Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018.

Abstract:

:Using a test-negative design, we assessed interim vaccine effectiveness (VE) for the 2017/18 epidemic of co-circulating influenza A(H3N2) and B(Yamagata) viruses. Adjusted VE for influenza A(H3N2), driven by a predominant subgroup of clade 3C.2a viruses with T131K + R142K + R261Q substitutions, was low at 17% (95% confidence interval (CI): -14 to 40). Adjusted VE for influenza B was higher at 55% (95% CI: 38 to 68) despite prominent use of trivalent vaccine containing lineage-mismatched influenza B(Victoria) antigen, suggesting cross-lineage protection.

journal_name

Euro Surveill

authors

Skowronski DM,Chambers C,De Serres G,Dickinson JA,Winter AL,Hickman R,Chan T,Jassem AN,Drews SJ,Charest H,Gubbay JB,Bastien N,Li Y,Krajden M

doi

10.2807/1560-7917.ES.2018.23.5.18-00035

subject

Has Abstract

pub_date

2018-02-01 00:00:00

issue

5

eissn

1025-496X

issn

1560-7917

journal_volume

23

pub_type

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