Immunotherapy for HPV Malignancies.

abstract：:The most common cause of morbidity and mortality in the United States is vascular disease, which afflicts a wide spectrum of organs such as the heart (cardiovascular system), brain (cerebrovascular system), kidney (renal system), liver (hepatic system), and extremities (peripheral vascular system). The most common pat...

journal_title：Seminars in radiation oncology

authors： Tripuraneni P,Giap H,Jani S

更新日期：1999-04-01 00:00:00

abstract：:Intensity-modulated radiation therapy (IMRT) is a term applied to a new technology that uses nonuniform radiation beams to achieve conformal dose distributions. This article reviews the use of a commercial system, the Peacock system, which uses a special multileaf collimator (MIMiC) to deliver the dose distribution us...

journal_title：Seminars in radiation oncology

authors： Grant W 3rd,Woo SY

更新日期：1999-01-01 00:00:00

abstract：:The beneficial effects of chemotherapy in patients with advanced head and neck cancer remain controversial in terms of survival, but have shown some promise in improving locoregional control and quality of life. In an effort to improve locoregional control and survival, a prospective phase II study was initiated using...

journal_title：Seminars in radiation oncology

authors： Chougule PB,Akhtar MS,Akerley W,Ready N,Safran H,McRae R,Nigri P,Bellino J,Koness J,Radie-Keane K,Wanebo H

更新日期：1999-04-01 00:00:00

abstract：:Paclitaxel enhances microtubule assembly and causes a cell cycle arrest in mitosis, the most radiosensitive phase. We conducted this study to improve our understanding of paclitaxel effects in vivo and to determine the maximum tolerated dose of paclitaxel preceding endobronchial radiation therapy (brachytherapy). The ...

journal_title：Seminars in radiation oncology

authors： Lee JS,Komaki R,Morice RC,Ro JY,Kalapurakal SK,Schea R,Murphy WK,Shin DM,Fox NT,Walsh GL,Hittelman WN,Hong WK

更新日期：1999-04-01 00:00:00

abstract：:The rationale for postmastectomy radiation is based on the prevention of locoregional recurrence in the chest wall, regional lymphatics, or both. The randomized trials of postmastectomy radiation in patients with one to three positive nodes receiving adjuvant chemotherapy have shown a proportional reduction in locoreg...

journal_title：Seminars in radiation oncology

authors： Fowble B

更新日期：1999-07-01 00:00:00

abstract：:The role of adjuvant chemotherapy in the treatment of patients with soft-tissue sarcomas remains controversial. The initial observation that extremity tumors might benefit more than tumors of other primary sites prompted careful review of published data. Eight of 9 studies showed improved disease-free and overall surv...

journal_title：Seminars in radiation oncology

authors： Benjamin RS

更新日期：1999-10-01 00:00:00

abstract：:The indications and results of postradical prostatectomy adjuvant pelvic radiation therapy (6,000 to 6,500 cGy) are reviewed. In patients with positive with positive surgical margins, 80% to 100% local tumor control has been reported; in 42 patients treated at our institution, the 5-year actuarial tumor control rate w...

journal_title：Seminars in radiation oncology

authors： Perez CA,Eisbruch A

更新日期：1993-07-01 00:00:00

abstract：:Today's imaging and computer technology has made significant advances in brachytherapy optimization and evaluation possible. Optimization may be of source strength or of source position (or both). An objective function of achieved versus desired doses is minimized, a global minimum being associated with an analytic so...

journal_title：Seminars in radiation oncology

authors： Anderson LL

更新日期：1993-10-01 00:00:00

abstract：:Staging technology and the 1983 international staging system for esophageal cancer have changed. The 1988 system is based on depth of wall penetration and regional lymph node involvement; it abandons the previous criteria of tumor length and degree of obstruction. The clinical reasoning behind this change is reviewed....

journal_title：Seminars in radiation oncology

authors： Jaklitsch MT,Harpole DH Jr,Healey EA,Sugarbaker DJ

更新日期：1994-07-01 00:00:00

abstract：:Locally advanced breast cancer patients are a heterogeneous group with a wide range of prognoses. They require a multimodality approach to the treatment of their illness with the interdigitation of surgery, chemotherapy, and radiation therapy. Systemic, chemotherapy has gained widespread acceptance for the treatment o...

