharge data for dementia patients, case matched on sex, age, comorbidity and surgical status on a 1 : 4 ratio to non-dementia patients. ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002770
更新日期:2013-06-20 00:00:00
abstract:INTRODUCTION:The rising popularity of social media, since their inception around 20 years ago, has been echoed in the growth of health-related research using data derived from them. This has created a demand for literature reviews to synthesise this emerging evidence base and inform future activities. Existing reviews ...
journal_title:BMJ open
pub_type: 杂志文章,评审
doi:10.1136/bmjopen-2018-022931
更新日期:2018-12-14 00:00:00