Abstract:
BACKGROUND:To investigate whether or not coadministration of tacrolimus (TAC) with prednisolone (PSL) can produce a beneficial effect in the treatment of polymyositis/ dermatomyositis (PM/DM). METHODS:We reviewed medical records of 32 PM/DM patients who had been admitted to our hospital, and abstracted those who had received TAC in addition to oral PSL for treatment. The clinical usefulness of TAC in PM/DM was objectively evaluated focusing upon the manual muscle strength test (MMT) score, serum creatine kinase (CK) and tapering of PSL. RESULTS:Nine patients with PM and 6 with DM were enrolled in this study. TAC was added because of difficulty in reduction of PSL in 12 patients and recurrence with corticosteroid-induced complications in the remaining 3. Both PM and DM patients showed significant increases in the MMT score and significant decreases in serum CK 1 to 3 months after starting TAC compared with before. Skin symptoms in a clinically amyopathic DM patient also improved 1 month after starting TAC. The daily dosage of PSL could be significantly reduced in both PM and DM after starting TAC compared with before. No serious adverse events ascribable to TAC occurred in any patients. CONCLUSION:Additional use of TAC with PSL may safely promote improvement of PM/DM and also accelerate tapering of the latter.
journal_name
BMC Musculoskelet Disordjournal_title
BMC musculoskeletal disordersauthors
Shimojima Y,Ishii W,Matsuda M,Tazawa K,Ikeda Sdoi
10.1186/1471-2474-13-228subject
Has Abstractpub_date
2012-11-22 00:00:00pages
228issn
1471-2474pii
1471-2474-13-228journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Musculoskeletal infections remain a major complication in orthopedic surgery. The local delivery of antibiotics provides the high levels required to treat an infection without systemic toxicity. However, the local toxicity of antibiotic carriers to the mesenchymal stem cells, as a result of both the peak con...
journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
doi:10.1186/s12891-017-1737-4
更新日期:2017-09-02 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:BMC musculoskeletal disorders
pub_type: 杂志文章
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更新日期:2019-07-31 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-10 00:00:00
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pub_type: 杂志文章
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