Abstract:
:Using a test-negative design, we assessed interim vaccine effectiveness (VE) for the 2017/18 epidemic of co-circulating influenza A(H3N2) and B(Yamagata) viruses. Adjusted VE for influenza A(H3N2), driven by a predominant subgroup of clade 3C.2a viruses with T131K + R142K + R261Q substitutions, was low at 17% (95% confidence interval (CI): -14 to 40). Adjusted VE for influenza B was higher at 55% (95% CI: 38 to 68) despite prominent use of trivalent vaccine containing lineage-mismatched influenza B(Victoria) antigen, suggesting cross-lineage protection.
journal_name
Euro Surveilljournal_title
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletinauthors
Skowronski DM,Chambers C,De Serres G,Dickinson JA,Winter AL,Hickman R,Chan T,Jassem AN,Drews SJ,Charest H,Gubbay JB,Bastien N,Li Y,Krajden Mdoi
10.2807/1560-7917.ES.2018.23.5.18-00035subject
Has Abstractpub_date
2018-02-01 00:00:00issue
5eissn
1025-496Xissn
1560-7917journal_volume
23pub_type
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