Cancer-associated fibroblast-derived CCL5 contributes to cisplatin resistance in A549 NSCLC cells partially through upregulation of lncRNA HOTAIR expression.

abstract：:Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive and malignant tumor that predominantly affects young males. No standard therapy is currently available for patients with DSRCT and the prognosis remains extremely poor. In this study, we report a thought-provoking DSRCT case. A 24-year-old male was admi...

journal_title：Oncology letters

authors： Watanabe T,Miyamoto S,Kitagori K,Horimatsu T,Morita S,Mashimo Y,Ezoe Y,Muto M,Chiba T

更新日期：2012-01-01 00:00:00

abstract：:Irinotecan hydrochloride (CPT-11) is reported to be involved in the downregulation of thymidylate synthase (TS), a target molecule of 5-fluorouracil (5-FU) and oral fluoropyrimidine S-1. Therefore, we hypothesized that a preceding administration of CPT-11 against S-1-resistant tumors may recover sensitivity to S-1. To...

journal_title：Oncology letters

authors： Takahata T,Itoh J,Satoh T,Ishiguro A,Matsumoto Y,Tanaka S,Saitoh S,Tohno H,Fukuda S,Saijo Y,Sakata Y

更新日期：2012-01-01 00:00:00

abstract：:Breast cancer is one of the most common types of cancer in women and is highly treatable by radiotherapy. However, repeated exposure to radiation results in tumor cell resistance. Understanding the molecular mechanisms involved in the response of tumors to γ-irradiation is important for improving radiotherapy. For thi...

journal_title：Oncology letters

authors： Jung S,Lee S,Lee J,Li C,Ohk JY,Jeong HK,Lee S,Kim S,Choi Y,Kim S,Lee H,Lee MS

更新日期：2012-01-01 00:00:00

abstract：:The purpose of the present study was to overcome resistance to imatinib (IM) by combining it with roscovitine (ROSC) and to investigate whether or not midkine (MK) had an effect on this combination in the treatment of glioblastoma (GBL). Human T98 GBL cells were used to evaluate the effects of IM (10 μM), ROSC (200 μM...

journal_title：Oncology letters

authors： Erguven M,Bilir A,Yazihan N,Korkmaz S,Aktas E,Ovalioglu C,Dundar T,Seyithanoglu H

更新日期：2012-01-01 00:00:00

abstract：:The prognosis of advanced hepatocellular carcinoma (HCC) remains poor, particularly for patients with portal vein tumor thrombosis. Chemotherapy is one of the most significant treatment options for patients with advanced HCC not indicated for hepatic resection, percutaneous ablation and transcatheter arterial chemoemb...

journal_title：Oncology letters

authors： Ueda H,Fukuchi H,Tanaka C

更新日期：2012-02-01 00:00:00

abstract：:Keratinocyte growth factor (KGF), also known as fibroblast growth factor-7, is mainly synthesized by mesenchymal cells. KGF modulates proliferation, differentiation, migration and adhesion to extracellular matrices of epithelial cells that specifically express the KGF receptor (KGFR). We previously reported that KGF i...

journal_title：Oncology letters

authors： Yamamoto T,Matsuda Y,Kawahara K,Naito Z,Ishiwata T

更新日期：2012-02-01 00:00:00

abstract：:In this report, we describe a case control study in a Chinese population aimed at identifying possible associations between susceptibility to cervical cancer and single nucleotide polymorphisms in XRCC1 194C>T, XRCC1 280G>A, XRCC1 399G>A, ERCC2 751A>C, ERCC2 156C>A, ERCC1 118C>T, PARP1 762T>C, RAD51 135G>C and HER2 65...

journal_title：Oncology letters

authors： Zhang L,Ruan Z,Hong Q,Gong X,Hu Z,Huang Y,Xu A

更新日期：2012-02-01 00:00:00

abstract：:S-1, an oral fluoropyrimidine derivative, has been approved for the treatment of non-small cell lung cancer (NSCLC) in Japan. In the present study, the efficacy and safety of S-1 monotherapy for elderly patients with previously treated NSCLC were retrospectively evaluated, and the efficacy of S-1 monotherapy was compa...

journal_title：Oncology letters

authors： Tomita Y,Oguri T,Takakuwa O,Nakao M,Kunii E,Uemura T,Ozasa H,Miyazaki M,Maeno K,Sato S

更新日期：2012-02-01 00:00:00

abstract：:The incidence of thyroid cancer has been on the increase in a number of countries, and certain genetic factors associated with the increased incidence of the papillary thyroid cancer (PTC) have been identified. However, little is known about the effect of mutations of the cystic fibrosis transmembrane conductance regu...

journal_title：Oncology letters

authors： Oh IH,Oh C,Yoon TY,Choi JM,Kim SK,Park HJ,Eun YG,Chung DH,Kwon KH,Choe BK

