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Higher risk of incident hepatitis C virus among young women who inject drugs compared with young men in association with sexual relationships: a prospective analysis from the UFO Study cohort.

Abstract：

BACKGROUND:Female injection drug users (IDUs) may report differences in injection behaviours that put them at greater risk for hepatitis C virus (HCV). Few studies have examined these in association with HCV incidence. METHODS:Longitudinal data from a cohort of 417 HCV-uninfected IDU aged 30 or younger were analysed. Cox proportional hazards was used to model female sex as a predictor of new HCV infection. General estimating equation (GEE) analysis was used to model female sex as a predictor of HCV-associated risk behaviour prospectively. RESULTS:Women were significantly more likely than men to become infected with HCV during study follow-up (HR 1.4, p<0.05), and were also more likely than men to report high-risk injecting behaviours, especially in the context of sexual and injecting relationships. Sex differences in injecting behaviours appeared to explain the relationship between sex and HCV infection. CONCLUSIONS:Young women's riskier injection practices lead to their higher rates of HCV infection. Further study on the impact of intimate partnership on women's risk behaviour is warranted.

journal_name

BMJ Open

journal_title

BMJ open

authors

Tracy D,Hahn JA,Fuller Lewis C,Evans J,Briceño A,Morris MD,Lum PJ,Page K

doi

10.1136/bmjopen-2014-004988

subject

Has Abstract

pub_date

2014-05-29 00:00:00

pages

e004988

issue

5

issn

2044-6055

pii

bmjopen-2014-004988

journal_volume

4

pub_type

杂志文章

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