journal_title：Seminars in radiation oncology

authors： Berg CD,Swain SM

更新日期：1994-10-01 00:00:00

abstract：:The need to include simple laboratory indices and performance status evaluation in treatment decision making has been shown by multivariate analyses. The conventional limited-stage extensive-stage division of prognostic groups no longer provides sufficient information. Indeed, some patients in the limited-stage group ...

journal_title：Seminars in radiation oncology

authors： Thatcher N,Anderson H,Burt P,Stout R

更新日期：1995-01-01 00:00:00

abstract：:Computer-controlled treatment machines and the delivery of conformal radiotherapy treatments using computer-controlled and/or automated delivery techniques have become an important new area of clinical and research activity in recent years. The historical experience with simple multileaf collimators and control system...

journal_title：Seminars in radiation oncology

authors： Fraass BA,McShan DL,Kessler ML

更新日期：1995-04-01 00:00:00

abstract：:The biophysical aspects of stereotaxic treatment are summarized, emphasizing the complex interplay between time-dose-fractionation, partial volume effect, physical dose distribution, and set-up uncertainties in influencing treatment outcome. The radiobiological advantage of dose-fractionation for normal tissue sparing...

journal_title：Seminars in radiation oncology

authors： Ling CC,Lo YC,Larson DA

更新日期：1995-07-01 00:00:00

abstract：:Diffuse large-cell and immunoblastic lymphoma (DLCL), considered together, are the most common histologic subtypes of non-Hodgkin's lymphoma (NHL). There will be approximately 15,500 new cases of DLCL in 1995 and this represents a dramatic increase over the last 20 years. The cause of KLCL is unknown, but its associat...

journal_title：Seminars in radiation oncology

authors： Shafman TD,Mauch PM

更新日期：1995-10-01 00:00:00

abstract：:The importance of tumor microenvironmental in malignant progression has been largely ignored. Tumor cells protect themselves from changes in the microenvironment due to a decrease in nutrients and oxygen by reducing macromolecular synthesis and inducing genes that will promote angiogenesis and tissue remodeling. This ...

journal_title：Seminars in radiation oncology

authors： Giaccia AJ

更新日期：1996-01-01 00:00:00

abstract：:A electronic text-based medical record system used in a radiation oncology department since 1990 is described. The database is composed of a group of subfiles linked with a powerful relational database. The clinically relevant subfile structures are described and the hardware and software requirements for the system a...

journal_title：Seminars in radiation oncology

authors： Sailer SL,Tepper JE,Margolese-Malin L,Rosenman JG,Chaney EL

更新日期：1997-01-01 00:00:00

abstract：:The starting Point for quality assessment for the Patterns of Care Study is to establish by consensus the current management guidelines for each site. This article presents decision trees, recommended treatment systems, and brief summaries of the guidelines developed for cancer of the esophagus, rectum, anus, breast, ...

journal_title：Seminars in radiation oncology

authors：

更新日期：1997-04-01 00:00:00

abstract：:Although radiation alone is the treatment of choice for patients with cervical cancer that is not surgically respectable, locoregional failures rates approach 50% for locally advanced stages of disease. Therefore, decades of clinical trials using chemoradiotherapy have been performed in an attempt to enhance cure rate...

journal_title：Seminars in radiation oncology

authors： Petereit DG,Kinsella TJ

更新日期：1997-10-01 00:00:00

abstract：:The key to effective use of the medical internal radiation dose (MIRD) schema in radioimmunotherapy (RIT) is to understand how it works and what the essential data input requirements are. The fundamental data are acquired from medical imaging. Image interpretation involves (1) collecting data to determine the source-o...

journal_title：Seminars in radiation oncology

authors： Fisher DR

更新日期：2000-04-01 00:00:00

abstract：:There are increasing requests for delivering a second course of radiation to patients who develop second primary tumors within or close to previous radiotherapy portal or late in-field recurrences. Rational treatment decisions demand rather precise knowledge on long-term recovery of occult radiation injury in various ...

journal_title：Seminars in radiation oncology

authors： Nieder C,Milas L,Ang KK

更新日期：2000-07-01 00:00:00

abstract：:Patients who receive radiation therapy for non-small cell lung cancer (NSCLC) will require accurate targeting of the grossly involved primary and nodal disease. However, the treatment of grossly uninvolved elective nodal sites that may harbor microscopic occult disease is controversial. In simple terms, physicians are...