更新日期：2012-02-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent forms of cancer affecting males worldwide, and knowledge of the immune defenses involved in PCa remains incomplete. Since the identification of immunity-related genes may have enormous implications for the understanding of PCa immunology, we recently reported the iden...

journal_title：Oncology letters

authors： Shaikhibrahim Z,Lindstrot A,Buettner R,Wernert N

更新日期：2012-03-01 00:00:00

abstract：:Epidural plasmacytoma is a rare clinical entity of plasma cell neoplasms. The optimal management of extra medullary plasmacytoma remains unclear, particularly for bulky masses. In this study, we report the case of a 35-year-old male who presented with the inability to walk, urinary incontinence and superficial and dee...

journal_title：Oncology letters

authors： Zeng Z,Zheng L,Lin J,Chen J

更新日期：2012-03-01 00:00:00

abstract：:Natural killer (NK) cell cytotoxicity is an effective defense against metastatic tumor cells or viruses in the blood. However, NK cytotoxicity against tumor cells may be inhibited by a fibrinogen coat adhered to the surface of tumor cells. Ganoderma lucidum (G. lucidum) polysaccharides have been reported for their inh...

journal_title：Oncology letters

authors： Zheng S,Jia Y,Zhao J,Wei Q,Liu Y

更新日期：2012-03-01 00:00:00

abstract：:In the present study, the case of a 34-year-old Chinese female who underwent in vitro fertilization resulting in a twin pregnancy was reported. Following in vitro fertilization, the patient was found to have a partial hydatidiform mole (PHM) with a co-existing twin by transvaginal sonography (TVS). At 16 weeks, the pr...

journal_title：Oncology letters

authors： Zhou X,Chen Y,Li Y,Duan Z

更新日期：2012-03-01 00:00:00

abstract：:Tumor epidermal growth factor receptor (EGFR) mutation analysis is significant for making treatment decisions for metastatic pulmonary adenocarcinoma. However, less than half of patients have adequate tumor samples for mutation analysis. Patients with adenocarcinoma of the lungs who were due to receive erlotinib treat...

journal_title：Oncology letters

authors： Chen YM,Fan WC,Tseng PC,Tsai CM,Chou TY,Wu CH,Chou KT,Lee YC,Perng RP,Whang-Peng J

更新日期：2012-03-01 00:00:00

abstract：:The use of computed tomography (CT) with regards to the clinical staging of patients with asymptomatic breast cancer has been on the increase in clinical practice. However, the benefits of routine CT have yet to be fully clarified. This study investigated the value of employing contrast-enhanced CT (CECT) to screen fo...

journal_title：Oncology letters

authors： Tanaka S,Sato N,Fujioka H,Takahashi Y,Kimura K,Iwamoto M,Uchiyama K

更新日期：2012-04-01 00:00:00

abstract：:Limited data suggest that extracapsular lymph node involvement (LNI) has a negative prognostic impact in gastrointestinal malignancies. The aim of this study was to assess the prevalence and prognostic impact of LNI in patients with primary resected rectal cancer. Between 1997 and 2007, 243 rectal cancer patients unde...

journal_title：Oncology letters

authors： Brabender J,Bollschweiler E,Hölscher AH,Strobel K,Gutschow C,Prenzel K,Grimminger P,Drebber U,Schröder W,Metzger R,Vallböhmer D

更新日期：2012-04-01 00:00:00

abstract：:Although docetaxel-based chemotherapy is therapeutically efficacious, drug resistance often leads to treatment failure in castration-resistant prostate cancer patients. The Notch signaling pathway plays a key role in prostate development and prostate cancer. We investigated whether silencing Notch-1 has therapeutic po...

journal_title：Oncology letters

authors： Ye QF,Zhang YC,Peng XQ,Long Z,Ming YZ,He LY

更新日期：2012-04-01 00:00:00

abstract：:The estrogen receptor α (ERα)-mediated pathway plays a critical role in breast cancer development and progression. KiSS1 was previously described as a metastasis suppressor gene in certain carcinomas. However, the role of KiSS1/GPR54 in breast cancer remains controversial. Whether the function of the KiSS1/GPR54 syste...

journal_title：Oncology letters

authors： Jarząbek K,Kozłowski L,Milewski R,Wołczyński S

更新日期：2012-04-01 00:00:00

abstract：:In the present study, we described a rare association of polycystic liver disease (PCLD) with intracranial meningiomas in patients included on a liver transplant list, focusing on the diagnosis, treatment and possible association with any genetic alterations. Two female patients, aged 39 and 49 years were included on ...

journal_title：Oncology letters

authors： Neto AB,Zanini MA,DA Silva AP,Winckler C,Dos Santos RM,Furtado ML

更新日期：2012-05-01 00:00:00

abstract：:Carcinomas comprise cohesive epithelial cells linked to one another by E-cadherin-based cell-cell junctions. Epithelial mesenchymal transition (EMT) enables carcinoma cells to migrate from the original tissue and invade into stromal components. The E-cadherin promoter is frequently repressed by specific transcriptiona...

