The effect of a new direct Factor Xa inhibitor on human osteoblasts: an in-vitro study comparing the effect of rivaroxaban with enoxaparin.

Abstract:

BACKGROUND:Current treatments for the prevention of thromboembolism include heparin and low-molecular weight heparins (LMWHs). A number of studies have suggested that long term administration of these drugs may adversely affect osteoblasts and therefore, bone metabolism. Xarelto™ (Rivaroxaban) is a new anti-thrombotic drug for the prevention of venous thromboembolism in adult patients undergoing elective hip and knee replacement surgery. The aim of this in vitro study was to investigate the possible effects of rivaroxaban on osteoblast viability, function and gene expression compared to enoxaparin, a commonly used LMWH. METHODS:Primary human osteoblast cultures were treated with varying concentrations of rivaroxaban (0.013, 0.13, 1.3 and 13 μg/ml) or enoxaparin (1, 10 and 100 μg/ml). The effect of each drug on osteoblast function was evaluated by measuring alkaline phosphatase activity. The MTS assay was used to assess the effect of drug treatments on cell proliferation. Changes in osteocalcin, Runx2 and BMP-2 messenger RNA (mRNA) expression following drug treatments were measured by real-time polymerase chain reaction (PCR). RESULTS:Rivaroxaban and enoxaparin treatment did not adversely affect osteoblast viability. However, both drugs caused a significant reduction in osteoblast function, as measured by alkaline phosphatase activity. This reduction in osteoblast function was associated with a reduction in the mRNA expression of the bone marker, osteocalcin, the transcription factor, Runx2, and the osteogenic factor, BMP-2. CONCLUSIONS:These data show that rivaroxaban treatment may negatively affect bone through a reduction in osteoblast function.

authors

Solayar GN,Walsh PM,Mulhall KJ

doi

10.1186/1471-2474-12-247

subject

Has Abstract

pub_date

2011-10-28 00:00:00

pages

247

issn

1471-2474

pii

1471-2474-12-247

journal_volume

12

pub_type

杂志文章
  • Measuring the morphological characteristics of thoracolumbar fascia in ultrasound images: an inter-rater reliability study.

    abstract:BACKGROUND:Chronic lower back pain is still regarded as a poorly understood multifactorial condition. Recently, the thoracolumbar fascia complex has been found to be a contributing factor. Ultrasound imaging has shown that people with chronic lower back pain demonstrate both a significant decrease in shear strain, and ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-018-2088-5

    authors: De Coninck K,Hambly K,Dickinson JW,Passfield L

    更新日期:2018-06-01 00:00:00

  • Reliability of four tests to assess body posture and the range of selected movements in individuals with spinal muscular atrophy.

    abstract:BACKGROUND:The majority of individuals with spinal muscular atrophy (SMA) experience progressive skeletal deformities which may affect the quality of life and mobility. To date, no studies have evaluated the reliability of tests assessing body posture and joint mobility in SMA patients. The purpose of this study was to...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-018-2389-8

    authors: Stępień A,Jędrzejowska M,Guzek K,Rekowski W,Stępowska J

    更新日期:2019-02-07 00:00:00

  • Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: part II - cervical spine musculature.

    abstract:BACKGROUND:It has been suggested that the quantification of paravertebral muscle composition and morphology (e.g. size/shape/structure) with magnetic resonance imaging (MRI) has diagnostic, prognostic, and therapeutic potential in contributing to overall musculoskeletal health. If this is to be realised, then consensus...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-018-2074-y

    authors: Elliott JM,Cornwall J,Kennedy E,Abbott R,Crawford RJ

    更新日期:2018-05-28 00:00:00

  • A single-nucleotide polymorphism rs708567 in the IL-17RC gene is associated with a susceptibility to and the curve severity of adolescent idiopathic scoliosis in a Chinese Han population: a case-control study.

    abstract:BACKGROUND:Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains controversial, genetic factors are thought to play key roles in the development of AIS. In a recent genome-wide association study, a polymorphism in the interleukin-17 receptor C (IL-17RC) gene was reported to be associated with the s...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-13-181

    authors: Zhou S,Qiu XS,Zhu ZZ,Wu WF,Liu Z,Qiu Y

    更新日期:2012-09-21 00:00:00

  • The effect of continuous ultrasound on chronic non-specific low back pain: a single blind placebo-controlled randomized trial.

    abstract:BACKGROUND:Non-specific chronic low back pain (NSCLBP) is one of the most common musculoskeletal disorders around the world including Iran. One of the most widely used modalities in the field of physiotherapy is therapeutic ultrasound (US). Despite its common use, there is still inconclusive evidence to support its eff...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2474-13-192

    authors: Ebadi S,Ansari NN,Naghdi S,Jalaei S,Sadat M,Bagheri H,Vantulder MW,Henschke N,Fallah E