journal_title：Seminars in radiation oncology

authors： Liengswangwong V,Bonner JA

更新日期：2000-10-01 00:00:00

abstract：:Imaging of gene expression is increasingly essential for cancer diagnosis, prediction of tumor response to various available therapies, and for monitoring response to therapy, whether it is gene or nongene therapy. Most of the work on developing techniques and methodologies for imaging gene expression has been perform...

journal_title：Seminars in radiation oncology

authors： Sullivan DC,Hoffman JM

更新日期：2001-01-01 00:00:00

abstract：:Histologic subtypes of low-grade gliomas include pilocytic astrocytomas (World Health Organization [WHO] grade I), diffuse infiltrating astrocytomas, oligodendrogliomas, and mixed oligo-astrocytomas (WHO grade II). Although extended survival is typical with these tumors, most patients eventually succumb to recurrent o...

journal_title：Seminars in radiation oncology

authors： Lesser GJ

更新日期：2001-04-01 00:00:00

abstract：:The use of three-dimensional radiotherapy (RT) and the prospective follow-up of patients for radiation-induced liver disease (RILD) have led to a more quantitative understanding of the partial organ tolerance of the liver compared with previous estimates based on clinical judgment alone. Parameters of both the Lyman n...

journal_title：Seminars in radiation oncology

authors： Dawson LA,Ten Haken RK,Lawrence TS

更新日期：2001-07-01 00:00:00

abstract：:Brachytherapy plays a significant role in the management of endometrial cancer. In the adjuvant setting, based on pathologic risk factors, intravaginal brachytherapy alone, external radiation therapy alone, or a combination of the two is recommended. For patients who are medically inoperable, brachytherapy with or wit...

journal_title：Seminars in radiation oncology

authors： Chadha M

更新日期：2002-01-01 00:00:00

abstract：:Radiation pneumonitis is a distinct clinical entity that differs from other pulmonary symptoms such as allergic pneumonitis, chemical pneumonitis, or pneumonia by various infectious agents. Recent research has supported the mechanism of cellular interaction between lung parenchymal cells and circulating immune cells m...

journal_title：Seminars in radiation oncology

authors： Chen Y,Williams J,Ding I,Hernady E,Liu W,Smudzin T,Finkelstein JN,Rubin P,Okunieff P

更新日期：2002-01-01 00:00:00

abstract：:Rectal adenocarcinoma almost invariably requires extirpative surgery to be cured. Although radiation therapy and concurrent chemotherapy often will elicit dramatic responses, the treatment morbidity limits the tolerable dose of radiation to about 45 to 50 Gy. Strategies to reduce procto/enteritis may permit higher dos...

journal_title：Seminars in radiation oncology

authors： Myerson R

更新日期：2002-01-01 00:00:00

abstract：:Intensity-modulated radiotherapy (IMRT) offers technical advantages over conventional external beam radiotherapy (CXRT) that might prove clinically advantageous in the management of gynecologic malignancies. Especially in the case of locally advanced cervical cancer, IMRT provides an opportunity to improve the therape...

journal_title：Seminars in radiation oncology

authors： Kavanagh BD,Schefter TE,Wu Q,Tong S,Newman F,Arnfield M,Benedict SH,McCourt S,Mohan R

更新日期：2002-07-01 00:00:00

abstract：:Approximately two thirds of all human solid tumors derive from epithelial tissues. The epidermal growth factor receptor (EGFR) serves as an important regulator of cellular growth in epithelial tumors. A spectrum of new anticancer agents have been specifically designed to target the EGFR in an effort to inhibit maligna...

journal_title：Seminars in radiation oncology

authors： Harari PM,Huang SM

更新日期：2002-07-01 00:00:00

abstract：:The clinical application of molecular markers in the diagnosis, staging, and management of breast cancer continues to expand. Although the use of molecular markers in local-regional disease does not approach the level of their application in the systemic management of breast cancer, a growing body of rature supports t...

journal_title：Seminars in radiation oncology

authors： Haffty BG

更新日期：2002-10-01 00:00:00