Abstract:
OBJECTIVE:To compare clinical and microbiological responses following non-surgical treatment of moderate to advanced adult periodontitis using subgingival scaling with and without adjunctive topical or systemic metronidazole. DESIGN:A single blind randomised clinical trial of 90 subjects, stratified for periodontitis disease severity and smoking status, divided into three treatment groups: 1. Subgingival scaling using ultrasonic scalers and local anaesthesia; 2. Subgingival scaling using ultrasonic scalers and local anaesthesia plus seven days of systemic metronidazole (200 mg tds); 3. Subgingival scaling using ultrasonic scalers and local anaesthesia plus two applications of 25% metronidazole gel one week apart in all sites with probing depths more than 4 mm. Evaluations were made before treatment, and 8 weeks and 24 weeks post treatment. MAIN OUTCOME MEASURES:Probing depths, probing attachment levels and bleeding on probing were measured using a Florida probe. Bacterial morphotypes were evaluated with darkfield microscopy. Results were analysed for all sites with baseline probing depths equal to or greater than Florida probe recordings of 4.6 mm using analysis of variance. RESULTS:84 subjects completed the trial and the three treatment groups did not differ at baseline for any clinical parameter. Mean probing depths were reduced following treatment by greater than 1.6 mm (Group 1 = 1.68 mm, Group 2 = 1.62 mm, Group 3 = 1.74 mm at six months post treatment) but no significant differences were detected between treatment groups at any time point. Similarly, no significant differences were detectable between treatments for changes in mean probing attachment levels, bleeding on probing, plaque scores or proportions of bacterial morphotypes. CONCLUSIONS:This study does not support the routine use of adjunctive metronidazole in the non-surgical treatment of periodontitis.
journal_name
Br Dent Jjournal_title
British dental journalauthors
Palmer RM,Matthews JP,Wilson RFdoi
10.1038/sj.bdj.4809695subject
Has Abstractpub_date
1998-06-13 00:00:00pages
548-52issue
11eissn
0007-0610issn
1476-5373journal_volume
184pub_type
临床试验,杂志文章,随机对照试验abstract:AIM:To determine if restrictive NHS contracts are of benefit in addressing health inequalities in oral health, by using an ecological approach based upon an area measure of material deprivation. METHODS:Postcodes of patients seen under all the restrictive contracts (49) within the North East of England were identified...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2009.857
更新日期:2009-10-24 00:00:00
abstract::To determine the pattern of antibiotic prescribing (source and type) for acute dental conditions in the emergency setting, a prospective cross-sectional study was undertaken of 500 consecutive new patients attending the examination and emergency clinic of the Cardiff Dental Hospital in May 1994. The source and type of...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809276
更新日期:1996-12-07 00:00:00
abstract::This paper describes the psychiatric disorders seen in 138 consecutive attenders at a psychiatric clinic in a dental hospital. The disorders were rated using a standardised interview, and assigned a diagnosis in accordance with a multiaxial classification known as the DSM-III. The rate of psychiatric disorder seen in ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4806683
更新日期:1989-01-07 00:00:00
abstract::A case of a white patch on the right lateral border of the tongue, found to be hyperkeratosis induced by long-term habitual placement of nicotine replacement lozenges (NiQuitin CQ) in the right lingual sulcus, is presented. The lesion became less evident once the patient varied the intraoral location and reduced his c...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.833
更新日期:2007-09-22 00:00:00
abstract::We report a case of Wegener's granulomatosis (WG), localised to the upper aerodigestive tract, which presented as an unusual form of hyperplastic gingivitis in a 36-year-old female. The clinical, serological and histopathological findings are described. The resemblance of the affected gums to over-ripe strawberries is...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808316
更新日期:1993-11-06 00:00:00
abstract::In the eighteenth century, a pedestrian strolling around Georgian London may have witnessed the bizarre sight of an ageing gentleman parading the streets on a painted horse and brandishing the jawbone of an ass. Not only was this man an eccentric, he was also a dentist. David Watkins here relates the remarkable story ...