    更新日期:2012-10-02 00:00:00

  • Hyaluronic acid affects the in vitro induction effects of synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration.

    abstract:BACKGROUND:It has been a common belief that articular cartilage tissue cannot regenerate in vivo. Recently, however, we have found that spontaneous hyaline cartilage regeneration can be induced in vivo by implanting a synthetic double-network (DN) hydrogel, which is composed of poly-(2-acrylamido-2-methylpropanesulfoni...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-14-56

    authors: Yoshikawa K,Kitamura N,Kurokawa T,Gong JP,Nohara Y,Yasuda K

    更新日期:2013-02-05 00:00:00

  • Development and validation of a health belief model based instrument for measuring factors influencing exercise behaviors to prevent osteoporosis in pre-menopausal women (HOPE).

    abstract:BACKGROUND:The health belief model (HBM) is the most commonly used conceptual framework for evaluating osteoporosis health belief and behaviors. The purpose of this study was to develop and evaluate the psychometric properties of a health belief model based questionnaire for exercise behavior for preventing osteoporosi...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-15-61

    authors: Soleymanian A,Niknami S,Hajizadeh E,Shojaeizadeh D,Montazeri A

    更新日期:2014-03-01 00:00:00

  • The tenocyte phenotype of human primary tendon cells in vitro is reduced by glucocorticoids.

    abstract:BACKGROUND:The use of corticosteroids (e.g., dexamethasone) as treatment for tendinopathy has recently been questioned as higher risks for ruptures have been observed clinically. In vitro studies have reported that dexamethasone exposed tendon cells, tenocytes, show reduced cell viability and collagen production. Littl...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-016-1328-9

    authors: Spang C,Chen J,Backman LJ

    更新日期:2016-11-10 00:00:00

  • Local pamidronate influences fracture healing in a rodent femur fracture model: an experimental study.

    abstract:BACKGROUND:Bisphosphonates are a main component in the therapy of osteoporosis and other bone resorptive diseases. Previous studies have shown a positive effect of systemically applied bisphosphonates on fracture healing. Nevertheless high doses are related to side effects like osteonecrosis of the jaw, nephrotoxis and...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-016-1113-9

    authors: Menzdorf L,Weuster M,Klüter T,Brüggemann S,Behrendt P,Fitchen-Oestern S,Varoga D,Seekamp A,Purcz N,Glueer CC,Pufe T,Lippross S

    更新日期:2016-06-09 00:00:00

  • The associations between indices of patellofemoral geometry and knee pain and patella cartilage volume: a cross-sectional study.

    abstract:BACKGROUND:Whilst patellofemoral pain is one of the most common musculoskeletal disorders presenting to orthopaedic clinics, sports clinics, and general practices, factors contributing to its development in the absence of a defined arthropathy, such as osteoarthritis (OA), are unclear.The aim of this cross-sectional st...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-11-87

    authors: Tanamas SK,Teichtahl AJ,Wluka AE,Wang Y,Davies-Tuck M,Urquhart DM,Jones G,Cicuttini FM

    更新日期:2010-05-10 00:00:00

  • CT-based analysis of muscle volume and degeneration of gluteus medius in patients with unilateral hip osteoarthritis.

    abstract:BACKGROUND:The gluteus medius (GMED) affects hip function as an abductor. We evaluated muscle volume and degeneration of the GMED by using CT-based analysis and assessed factors that affect hip abductor strength in patients with unilateral hip osteoarthritis (OA). METHODS:We examined clinical and imaging findings asso...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-017-1828-2

    authors: Momose T,Inaba Y,Choe H,Kobayashi N,Tezuka T,Saito T

    更新日期:2017-11-15 00:00:00

  • Segmentation of the lateral femoral notch sign with MRI using a new measurement technique.

    abstract:BACKGROUND:The goal of this present study was to precisely determine the dimension and location of the impaction fracture on the lateral femoral condyle in patients with an ACL rupture. METHODS:All patients with post-injury bi-plane radiographs and MRI images after sustaining a tear to the anterior cruciate ligament w...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-015-0677-0

    authors: Hoffelner T,Pichler I,Moroder P,Osti M,Hudelmaier M,Wirth W,Resch H,Auffarth A

    更新日期:2015-08-21 00:00:00

  • Prognosis of patients with whiplash-associated disorders consulting physiotherapy: development of a predictive model for recovery.

    abstract:BACKGROUND:Patients with whiplash-associated disorders (WAD) have a generally favourable prognosis, yet some develop longstanding pain and disability. Predicting who will recover from WAD shortly after a traffic collision is very challenging for health care providers such as physical therapists. Therefore, we aimed to ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-13-264

    authors: Bohman T,Côté P,Boyle E,Cassidy JD,Carroll LJ,Skillgate E

    更新日期:2012-12-29 00:00:00

  • Effects of plasma magnesium and prolactin on quantitative ultrasound measurements of heel bone among schizophrenic patients.

