Abstract:
:We took advantage of the ability of human telomeres to silence neighboring genes (telomere position effect or TPE) to design a high-throughput screening assay for drugs altering telomeres. We identified, for the first time, that two dietary flavones, acacetin and chrysin, are able to specifically alleviate TPE in human cells. We further investigated their influence on telomere integrity and showed that both drugs drastically deprotect telomeres against DNA damage response. However, telomere deprotection triggered by shelterin dysfunction does not affect TPE, indicating that acacetin and chrysin target several functions of telomeres. These results show that TPE-based screening assays represent valuable methods to discover new compounds targeting telomeres.Molecular Therapy-Nucleic Acids (2013) 2, e116; doi:10.1038/mtna.2013.42; published online 20 August 2013.
journal_name
Mol Ther Nucleic Acidsjournal_title
Molecular therapy. Nucleic acidsauthors
Boussouar A,Barette C,Nadon R,Saint-Léger A,Broucqsault N,Ottaviani A,Firozhoussen A,Lu Y,Lafanechère L,Gilson E,Magdinier F,Ye Jdoi
10.1038/mtna.2013.42subject
Has Abstractpub_date
2013-08-20 00:00:00pages
e116issn
2162-2531pii
mtna201342journal_volume
2pub_type
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
doi:10.1016/j.omtn.2019.12.032
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
doi:10.1016/j.omtn.2018.07.014
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
doi:10.1016/j.omtn.2020.01.004
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章,评审
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
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journal_title:Molecular therapy. Nucleic acids
pub_type: 杂志文章,评审
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journal_title:Molecular therapy. Nucleic acids
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