journal_title:British dental journal
pub_type: 传,历史文章,杂志文章
doi:10.1038/sj.bdj.4807021
更新日期:1989-11-11 00:00:00
abstract::Introduction and context This paper describes how research and evidence influenced Welsh Government policy to fund a programme (Gwên am Byth - A Lasting Smile) with the aim of improving the oral health of older people living in care homes. It describes how collaborative multi-agency working supported development and d...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-020-2400-2
更新日期:2020-12-01 00:00:00
abstract::The dental treatment needs of 8- and 9-year-old children registered with a GDP for at least 6 months were compared with the dental treatment needs of children from a similar social background who were neither registered nor regularly attending the Community Dental Service. The children were examined by one of the auth...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808630
更新日期:1994-12-10 00:00:00
abstract::Treatment of the cavity with silver diamine fluoride before placement of glass ionomer cement containing CPP-ACP enhances anticariogenic effect in vitro. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.580
更新日期:2017-07-07 00:00:00
abstract::Objectives The objectives of the prospective study were to establish the prevalence of distal caries (DC) in the mandibular second molar and to assess the outcomes of these diseased teeth in our population. Further aims were to identify associated risk factors and to design a protocol for prevention.Methods Clinical a...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2016.677
更新日期:2016-09-23 00:00:00
abstract::Techniques of linear regression and correlation analysis are discussed and illustrated by means of dentally-related examples. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4806811
更新日期:1989-04-22 00:00:00
abstract:OBJECTIVE:To analyse the factors affecting the clinical performance and those influencing the survival of resin-retained bridgework provided at a UK dental teaching hospital between 1994 and 2001. DESIGN:A prospective analysis of restorations provided at a single centre using case notes with all patients invited for r...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2015.250
更新日期:2015-04-10 00:00:00
abstract::Having listened to, examined, tested, diagnosed and recommended a course of action to the patient, treatment will usually follow at the same or subsequent visits. In the vast majority of cases, the foregoing will have proceeded without a hitch, and the treatment completed to the satisfaction of both the practitioner a...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4806759
更新日期:1989-03-11 00:00:00
abstract:OBJECTIVES:To determine the range and frequency of diagnoses in specimens submitted for histopathological examination by general dental practitioners (GDPs). METHODS:A retrospective analysis was carried out of all cases submitted by GDPs for the period 1974-2003, using a Foxpro Windows database. The data were collated...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4813464
更新日期:2006-04-22 00:00:00
abstract::This section of the series introduces the topic of WWW search engines and directory sites; showing you how to find information using a search engine and a directory. It also covers other ways of searching for information on the internet. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809825
更新日期:1998-10-24 00:00:00
abstract::Discrepancies of the incisal edges of the anterior teeth, particularly in the upper jaw, could adversely affect dental aesthetics. This paper presents an easy and straight forward treatment of such a case, which was accomplished taking the patient's demands and profession into consideration. In dentistry, the social s...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4811801
更新日期:2004-11-13 00:00:00
abstract::A case of extreme distal migration of the left maxillary canine is reported. The canine had erupted buccal to the contact area between the left second premolar and first molar. Past reports of similar ectopia are reviewed. ...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.4807091
更新日期:1990-01-20 00:00:00
abstract::There are various motivators that prompt people to study dentistry but there is evidence that the salience of each varies according to gender and black and minority ethnic (BME) group. Given the current focus on inequality within the science, technology, engineering, medicine and mathematics (STEMM) academic disciplin...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.22
更新日期:2017-01-13 00:00:00
abstract::There are certain advantages to restoring a complete arch simultaneously, however, attempting to do this requires that the dentist maintains control during all stages of treatment. Maintaining control alleviates the preassure of time, which in turn allows for precision to be obtained at all clinical and laboratory sta...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2008.3
更新日期:2008-01-26 00:00:00
abstract::A fifth mandibular incisor is a eumorphic supernumerary tooth and has rarely been described in the medical literature. We report here a large Lebanese consanguineous family where four individuals displayed five incisors in the anterior mandible. Such familial observation has not been previously described. The possibil...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4811648
更新日期:2004-09-25 00:00:00
abstract::Widely varying prevalence rates of oral lesions in patients with Crohn's disease have been reported, ranging from 0.5% to 37%. These manifestations may coincide with or precede intestinal symptoms. Oral manifestations can be classified as specific lesions, when macroscopic examination shows similar changes to those ob...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2016.954
更新日期:2016-12-16 00:00:00
abstract::Potential proteolytic and hydrolytic enzymes of inflammatory cell origin might serve as biomarkers of periodontal disease activity. The role of these enzymes in periodontal pathology, particularly in respect of collagen and proteoglycan degradation, is discussed. The cellular location of these enzymes and their normal...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.4809599
更新日期:1998-03-28 00:00:00
abstract:OBJECTIVE:To provide information relevant to the current and predicted future profile of the UK's specialist workforce in paediatric dentistry. DESIGN:Postal questionnaire. SUBJECTS:Two hundred and twenty-one registered dentists whose names appeared on the Specialist List in Paediatric Dentistry and who were identifi...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2010.499
更新日期:2010-06-01 00:00:00
abstract::The principal aim of this study was to assess the feasibility of conducting a systematic examination of the oral mucosa, as an integral part of the routine dental check-up and in conditions comparable with those in NHS dental practice. A total of 1949 individuals, who were already registered as patients with an indust...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808894
更新日期:1995-10-07 00:00:00
abstract::Safeguarding children from maltreatment and neglect is part of the responsibility of all health professionals, and dental practitioners may be in a unique position to recognise and respond to concerns of this kind. This article outlines some of the ways that abuse can present to the dental team and describes the actio...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.322
更新日期:2007-04-14 00:00:00
abstract::This fourth paper in the Future of Dentistry series examines the future of dental practice, particularly in terms of the National Health Service. David Watson-James' vision is, he explains, intrinsically linked to past and present developments in dentistry and as the last 50 years has seen dental practice largely infl...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809290
更新日期:1997-01-11 00:00:00
abstract::Email is a computer based method of sending messages from one computer to another. From its humble beginnings 40 years, it has matured to become a crucial tool in utilising the power of the Internet. More people have access to email than to any other Internet application, and despite the problems with spam email and v...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.271
更新日期:2007-04-14 00:00:00
abstract::The value of glove wearing as part of dental surgery cross-infection control regimen is negated if gloves are punctured during use. An assessment of the procedures most likely to give rise to glove puncture is therefore of importance. Accordingly, 892 gloves worn by two dentists in general practice were examined for p...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808187
更新日期:1993-06-05 00:00:00
abstract::A case is described in which a patient who was originally treated by radical mandibular surgery including rib grafting, having been told that she had a dentigerous cyst, presented 49 years later with a follicular ameloblastoma. The case is discussed in an attempt to determine whether the initial diagnosis could have b...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808126
更新日期:1993-03-20 00:00:00
abstract::I believe the time is coming when we should consider dropping the term 'malocclusion'. In its present meaning it is too mechanical and misrepresents the fundamental fact that an occlusion can only be judged against the tissue reactions to it or the patient's assessment of it. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.372
更新日期:2007-05-12 00:00:00