    abstract:BACKGROUND:Osteoporosis is a bone disease that can reduce both bone mass and bone strength. It can cause serious fractures of bones, along with causing significant and even devastating physical, psychological and financial consequences for patients and their family members. Many reports have revealed that the prevalenc...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-11-35

    authors: Renn JH,Yang NP,Chou P

    更新日期:2010-02-17 00:00:00

  • Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women.

    abstract:BACKGROUND:Osteoporosis, a disease characterized by low bone mineral density (BMD), is an important health problem in Mexico. BMD is a highly heritable trait, with heritability estimates of 50-85%. Several candidate genes have been evaluated to identify those involved in BMD variation and the etiology of osteoporosis. ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-15-400

    authors: Velázquez-Cruz R,Jiménez-Ortega RF,Parra-Torres AY,Castillejos-López M,Patiño N,Quiterio M,Villarreal-Molina T,Salmerón J

    更新日期:2014-11-28 00:00:00

  • Work-life conflict and musculoskeletal disorders: a cross-sectional study of an unexplored association.

    abstract:BACKGROUND:The health consequences of work-family or rather work-life conflict (WLC) have been studied by numerous researchers. The work-related causes of musculoskeletal disorders (MSD) are also well explored. And stress (at work) has been found to be a consequence of WLC as well as a cause of MSD. But very little is ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-12-60

    authors: Hämmig O,Knecht M,Läubli T,Bauer GF

    更新日期:2011-03-16 00:00:00

  • A novel method for measurement of the occipital-cervical distance via the occiput-C4 distance.

    abstract:BACKGROUND:The aim of the present study was to describe and measure the occipital-cervical distance by a novel method utilizing the occiput-C4 distance (OC4D) in normal subjects, as a proposed tool to guide restoration of vertical dislocations of the occipitocervical region in patients with basilar invaginations and fo...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-03398-9

    authors: Tang C,Yang S,Liao YH,Tang Q,Ma F,Wang Q,Zhong J

    更新日期:2020-06-15 00:00:00

  • Detecting functional change in response to exercise in knee osteoarthritis: a comparison of two computerized adaptive tests.

    abstract:BACKGROUND:The intent of this study was to examine and compare the ability to detect change of two patient reported outcome (PRO) instruments that use a computerized adaptive test (CAT) approach to measurement. The Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function scale is a generic P...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12891-018-1942-9

    authors: Chang FH,Jette AM,Slavin MD,Baker K,Ni P,Keysor JJ

    更新日期:2018-01-23 00:00:00

  • The results of meniscal allograft transplantation surgery: what is success?

    abstract:BACKGROUND:Meniscal allograft transplantation (MAT) may improve symptoms and function, and may limit premature knee degeneration in patients with symptomatic meniscal loss. The aim of this retrospective study was to examine patient outcomes after MAT and to explore the different potential definitions of 'success' and '...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-3165-0

    authors: Searle H,Asopa V,Coleman S,McDermott I

    更新日期:2020-03-12 00:00:00

  • Three-dimensional printing of patient-specific plates for the treatment of acetabular fractures involving quadrilateral plate disruption.

    abstract:BACKGROUND:Complicated acetabular fractures comprise the most challenging field for orthopedists. The purpose of this study was to develop three-dimensional printed patient-specific (3DPPS) Ti-6Al-4 V plates to treat complicated acetabular fractures involving quadrilateral plate (QLP) disruption and to evaluate their e...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-03370-7

    authors: Wang C,Chen Y,Wang L,Wang D,Gu C,Lin X,Liu H,Chen J,Wen X,Liu Y,Huang F,Yao L,Fan S,Huang W,Dong J

    更新日期:2020-07-10 00:00:00

  • Mid- and long-term clinical results of surgical therapy in unicameral bone cysts.

    abstract:BACKGROUND:Unicameral (or simple) bone cysts (UBC) are benign tumours most often located in long bones of children and adolescents. Pathological fractures are common, and due to high recurrence rates, these lesions remain a challenge to treat. Numerous surgical procedures have been proposed, but there is no general con...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-12-281

    authors: Hagmann S,Eichhorn F,Moradi B,Gotterbarm T,Dreher T,Lehner B,Zeifang F

    更新日期:2011-12-13 00:00:00

  • Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes.