journal_title：Oncology letters

authors： Tomizawa Y,Wu TT,Wang KK

更新日期：2012-05-01 00:00:00

abstract：:The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis, and consists of Aurora B kinase, INCENP, Survivin and Borealin. Aurora B is a member of a family of serine/threonine protein kinases, and Survivin belongs to the inhibitors of apoptosis (IAP) gene family, and is also ...

journal_title：Oncology letters

authors： Tuncel H,Shimamoto F,Kaneko Guangying Qi H,Aoki E,Jikihara H,Nakai S,Takata T,Tatsuka M

更新日期：2012-05-01 00:00:00

abstract：:Multiple myeloma (MM) is the second most commonly diagnosed hematologic malignancy. Although new drugs, including bortezomib and lenalidomide, have improved the treatment landscape for MM patients, MM remains incurable. Therefore, screening for novel anti-myeloma drugs is necessary. Gambogic acid (GA), the main active...

journal_title：Oncology letters

authors： Yang LJ,Chen Y,He J,Yi S,Wen L,Zhao S,Cui GH

更新日期：2012-05-01 00:00:00

abstract：:The expression profiles of genes normally enriched in embryonic stem (ES) cells (stemness factors) are associated with poor clinical outcome in solid tumors. However, whether such gene expression is responsible for tumor initiation and progression remains to be determined. The tumor suppressor gene p53 is known to att...

journal_title：Oncology letters

authors： Yamamoto K,Ishii H,Moon JH,Haraguchi N,Doki Y,Mori M

更新日期：2012-06-01 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) has been reported to transactivate the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2), which are frequently overexpressed in numerous types of cancer and are known to be significant regulators of angiogenesis. Few studies have investi...

journal_title：Oncology letters

authors： Li X,Ji Z,Ma Y,Qiu X,Fan Q,Ma B

更新日期：2012-06-01 00:00:00

abstract：:In this study, we examined the efficacy and toxicity of S-1 with cisplatin as a second-line palliative chemotherapy for gemcitabine-refractory pancreatic cancer patients. Patients who had been previously treated with gemcitabine-based chemotherapy as palliative first-line chemotherapy received S-1/cisplatin [body surf...

journal_title：Oncology letters

authors： Kim HJ,Yun J,Kim HJ,Kim KH,Kim SH,Lee TH,Lee SC,Bae SB,Kim CK,Lee NS,Moon JH,Park SH,Lee KT,Park SK,Won JH,Park HS,Hong DS

更新日期：2012-06-01 00:00:00

abstract：:Abdominal pain with an associated pelvic mass is a common problem in everyday practice. Concerns about ectopic pregnancy, torsion of an enlarged ovary or malignancy usually dominate the diagnostic evaluation. On physical and imaging examination, when a palpable painful mass is present in the pelvis and the two ovaries...

journal_title：Oncology letters

authors： Imai A,Ichigo S,Takagi H,Matsunami K,Watanabe S,Murase T,Ikeda T

更新日期：2012-07-01 00:00:00

abstract：:Malignant granular cell tumors (MGCT) are rare mesenchymal soft tissue neoplasms of Schwann cell origin without adequate follow-up. This study describes a case of MGCT with right breast metastasis following two local recurrences. The patient consented to a right breast lumpectomy with right axillary dissection, a righ...

journal_title：Oncology letters

authors： Chen J,Wang L,Xu J,Pan T,Shen J,Hu W,Yuan X

更新日期：2012-07-01 00:00:00

abstract：:Aberrant cell cycle control and apoptosis deregulation are involved in biliary carcinogenesis. The tumor suppressor gene p53 and its key negative regulator murine double minute 2 (mdm2) cooperate in modulating these basic cell functions and germline p53 alteration promotes cholangiocarcinoma (CCA) formation in animal ...

journal_title：Oncology letters

authors： Zimmer V,Höblinger A,Mihalache F,Assmann G,Acalovschi M,Lammert F

更新日期：2012-07-01 00:00:00

abstract：:Vitamin K2 (VK2) exerts cell growth inhibitory effects in various human cancer cells such as SMMC-7721 hepatocellular carcinoma (HCC) cells. BCL-2 is an antiapoptotic protein that is frequently overexpressed in numerous tumors. Modulation of multiple antiapoptotic signaling pathways involving BCL-2, which are related ...

journal_title：Oncology letters

authors： Yao Y,Li L,Zhang H,Jia R,Liu B,Zhao X,Zhang L,Qian G,Fan X,Ge S

更新日期：2012-07-01 00:00:00

abstract：:Recent studies have demonstrated the existence of a minority of tumor cells possessing the stem cell properties of self-renewal and differentiation in leukemia and several solid tumors. However, these cells do not possess the normal regulatory mechanisms of stem cells. Following transplantation, they are capable of in...

journal_title：Oncology letters

authors： Meng M,Zhao XH,Ning Q,Hou L,Xin GH,Liu LF

更新日期：2012-08-01 00:00:00