Abstract:
:The ongoing pandemic of coronavirus disease 2019 (COVID-19) posed a major challenge to the public health. Currently, no proven antiviral treatment for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is available. Here we report compounds pentalysine β-carbonylphthalocyanine zinc (ZnPc5K) and chlorin e6 (ce6) potently inhibited the viral infection and replication in vitro with EC50 values at nanomolar level. These compounds were first identified by screening a panel of photosensitizers for photodynamic viral inactivation. Such viral inactivation strategy is implementable, and has unique advantages, including resistance to virus mutations, affordability compared to the monoclonal antibodies, and lack of long-term toxicity.
journal_name
Dyes Pigmjournal_title
Dyes and pigments : an international journalauthors
Yu S,Sun G,Sui Y,Li H,Mai Y,Wang G,Zhang N,Bi Y,Gao GF,Xu P,Jiang L,Yuan C,Yang Y,Huang Mdoi
10.1016/j.dyepig.2021.109570keywords:
["COVID-19","Photodynamic","Photosensitizer","SARS-CoV-2 inactivation"]subject
Has Abstractpub_date
2021-10-01 00:00:00pages
109570eissn
0143-7208issn
1873-3743pii
S0143-7208(21)00436-8journal_volume
194pub_type
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journal_title:Dyes and pigments : an international journal
pub_type: 杂志文章
doi:10.1016/j.dyepig.2021.109629
更新日期:2021-10-01 00:00:00