    abstract:BACKGROUND:Oxidative stress (OxS) has recently been linked with osteoporosis; however, we do not know the influence of OxS as an independent risk factor for this disease. METHODS:We conducted a case-control study in 94 subjects > or =60 years of age, 50 healthy and 44 with osteoporosis. We measured total antioxidant s...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-8-124

    authors: Sánchez-Rodríguez MA,Ruiz-Ramos M,Correa-Muñoz E,Mendoza-Núñez VM

    更新日期:2007-12-19 00:00:00

  • Patients' experiences of living with and receiving treatment for fibromyalgia syndrome: a qualitative study.

    abstract:BACKGROUND:Fibromyalgia syndrome (FMS) presents a challenge for patients and health care staff across many medical specialities. The aetiology is multi-dimensional, involving somatic, psychological and social factors. Patients' views were obtained to understand their experience of living with this long-term condition, ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-10-124

    authors: Lempp HK,Hatch SL,Carville SF,Choy EH

    更新日期:2009-10-07 00:00:00

  • Development and validation of a Spanish translation of the Yale activity questionnaire.

    abstract:BACKGROUND:Valid measures of physical activity are critical research tools. The objective of this study was to develop a Spanish translation of the Yale Physical Activity Survey, and to provide preliminary evidence of its validity in a population of Dominican patients with lower extremity arthritis. METHODS:A Dominica...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-15-120

    authors: Katz JN,Perez MT,Niu NN,Dong Y,Brownlee SA,Elman SA,Stenquist DS,Santiago A,Sanchez ES,Collins JE

    更新日期:2014-04-07 00:00:00

  • Innervation of nociceptors in intact human menisci along the longitudinal axis: semi-quantitative histological evaluation and clinical implications.

    abstract:BACKGROUND:The mechanism of pain after meniscus injury remains unknown. After injury, some individuals suffered from acute pain, while others suffer from delayed pain. A precise nociceptor distribution pattern may provide the answer to this question. METHODS:Twenty-two intact menisci (paired medial and lateral menisci...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-019-2706-x

    authors: Lin Y,Zhang K,Li Q,Li J,Xu B

    更新日期:2019-07-22 00:00:00

  • GLA:D® Back group-based patient education integrated with exercises to support self-management of back pain - development, theories and scientific evidence.

    abstract:BACKGROUND:Clinical guidelines recommend that people with back pain be given information and education about their back pain, advice to remain active and at work, and exercises to improve mobility and physical activity. Guidelines, however, rarely describe how this is best delivered. The aim of this paper is to present...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-018-2334-x

    authors: Kjaer P,Kongsted A,Ris I,Abbott A,Rasmussen CDN,Roos EM,Skou ST,Andersen TE,Hartvigsen J

    更新日期:2018-11-29 00:00:00

  • Delayed union of femoral fractures in older rats:decreased gene expression.

    abstract:BACKGROUND:Fracture healing slows with age. While 6-week-old rats regain normal bone biomechanics at 4 weeks after fracture, one-year-old rats require more than 26 weeks. The possible role of altered mRNA gene expression in this delayed union was studied. Closed mid-shaft femoral fractures were induced followed by euth...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-2-2

    authors: Meyer RA,Meyer MH,Phieffer LS,Banks DM

    更新日期:2001-01-01 00:00:00

  • Timing for closed reduction procedure for developmental dysplasia of the hip and its failure analysis.

    abstract:BACKGROUND:It remains controversial whether the older age to perform closed reduction (CR) procedure for developmental dysplasia of the hip (DDH), the higher incidence of complications. The aim of this study is to evaluate the midterm outcome of CR for DDH among different age groups, and to analyze and identify risk fa...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-020-03635-1

    authors: Zhang Z,Li H,Li H,Zhang Z

    更新日期:2020-09-14 00:00:00

  • Characterization of a novel polyvinyl alcohol/chitosan porous hydrogel combined with bone marrow mesenchymal stem cells and its application in articular cartilage repair.

    abstract:BACKGROUND:Different substances are combined to compensate for each other's drawbacks and create an appropriate biomaterial. A novel Polyvinyl alcohol (PVA)/chitosan (CS) porous hydrogel was designed and applied to the treatment of osteochondral defects. METHODS:Hydrogels of various PVA/CS ratios were tested for physi...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/s12891-019-2644-7

    authors: Peng L,Zhou Y,Lu W,Zhu W,Li Y,Chen K,Zhang G,Xu J,Deng Z,Wang D

    更新日期:2019-05-29 00:00:00

  • Use of imaging biomarkers to assess perfusion and glucose metabolism in the skeletal muscle of dystrophic mice.

    abstract:BACKGROUND:Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cytoskeletal protein, dystrophin, from the glycoprotein membrane complex, thus increasing the suscepti...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2474-12-127

    authors: Ahmad N,Welch I,Grange R,Hadway J,Dhanvantari S,Hill D,Lee TY,Hoffman LM

    更新日期:2011-06-04 00:00:00