Profiles of responses of immunological factors to different subtypes of Kawasaki disease.

Abstract:

BACKGROUND:The responses of immunological factors to different subtypes of Kawasaki disease (KD) remain poorly understood. METHODS:We recruited 388 patients with KD, 160 patients with infectious febrile disease and 85 normal children who served as control subjects. Both the levels and percentages of T lymphocyte subsets, natural killer cells (NK cells) and B cells were analyzed via flow cytometry. The levels of serum IgG, IgM, IgA and C3, C4 were assessed via velocity scatter turbidimetry. RESULTS:The most significant differences noted between the patients with infectious febrile disease and the normal children were the elevated levels of B cells, C3 and the ratio of CD4/CD8, and the decreased levels of CD8+ T cells and NK cells, as well as the moderate increase in the absolute value of the CD3+ cells. The decreased T cell levels and the elevated B cell levels were helpful in distinguishing typical KD from atypical KD; the elevated T cell levels, the elevated NK cell and B cell levels and the decreased B cell levels were helpful in predicting the effectiveness of IVIG; low C3 and C4 levels were linked with prodromal infections. CONCLUSIONS:Lymphocytes subsets and complement markers may be useful in differentiating among the different subtypes of KD and in helping clinicians understand the pathophysiology of KD.

authors

Ding Y,Li G,Xiong LJ,Yin W,Liu J,Liu F,Wang RG,Xia K,Zhang SL,Zhao L

doi

10.1186/s12891-015-0744-6

subject

Has Abstract

pub_date

2015-10-23 00:00:00

pages

315

issn

1471-2474

pii

10.1186/s12891-015-0744-6

journal_volume

16

pub_type

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